Journal of Nanoparticle Research最新文献_第2页

Cu₂SnS₃ nano-spheres as a potent therapeutic agents: exploring their antibacterial, antioxidant, and cytotoxic competencies

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-31 DOI: 10.1007/s11051-025-06237-x

Jolly B. Raval, Sunil H. Chaki, Sefali R. Patel, Yati H. Vaidya, Ankurkumar J. Khimani, Parth Thakor, Anjali B. Thakkar, Milind P. Deshpande

{"title":"Cu₂SnS₃ nano-spheres as a potent therapeutic agents: exploring their antibacterial, antioxidant, and cytotoxic competencies","authors":"Jolly B. Raval, Sunil H. Chaki, Sefali R. Patel, Yati H. Vaidya, Ankurkumar J. Khimani, Parth Thakor, Anjali B. Thakkar, Milind P. Deshpande","doi":"10.1007/s11051-025-06237-x","DOIUrl":"10.1007/s11051-025-06237-x","url":null,"abstract":"<div><p>Cu₂SnS₃ (CTS) is potent substitute for conventional compounds due to adjustable bandgap, conductivity of p-type, adaptable morphology, easy to synthesize, and superior thermoelectric properties. In this work, the CTS nano-spheres are synthesized by hydrothermal technique. The synthesized CTS nano-spheres are employed for the antibacterial, antioxidant, and cytotoxic application. Structural analysis by X-ray diffraction confirms cubic unit cell structure of CTS nano-spheres. The energy-dispersive X-ray analysis showed CTS nano-spheres to be copper-rich and tin-deficient. Scanning electron microscopy images revealed nano-spheres with needle-like surface features. The CTS nano-spheres possess direct bandgap of 1.58 eV, confirmed by diffuse reflectance spectroscopy. The antibacterial activity shows 100% activity index with higher zone of inhibition in <i>Listeria monocytogenes</i> and <i>Staphylococcus aureus.</i> The antioxidant activity of CTS nano-spheres determined using the DPPH assay showed IC<sub>50</sub> value of 61.60 µg/ml stating moderate antioxidant efficiency. The in vitro cytotoxic analysis is carried out by employing A549 lung cancer cell lines. The in vivo and vitro cytotoxic analysis provided the potent cytotoxicity of CTS nano-spheres, as reflected in LC<sub>50</sub> value of 40.40 µg/ml and IC<sub>50</sub> value of 57.75 ± 2.34 μg/ml. The mechanistic evolution of CTS nano-spheres for their antibacterial activity is proposed in this work. The leaching behaviour of CTS nano-spheres revealed higher leaching of Sn<sup>4+</sup> ions than Cu<sup>+</sup> ions, contributing to their strong antibacterial activity. The zeta potential of CTS nano-spheres is found to be − 30.70 mV, which showed less agglomeration of CTS nano-spheres, depicting an efficient antibacterial activity. The obtained results are rigorously analysed and supported with relevant data.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial properties of carbon “quantum” dots for food safety applications

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-31 DOI: 10.1007/s11051-025-06239-9

Jordan Collins, Liju Yang, Xiuli Dong, Ya-Ping Sun

{"title":"Antimicrobial properties of carbon “quantum” dots for food safety applications","authors":"Jordan Collins, Liju Yang, Xiuli Dong, Ya-Ping Sun","doi":"10.1007/s11051-025-06239-9","DOIUrl":"10.1007/s11051-025-06239-9","url":null,"abstract":"<div><p>Carbon dots represent a rapidly advancing and expanding research field, with a large number of literature reports on their potential technological applications including those relevant to food safety. In this article, the dot samples prepared by the deliberate chemical functionalization of preexisting small carbon nanoparticles or by thermal carbonization of various organic precursors under different processing conditions are highlighted and critiqued for their similarities and differences in sample structure-morphology and properties, especially antimicrobial properties for their food safety–related uses. Also highlighted and discussed are representative recent examples for the use of dot samples to inactivate foodborne pathogens, disrupt biofilms or prevent their formation, and extend the shelf life of food products, which involve different antibacterial mechanisms. Some perspectives on the further development of the carbon dots–based/derived antimicrobial platform and related excellent application opportunities in food safety are provided.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06239-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced electrochemical detection of SARS-CoV-2 IgG using magnetic nanocomplexes: evaluation of preparation processes and sensor stability

