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Changes in the Repertoire of Extracellular Vesicles Secreted by Skin Keratinocytes by the Human Protein SLURP-2 人蛋白SLURP-2在皮肤角质形成细胞分泌的细胞外囊泡库中的变化
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-04-11 DOI: 10.1134/S1607672924601355
T. Y. Gornostaeva, O. V. Shlepova, I. D. Kukushkin, A. S. Paramonov,  M. P. Kirpichnikov, E. N. Lyukmanova
{"title":"Changes in the Repertoire of Extracellular Vesicles Secreted by Skin Keratinocytes by the Human Protein SLURP-2","authors":"T. Y. Gornostaeva,&nbsp;O. V. Shlepova,&nbsp;I. D. Kukushkin,&nbsp;A. S. Paramonov,&nbsp; M. P. Kirpichnikov,&nbsp;E. N. Lyukmanova","doi":"10.1134/S1607672924601355","DOIUrl":"10.1134/S1607672924601355","url":null,"abstract":"<p>Extracellular vesicles secreted by keratinocytes are involved in intercellular interactions and contain various proteins, mRNA and miRNA, lipids, due to which they can activate cell migration and proliferation. The secreted human protein SLURP-2 regulates growth and differentiation of epithelial cells and affects proliferation and migration of keratinocytes. In this work, we showed that extracellular vesicles secreted by keratinocytes in the presence of SLURP-2 stimulate migration of HaCaT keratinocytes. It was also found that the expression of miRNA-96 and miRNA-183, suppressing cell migration and proliferation, is decreased in the vesicles secreted by keratinocytes in presence of SLURP-2. Thus, it is shown that the stimulation of keratinocyte migration in presence of SLURP-2 is associated, in particular, with a change in the repertoire of extracellular vesicles secreted by these cells.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"521 1","pages":"160 - 164"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the Functional Role of the Conserved Sequence at the 5'-End of the Fourth Intron of the mod(mdg4) Gene in Trans-Splicing in Drosophila melanogaster 果蝇mod（mdg4）基因第4内含子5′端保守序列在反式剪接中的功能研究
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-04-11 DOI: 10.1134/S1607672924601410
Iu. V. Soldatova, O. Beginyazova,  P. G. Georgiev, M. V. Tikhonov
{"title":"Investigation of the Functional Role of the Conserved Sequence at the 5'-End of the Fourth Intron of the mod(mdg4) Gene in Trans-Splicing in Drosophila melanogaster","authors":"Iu. V. Soldatova,&nbsp;O. Beginyazova,&nbsp; P. G. Georgiev,&nbsp;M. V. Tikhonov","doi":"10.1134/S1607672924601410","DOIUrl":"10.1134/S1607672924601410","url":null,"abstract":"<p>Alternative splicing is an important mechanism that provides genetic diversity of proteins. Unique loci have been identified in <i>Drosophila melanogaster</i>, where mRNA diversity arises as a result of <i>trans</i>-splicing—a process in which exons from different pre-mRNAs are joined together. The <i>trans</i>-splicing in the <i>mod(mdg4)</i> locus, which encodes more than 31 isoforms, has been studied in detail. Important elements for this process include previously described conserved sequences in the fourth intron. The aim of this study is to further characterize the conserved motifs of the fourth intron, specifically the element at the 5'-end of the intron. Using model transgenic lines, it has been shown that introduced changes in the sequence of the studied element lead to a disruption of <i>trans</i>-splicing. In contrast, similar changes in the endogenous locus did not result in a disruption of <i>trans</i>-splicing. Thus, the conserved element plays a role in <i>trans</i>-splicing but is not critical.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"521 1","pages":"169 - 173"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a Highly Conserved Region Critical for the Functionality of the Cp190 Protein in Drosophila melanogaster 黑腹果蝇Cp190蛋白功能高度保守区域的鉴定
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-04-11 DOI: 10.1134/S1607672924601434
L. S. Melnikova, K. I. Balagurov,  P. G. Georgiev, A. K. Golovnin
