Respirology Case ReportsPub Date : 2025-08-05eCollection Date: 2025-08-01DOI: 10.1002/rcr2.70309
Yu-Tzu Chien, Yung-Chia Huang, Chia-Hung Hsu
{"title":"Chronic Cough Caused by Adenoid Cystic Carcinoma.","authors":"Yu-Tzu Chien, Yung-Chia Huang, Chia-Hung Hsu","doi":"10.1002/rcr2.70309","DOIUrl":"10.1002/rcr2.70309","url":null,"abstract":"<p><p>Tracheal tumours can develop as primary neoplasms or as extensions from adjacent organs such as the lungs or larynx. We present a case of a man diagnosed with adenoid cystic carcinoma of the trachea.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70309"},"PeriodicalIF":0.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Bronchoscopic Removal of Aspergilloma in Patients With Non-Surgical Indications.","authors":"Takatoshi Tetsuka, Yusuke Nakamura, Yuto Goto, Sunao Mikura, Nana Yazawa, Hiromichi Suzuki, Yasuo Shimizu, Seiji Niho","doi":"10.1002/rcr2.70310","DOIUrl":"10.1002/rcr2.70310","url":null,"abstract":"<p><p>A 76-year-old man was diagnosed with aspergilloma in the left upper lobe. Due to advanced age and recurring colon cancer, surgery was not an option. The aspergilloma was removed with biopsy forceps. Then, the lesion and sputum were decreased. Bronchoscopic removal can be considered, particularly for patients without surgical indications.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70310"},"PeriodicalIF":0.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-08-04eCollection Date: 2025-08-01DOI: 10.1002/rcr2.70293
Rong Gao, Jinyan Yu, Xuejiao Lv, Chunling Dong
{"title":"Rapid Progression of Primary Pulmonary NUT Midline Carcinoma: A Case Report and Literature Review.","authors":"Rong Gao, Jinyan Yu, Xuejiao Lv, Chunling Dong","doi":"10.1002/rcr2.70293","DOIUrl":"10.1002/rcr2.70293","url":null,"abstract":"<p><p>Primary pulmonary nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare malignancy with characteristics that resemble those of squamous cell carcinoma, thus making it prone to both misdiagnosis and missed diagnosis. Primary pulmonary NMC is highly malignant and associated with poor prognosis, with no standardised effective treatments for patients who cannot undergo surgery. Concurrent or sequential chemoradiotherapy is considered an effective approach, and some targeted drugs have been clinically tested and demonstrated favourable results. We present a case of primary pulmonary NMC with cervical lymph node metastasis, in which the patient experienced temporary symptom relief after receiving anlotinib and chemotherapy combined with immunotherapy. However, the condition rapidly worsened, and the patient died within 1 month of diagnosis. We believe that combining anlotinib with chemotherapy as well as reducing the chemotherapy interval can be effective in the treatment of primary pulmonary NMC.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70293"},"PeriodicalIF":0.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-08-04eCollection Date: 2025-08-01DOI: 10.1002/rcr2.70311
Shogo Toyama, Kohei Fujita, Naoki Fujimoto, Yuta Okada, Saiki Yoshimura, Kiminobu Tanizawa
{"title":"Simultaneous Placement of Multiple Airway Stents in Three Patients With Extensive Airway Stenosis: A Case Series.","authors":"Shogo Toyama, Kohei Fujita, Naoki Fujimoto, Yuta Okada, Saiki Yoshimura, Kiminobu Tanizawa","doi":"10.1002/rcr2.70311","DOIUrl":"10.1002/rcr2.70311","url":null,"abstract":"<p><p>Airway stenting is a critical therapeutic intervention for managing airway obstruction caused by both malignant and benign conditions. While Dumon Y-stent placement is sometimes indicated for patients with extensive airway narrowing, facilities capable of performing rigid bronchoscopy are limited. In such cases, the use of multiple self-expanding metallic stents (SEMS) via flexible bronchoscopy under local anaesthesia presents a valuable alternative. We report three cases in which multiple airway stents were placed simultaneously using this approach. Case 1 involved a patient with stage IV squamous cell lung cancer, in whom the primary tumour caused extrinsic tracheal compression and direct invasion of the right main bronchus. Cases 2 and 3 were diagnosed clinically with tracheomalacia. In all three cases, the placement of multiple SEMS successfully relieved airway stenosis, improved oxygenation, and reduced dyspnoea, without major complications. These cases support the potential of simultaneous multiple SEMS placement as a safe and effective therapeutic option for patients with extensive airway narrowing.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70311"},"PeriodicalIF":0.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-08-04eCollection Date: 2025-08-01DOI: 10.1002/rcr2.70308