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-31 DOI: 10.1007/s11051-025-06240-2

Nimet Yildirim-Tirgil, Ezgi Ayni, Kubra Kaya

{"title":"Enhanced electrochemical detection of SARS-CoV-2 IgG using magnetic nanocomplexes: evaluation of preparation processes and sensor stability","authors":"Nimet Yildirim-Tirgil, Ezgi Ayni, Kubra Kaya","doi":"10.1007/s11051-025-06240-2","DOIUrl":"10.1007/s11051-025-06240-2","url":null,"abstract":"<div><p>This study focuses on the development of a novel electrochemical biosensor for the sensitive detection of SARS-CoV-2-specific IgG antibodies. The biosensor utilizes magnetic nanocomplexes, synthesized through three distinct methods, each varying the attachment sequence of the spike protein and aminoferrocene (A-Fc) to magnetic beads. This comparative approach allowed for a thorough evaluation of the impact of preparation methods on electrochemical performance. Process 1 involved initial spike protein binding followed by A-Fc attachment, while process 2 reversed this sequence. Process 3 combined both components before attachment. These nanocomplexes were further captured IgG from the samples, and the resulting complexes were detected on anti-IgG-immobilized MWCNT-modified SPE surfaces. Electrochemical techniques, including cyclic voltammetry and differential pulse voltammetry, revealed process 2 as the most effective, demonstrating superior sensitivity and peak current responses. This outcome was supported by Raman spectroscopy and scanning electron microscopy, which highlighted the enhanced chemical modifications and surface morphology achieved through this method. Long-term stability tests showed that process 2 nanocomplexes retained over 90% of their electrochemical activity after 13 weeks. In serum analysis, they demonstrated high recovery rates (90.83%) and low variability, outperforming processes 1 and 3. These findings establish process 2 as a reliable method for fabricating magnetic nanocomplexes, offering a robust platform for SARS-CoV-2 IgG detection and biosensing applications.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable halogen-free polymer composites for next-generation flexible electronics

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-30 DOI: 10.1007/s11051-025-06234-0

Maziyar Sabet

引用次数: 0

Stimuli-responsive nanoparticles: a novel approach for melanoma treatment

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-30 DOI: 10.1007/s11051-025-06231-3

Biswajit Rout, Sandeep Kr Maharana, Aakanchha Jain

{"title":"Stimuli-responsive nanoparticles: a novel approach for melanoma treatment","authors":"Biswajit Rout, Sandeep Kr Maharana, Aakanchha Jain","doi":"10.1007/s11051-025-06231-3","DOIUrl":"10.1007/s11051-025-06231-3","url":null,"abstract":"<p>Melanoma is a lethal form of skin cancer with a short prognosis, frequent metastases, malignant development, and quick recurrence. Conventional treatment options have multiple shortcomings in treating melanoma, such as poor patient compliance, high cost, frequent side effects, and others. All these limitations demand new and innovative alternatives to address the rising incidence and burgeoning healthcare burden of melanoma. In recent years, stimuli-responsive nanoparticles have emerged as one such alternative. These smart nanoparticles are engineered to release drug molecules in response to specific internal or external stimuli, thereby enhancing the precision of drug delivery and improving the therapeutic outcome against malignancies like melanoma. Additionally, some of these nanoparticles are capable of generating reactive oxygen species and excess heat upon activation by specific triggers, enabling them to kill cancer cells directly. This makes stimuli-responsive nanoparticles one of the most versatile nanocarrier systems in the fight against melanoma. This review highlights various stimuli-responsive nanoparticles, their preparation, and modes of action, as well as summarizes certain research findings, emphasizing their potential applications in melanoma treatment. Finally, it ends with a quick overview of the difficulties and prospects associated with these nanoparticles.</p>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing the societal impacts of nanotechnology applications in food and agricultural systems

