发布求助
文献互助 智能选刊 最新文献

Doklady Biochemistry and Biophysics最新文献

筛选
英文 中文
Hepatoprotective Effect of Moringa Oil on Rats under Fungicide Toxicity 辣木油对杀真菌剂毒性大鼠肝脏的保护作用
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-02-20 DOI: 10.1134/S1607672923600367
Khalid S. Alotaibi, Daklallah A. Almalki
{"title":"Hepatoprotective Effect of Moringa Oil on Rats under Fungicide Toxicity","authors":"Khalid S. Alotaibi,&nbsp;Daklallah A. Almalki","doi":"10.1134/S1607672923600367","DOIUrl":"10.1134/S1607672923600367","url":null,"abstract":"<p>The present study is designed to evaluate whether pretreatment with moringa would have a protective effect on thioacetamide (TAA)-induced liver fibrosis, assessing biochemical and histopathological changes in Wistar male rats. Exposure to TAA induced notable biochemical and histopathological alterations. Liver fibrosis induced by TAA, along with associated biochemical and histological damage, has not been previously investigated in male rats supplemented with moringa oil. The experiment involved forty male rats distributed across four groups, each comprising ten rats. Group 1 served as controls and received intraperitoneal injections of saline solution twice weekly for six weeks. Group 2 rats were injected with 300 mg/kg body weight of TAA (Sigma-Aldrich Corp.) twice weekly for the same duration. Group 3 rats were orally supplemented with moringa oil at 800 mg/kg body weight/day and received intraperitoneal injections of TAA at the same dosage as Group 2 for six weeks. Finally, Group 4 rats were injected with saline solution twice weekly and orally supplemented with moringa oil at 800 mg/kg body weight/day for the same period. At the end of the experiment, we determined body weight and performed liver function analysis. Additionally, we examined the liver histology of the different groups. Results showed that moringa oil treatment protected rat livers from TAA toxicity by improving liver function analysis and preventing liver fibrosis. Moringa oil can be considered a promising agent for protection against TAA toxicity.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1 supplement","pages":"S53 - S59"},"PeriodicalIF":0.8,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Otu and Rif1 Double Mutant Enables Analysis of Satellite DNA in Polytene Chromosomes of Ovarian Germ Cells in Drosophila melanogaster Otu和Rif1双突变体可用于分析黑腹果蝇卵巢生殖细胞多腺染色体中的卫星DNA。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-02-09 DOI: 10.1134/S160767292360046X
T. D. Kolesnikova, A. R. Nokhova, A. S. Shatskikh, M. S. Klenov,  I. F. Zhimulev
{"title":"Otu and Rif1 Double Mutant Enables Analysis of Satellite DNA in Polytene Chromosomes of Ovarian Germ Cells in Drosophila melanogaster","authors":"T. D. Kolesnikova,&nbsp;A. R. Nokhova,&nbsp;A. S. Shatskikh,&nbsp;M. S. Klenov,&nbsp; I. F. Zhimulev","doi":"10.1134/S160767292360046X","DOIUrl":"10.1134/S160767292360046X","url":null,"abstract":"<p>Polytene chromosomes in <i>Drosophila</i> serve as a classical model for cytogenetic studies. However, heterochromatic regions of chromosomes are typically under-replicated, hindering their analysis. Mutations in the <i>Rif1</i> gene lead to additional replication of heterochromatic sequences, including satellite DNA, in salivary gland cells. Here, we investigated the impact of the <i>Rif1</i> mutation on heterochromatin in polytene chromosomes formed in ovarian germ cells due to the <i>otu</i> gene mutation. By the analysis of <i>otu</i><sup><i>11</i></sup><i>; Rif1</i><sup><i>1</i></sup> double mutants, we found that, in the presence of the <i>Rif1</i> mutation, ovarian cells undergo additional polytenization of pericentromeric regions. This includes the formation of large chromatin blocks composed of satellite DNA. Thus, the effects of the <i>Rif1</i> mutation are similar in salivary gland and germ cells. The <i>otu</i><sup><i>11</i></sup><i>; Rif1</i><sup><i>1</i></sup> system opens new possibilities for studying factors associated with heterochromatin during oogenesis.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1 supplement","pages":"S87 - S91"},"PeriodicalIF":0.8,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty Acid Profile of Juvenile Arctic Char (Salvelinus alpinus Complex) from Natural Ecosystems and Aquaculture 来自自然生态系统和水产养殖的北极红点鲑幼鱼（Salvelinus alpinus Complex）的脂肪酸谱。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-02-09 DOI: 10.1134/S1607672923700680
