Jaro-Journal of the Association for Research in Otolaryngology最新文献

{"title":"Developing a Calibration Method to Minimize Variability in Auditory Evoked Potentials.","authors":"Joseph Pinkl, Tao Shen, Jinsai Cheng, John Hawks, Jianxin Bao","doi":"10.1007/s10162-025-00982-5","DOIUrl":"10.1007/s10162-025-00982-5","url":null,"abstract":"<p><strong>Purpose: </strong>To reduce amplitude variability of auditory evoked potentials (AEPs) we developed a circuit that generates an electric calibration pulse (CalPulse) following each evoking sound presentation. We aim to determine if external CalPulse signals can function as a reliable calibration reference for AEP amplitude measurements.</p><p><strong>Methods: </strong>The CalPulse circuit was integrated with an AEP recording montage. The amplitude and morphology of two CalPulse signals (square wave and sine wave) was first assessed in vitro with electrodes submerged in saline. Repeatability of the two signals was then compared in vivo using five (3 male/2 female) 4-month-old CBA/CAJ mice and four unique auditory brainstem response (ABR) configurations. Sine wave CalPulse amplitudes were subsequently used to adjust raw ABR wave-1 amplitudes in a sample of 38 (19 male/19 female) CBA/CaJ mice. Variability in adjusted wave-1 amplitudes was compared with raw amplitudes. Measurements were repeated every month for 4 months (8 to 11 months old) to evaluate its potential as a tool to detect age-related changes in auditory function.</p><p><strong>Results: </strong>Wave quality examinations indicate that both CalPulse signal types are stable in vitro, with the sine wave signal being more repeatable when recorded in vivo. Sine wave CalPulse amplitudes correlated positively with ABR wave-1 amplitudes. Normalizing wave-1 amplitudes with CalPulse measures significantly reduced within-subject variability. Normalized wave-1 amplitudes showed a significant decrease at 10 months of age consistent with age-related cochlear synaptopathy, while uncalibrated wave-1 amplitudes from the same recordings failed to detect this decrease.</p><p><strong>Conclusion: </strong>Our new calibration circuit can be used to improve diagnostic sensitivity of AEP measures.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"111-126"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Inner Ear and Aging Brain: A Cross-Sectional Study of Vestibular Function and Morphometric Variations in the Entorhinal and Trans-Entorhinal Cortex.","authors":"Claire J Vania, Dominic Padova, J Tilak Ratnanather, Yuri Agrawal","doi":"10.1007/s10162-025-00977-2","DOIUrl":"10.1007/s10162-025-00977-2","url":null,"abstract":"<p><strong>Purpose: </strong>While the vestibular system is crucial for balance, posture, and stable vision, emerging evidence connects vestibular loss in older adults to spatial cognitive deficits. However, the specific neural pathways remain unclear. This study examines morphometric changes in the entorhinal cortex (ERC) and trans-entorhinal cortex (TEC), key regions in the vestibular spatial cognitive network, with vestibular function.</p><p><strong>Methods: </strong>This cross-sectional study used T1-weighted MRI images and vestibular physiological data from 103 Baltimore Longitudinal Study of Aging participants (74 males and 29 females). Vestibular function was assessed through the cervical vestibular-evoked myogenic potential (cVEMP), ocular VEMP (oVEMP), and video head-impulse test (vHIT), examining both categorical presence/absence of responses and continuous measures (cVEMP amplitude, oVEMP amplitude, and VOR gain). Morphometric changes in the ERC and TEC were analyzed by examining surface expansions and contractions relative to average shapes.</p><p><strong>Results: </strong>Reduced saccular function correlated with surface expansion in the left ERC's pro-rhinal, right ERC's intermediate caudal and superior regions, and right TEC's sulcal region. The decreased utricular function was associated with surface contraction in the left lateral TEC, left ERC's anterior sulcal and trans-entorhinal regions, and surface expansion in the lateral region of the left ERC. Reduced canal function showed surface contraction in the right ERC's pro-rhinal and lateral regions and the right TEC's posterior sulcal and trans-entorhinal regions.</p><p><strong>Conclusion: </strong>These findings highlight the intricate link between vestibular function and ERC/TEC morphology, emphasizing their role in spatial and cognitive abilities. Future research will assess if structural changes due to vestibular loss contribute to cognitive deficits in aging and Alzheimer's disease.