Jaro-Journal of the Association for Research in Otolaryngology最新文献

{"title":"A Phenome-Wide Comorbidity Atlas of Age-Related Hearing Loss, Speech-in-Noise Deficits, and Tinnitus: Distinguishing Causal Signals from Correlation.","authors":"Ishan Sunilkumar Bhatt, Denise Tucker, Mitra Britton, Ashely Hoffa, Brandon J Pate, Raquel Dias, Juan Antonio Raygoza Garay","doi":"10.1007/s10162-025-01008-w","DOIUrl":"https://doi.org/10.1007/s10162-025-01008-w","url":null,"abstract":"<p><strong>Purpose: </strong>The present study employed a data-driven and hypothesis-free approach to identify comorbidities associated with age-related hearing loss (ARHL), speech-in-noise (SIN) deficits, and tinnitus.</p><p><strong>Methods: </strong>The study performed phenome-wide co-occurrence association analyses using the UK Biobank cohort to identify comorbidities associated with ARHL (N = 429,318), SIN deficits (N = 437,155), tinnitus (N = 172,527), and tinnitus severity (N = 57,657). Medical health records were accessed to obtain ICD-10 codes, which were converted into phecodes reflecting a modern disease classification. The statistical analysis was conducted to identify comorbidities associated with ARHL, SIN deficits, tinnitus, and tinnitus severity while statistically controlling for age, sex, ethnicity, and genetic ethnicity. Phenotype risk scores (PheRS) for hearing conditions were calculated. A complementary phenome-wide genetic correlation analysis was conducted to identify genetic comorbidities associated with these conditions. We utilized the summary statistics of recent genome-wide association studies of ARHL (N = 723,266), SIN deficits (N = 443,482), tinnitus (N = 132,438), and tinnitus severity (N = 132,438). The results of the phenome-wide association analyses were subjected to enrichment analysis to identify trait categories involved in hearing conditions. A complementary phenome-wide latent causal variant (LCV) analysis was employed to obtain causal inference by distinguishing between horizontal pleiotropy and true causality.</p><p><strong>Results: </strong>The phenome-wide co-occurrence association analysis identified 383, 449, 283, and 216 medical conditions associated (FDR p < 0.05) with ARHL, SIN deficits, tinnitus, and tinnitus severity, respectively. Gastrointestinal conditions revealed significant enrichment across all traits. Respiratory, genitourinary, and sense organs showed significant enrichment with ARHL, SIN deficits, and tinnitus. SIN deficits and tinnitus severity showed significant enrichment with mental Health and neurological conditions. Elevated PheRS significantly increased the risk of expressing their respective phenotypes. A phenome-wide genetic correlation analysis identified 376, 254, 97, and 188 health traits associated with ARHL, SIN deficits, tinnitus, and tinnitus severity, respectively. Mental health and medical symptoms were significantly enriched for all hearing conditions in the genetic correlation analyses. The results of LCV analyses revealed widespread horizontal pleiotropy driving most genetic correlations. In contrast, only a few traits demonstrated a true causal relationship.</p><p><strong>Conclusion: </strong>This study mapped phenotypic and genotypic comorbidity profiles of ARHL, SIN deficits, tinnitus, and tinnitus severity. We observed a robust enrichment of gastrointestinal traits with all hearing conditions, suggesting a potential role of gut dysbiosis in their pathogenesis. The","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into Stria Vascular Function, Stria Immunity, and Age-Related Hearing Loss.","authors":"Xiaorui Shi","doi":"10.1007/s10162-025-01010-2","DOIUrl":"https://doi.org/10.1007/s10162-025-01010-2","url":null,"abstract":"<p><p>The microvasculature plays a crucial role in maintaining auditory health by delivering essential nutrients such as glucose, ions, growth factors, and hormones, while also facilitating the elimination of metabolic waste. Simultaneously, the innate immune system acts as a protective barrier against cochlear damage caused by infections, toxic substances, and foreign agents. The normal functioning of these two systems creates an appropriate microenvironment that supports the health of sensory hair cells and spiral ganglion neurons. Disruptions in blood flow or inappropriate activation of the immune response can result in cochlear hypoxia and inflammation, both of which are linked to various auditory disorders. Understanding the characteristics and functions of these two systems could offer valuable insights into their distinct roles, potentially leading to the development of new treatments for hearing disorders associated with their dysfunction. This review covers the cellular characteristics and functions of both the vascular network and the innate immune cells within the stria vascularis, with a particular focus on how changes in both systems contribute to age-related hearing loss (ARHL), a common sensory deficit affecting the elderly population.