{"title":"Identification of a Highly Conserved Region Critical for the Functionality of the Cp190 Protein in Drosophila melanogaster","authors":"L. S. Melnikova,&nbsp;K. I. Balagurov,&nbsp; P. G. Georgiev,&nbsp;A. K. Golovnin","doi":"10.1134/S1607672924601434","DOIUrl":"10.1134/S1607672924601434","url":null,"abstract":"<p>The CP190 protein binds to both housekeeping gene promoters and insulator/boundary elements and plays a critical role in their activity. The aim of this work was to study the effect of deletions in highly conserved regions of the CP190 protein on its functionality. It was shown that deletion of the sequence from 664 to 700 aa leads to a lethal phenotype. Thus, a new region was identified in CP190 that plays an important role in the interaction of the CP190 protein with as yet unidentified partner proteins, stabilization of protein complexes formed by CP190, and their recruitment to chromatin.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"521 1","pages":"178 - 182"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bxd PRE from Bithorax Complex of Drosophila melanogaster Has Weak Insulator Activity 黑腹果蝇双胸复合体bxd PRE具有弱绝缘体活性
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-04-11 DOI: 10.1134/S1607672924601513
A. N. Ibragimov, O. V. Kyrchanova, Y. E. Vorontsova, E. N. Kozlov, V. O. Dubrovskaya,  P. G. Georgiev
{"title":"The bxd PRE from Bithorax Complex of Drosophila melanogaster Has Weak Insulator Activity","authors":"A. N. Ibragimov,&nbsp;O. V. Kyrchanova,&nbsp;Y. E. Vorontsova,&nbsp;E. N. Kozlov,&nbsp;V. O. Dubrovskaya,&nbsp; P. G. Georgiev","doi":"10.1134/S1607672924601513","DOIUrl":"10.1134/S1607672924601513","url":null,"abstract":"<p>The autonomous functioning of regulatory domains in the Bithorax complex (BX-C) of <i>Drosophila melanogaster</i> is maintained by boundaries (insulators) that prevent inappropriate enhancer–promoter interactions. Polycomb response elements (PREs) maintain epigenetic memory within regulatory domains and are often located near insulators, enhancing their blocking activity. The <i>bxd</i> PRE is a well-characterized silencer that regulates the <i>bxd</i>/<i>pbx</i> domain of the <i>Ubx</i> gene in the first abdominal segment. We used a boundary replacement strategy to assess the insulator activity of the <i>bxd</i> PRE. Substituting the <i>bxd</i> PRE for the <i>Fab-</i>7 boundary, which separates the <i>Abd-B</i> regulatory domains in the BX-C, revealed that the <i>bxd</i> PRE has weak insulator activity.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"521 1","pages":"183 - 186"},"PeriodicalIF":0.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Role of Bap170 Domains in Enhancer-Dependent Gene Activity in Drosophila melanogaster Bap170结构域在果蝇增强子依赖基因活性中的功能作用。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-01-31 DOI: 10.1134/S1607672924601409
V. K. Chmykhalo, D. Amendola, Y. V. Shidlovskii, L. A. Lebedeva,  P. Schedl, E. Giordano
{"title":"Functional Role of Bap170 Domains in Enhancer-Dependent Gene Activity in Drosophila melanogaster","authors":"V. K. Chmykhalo,&nbsp;D. Amendola,&nbsp;Y. V. Shidlovskii,&nbsp;L. A. Lebedeva,&nbsp; P. Schedl,&nbsp;E. Giordano","doi":"10.1134/S1607672924601409","DOIUrl":"10.1134/S1607672924601409","url":null,"abstract":"<p>The Bap170 subunit of the SWI/SNF chromatin remodeler exhibits activator functions when artificially recruited to the <i>LacZ</i> reporter promoter in enhancer-dependent transcription. In this study, the functional significance of Bap170 protein domains in reporter activation was analyzed. Deletion of the ARID domain does not reduce Bap170 activity. Increased expression of the <i>LacZ</i> reporter was observed in the form of Bap170 without a region that includes LXXLL motifs. Deletions of the central (RFX domain and IDRs) and C-terminal region (zinc fingers) of Bap170 lead to a significant decrease in transgene expression. Apparently, these regions of Bap170 are critical for the function of this protein in enhancer-dependent transcription.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"520 1","pages":"152 - 155"},"PeriodicalIF":0.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionarily Conserved DHX9/MLE Helicase Is Involved in the Regulation of Its Own mRNA Expression Level in Drosophila melanogaster 进化保守的DHX9/MLE解旋酶参与果蝇自身mRNA表达水平的调控
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-01-31 DOI: 10.1134/S1607672924601239
I. A. Zolin,  S. G. Georgieva, J. V. Nikolenko
