Yanlian Lu, Zhengjie Liu, Mengmeng Ji, Lili Ren, Yanru Song, Guoqiang Zhou, Hua Yang, Kun Ge
{"title":"锶掺杂羟基磷灰石纳米复合材料通过调节骨形成和抑制癌细胞干性治疗乳腺癌骨转移","authors":"Yanlian Lu, Zhengjie Liu, Mengmeng Ji, Lili Ren, Yanru Song, Guoqiang Zhou, Hua Yang, Kun Ge","doi":"10.1007/s11051-025-06407-x","DOIUrl":null,"url":null,"abstract":"<div><p>Bone metastases is the most common incidence in the advanced stage of breast cancer patients. In clinic, chemotherapeutic drugs and anti-resorptive drugs are used to suppress cancer cell and osteoclast activity for the decreased incidence of bone-related events. However, the progression-free and 5-year survival rate is still very low in patients with breast cancer bone metastasis. Once bone metastasis occurs, tumor cells disrupt the bone microenvironment’s balance, causing osteolytic lesions and strengthening tumor cell stemness to accelerate metastasis. Therefore, addressing the complexity of bone microenvironment, this work developed new targeted therapeutic nanocomposites 20%Sr/HAP@CS@miR34a for breast cancer bone metastasis. The twenty-percentage strontium-doped hydroxyapatite nanoparticles (20%Sr/HAP) were prepared by hydrothermal method and had the ability to promote osteogenic differentiation and inhibit osteoclast differentiation. The nanocomposites 20%Sr/HAP@CS@miR34a was constructed by modifying chitosan and loading miR34a. 20%Sr/HAP@CS showed safe and bone-targeting capacity in mice after intravenous injection. 20%Sr/HAP@CS@miR34a weakened the stemness of breast cancer cells and decreased invasion and metastasis. 20%Sr/HAP@CS@miR34a also suppressed the formation of osteoclast-like cells in vitro and alleviated osteolysis in the 3D co-culture model of breast cancer bone metastasis. Therefore, 20%Sr/HAP@CS@miR34a nanocomposites provide a bone-targeting therapeutic strategy in the bone microenvironment for breast cancer bone metastasis.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 10","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Strontium-doped hydroxyapatite nanocomposites for breast cancer bone metastasis therapy by modulating bone formation and suppressing cancer cell stemness\",\"authors\":\"Yanlian Lu, Zhengjie Liu, Mengmeng Ji, Lili Ren, Yanru Song, Guoqiang Zhou, Hua Yang, Kun Ge\",\"doi\":\"10.1007/s11051-025-06407-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bone metastases is the most common incidence in the advanced stage of breast cancer patients. In clinic, chemotherapeutic drugs and anti-resorptive drugs are used to suppress cancer cell and osteoclast activity for the decreased incidence of bone-related events. However, the progression-free and 5-year survival rate is still very low in patients with breast cancer bone metastasis. Once bone metastasis occurs, tumor cells disrupt the bone microenvironment’s balance, causing osteolytic lesions and strengthening tumor cell stemness to accelerate metastasis. Therefore, addressing the complexity of bone microenvironment, this work developed new targeted therapeutic nanocomposites 20%Sr/HAP@CS@miR34a for breast cancer bone metastasis. The twenty-percentage strontium-doped hydroxyapatite nanoparticles (20%Sr/HAP) were prepared by hydrothermal method and had the ability to promote osteogenic differentiation and inhibit osteoclast differentiation. The nanocomposites 20%Sr/HAP@CS@miR34a was constructed by modifying chitosan and loading miR34a. 20%Sr/HAP@CS showed safe and bone-targeting capacity in mice after intravenous injection. 20%Sr/HAP@CS@miR34a weakened the stemness of breast cancer cells and decreased invasion and metastasis. 20%Sr/HAP@CS@miR34a also suppressed the formation of osteoclast-like cells in vitro and alleviated osteolysis in the 3D co-culture model of breast cancer bone metastasis. Therefore, 20%Sr/HAP@CS@miR34a nanocomposites provide a bone-targeting therapeutic strategy in the bone microenvironment for breast cancer bone metastasis.</p></div>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":\"27 10\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11051-025-06407-x\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06407-x","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Strontium-doped hydroxyapatite nanocomposites for breast cancer bone metastasis therapy by modulating bone formation and suppressing cancer cell stemness
Bone metastases is the most common incidence in the advanced stage of breast cancer patients. In clinic, chemotherapeutic drugs and anti-resorptive drugs are used to suppress cancer cell and osteoclast activity for the decreased incidence of bone-related events. However, the progression-free and 5-year survival rate is still very low in patients with breast cancer bone metastasis. Once bone metastasis occurs, tumor cells disrupt the bone microenvironment’s balance, causing osteolytic lesions and strengthening tumor cell stemness to accelerate metastasis. Therefore, addressing the complexity of bone microenvironment, this work developed new targeted therapeutic nanocomposites 20%Sr/HAP@CS@miR34a for breast cancer bone metastasis. The twenty-percentage strontium-doped hydroxyapatite nanoparticles (20%Sr/HAP) were prepared by hydrothermal method and had the ability to promote osteogenic differentiation and inhibit osteoclast differentiation. The nanocomposites 20%Sr/HAP@CS@miR34a was constructed by modifying chitosan and loading miR34a. 20%Sr/HAP@CS showed safe and bone-targeting capacity in mice after intravenous injection. 20%Sr/HAP@CS@miR34a weakened the stemness of breast cancer cells and decreased invasion and metastasis. 20%Sr/HAP@CS@miR34a also suppressed the formation of osteoclast-like cells in vitro and alleviated osteolysis in the 3D co-culture model of breast cancer bone metastasis. Therefore, 20%Sr/HAP@CS@miR34a nanocomposites provide a bone-targeting therapeutic strategy in the bone microenvironment for breast cancer bone metastasis.
期刊介绍:
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.