A. E. Rudchenko, V. A. Karpov,  N. N. Sushchik, L. A. Glushchenko,  M. I. Gladyshev
{"title":"Fatty Acid Profile of Juvenile Arctic Char (Salvelinus alpinus Complex) from Natural Ecosystems and Aquaculture","authors":"A. E. Rudchenko,&nbsp;V. A. Karpov,&nbsp; N. N. Sushchik,&nbsp;L. A. Glushchenko,&nbsp; M. I. Gladyshev","doi":"10.1134/S1607672923700680","DOIUrl":"10.1134/S1607672923700680","url":null,"abstract":"<p>Significant differences in the fatty acid composition of the muscle tissue of juvenile Arctic char <i>Salvelinus alpinus</i> (Linnaeus, 1758) from the natural habitat (Lake Sobach’e) and aquaculture, as well as juveniles of the anadromous form of char (malma) <i>Salvelinus malma</i> (Walbaum, 1792) from the Avacha River were found. The observed differences between aquaculture and wild juvenile char were associated with different food sources. The muscle tissue of juvenile char from natural habitat was characterized by significantly higher levels of fatty acids–biomarkers of diatoms, as well as biomarkers of marine copepods in the anadromous form. In the fatty acid composition of juvenile char from aquaculture, significantly higher levels of linoleic acid were revealed, as well as long-chain monounsaturated acids, the source of which could be aquaculture feed. The identified differences did not have a significant effect on the content of eicosapentaenoic and docosahexaenoic acids in the muscle tissue of juvenile aquaculture and wild char. The content of biochemically valuable omega 3 polyunsaturated fatty acids in juvenile char from natural ecosystems and aquaculture was similar.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1 supplement","pages":"S92 - S95"},"PeriodicalIF":0.8,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aberrant Repair of 8-Oxoguanine in Short DNA Bulges 短 DNA 凸起中 8-氧鸟嘌呤的异常修复
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-02-09 DOI: 10.1134/S1607672923600355
D. A. Eroshenko, E. A. Diatlova, V. M. Golyshev, A. V. Endutkin,  D. O. Zharkov
{"title":"Aberrant Repair of 8-Oxoguanine in Short DNA Bulges","authors":"D. A. Eroshenko,&nbsp;E. A. Diatlova,&nbsp;V. M. Golyshev,&nbsp;A. V. Endutkin,&nbsp; D. O. Zharkov","doi":"10.1134/S1607672923600355","DOIUrl":"10.1134/S1607672923600355","url":null,"abstract":"<p>The presence of DNA damage can increase the likelihood of DNA replication errors and promote mutations. In particular, pauses of DNA polymerase at the site of damage can lead to polymerase slippage and the formation of 1–2-nucleotide bulges. Repair of such structures using an undamaged DNA template leads to small deletions. One of the most abundant oxidative DNA lesions, 8-oxoguanine (oxoG), was shown to induce small deletions, but the mechanism of this phenomenon is currently unknown. We studied the aberrant repair of oxoG located in one- and two-nucleotide bulges by the <i>Escherichia coli</i> and human base excision repair systems. Our results indicate that the repair in such substrates can serve as a mechanism for fixing small deletions in bacteria but not in humans.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1 supplement","pages":"S82 - S86"},"PeriodicalIF":0.8,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Efficacy of Anti-Cancer Drugs on Organoid Models Derived from Prostate Cancer 评估抗癌药物对前列腺癌类器官模型的疗效
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-02-09 DOI: 10.1134/S1607672923700692
M. O. Silkina, A. V. Razumovskaya, S. V. Nikulin,  A. G. Tonevitsky, B. Ya. Alekseev
{"title":"Assessing the Efficacy of Anti-Cancer Drugs on Organoid Models Derived from Prostate Cancer","authors":"M. O. Silkina,&nbsp;A. V. Razumovskaya,&nbsp;S. V. Nikulin,&nbsp; A. G. Tonevitsky,&nbsp;B. Ya. Alekseev","doi":"10.1134/S1607672923700692","DOIUrl":"10.1134/S1607672923700692","url":null,"abstract":"<p>It was proven that tumor organoids effectively mirror the phenotypic and genetic traits of the original biomaterial. It was reported that outcomes from drug testing in organoid cultures can accurately represent the clinical response observed in patients. In this study, an organoid culture was derived from biopsy material of prostate cancer (PC). Subsequently, clinical practice drugs, docetaxel and enzalutamide, were tested on this organoid culture. Various techniques for evaluating the efficacy of drugs in vitro were compared. The half-maximal inhibitory concentration of docetaxel was found to be markedly lower compared to that of enzalutamide. However, when tested at clinically relevant concentrations and incubation times, enzalutamide was more effective than docetaxel. Therefore, it is crucial to optimize the testing conditions for drugs on in vitro cultures for their subsequent application in clinical practice.</p>","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1 supplement","pages":"S96 - S99"},"PeriodicalIF":0.8,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Antibodies to Domain I β2-Glycoprotein 1 in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus 勘误：抗磷脂综合征和系统性红斑狼疮患者中的域 I β2-糖蛋白 1 抗体