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"171-184"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for the Auditory Nerve Generating Envelope Following Responses When Measured from Eardrum Electrodes.","authors":"Skyler G Jennings, Jessica Chen, Nathan Johansen, Shawn S Goodman","doi":"10.1007/s10162-025-00979-0","DOIUrl":"10.1007/s10162-025-00979-0","url":null,"abstract":"<p><p>Steady-state auditory evoked potentials are useful for studying the human auditory system and diagnosing hearing disorders. Identifying the generators of these potentials is essential for interpretation of data and for determining appropriate clinical and research applications. Here we infer putative generators of a steady-state potential measured from an electrode on the eardrum and compare this potential with the traditional envelope following response (EFR) measured from an electrode on the high forehead (N = 18, 10 female). We hypothesized that responses from the eardrum electrode would be consistent with an auditory nerve (AN) compound action potential (CAP) evoked by each cycle of the stimulus envelope, resulting in a potential we call CAP_ENV. Steady-state potentials were evoked by a 90 dB peSPL, 3000-Hz puretone carrier whose envelope was modulated by a tone sweep with frequencies from 20 to 160 Hz or 80 to 640 Hz. We calculated group delay to infer potential generators. We also compared the empirically measured CAP_ENV with simulated CAP_ENV from a humanized model of AN responses. Response latencies and model simulations support the interpretation that CAP_ENV is generated by the AN rather than hair cell or brainstem generators for all modulation frequencies tested. Conversely, latencies for the traditional EFR were consistent with a shift from cortical to brainstem generators as the modulation frequency increased from 20 to 200 Hz. We propose that CAP_ENV may be a fruitful tool for assessing AN function in humans with suspected AN fiber loss and/or temporal coding disorders.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"147-162"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cochlear Basal Turn Patency in Children with Hearing Loss.","authors":"Marina Aramendi, Mariana Raviolo, Ina Sorge, Sylvia Meuret, Martin Sorge, Franz Wolfgang Hirsch, Daniel Gräfe","doi":"10.1007/s10162-025-00981-6","DOIUrl":"10.1007/s10162-025-00981-6","url":null,"abstract":"<p><strong>Purpose: </strong>A patency at the cochlear basal turn (CBTP) can lead to an abrupt leakage of CSF, known as intraoperative CSF gusher. To date, there is no established technique for predicting an intraoperative CSF gusher. We aim to establish the prevalence, width and anatomical variation of CBTP in patients with and without hearing loss as well as to estimate its association between intraoperative CSF gusher.</p><p><strong>Methods: </strong>A retrospective review of high-resolution CT images and medical records from 165 pediatric patients (330 ears) was conducted (57 males/108 females). Patients were grouped based on audiometry results: a hearing loss group and healthy controls. The presence and size of CBTP was assessed using multiplanar reconstruction techniques. The incidence of intraoperative CSF gusher was recorded and correlated with the width of CBTP.</p><p><strong>Results: </strong>Cochlear basal turn patency was found in 44.2% of ears without significant differences between both groups (p = 0.06). Intraoperative CSF gusher occurred in 5.1% of cases, more frequently in ears with inner ear malformations (27.3%). A CBTP larger than 0.75 mm did not predict intraoperative CSF gusher (p = 0.55). Enlarged vestibular aqueduct was significantly the more common malformation in patients with intraoperative CSF gusher (p < 0.01).</p><p><strong>Conclusion: </strong>Intraoperative CSF gusher highlights the need for reliable imaging predictors. Yet, CBTP alone does not predict this phenomenon, indicating other contributing factors beyond known imaging findings.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"163-170"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.","authors":"Aleksandra Ivanovic, Jeffrey Tao Cheng, Margaux Schmeltz, Wilhelm Wimmer, Christian M Schlepuetz, Aaron K Remenschneider, Anne Bonnin, Lukas Anschuetz","doi":"10.1007/s10162-024-00971-0","DOIUrl":"10.1007/s10162-024-00971-0","url":null,"abstract":"<p><strong>Purpose: </strong>There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).</p><p><strong>Methods: </strong>We examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512 Hz, stimulated at 110 dB and 120 dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method.</p><p><strong>Results: </strong>The normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5-10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.