Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.

IF 2.4 3区医学 Q3 NEUROSCIENCES

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2025-01-14 DOI:10.1007/s10162-024-00971-0

Aleksandra Ivanovic, Jeffrey Tao Cheng, Margaux Schmeltz, Wilhelm Wimmer, Christian M Schlepuetz, Aaron K Remenschneider, Anne Bonnin, Lukas Anschuetz

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引用次数: 0

Abstract

Purpose: There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).

Methods: We examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512 Hz, stimulated at 110 dB and 120 dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method.

Results: The normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5-10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.

Conclusion: In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear's biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.

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来源期刊

Jaro-Journal of the Association for Research in Otolaryngology 医学-耳鼻喉科学

CiteScore

4.10

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： JARO is a peer-reviewed journal that publishes research findings from disciplines related to otolaryngology and communications sciences, including hearing, balance, speech and voice. JARO welcomes submissions describing experimental research that investigates the mechanisms underlying problems of basic and/or clinical significance. Authors are encouraged to familiarize themselves with the kinds of papers carried by JARO by looking at past issues. Clinical case studies and pharmaceutical screens are not likely to be considered unless they reveal underlying mechanisms. Methods papers are not encouraged unless they include significant new findings as well. Reviews will be published at the discretion of the editorial board; consult the editor-in-chief before submitting.