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on the Role of the Stria Vascularis in Menière's Disease Pathogenesis.","authors":"Pablo Cruz-Granados, Sreeparna Das, Kiana Bagheri-Loftabad, Jose A Lopez-Escamez","doi":"10.1007/s10162-025-01006-y","DOIUrl":"https://doi.org/10.1007/s10162-025-01006-y","url":null,"abstract":"<p><strong>Purpose: </strong>The stria vascularis (SV) is a secretory epithelium that maintains fluid homeostasis and generates the endocochlear potential in the cochlear duct. Multiomic studies have identified genes in the SV that could contribute to the pathogenesis of Menière's Disease (MD), a disorder defined by episodic vertigo, sensorineural hearing loss, and tinnitus. This systematic review identified genes expressed in the SV cell types (marginal, intermediate, and basal) and gap junction proteins to evaluate their pathophysiological connections to MD.</p><p><strong>Methods: </strong>We conducted a literature search on 1293 articles relevant to MD and SV that were screened for SV genes involved in MD. Following quality assessment, 130 studies met the inclusion criteria, comprising 26 human studies, 101 animal studies, and three human-animal studies.</p><p><strong>Results: </strong>Seven immune-related and six auditory-related genes were identified: CACNA1D, ESRRB, HGF, KCNE1, MDH1, QSOX1, and SLC12A2 (marginal cells); ACTB, TMEM176A, and TMEM176B (intermediate cells); and ACTN1, COL11A2, and GSTM1 (basal cells). Gene-set-enrichment-analysis revealed pathways involving gap-junction assembly and electrical coupling. International Mouse Phenotyping Consortium data showed Gja1 and Kcne1 knockouts have immune system abnormalities. Single-cell RNA sequencing data of the lateral wall revealed high expression of Coch, Dtna, and Prkcb in fibrocytes, Reisner's cells, and immune cells. Furthermore, TWEAK released from intermediate cells and bound to its receptor (TNFRSF12A) in the marginal cells may upregulate NF-κB inflammatory response in MD patients.</p><p><strong>Conclusion: </strong>We hypothesize that some SV genes may contribute to the audiovestibular phenotype in MD, but most of them play a role in the altered immune response found in Sporadic MD.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief Acoustic Tinnitus Suppression as a Diagnostic Procedure in Clinical Routine: Feasibility and Results.","authors":"Stefan Schoisswohl, Martin Vizethum, Martin Schecklmann, Andreas Reissmann, Veronika Vielsmeier, Katharina Kerkel, Berthold Langguth","doi":"10.1007/s10162-025-01004-0","DOIUrl":"https://doi.org/10.1007/s10162-025-01004-0","url":null,"abstract":"<p><p>Brief acoustic tinnitus suppression (BATS) is a well-known phenomenon among tinnitus patients. Most knowledge about BATS comes from experiments applying filtered, modulated, or customized stimuli in selected patient populations. Testing BATS in clinical routine could provide valuable information for patient subtyping and assistance in treatment decision-making. Here, we investigated the feasibility of BATS tests beyond controlled experimental settings. Seventy individuals with tinnitus (29 female) were tested for BATS using white noise as part of a first consultation visit at the Interdisciplinary Tinnitus Center in Regensburg. The procedure turned out to be feasible under clinical routine conditions. Thirty-five patients (50%) reported some form of tinnitus suppression, with 6 (8.6%) reporting at least 50% reduction and 1 (1.4%) complete absence of their tinnitus percept. The degree of suppression was rated as relevant improvement by most patients. In summary, the integration of BATS assessments was feasible and provided valuable information about the patients' tinnitus.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Targeting of AAV Gene Therapy for Inner Ear Following Systemic Delivery: Preliminary Findings and Transduction Pattern in Rat Cochlea.","authors":"Zannatul Ferdous, Trung N Le, Zhifen Zhang, Yumai Situ","doi":"10.1007/s10162-025-01009-9","DOIUrl":"https://doi.org/10.1007/s10162-025-01009-9","url":null,"abstract":"<p><strong>Purpose: </strong>Delivery of therapeutics to the inner ear is complicated by their inaccessible location and the presence of the blood-labyrinth barrier that restricts most blood-borne compounds from entering the inner ear. This study addresses the challenge of optimal delivery in treating inner ear disease, focusing on magnetic targeting gene therapy using adeno-associated virus (AAV).