{"title":"Evolutionarily Conserved DHX9/MLE Helicase Is Involved in the Regulation of Its Own mRNA Expression Level in Drosophila melanogaster","authors":"I. A. Zolin,&nbsp; S. G. Georgieva,&nbsp;J. V. Nikolenko","doi":"10.1134/S1607672924601239","DOIUrl":"10.1134/S1607672924601239","url":null,"abstract":"<p>The MLE helicase of <i>D. melanogaster</i>, like its ortholog DHX9 in mammals, is involved in a wide range of processes related to the regulation of gene expression. In the present study, we investigated the impact of the <i>mle[9]</i> mutation on its own mRNA expression level. It was shown that in addition to the previously described deletion in the catalytic domain of the protein, which impairs its helicase activity, the <i>mle[9]</i> mutation contains an additional small deletion in the C-terminal domain. In the <i>mle[9]</i> mutation background, there was a threefold increase in the expression of the main transcript of the <i>mle</i> gene encoding the full-length protein. Binding of MLE to chromatin at the coding region and promoters of the <i>mle</i> gene and nearby enhancers was analyzed. To exclude the influence of dosage compensation, experiments were performed on females. The data obtained indicate the role of MLE in specific regulation of its own mRNA expression level in vivo at the adult stage.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"520 1","pages":"1 - 5"},"PeriodicalIF":0.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Investigation of the Conservatism of Sequences Defining trans-Splicing in the mod(mdg4) Locus across Drosophila and Silkworm Species 果蝇和家蚕mod（mdg4）基因座反式剪接序列的保守性研究
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-01-31 DOI: 10.1134/S1607672924601021
O. Beginyazova, I. V. Soldatova,  P. G. Georgiev, M. V. Tikhonov
{"title":"An Investigation of the Conservatism of Sequences Defining trans-Splicing in the mod(mdg4) Locus across Drosophila and Silkworm Species","authors":"O. Beginyazova,&nbsp;I. V. Soldatova,&nbsp; P. G. Georgiev,&nbsp;M. V. Tikhonov","doi":"10.1134/S1607672924601021","DOIUrl":"10.1134/S1607672924601021","url":null,"abstract":"<p>Splicing, a key step in mRNA maturation, plays a crucial role in the regulation of eukaryotic gene expression. The formation of chimeric mRNAs from two transcripts during splicing is typically a prohibited process; however, in insects, <i>trans</i>-splicing is a primary mechanism for increasing protein diversity for several loci. The aim of this study is to investigate the evolutionary conservativeness of sequences responsible for <i>trans</i>-splicing in the <i>mod(mdg4)</i> locus among species from the Drosophilidae family (order Diptera) and the silkworm (<i>Bombyx mori</i>), which belongs to the order Lepidoptera. Using model transgenic lines, it was shown that sequences from distant <i>Drosophila</i> species retain the ability to support <i>trans</i>-splicing in <i>D. melanogaster</i>. In contrast, analogous sequences in <i>Bombyx mori</i> do not support <i>trans</i>-splicing. Thus, the RNA motifs and their binding hypothetical protein factors, defining <i>trans</i>-splicing, remain conserved among the Drosophilidae group, but have functionally diverged between Diptera and Lepidoptera.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"520 1","pages":"144 - 147"},"PeriodicalIF":0.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GALA3-Containing Modular Nanotransporters Are Capable of Delivering Keap1 Monobody to Target Cells and Inhibiting the Formation of Reactive Oxygen Species in the Cells 含有gala3的模块化纳米转运体能够将Keap1单体递送到靶细胞并抑制细胞中活性氧的形成。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-01-31 DOI: 10.1134/S1607672924601252
Y. V. Khramtsov, E. S. Bunin, A. V. Ulasov, T. N. Lupanova, G. P. Georgiev, A. S. Sobolev
{"title":"GALA3-Containing Modular Nanotransporters Are Capable of Delivering Keap1 Monobody to Target Cells and Inhibiting the Formation of Reactive Oxygen Species in the Cells","authors":"Y. V. Khramtsov,&nbsp;E. S. Bunin,&nbsp;A. V. Ulasov,&nbsp;T. N. Lupanova,&nbsp;G. P. Georgiev,&nbsp;A. S. Sobolev","doi":"10.1134/S1607672924601252","DOIUrl":"10.1134/S1607672924601252","url":null,"abstract":"<p>In the previously created modular nanotransporter (MNT) capable of delivering a monobody to Keap1 into the cytosol, the endosomolytic module, translocation domain of diphtheria toxin (DTox), was replaced by the endosomolytic peptide GALA3. It was found that this substitution more than doubles the lifetime of MNT in the blood. Using confocal microscopy, it was shown that MNT with GALA3 was internalized into AML12 cells mainly due to binding to the epidermal growth factor receptor, and is also able to exit from endosomes into the cytosol. Using cellular thermal shift assay, it was shown that MNT with GALA3 and MNT with DTox are equally effective in disrupting the formation of the Nrf2 complex with Keap1, which led to similar protection of AML12 cells from the action of hydrogen peroxide. The obtained results allow not only optimizing the systemic use of MNT, but can also serve as a basis for creating agents aimed at treating diseases associated with oxidative stress.