James Nolan, Maxter Thai, Vanessa Moore, Daniel Henderson, David Reid
{"title":"Guillain-Barre Syndrome in Patients With Cystic Fibrosis: A Case Series.","authors":"James Nolan, Maxter Thai, Vanessa Moore, Daniel Henderson, David Reid","doi":"10.1002/rcr2.70308","DOIUrl":"10.1002/rcr2.70308","url":null,"abstract":"<p><p>People with cystic fibrosis (CF) typically experience chronic respiratory infections, but neurological sequelae are rare. Guillain-Barre Syndrome (GBS) is classically precipitated by a respiratory or gastrointestinal infection, although other rarer aetiologies exist. This case series outlines four adults with CF who developed GBS. The association with acute and chronic respiratory infections in people with CF is explored, as well as other potential precipitants. An autoimmune phenomenon in the context of chronic systemic inflammation or a possible contributory role of dysfunctional CFTR protein is also considered.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70308"},"PeriodicalIF":0.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pembrolizumab-Induced Severe Pneumonitis in a Patient With Lung Adenocarcinoma After Umbilical Cord Blood Transplantation: A Case Report.","authors":"Shunta Yamamoto, Hiroki Kabata, Yuri Fukasawa, Kohei Fukuzawa, Masahito Mizobe, Risako Suzuki, Akira Miyakawa, Keiko Ohgino, Hideki Terai, Jun Kato, Hiroyuki Yasuda, Koichi Fukunaga","doi":"10.1002/rcr2.70307","DOIUrl":"10.1002/rcr2.70307","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) are essential treatments for lung cancer, but their safety following allogeneic haematopoietic stem cell transplantation (allo-HSCT) remains unclear. We report a case of a 66-year-old man who underwent umbilical cord blood transplantation for acute lymphoblastic leukaemia and later developed lung adenocarcinoma. Pembrolizumab monotherapy was initiated, but the patient developed severe steroid-refractory immune-related pneumonitis, leading to mortality 56 days after treatment initiation. Given the scarcity of reports on ICI use in lung cancer patients with prior HSCT, this case highlights critical safety considerations.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70307"},"PeriodicalIF":0.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-08-03eCollection Date: 2025-08-01DOI: 10.1002/rcr2.70300
Sammy Onyancha, Ramin Lonnes, Peter Hollaus, Waldemar Schreiner, Gernot Rohde
{"title":"Mycobacterial Infections Mimicking Malignancy in Solitary Pulmonary Lesions: A Cone Beam CT-Guided Biopsy Case Series.","authors":"Sammy Onyancha, Ramin Lonnes, Peter Hollaus, Waldemar Schreiner, Gernot Rohde","doi":"10.1002/rcr2.70300","DOIUrl":"10.1002/rcr2.70300","url":null,"abstract":"<p><p>Solitary pulmonary lesions are often associated with malignancy. Cone beam computed tomography (CBCT) enhances bronchoscopic biopsy accuracy by confirming tool-in-lesion positioning. We present five cases of solitary pulmonary nodules initially suspected to be malignant based on imaging and clinical context. Despite clear tool-in-lesion confirmation via CBCT, initial pathology was non-diagnostic for malignancy. Upon further microbiological analysis, four cases were diagnosed as mycobacterial infections. A fifth case, which underwent surgical resection due to persistent diagnostic uncertainty, was subsequently found to harbour mycobacterial infection; retrospective review of the original biopsy also confirmed this. These cases highlight the importance of including mycobacterial infections such as tuberculoma in the differential diagnosis of solitary pulmonary nodules and stress the need for comprehensive microbiological evaluation in CBCT-confirmed biopsies, especially when histology is non-malignant. Our findings also emphasise the potential diagnostic utility of microbiological tests-including PCR-even prior to histology review when CBCT confirms tool-in-lesion. This approach may prevent unnecessary surgical interventions and associated morbidity.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70300"},"PeriodicalIF":0.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-08-03eCollection Date: 2025-08-01DOI: 10.1002/rcr2.70299