</p><p><strong>Methods: </strong>The investigation explores three AAV serotypes (AAV2 Quad Mut, AAV2 pANC80L65, and AAV9 PHP.eB) delivered systemically, tagged with a brain-derived nerve growth factor (BDNF) transgene and GFP reporter protein, and captured with superparamagnetic nanoparticles. External magnets target AAV delivery to the Left ear of both male and female Long Evans rats. After 2 weeks, we evaluated tropism and transduction in both cochleae and assessed distribution in other major organs (heart, lung, liver, kidney, spleen, and brain) using immunohistochemistry, real-time polymerase chain reaction, and enzyme-linked immunosorbent assays. Six animals were used for each experimental group.</p><p><strong>Results: </strong>Immunofluorescence analysis demonstrated the qualitative distribution of AAVs in sensory cells and spiral ganglion neurons (SGN) in both ears. A significant increase in BDNF gene expression in the targeted left ear of rats administered AAV2 Quad Mut was observed. A single dose of magnetic targeting of AAV2 Quad Mut effectively transduced SGN and enhanced BDNF expression, leading to the restoration of ouabain-induced SGN loss and hearing loss (HL).</p><p><strong>Conclusion: </strong>These findings indicate the potential of magnetic targeting to direct gene therapy following systemic delivery, paving the way for future applications in the treatment of HL.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells.","authors":"Chuan Zhi Foo, Anne Duggan, Elizabeth T Bartom, Litao Tao, Jaime García-Añoveros","doi":"10.1007/s10162-025-01005-z","DOIUrl":"https://doi.org/10.1007/s10162-025-01005-z","url":null,"abstract":"<p><strong>Purpose: </strong>The mammalian cochlea has two types of low abundance and highly specialized inner (IHC) and outer (OHC) mechanosensory hair cells. Their malfunction or death is a common cause of congenital and acquired deafness. IHCs and OHCs exhibit different transcriptomes during development. We wondered how differences in gene expression are regulated at the chromatin level in developing IHCs and OHCs, and whether there were also differences in mRNA splicing between IHCs and OHCs.</p><p><strong>Methods: </strong>We separately collected developing mouse IHCs and OHCs to identify their mRNAs and chromatin states. We examined their transcriptomes by bulk (full coverage) RNA-seq from six biological replicates each to reveal differences in gene expression and in alternative mRNA splicing. We also examined their chromatin conformation by bulk ATAC-seq from two biological replicates each to reveal open vs. closed promoter and enhancer elements. We then compared ATAC-seq with RNA-seq datasets to determine if differential chromatin accessibility can account for differential gene expression. Each biological replicate consists of hair cells pooled from multiple neonatal mice of both sexes.</p><p><strong>Results: </strong>We found that developing IHCs and OHCs have differentially accessible promoters in many differentially expressed genes. This includes functional genes whose expression is incipient in neonatal hair cells but will be maintained throughout life, and developmental genes which are only expressed transiently. We also found that different mRNA isoforms result from alternative mRNA splicing and transcription start sites. Finally, our data reveals that cochlear hair cells utilize unique promoters and mRNA isoforms absent in other cell types.</p><p><strong>Conclusion: </strong>Differential transcriptomes between developing hair cell types result from pre- and post-transcriptional mechanisms. The unique promoters and mRNA isoforms in cochlear HCs highlight the importance of elucidating transcriptomes and epigenomes of rare cell types. We provide a comprehensive resource for the identification of promoters and mRNA isoforms of genes expressed by neonatal IHCs or OHCs, which is publicly-accessible for visualization of any gene of interest at  https://igvviewer.s3.us-east-2.amazonaws.com/index.html .