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-29 DOI: 10.1007/s11051-025-06235-z

Melanie Kah, Carmen Gomes

{"title":"Increasing the societal impacts of nanotechnology applications in food and agricultural systems","authors":"Melanie Kah, Carmen Gomes","doi":"10.1007/s11051-025-06235-z","DOIUrl":"10.1007/s11051-025-06235-z","url":null,"abstract":"<div><p>This short perspective reflects on the last two decades of intense research in the field of nanoscale science and engineering for agriculture and food systems. Despite significant advances in knowledge and innovation that are well recognized in the scientific community, only a small number of nanoproducts have reached the market, and the societal impact of the research thus remains relatively limited. We want to reflect on what may be key reasons for this and propose four tips that will help reframe and improve some of our research practices with the aim of increasing our impact. Our views were collected through consultations and engagement with a wide range of stakeholders inside and outside of the scientific field, including regulators, successful entrepreneurs, potential users, and consumers. We want to encourage scientists to increase their consideration of actors outside of the scientific field in order to develop nanotechnologies that are needed, competitive, and acceptable to both regulators and users/consumers. The benefits of a technology must be assessed with a better consideration of the whole system (instead of a small part of it) and in a specific context that recognizes climatic, cultural, political, and economic differences. Essential qualities to increase our impact include a high capacity to continuously adapt and work in teams that bring a multidisciplinary and multisectoral understanding of the system, which is not always fully compatible with the way academic performances are currently evaluated.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06235-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the photothermal conversion performance of gold nanorods

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-28 DOI: 10.1007/s11051-025-06236-y

Guo-Wei Li, Hang-Yu Yan, Feng-Yuan Zhang, Run-Min Liu, Meng-Dai Luoshan, Li Zhou, Qu-Quan Wang

引用次数: 0

β-cyclodextrin inclusion complex as a potent delivery system for enhanced cytotoxicity of paclitaxel in triple-negative breast cancer cells

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-25 DOI: 10.1007/s11051-025-06229-x

Kamini Velhal, Parvindar Sah, Smitali Patil, Rajesh Raut, Ramesh Yamgar, Jaya Lakkakula, Imran Uddin

{"title":"β-cyclodextrin inclusion complex as a potent delivery system for enhanced cytotoxicity of paclitaxel in triple-negative breast cancer cells","authors":"Kamini Velhal, Parvindar Sah, Smitali Patil, Rajesh Raut, Ramesh Yamgar, Jaya Lakkakula, Imran Uddin","doi":"10.1007/s11051-025-06229-x","DOIUrl":"10.1007/s11051-025-06229-x","url":null,"abstract":"<div><p>The toxicity of drugs to normal cells exhibits a significant risk to human health. Currently, researchers worldwide are striving to develop custom-designed drugs that have reduced toxicity and fewer side effects. Polymeric nanoparticles have drawn interest in being a suitable anticancer drug carrier and molecular visualization. Paclitaxel (PTX) has great potential as an anticancer drug though it suffers from poor aqueous solubility, limiting its therapeutic efficacy. This study investigated a novel β-cyclodextrin (β-CD) inclusion complex for enhanced PTX delivery against triple-negative human breast cancer (aka. MDA-MB-231). Molecular docking simulations indicated the strongest binding between β-CD and PTX compared to α-CD and γ-CD. The 1:2 molar ratio of β-CD to PTX achieved the highest entrapment efficiency (over 95.23%) and improved PTX solubility. Characterization techniques confirmed the successful formation of inclusion complex PTX-β-CD (IC). The IC exhibited critical cytotoxicity against MDA-MB-231. It diminishes colony formation and hampers the migration of cells. Evaluation of cellular morphology by apoptosis assays demonstrated the formulations’ impact on both the cytoskeleton and cytotoxicity of MDA-MB-231, potentially inducing apoptosis. The synthesized IC shows significant potential for pharmaceutical development.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the efficacy of green nanoparticles in enhancing plant defense: a mechanistic investigation into immune response activation

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-24 DOI: 10.1007/s11051-025-06226-0

