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Study of the Role of Long Noncoding roX RNA in Maintaining of the Dosage Compensation Complex in Drosophila melanogaster. 研究长非编码 roX RNA 在维持黑腹果蝇剂量补偿复合物中的作用
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-01-07 DOI: 10.1134/S160767292370062X
V A Babosha, P G Georgiev, O G Maksimenko
{"title":"Study of the Role of Long Noncoding roX RNA in Maintaining of the Dosage Compensation Complex in Drosophila melanogaster.","authors":"V A Babosha, P G Georgiev, O G Maksimenko","doi":"10.1134/S160767292370062X","DOIUrl":"10.1134/S160767292370062X","url":null,"abstract":"<p><p>The proteins MSL1, MSL2, MSL3, MLE, and MOF and noncoding RNAs roX1 and roX2 form the Drosophila dosage compensation complex (DCC), which specifically binds to the X chromosome of males. It is known that noncoding RNA roX are primary component of the DCC in the process of assembly and spreading of the complex among the X chromosome of males. However, the role of this RNA in maintaining the structure of the already assembled complex remains unclear. In this work, we have shown that the full-assembled dosage compensation complex dissociates rather weakly when treated with RNases: the MLE helicase is effectively released from the complex, and the remaining protein components (MSL1, MSL2, and MSL3) undergo partial disassembly and continue to be part of subcomplexes. The results confirm the importance of the noncoding roX2 RNA not only in the processes of initiation of DCC assembly but also at the stage of maintaining the structure of the already assembled complex.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139376968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Comparative Pharmacoeconomic Effectiveness of Interleukin-17 Inhibitors for the Treatment of Ankylosing Spondylitis. 勘误：白细胞介素-17抑制剂治疗强直性脊柱炎的药物经济学效果比较。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1134/S1607672923050058
T V Dubinina, I Z Gaidukova, N A Sableva, K V Sapozhnikov, V D Sokolova, D G Tolkacheva
{"title":"Erratum to: Comparative Pharmacoeconomic Effectiveness of Interleukin-17 Inhibitors for the Treatment of Ankylosing Spondylitis.","authors":"T V Dubinina, I Z Gaidukova, N A Sableva, K V Sapozhnikov, V D Sokolova, D G Tolkacheva","doi":"10.1134/S1607672923050058","DOIUrl":"10.1134/S1607672923050058","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia. Wtx 毒素的合成肽片段能降低全身麻醉大鼠的血压
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2023-09-12 DOI: 10.1134/S1607672923700497
M S Severyukhina, A M Ismailova, E R Shaykhutdinova, I A Dyachenko, N S Egorova, A N Murashev, V I Tsetlin, Yu N Utkin
{"title":"Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia.","authors":"M S Severyukhina, A M Ismailova, E R Shaykhutdinova, I A Dyachenko, N S Egorova, A N Murashev, V I Tsetlin, Yu N Utkin","doi":"10.1134/S1607672923700497","DOIUrl":"10.1134/S1607672923700497","url":null,"abstract":"<p><p>Previously, it was shown that the non-conventional toxin WTX from the venom of the cobra Naja kaouthia, when administered intravenously, caused a decrease in blood pressure (BP) and an increase in heart rate (HR) in rats [13]. To identify the site of the toxin molecule responsible for these effects, we studied the influence of synthetic peptide fragments of the WTX on BP and HR in normotensive male Sprague-Dawley rats under general anesthesia induced by Telazol and Xylazine. It was found that peptides corresponding to the WTX central polypeptide loop, stabilized by a disulfide bond, at intravenous injection at concentrations from 0.1 to 1.0 mg/mL caused a dose-dependent decrease in BP, with the HR increasing only in the first 5-10 min after administration. Thus, WTX fragments corresponding to the central polypeptide loop reproduce the decrease in blood pressure caused by the toxin.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10278136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N6-(5-Phenylpentan-1-yl)adenine-A New Non-competitive Receptor-Specific Anti-cytokinin. N6-(5-苯基戊-1-基)腺嘌呤--一种新的非竞争性受体特异性抗细胞分裂素。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-01-08 DOI: 10.1134/S1607672923700679