</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrated System for Comprehensive Mouse Peripheral Vestibular Function Evaluation Based on Vestibulo-ocular Reflex.","authors":"Tong Zhao, Shijie Xiao, Wenda Liu, Jinhao Zhong, Binxian Sun, Fangyi Chen","doi":"10.1007/s10162-025-01007-x","DOIUrl":"https://doi.org/10.1007/s10162-025-01007-x","url":null,"abstract":"<p><strong>Purpose: </strong>In the fields of both vestibular and auditory research, reliable vestibular function tests are essential. However, unlike the auditory function tests, which use standard Auditory Brainstem Response (ABR) equipment, there is no equivalent widely adopted apparatus for vestibular tests. Vestibulo-ocular reflexes (VORs) are the compensatory ocular reflexes that ensure stable vision during head motion. VORs are widely used in clinics to diagnose vestibular deficits. In the research, VORs have been used by various groups to evaluate the mouse vestibular function. However, the effectiveness of VOR tests has not been systematically evaluated with appropriate mouse models, and the lack of commercial equipment hampers its accessibility, confining vestibular testing to a select few labs.</p><p><strong>Methods: </strong>In this study, we developed an integrated and surgery-free instrument system with both angular VOR (aVOR) and off-vertical axis rotation (OVAR) modes for evaluating mouse vestibular function. In addition, the eye rotation calibrations used in this study standardize the data between instruments. To demonstrate its validity and efficacy of the testing equipment, we evaluated four mouse models, including both genders, with peripheral vestibular deficits: 1) mice injected with the vestibulotoxic drug 3,3'-iminodiproprionitrile (IDPN, 2 mg/g and 4 mg/g, 3 male/3 female per group); 2) Critical MET-related mutant mice (Cdh23^v2J/v2J, 4 male/4 female and TMC1^-/-, 6 male/5 female); 3) Vestibular-specific mutant mice (Zpld1^-/-, 6 male/6 female, for semicircular canal dysfunction and Otop1^tlt/tlt, 3 male/2 female, for otoconia deficient); 4) Unilateral vestibular lesion (UVL) mouse model (3 male/3 female per group) where gentamicin was injected into horizontal semicircular canal.</p><p><strong>Results: </strong>The results showed: 1) Quantification of vestibular deficits can be achieved as a daily routine; 2) Both the horizontal semicircular canal and otolith organs can be assessed, respectively; and 3) The lesion side of UVL can be identified.</p><p><strong>Conclusion: </strong>These test results reveal the potential of our system as standard equipment for evaluating common vestibular deficits in mice.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Auditory-Nerve Implant Enhances Brainstem Phase Locking to Electric Pulse Trains.","authors":"John C Middlebrooks, Matthew L Richardson, Robert P Carlyon, Harrison W Lin","doi":"10.1007/s10162-025-01003-1","DOIUrl":"https://doi.org/10.1007/s10162-025-01003-1","url":null,"abstract":"<p><strong>Purpose: </strong>Present-day cochlear implants (CIs) can deliver usable speech reception in quiet surroundings. Most CI users, however, show impaired sensitivity to temporal fine structure, which hampers their use of pitch contours and spatial cues to segregate competing talkers. In previous short-term animal studies, we used intraneural (IN) electrodes to stimulate pathways originating from various cochlear turns. Neurons in the inferior colliculus synchronized to apical stimulation at higher rates than to stimulation of the middle-to-basal pathways that are stimulated primarily by today's CIs. Here, we use non-invasive recordings to test the safety and efficacy of up to 6 months of IN implantation and stimulation in cats.</p><p><strong>Methods: </strong>Deafened cats (ten female, two male) were implanted with IN and/or conventional CI electrodes. The IN electrodes were single activated-iridium shanks that targeted apical-turn fibers. Scalp recordings were made from sedated animals at 2-3-week intervals. Auditory brainstem responses to single electrical pulses (eABR) tracked sensitivity and growth of responses. Frequency following responses to electrical pulse trains (eFFR) assessed brainstem temporal transmission at varying pulse rates.</p><p><strong>Results: </strong>Thresholds for eABR were lower for IN than for CI stimulation, dynamic ranges were wider, and (by inference) spread of activation was more restricted. The eFFR evaluated at latencies comparable to those of inferior-colliculus spikes synchronized at maximum pulse rates averaging > 360 pulses/s for IN compared to ~ 240 pulses/s for CI stimulation. The eABR thresholds and eFFR cutoff rates were stable out to 6 months after implantation.</p><p><strong>Conclusions: </strong>The results demonstrate the safety and efficacy of chronic IN stimulation in an animal model. In a future clinical device, an IN electrode could augment cochlear-implant performance by enhancing temporal acuity, thereby improving speech reception amid competing sounds.