Jesús A. Serrato-Barragan, Francisco Casillas-Figueroa, Roberto Luna-Vázquez-Gómez, Balam Ruiz-Ruiz, D. Garibo, Ana G. Rodríguez-Hernández, Alexey Pestryakov, Nina Bogdanchikova
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引用次数: 0
Abstract
Nowadays, nanomedicine has been a highly explored area for finding potential solutions to global public health problems. In nanomedicine, silver nanoparticles are the most studied nanoparticles due to their excellent antibacterial, fungicidal, antiviral, and anticancer properties. Recently, our research group has revealed some extraordinary properties that significantly impact nano-cancerology for specific commercial ArgovitTM AgNP formulations. It was shown that they (1) are 2 to 200 times (on average 52 times) more active than the other 16 AgNP formulations studied earlier in inhibiting the growth of 7 cancer cell lines, and (2) they selectively inhibit the growth of cancer cells with the selectivity index reaching 16. Results of the present work obtained with HRTEM, DLS, UV-visible spectroscopy, and electrophoresis indicate that the structure of AgNP of the ArgovitTM formulation family is atypical, which cannot be explained from the point of view of the structure of usual AgNPs (Ag cores surrounded by stabilizer molecules). It was hypothesized that these matrices can be represented by nano- and microgels formed by the stabilizer. The formation of these atypical structures can cause their remarkable biomedical properties, which are highly desirable for nano-oncology. These results represent the first step towards shedding light on the structure of AgNPs of the ArgovitTM formulation family.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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