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"520 1","pages":"148 - 151"},"PeriodicalIF":0.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New N6-Substituted Adenine Derivatives with High Antiviral Activity against RNA-Containing Viruses 对含rna病毒具有高抗病毒活性的新型n6取代腺嘌呤衍生物。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-01-22 DOI: 10.1134/S1607672924600787
A. A. Zenchenko, Yu. D. Semenova, E. R. Naberezhnaya, Ya. D. Gumennaya, A. V. Lipatova, V. E. Oslovsky
{"title":"New N6-Substituted Adenine Derivatives with High Antiviral Activity against RNA-Containing Viruses","authors":"A. A. Zenchenko,&nbsp;Yu. D. Semenova,&nbsp;E. R. Naberezhnaya,&nbsp;Ya. D. Gumennaya,&nbsp;A. V. Lipatova,&nbsp;V. E. Oslovsky","doi":"10.1134/S1607672924600787","DOIUrl":"10.1134/S1607672924600787","url":null,"abstract":"<p>In this work, two new compounds, <i>N</i><sup>6</sup>-(4,5-dimethoxyphenyl)adenine and <i>N</i><sup>6</sup>-(3,5-di-trifluoromethylphenyl)adenine, with a broad range of antiviral activity against RNA viruses were identified. We showed that these compounds exhibit pronounced antiviral activity against human poliovirus types 1, 2, and 3, belonging to enterovirus C species. Both compounds also demonstrated pronounced antiviral activity against Coxsackie viruses B3, B5, and B6, belonging to enterovirus B species. In addition, the compounds demonstrated antiviral activity against Newcastle disease virus, which belongs to the paramyxovirus genus. The compounds discovered in this work can subsequently serve as prototypes for the development of new antiviral drugs against epidemiologically significant human RNA viruses.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"520 1","pages":"38 - 41"},"PeriodicalIF":0.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-molecular-weight Ligand of the Thyroid-stimulating Hormone Receptor with the Activity of a Partial Agonist and a Negative Allosteric Modulator 具有部分激动剂和负变构调节剂活性的促甲状腺激素受体的低分子配体。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2025-01-22 DOI: 10.1134/S1607672924600799
K. V. Derkach, E. A. Didenko, V. N. Sorokoumov, I. O. Zakharova, A. O. Shpakov
{"title":"Low-molecular-weight Ligand of the Thyroid-stimulating Hormone Receptor with the Activity of a Partial Agonist and a Negative Allosteric Modulator","authors":"K. V. Derkach,&nbsp;E. A. Didenko,&nbsp;V. N. Sorokoumov,&nbsp;I. O. Zakharova,&nbsp;A. O. Shpakov","doi":"10.1134/S1607672924600799","DOIUrl":"10.1134/S1607672924600799","url":null,"abstract":"<p>Graves’ disease is caused by overactivation of the thyroid-stimulating hormone receptor (TSHR). One approach for its treatment may be the use of negative allosteric modulators (NAM) of TSHR, which normalize TSHR activity and do not cause thyroid hormone (TH) deficiency. The aim of the work was to study the effect of a new compound 5-amino-4-(4-bromophenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid <i>N</i>-<i>tert</i>-butylamide (TPY4) on the basal and TSH-stimulated TH production in cultured FRTL-5 thyrocytes and on basal and thyrotropin-releasing hormone (TRH)-stimulated TH levels in the blood of rats. TPY4 stimulated TH production by thyrocytes and increased TH levels when administered intraperitoneally and orally in rats. It also decreased the TSH-stimulated TH production in thyrocytes and the TRH-stimulated TH levels in rats. Thus, TPY4 is the first known allosteric regulator of TSHR, combining the properties of NAM and a partial agonist, and can be considered as a prototype of drugs for the treatment of Graves’ disease.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"520 1","pages":"53 - 57"},"PeriodicalIF":0.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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