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinnitus Measured in Everyday Life: A Literature Review of Ecological Momentary Assessment Studies.","authors":"Milena Engelke, Sebastian Müller, Berthold Langguth, Rüdiger Pryss, Winfried Schlee","doi":"10.1007/s10162-025-00995-0","DOIUrl":"10.1007/s10162-025-00995-0","url":null,"abstract":"<p><p>Tinnitus, a common auditory phenomenon, often presents with considerable between-person heterogeneity and within-person fluctuations. To understand the pathophysiological mechanisms and advance patient-centred care, it is essential to recognise these variations. Ecological Momentary Assessment (EMA) is a (close-to) real-time data collection method that offers insights into short- and long-term fluctuations of subjective symptoms and their interaction with psychological, environmental, and physiological factors. EMA applied in tinnitus research has shown promise in capturing the nuances of tinnitus experience in naturalistic settings, minimizing recall bias inherent in traditional retrospective methods. This narrative literature review aims to provide a comprehensive up-to-date picture of EMA in tinnitus research by describing previous and current applications, summarising scientific findings, and identifying research gaps by drawing lessons from adjacent mental health fields. 28 publications were identified and assigned to six different topics based on thematic and methodological matters. We highlight contributions of EMA methodology for tinnitus research such as findings on momentary and longitudinal symptom interactions, circadian rhythms, individual differences in symptom patterns and its contributions to treatment evaluation. Emerging technologies, including machine learning, are opening new avenues for personalised tinnitus understanding and management. Despite promising advances, challenges such as data reliability, participant compliance, and integration with sensor-based passive data collection remain areas for further exploration. Drawing lessons from adjacent mental health fields, we propose future directions for EMA in tinnitus research, emphasizing the integration of multimodal data, advanced analytics, and ecological validity to enhance the understanding and management of chronic tinnitus.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"369-388"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How the Human Cochlea Moves: Biomechanical Modeling of a Wide, Layered Osseous Spiral Lamina.","authors":"Andrew A Tubelli, Paul A Secchia, Stefan Raufer, Hideko Heidi Nakajima, Sunil Puria","doi":"10.1007/s10162-025-01000-4","DOIUrl":"10.1007/s10162-025-01000-4","url":null,"abstract":"<p><strong>Purpose: </strong>The human cochlear partition (CP) at the high-frequency region features a radially wide, layered osseous spiral lamina (OSL) and a soft-tissue bridge connecting it to the basilar membrane (BM). The OSL consists of two thin bony plates separated by a cavernous space that serves as a conduit for auditory nerve fibers. We used a finite element model with two fluid chambers, incorporating novel implementations of the CP features, to study the human cochlea. Model results were compared with experimental measurements of CP motion.</p><p><strong>Methods: </strong>Model geometrical and material properties either came from the literature or were tuned to produce a frequency-place map for the passive human cochlea and measurements of the CP velocity normalized to the stapes velocity in human cadaver temporal bones. The best frequency (BF) for the experimental measurements' seven specimens ranged from 9.5 to 14.4 kHz.</p><p><strong>Results: </strong>The model motion results of the basal CP had similar trends to the experimentally measured results in both magnitude and phase. Sensitivity analysis studies changing material-property parameters of the nerve-fiber layer between the OSL plates produced small changes and showed negligible stress along a neutral axis compared to the outer OSL plates.</p><p><strong>Conclusion: </strong>Our model, which incorporated human cochlear structures like the wide OSL with a layer sandwiched between the plates for auditory nerve fibers, successfully simulated CP motion, exhibiting trends that closely resembled experimental data. The relatively wide three-layered OSL structure's neutral axis may serve as a stress-free conduit for the passage of auditory nerve fibers.</p>","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":" ","pages":"451-466"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}