Himanshu Joshi

{"title":"Exploring the efficacy of green nanoparticles in enhancing plant defense: a mechanistic investigation into immune response activation","authors":"Himanshu Joshi","doi":"10.1007/s11051-025-06226-0","DOIUrl":"10.1007/s11051-025-06226-0","url":null,"abstract":"<div><p>Green nanoparticles (GNPs), biosynthesized using environment-friendly means, are attractive candidates for enhancing plant productivity and boosting sustainable agriculture. The article discusses the significant benefits that green nanoparticles bring to plant health by enhancing their defense mechanisms. GNPs, derived from natural sources, can interact with plant cells, leading to the induction of a cascade of defense responses. Entry of GNPs in plant cells leads to activation pattern recognition receptors (PRRs), leading to the production of reactive oxygen species (ROS) and the subsequent activation of defense-related genes. In addition, GNPs also induce systemic acquired resistance (SAR) as well as induced systemic resistance (ISR), priming the plant for augmenting defense against a wide range of pathogens. Additionally, GNPs interact with plant hormone pathways, altering the levels of phytohormones, including salicylic acid, jasmonic acid, and ethylene, resulting in optimized immune response. Additionally, the current review also elucidates the advantages of using green nanoparticles to increase disease resistance, improve pest management, and advance sustainable agriculture, highlighting their edge over traditional methods. The article discusses the challenges of formulating green nanoparticles for their optimization to make them cost-effective and points out promising future directions in this field. Furthermore, the review focuses on the beneficial role of gold nanoparticles in protecting plants, including their role in the plant’s immune system. The present study also highlights the relation between systemic acquired resistance and induced systemic resistance and its role in prompting these plant responses.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06226-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced antimicrobial activity of Cinnamomum zeylanicum essential oil nanoemulsions against Helicobacter pylori: a microfluidic-based assessment

IF 2.1 4区材料科学

Journal of Nanoparticle Research Pub Date : 2025-01-24 DOI: 10.1007/s11051-025-06227-z

Madineh Moradialvand, Parastoo Saniee, David Julian McClements, Hasan Rafati

{"title":"Enhanced antimicrobial activity of Cinnamomum zeylanicum essential oil nanoemulsions against Helicobacter pylori: a microfluidic-based assessment","authors":"Madineh Moradialvand, Parastoo Saniee, David Julian McClements, Hasan Rafati","doi":"10.1007/s11051-025-06227-z","DOIUrl":"10.1007/s11051-025-06227-z","url":null,"abstract":"<div><p>Exploring innovative approaches to combat <i>Helicobacter pylori</i> infections, this study investigates the antimicrobial efficacy of nanoemulsions derived from <i>Cinnamomum zeylanicum</i> (cinnamon) essential oil using an advanced microfluidic platform. Clinical isolates of <i>H. pylori</i> were obtained from gastric biopsies of five patients presenting with gastrointestinal complications at the Shariati Hospital in Tehran. Two nanoemulsion formulations (F<sub>1</sub> and F<sub>2</sub>) were developed with distinct particle sizes of 78 nm and 152 nm, respectively, achieved through varying surfactant concentrations. The antibacterial activity was systematically evaluated across multiple parameters, including particle size, concentration gradients (25–300 µg/mL), and residence times (2.5–45 min) within a custom-designed microfluidic device. Bacterial membrane disruption was quantitatively assessed through protein and nucleic acid release measurements, with maximum absorbance values of 1.50 (OD<sub>280nm</sub>) and 0.6 (OD<sub>260nm</sub>) observed for the F<sub>1</sub> as small size formulation. Scanning electron microscopy revealed significant morphological alterations in bacterial structure upon exposure to the nanoemulsions. Notably, the F<sub>1</sub> formulation (78 nm) demonstrated superior antimicrobial activity, achieving efficacy comparable to 70% ethanol at concentrations of 100 µg/mL within 2.5 min of exposure. This study presents a novel integration of nanotechnology and microfluidics for rapid assessment of natural antimicrobial compounds, offering potential applications in food preservation and therapeutic interventions against <i>H. pylori</i> infections.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0