A A Zenchenko, E M Savelieva, M S Drenichev, G A Romanov, V E Oslovsky
{"title":"N<sup>6</sup>-(5-Phenylpentan-1-yl)adenine-A New Non-competitive Receptor-Specific Anti-cytokinin.","authors":"A A Zenchenko, E M Savelieva, M S Drenichev, G A Romanov, V E Oslovsky","doi":"10.1134/S1607672923700679","DOIUrl":"10.1134/S1607672923700679","url":null,"abstract":"<p><p>For the first time, N<sup>6</sup>-(5-phenylpentan-1-yl)adenine, a synthetic adenine derivative with a receptor-specific anticytokinin effect, was obtained. This compound exhibits a pronounced anticytokinin effect, reducing cytokinin-induced expression of the GUS reporter gene when interacting with the cytokinin receptor CRE1/AHK4 of the model plant Arabidopsis thaliana. This effect manifests itself much weaker with the related AHK2 receptor and is not observed at all with the AHK3 receptor. We showed that N<sup>6</sup>-(5-phenylpentan-1-yl)adenine does not bind to the ligand-binding sites of the Arabidopsis cytokinin receptors, which does not allow it to be classified as a true cytokinin antagonist. Despite the currently unknown mechanism of action, this compound may find its use as a component of plant growth regulators. Like true anticytokinins, it enhances root growth of Arabidopsis seedlings, apparently suppressing the action of endogenous cytokinins on the \"root\" receptor CRE1/AHK4.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139376965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Chromatin Structure Modifiers on the trans-Acting Heterochromatin Position Effect in Drosophila melanogaster. 染色质结构修饰剂对黑腹果蝇反式异染色质位置效应的影响
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-02-20 DOI: 10.1134/S160767292470073X
A A Solodovnikov, S A Lavrov, A S Shatskikh, V A Gvozdev
{"title":"Effects of Chromatin Structure Modifiers on the trans-Acting Heterochromatin Position Effect in Drosophila melanogaster.","authors":"A A Solodovnikov, S A Lavrov, A S Shatskikh, V A Gvozdev","doi":"10.1134/S160767292470073X","DOIUrl":"10.1134/S160767292470073X","url":null,"abstract":"<p><p>The heterochromatin position effect is manifested in the inactivation of euchromatin genes transferred to heterochromatin. In chromosomal rearrangements, genes located near the new eu-heterochromatin boundary in the rearrangement (cis-inactivation) and, in rare cases, genes of a region of the normal chromosome homologous to the region of the eu-heterochromatin boundary of the chromosome with the rearrangement (trans-inactivation) are subject to inactivation. The In(2)A4 inversion is able to trans-inactivate the UAS-eGFP reporter gene located on the normal chromosome. We knockdown a number of chromatin proteins using temperature-controlled RNA interference and investigated the effect of knockdown on trans-inactivation of the reporter. We found suppression of trans-inactivation by knockdowns of Su(var)2-HP2, a protein that binds to the key heterochromatin protein HP1a, SAYP, a subunit of the chromatin remodelling complex, and Eggless histone methyltransferase (SETDB1), which introduces a H3K9me3 histone mark, recognized by the HP1a protein. The method of studying the effects of gene knockdown on heterochromatin position effects presented in this work is of independent methodological interest.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of the Association of Ouib and Nom with Heterochromatin in Drosophila melanogaster. 黑腹果蝇中 Ouib 和 Nom 与异染色质的关联研究
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-03-12 DOI: 10.1134/S1607672924700741
Y V Pekina, V A Babosha, P G Georgiev, A A Fedotova
