揭示了纳米银纳米粒子的结构及其在纳米肿瘤学领域的应用前景

IF 2.6 4区 材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Jesús A. Serrato-Barragan, Francisco Casillas-Figueroa, Roberto Luna-Vázquez-Gómez, Balam Ruiz-Ruiz, D. Garibo, Ana G. Rodríguez-Hernández, Alexey Pestryakov, Nina Bogdanchikova
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引用次数: 0

摘要

目前,纳米医学已成为一个高度探索的领域,为全球公共卫生问题寻找潜在的解决方案。在纳米医学中,银纳米粒子是研究最多的纳米粒子,因为它们具有优异的抗菌、杀真菌、抗病毒和抗癌特性。最近,我们的研究小组发现了一些非凡的特性,这些特性对特定的ArgovitTM AgNP商业配方的纳米肿瘤学有重大影响。结果表明:(1)与其他16种AgNP制剂相比,其抑制7种癌细胞生长的活性提高2 ~ 200倍(平均52倍);(2)选择性抑制癌细胞生长,选择性指数达到16。HRTEM、DLS、紫外可见光谱和电泳结果表明,ArgovitTM配方家族的AgNP结构不典型,不能用通常的AgNP (Ag芯被稳定剂分子包围)的结构来解释。假设这些基质可以用稳定剂形成的纳米和微凝胶来表示。这些非典型结构的形成可以导致它们显著的生物医学特性,这是纳米肿瘤学非常需要的。这些结果代表了揭示ArgovitTM配方家族AgNPs结构的第一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Shedding light on the structure of silver nanoparticles with promising properties for nano-oncology

Nowadays, nanomedicine has been a highly explored area for finding potential solutions to global public health problems. In nanomedicine, silver nanoparticles are the most studied nanoparticles due to their excellent antibacterial, fungicidal, antiviral, and anticancer properties. Recently, our research group has revealed some extraordinary properties that significantly impact nano-cancerology for specific commercial ArgovitTM AgNP formulations. It was shown that they (1) are 2 to 200 times (on average 52 times) more active than the other 16 AgNP formulations studied earlier in inhibiting the growth of 7 cancer cell lines, and (2) they selectively inhibit the growth of cancer cells with the selectivity index reaching 16. Results of the present work obtained with HRTEM, DLS, UV-visible spectroscopy, and electrophoresis indicate that the structure of AgNP of the ArgovitTM formulation family is atypical, which cannot be explained from the point of view of the structure of usual AgNPs (Ag cores surrounded by stabilizer molecules). It was hypothesized that these matrices can be represented by nano- and microgels formed by the stabilizer. The formation of these atypical structures can cause their remarkable biomedical properties, which are highly desirable for nano-oncology. These results represent the first step towards shedding light on the structure of AgNPs of the ArgovitTM formulation family.

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来源期刊
Journal of Nanoparticle Research
Journal of Nanoparticle Research 工程技术-材料科学:综合
CiteScore
4.40
自引率
4.00%
发文量
198
审稿时长
3.9 months
期刊介绍: The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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