黑腹果蝇染色质重塑复合体特定亚基 SAYP 和 BAP170 过表达的影响

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2024-10-31 DOI:10.1134/S160767292460088X

V K Chmykhalo, Y V Shidlovskii, L A Lebedeva, P Schedl, E Giordano

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引用次数: 0

摘要

我们分析了Bap170和e(y)3 (SAYP)基因在黑腹蝇中表达增加的表型表现。通过翼盘模型，我们发现翼盘中Bap170和e(y)3基因的中度共表达会导致翅脉异常，这可能是表皮生长因子受体/Ras/MAPK信号通路受抑制所致。在翅盘中强烈诱导上述基因的共表达会导致成虫的翅发育完全受抑制。Bap170和e(y)3的普遍共表达在一龄幼虫阶段是致死的，并导致黑色素瘤的形成。只有当 Bap170 和 e(y)3 共同表达时，才能观察到上述表型。这些证据表明，这些基因的联合作用具有强大的协同效应，表现为细胞增殖和分化的过度活跃。

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Effects of Overexpression of Specific Subunits SAYP, BAP170 of the Chromatin Remodeling Complex in Drosophila Melanogaster.

The phenotypic manifestations of increased expression of the Bap170 and e(y)3 (SAYP) genes in D. melanogaster were analyzed. Using the wing disc model, we show that moderate co-expression of Bap170 and e(y)3 genes in wing discs leads to abnormalities in wing veining. which was probably caused by suppression of EGFR/Ras/MAPK signaling pathways. Strong induction of co-expression of the above genes in wing discs leads to complete suppression of wing development in adults. Ubiquitous co-expression of Bap170 and e(y)3 is lethal at the 1st instar larval stage and leads to the formation of melanotic tumors. The above phenotypes are observed exclusively when Bap170 and e(y)3 are co-expressed. This evidence suggests a robust synergistic effect of the combined action of these genes, which is manifested in the hyperactivity of cell proliferation and differentiation.

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.