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-01-24 DOI: 10.1134/S160767292305006X
T. M. Reshetnyak, F. A. Cheldieva, M. V. Cherkasova, S. I. Glukhova, A. M. Lila, E. L. Nasonov
{"title":"Erratum to: Antibodies to Domain I β2-Glycoprotein 1 in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus","authors":"T. M. Reshetnyak,&nbsp;F. A. Cheldieva,&nbsp;M. V. Cherkasova,&nbsp;S. I. Glukhova,&nbsp;A. M. Lila,&nbsp;E. L. Nasonov","doi":"10.1134/S160767292305006X","DOIUrl":"10.1134/S160767292305006X","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1","pages":"358 - 358"},"PeriodicalIF":0.8,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia 勘误：Wtx 毒素的合成肽片段可降低全身麻醉大鼠的血压。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-01-24 DOI: 10.1134/S1607672923050095
M. S. Severyukhina, A. M. Ismailova, E. R. Shaykhutdinova, I. A. Dyachenko, N. S. Egorova, A. N. Murashev,  V. I. Tsetlin, Yu. N. Utkin
{"title":"Erratum to: Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia","authors":"M. S. Severyukhina,&nbsp;A. M. Ismailova,&nbsp;E. R. Shaykhutdinova,&nbsp;I. A. Dyachenko,&nbsp;N. S. Egorova,&nbsp;A. N. Murashev,&nbsp; V. I. Tsetlin,&nbsp;Yu. N. Utkin","doi":"10.1134/S1607672923050095","DOIUrl":"10.1134/S1607672923050095","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1","pages":"355 - 355"},"PeriodicalIF":0.8,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Are the Goals of Therapy Achievable in Patients with Rheumatoid Arthritis Receiving Upadacitinib in Real Clinical Practice? 勘误：在实际临床实践中，接受乌达帕替尼治疗的类风湿关节炎患者能否实现治疗目标？
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-01-24 DOI: 10.1134/S1607672923050010
V. N. Amirdzhanova, A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, R. R. Samigullina, V. I. Mazurov, O. N. Anoshenkova, N. A. Lapkina, A. A. Baranov, T. Yu. Grineva, A. M. Lila, E. L. Nasonov
{"title":"Erratum to: Are the Goals of Therapy Achievable in Patients with Rheumatoid Arthritis Receiving Upadacitinib in Real Clinical Practice?","authors":"V. N. Amirdzhanova,&nbsp;A. E. Karateev,&nbsp;E. Yu. Pogozheva,&nbsp;E. S. Filatova,&nbsp;R. R. Samigullina,&nbsp;V. I. Mazurov,&nbsp;O. N. Anoshenkova,&nbsp;N. A. Lapkina,&nbsp;A. A. Baranov,&nbsp;T. Yu. Grineva,&nbsp;A. M. Lila,&nbsp;E. L. Nasonov","doi":"10.1134/S1607672923050010","DOIUrl":"10.1134/S1607672923050010","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1","pages":"363 - 363"},"PeriodicalIF":0.8,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Different Clinical Relevance of Anti-Citrullinated Protein Antibodies in RA Patients 勘误：RA患者抗瓜氨酸蛋白抗体的不同临床意义。
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-01-24 DOI: 10.1134/S1607672923050034
A. S. Avdeeva, M. V. Cherkasova, E. L. Nasonov
{"title":"Erratum to: Different Clinical Relevance of Anti-Citrullinated Protein Antibodies in RA Patients","authors":"A. S. Avdeeva,&nbsp;M. V. Cherkasova,&nbsp;E. L. Nasonov","doi":"10.1134/S1607672923050034","DOIUrl":"10.1134/S1607672923050034","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1","pages":"361 - 361"},"PeriodicalIF":0.8,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Structure Analysis of the MatA Locus of Sexual Compatibility in the Edible Mushroom Pleurotus ostreatus 勘误：食用菌褶菌性相容性 MatA 基因座的结构分析
IF 0.8 4区 生物学
Doklady Biochemistry and Biophysics Pub Date : 2024-01-24 DOI: 10.1134/S1607672923050071
A. V. Shnyreva, A. A. Shnyreva
{"title":"Erratum to: Structure Analysis of the MatA Locus of Sexual Compatibility in the Edible Mushroom Pleurotus ostreatus","authors":"A. V. Shnyreva,&nbsp;A. A. Shnyreva","doi":"10.1134/S1607672923050071","DOIUrl":"10.1134/S1607672923050071","url":null,"abstract":"","PeriodicalId":529,"journal":{"name":"Doklady Biochemistry and Biophysics","volume":"513 1","pages":"357 - 357"},"PeriodicalIF":0.8,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信