{"title":"Study of the Association of Ouib and Nom with Heterochromatin in Drosophila melanogaster.","authors":"Y V Pekina, V A Babosha, P G Georgiev, A A Fedotova","doi":"10.1134/S1607672924700741","DOIUrl":"10.1134/S1607672924700741","url":null,"abstract":"<p><p>In Drosophila, a large group of actively transcribed genes is located in pericentromeric heterochromatin. It is assumed that heterochromatic proteins recruit transcription factors to gene promoters. Two proteins, Ouib and Nom, were previously shown to bind to the promoters of the heterochromatic genes nvd and spok. Interestingly, Ouib and Nom are paralogs of the M1BP protein, which binds to the promoters of euchromatic genes. We have shown that, like M1BP, the Quib and Nom proteins bind to CP190, which is involved in the recruitment of transcription complexes to promoters. Unlike heterochromatic proteins, Ouib and Nom do not interact with the major heterochromatic protein HP1a and bind to euchromatic promoters on polytene chromosomes from the larval salivary glands. The results suggest a new mechanism for the recruitment of transcription factors into the heterochromatic compartment of the nucleus.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Anti-topoisomerase 1 Antibody Level Changes after B Cell Depletion Therapy in Systemic Sclerosis. 勘误：系统性硬化症患者接受 B 细胞清除疗法后抗拓扑异构酶 1 抗体水平的变化。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1134/S1607672923050022
L P Ananyeva, L A Garzanova, O A Koneva, M N Starovoytova, O V Desinova, O B Ovsyannikova, R U Shayakhmetova, M V Cherkasova, A P Aleksankin, E L Nasonov
{"title":"Erratum to: Anti-topoisomerase 1 Antibody Level Changes after B Cell Depletion Therapy in Systemic Sclerosis.","authors":"L P Ananyeva, L A Garzanova, O A Koneva, M N Starovoytova, O V Desinova, O B Ovsyannikova, R U Shayakhmetova, M V Cherkasova, A P Aleksankin, E L Nasonov","doi":"10.1134/S1607672923050022","DOIUrl":"10.1134/S1607672923050022","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Contributing Factors of Diabetes Mellitus among Patients with Gout (Results of the Long-Term Prospective Study). 勘误：痛风患者患糖尿病的诱因（长期前瞻性研究结果）。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1134/S1607672923050083
O V Zheliabina, M S Eliseev, S I Glukhova, E L Nasonov
{"title":"Erratum to: Contributing Factors of Diabetes Mellitus among Patients with Gout (Results of the Long-Term Prospective Study).","authors":"O V Zheliabina, M S Eliseev, S I Glukhova, E L Nasonov","doi":"10.1134/S1607672923050083","DOIUrl":"10.1134/S1607672923050083","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Global Antiphospholipid Syndrome Score (GAPSS) in Patients with Systemic Lupus Erythematosus. 勘误：系统性红斑狼疮患者的全球抗磷脂综合征评分 (GAPSS)。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1134/S1607672923050046
F A Cheldieva, T M Reshetnyak, A A Shumilova, K S Nurbaeva, M V Cherkasova, A M Lila, E L Nasonov
{"title":"Erratum to: Global Antiphospholipid Syndrome Score (GAPSS) in Patients with Systemic Lupus Erythematosus.","authors":"F A Cheldieva, T M Reshetnyak, A A Shumilova, K S Nurbaeva, M V Cherkasova, A M Lila, E L Nasonov","doi":"10.1134/S1607672923050046","DOIUrl":"10.1134/S1607672923050046","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aberrant Repair of 8-Oxoguanine in Short DNA Bulges. 短 DNA 凸起中 8-氧鸟嘌呤的异常修复
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2023-12-01 Epub Date: 2024-02-09 DOI: 10.1134/S1607672923600355
D A Eroshenko, E A Diatlova, V M Golyshev, A V Endutkin, D O Zharkov
{"title":"Aberrant Repair of 8-Oxoguanine in Short DNA Bulges.","authors":"D A Eroshenko, E A Diatlova, V M Golyshev, A V Endutkin, D O Zharkov","doi":"10.1134/S1607672923600355","DOIUrl":"10.1134/S1607672923600355","url":null,"abstract":"<p><p>The presence of DNA damage can increase the likelihood of DNA replication errors and promote mutations. In particular, pauses of DNA polymerase at the site of damage can lead to polymerase slippage and the formation of 1-2-nucleotide bulges. Repair of such structures using an undamaged DNA template leads to small deletions. One of the most abundant oxidative DNA lesions, 8-oxoguanine (oxoG), was shown to induce small deletions, but the mechanism of this phenomenon is currently unknown. We studied the aberrant repair of oxoG located in one- and two-nucleotide bulges by the Escherichia coli and human base excision repair systems. Our results indicate that the repair in such substrates can serve as a mechanism for fixing small deletions in bacteria but not in humans.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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