</p><p><strong>Conclusion: </strong>In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear's biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"63-75"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reduced Cortilymph Flow Path in the Short-Wave Region Allows Outer Hair Cells to Produce Focused Traveling-Wave Amplification.","authors":"John J Guinan, Nam Hyun Cho, Sunil Puria","doi":"10.1007/s10162-025-00976-3","DOIUrl":"10.1007/s10162-025-00976-3","url":null,"abstract":"<p><strong>Purpose: </strong>Recent measurements show organ-of-Corti (OoC) motions that do not fit the classic hypothesis that outer hair cells (OHCs) amplify by pushing on the basilar membrane (BM) through stiff Deiters cells. One particularly surprising motion is that far below the best frequency (BF), the transverse motion of the OHC bottom is much greater than BM or reticular lamina (RL) motions.</p><p><strong>Methods: </strong>We explore this with (1) data from seven gerbils showing that the ratio, Rohc, of transverse motions at the OHC top to the OHC bottom is small at low frequencies but large near BF and (2) a heuristic model for the impedances of structures in a transverse cut through the OoC (the TOoC model) that accounts for Rohc.</p><p><strong>Results: </strong>The key idea is that when OHCs cyclically squeeze/expand, they force fluid out/into the space surrounding the OHCs which changes the local OoC area. At each time instant, cortilymph flows longitudinally along the tunnels from where OHCs squeeze to where OHCs expand, which is one-half the traveling-wave wavelength, λ. The impedance seen by OHCs for forcing cortilymph out/into and along the tunnels is termed Z_OUT. Assuming that Z_OUT decreases as λ gets shorter, the model Rohc shows the same frequency pattern as Rohc measurements.</p><p><strong>Conclusion: </strong>Cyclic OHC forces produce OoC area changes consistent with those hypothesized to drive traveling-wave amplification. Z_OUT variation with λ allows wide-band OHC motility to produce large OoC area changes and RL motions only near BF where λ is small, thereby producing narrow-band traveling-wave amplification. The model accounts for why, at low frequencies, the motion at the bottom of the OHCs is larger than BM motion. The model also explains why the OoC has longitudinal fluid spaces that connect to the fluid surrounding the OHCs.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"49-61"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sources of Microstructure in Mammalian Cochlear Responses.","authors":"James B Dewey","doi":"10.1007/s10162-025-00974-5","DOIUrl":"10.1007/s10162-025-00974-5","url":null,"abstract":"<p><p>Quasiperiodic fluctuations with frequency are observed in a variety of responses that either originate from or strongly depend on the cochlea's active mechanics. These spectral microstructures are unique and stable features of individual ears and have been most thoroughly studied in behavioral hearing thresholds and otoacoustic emissions (OAEs). While the exact morphology of the microstructure patterns may differ across measurement types, the patterns are interrelated and are thought to depend on common mechanisms. This review summarizes the characteristics and proposed origins of the microstructures observed in behavioral and OAE responses, as well as other mechanical and electrophysiological responses of the mammalian cochlea. Throughout, the work of Glenis Long and colleagues is highlighted. Long contributed greatly to our understanding of microstructure and its perceptual consequences, as well as to the development of techniques for reducing the impact of microstructure on OAE-based assays of cochlear function.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"1-15"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Patient-Specific Variations in Intra-Cochlear Neural Health Estimated Using Psychophysical Thresholds and Panoramic Electrically Evoked Compound Action Potentials (PECAPs).","authors":"Tommy Peng, Charlotte Garcia, Mica Haneman, Maureen J Shader, Robert P Carlyon, Colette M McKay","doi":"10.1007/s10162-024-00972-z","DOIUrl":"10.1007/s10162-024-00972-z","url":null,"abstract":"<p><strong>Purpose: </strong>Variations in neural survival along the cochlear implant electrode array leads to off-place listening, resulting in poorer speech understanding outcomes for recipients. Therefore, it is important to develop and compare clinically viable tests to identify these patient-specific intra-cochlear neural differences.</p><p><strong>Methods: </strong>Nineteen experienced cochlear implant recipients (9 males and 10 females) were recruited for this study. We estimated the neural health along the electrode array for a group of experienced adult implant recipients using two methods: the difference between psychophysical detection thresholds in bipolar vs. monopolar mode and the panoramic electrically evoked compound action potential method (PECAP). We hypothesised that: neural health estimated using both methods at single electrodes will be correlated at the participant level and the group level; and participants with larger variations in neural health along the electrode array will have poorer speech outcomes.