T. Y. Gornostaeva, O. V. Shlepova, I. D. Kukushkin, A. S. Paramonov, M. P. Kirpichnikov, E. N. Lyukmanova
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Changes in the Repertoire of Extracellular Vesicles Secreted by Skin Keratinocytes by the Human Protein SLURP-2
Extracellular vesicles secreted by keratinocytes are involved in intercellular interactions and contain various proteins, mRNA and miRNA, lipids, due to which they can activate cell migration and proliferation. The secreted human protein SLURP-2 regulates growth and differentiation of epithelial cells and affects proliferation and migration of keratinocytes. In this work, we showed that extracellular vesicles secreted by keratinocytes in the presence of SLURP-2 stimulate migration of HaCaT keratinocytes. It was also found that the expression of miRNA-96 and miRNA-183, suppressing cell migration and proliferation, is decreased in the vesicles secreted by keratinocytes in presence of SLURP-2. Thus, it is shown that the stimulation of keratinocyte migration in presence of SLURP-2 is associated, in particular, with a change in the repertoire of extracellular vesicles secreted by these cells.
期刊介绍：
Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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