</p><p><strong>Results: </strong>At the individual level, the two neural measures correlated significantly across electrodes (p < 0.05) for 5 out of 15 participants. At the group level, we observed a weak but significant across-electrode correlation (R² = 0.111, p < 0.001). While a larger variation in neural measures estimated from psychophysical thresholds was associated with lower phoneme speech scores (R² = 0.499, p < 0.01), no significant association was found between variations in PECAP's neural health estimates and phoneme speech scores (R² = 0.082, p = 0.366).</p><p><strong>Conclusion: </strong>Our evidence suggests that both methods likely quantify a shared underlying neural basis, hypothesised to be the neural health along the cochlear implant array. The differences between the two measures may be attributed to differences in stimulus rate or loudness used to elicit responses and/or the influence of factors arising more centrally than the auditory nerve.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"77-91"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ins and Outs of Distortion Product Otoacoustic Emission Growth: A Review.","authors":"Courtney Coburn Glavin, Sumitrajit Dhar","doi":"10.1007/s10162-024-00969-8","DOIUrl":"10.1007/s10162-024-00969-8","url":null,"abstract":"<p><p>Otoacoustic emissions (OAEs) are low-level signals generated from active processes related to outer hair cell transduction in the cochlea. In current clinical applications, OAEs are typically used to detect the presence or absence of hearing loss. However, their potential extends far beyond hearing screenings. Dr. Glenis Long realized this unfulfilled potential decades ago. She subsequently devoted a large portion of her storied scientific career to understanding OAEs and cochlear mechanics, particularly at the intersection of OAEs and perceptual measures. One specific application of OAEs that has yet to be translated from research laboratories to the clinic is using them to non-invasively characterize cochlear nonlinearity-a hallmark feature of a healthy cochlea-across a wide dynamic range. This can be done by measuring OAEs across input levels to obtain an OAE growth, or input-output (I/O), function. In this review, we describe distortion product OAE (DPOAE) growth and its relation to cochlear nonlinearity and mechanics. We then review biological and measurement factors that are known to influence OAE growth and finish with a discussion of potential applications. Throughout the review, we emphasize Dr. Long's many contributions to the field.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"17-32"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Do Mismatch Negativity (MMN) Responses Tell Us About Tinnitus?","authors":"Ekaterina A Yukhnovich, Kai Alter, William Sedley","doi":"10.1007/s10162-024-00970-1","DOIUrl":"10.1007/s10162-024-00970-1","url":null,"abstract":"<p><p>Due to the heterogeneous causes, symptoms and associated comorbidities with tinnitus, there remains an unmet need for a clear biomarker of tinnitus presence. Previous research has suggested a \"final pathway\" of tinnitus presence, which occurs regardless of the specific mechanisms that resulted in alterations of auditory predictions and, eventually, tinnitus perception. Predictive inference mechanisms have been proposed as the possible basis for this final unifying pathway. A commonly used measure of prediction violation is mismatch negativity (MMN), an electrical potential generated in response to most stimuli that violate an established regularity. This narrative review discusses 16 studies comparing MMN between tinnitus and non-tinnitus groups. Methods varied considerably, including type of deviant, type of paradigm and carrier frequency. A minority of studies matched groups for age, sex and hearing, with few measuring hyperacusis. Frequency deviants were the most widely studied; at frequencies remote from tinnitus, MMN was consistently smaller in tinnitus groups, though hyperacusis or altered distress or attention could not be ruled out as explanatory factors. Few studies have used tinnitus-related frequencies; these showed larger MMN to upward frequency deviants above the tinnitus frequency, and larger MMN to upward intensity deviants at or close to the tinnitus frequency. However, the latter appears a correlate of hyperacusis rather than tinnitus, and tinnitus groups without hyperacusis instead show larger MMN to downward intensity deviants than controls. Other factors that affect MMN amplitudes included age, attention, and the specific characteristics of the range of stimuli across a particular experiment paradigm. As such, MMN cannot presently be considered a specific biomarker of tinnitus, but showed potential to objectively characterise a number of auditory processing traits relevant to tinnitus and hyperacusis.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"33-47"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}