Sammy Onyancha, Ahmad Sajad Soltani, Ramin Lonnes, Peter Hollaus, Waldemar Schreiner, Gernot Rohde
{"title":"Bronchoscopic Drainage of a Persistent Lung Abscess Using CBCT-Guided Aspiration Under Superimposed High-Frequency Jet Ventilation.","authors":"Sammy Onyancha, Ahmad Sajad Soltani, Ramin Lonnes, Peter Hollaus, Waldemar Schreiner, Gernot Rohde","doi":"10.1002/rcr2.70299","DOIUrl":"10.1002/rcr2.70299","url":null,"abstract":"<p><p>Lung abscesses represent complex localised infections of the lung parenchyma. If they fail to resolve with conventional medical and surgical therapy, they pose a significant clinical challenge, particularly when the lesion is poorly accessible to percutaneous or open drainage. The evolution of advanced bronchoscopic techniques including cone-beam computed tomography (CBCT) and superimposed high-frequency jet ventilation (SHFJV) now allows for precise, minimally invasive interventions in such complex cases. We report a case of a persistent right upper lobe abscess due to invasive pulmonary infection that was successfully drained bronchoscopically. CBCT imaging enabled real-time, three-dimensional localisation and confirmation of needle placement within the abscess cavity. SHFJV, delivered through a jet converter system and endotracheal tube, stabilised the lung and minimised motion artefact during imaging and intervention. This case highlights the potential for bronchoscopic intervention in the multidisciplinary management of complex pulmonary infections. This procedure, performed entirely through flexible bronchoscopy, demonstrates how newer technical innovations enhance procedural accuracy, improve safety, and expand the therapeutic potential of interventional pulmonology beyond the traditional confines of rigid bronchoscopy.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70299"},"PeriodicalIF":0.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endobronchial Valve Treatment for Persistent Air Leak and Endoscopic Lung Volume Reduction of Native Lung in a Single Lung Transplant Recipient: A Case Report and Literature Review.","authors":"Joscha Godts, Isabelle Etienne, Christiane Knoop, Dimitri Leduc, Youri Sokolow, Maarten Vander Kuylen, Olivier Taton","doi":"10.1002/rcr2.70305","DOIUrl":"10.1002/rcr2.70305","url":null,"abstract":"<p><p>The use of endobronchial valves (EBV) is a recommended treatment for persistent air leak (PAL) and endoscopic lung volume reduction (ELVR) in selected patients with severe emphysema and absence of collateral ventilation. We report the case of a 52-year-old man who was scheduled for a bilateral sequential lung transplantation, converted to a left single lung transplantation (SLTx) after failure to remove the right lung due to prior thoracic surgery. The post-operative course was complicated by a PAL on the right non-transplanted side, unresponsive to prolonged drainage. Placement of EBV in the right upper and middle lobes, following collateral ventilation evaluation with the Chartis system, resulted in the resolution of the air leak and a concomitant lung volume reduction. Based on a literature review regarding ELVR in single-lung transplanted recipients, we suggest that ELVR with EBV could be a therapeutic option with an acceptable safety profile in this unique population.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70305"},"PeriodicalIF":0.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regorafenib Induced Interstitial Pneumonia in a Patient With Refractory Rectal Cancer.","authors":"Tomo Tsunoda, Yoshiyuki Oyama, Ryota Miyamoto, Taisuke Ito, Takuro Akashi, Kazuo Tsuchiya, Masaki Ikeda","doi":"10.1002/rcr2.70286","DOIUrl":"10.1002/rcr2.70286","url":null,"abstract":"<p><p>Regorafenib, a multi-targeted tyrosine kinase inhibitor (TKI), is indicated for refractory colorectal carcinoma, gastrointestinal stromal tumours (GIST), and hepatocellular carcinoma (HCC). We present a case involving a 66-year-old male patient with refractory colorectal cancer who developed interstitial pneumonia as a consequence of regorafenib therapy. Three months following the initiation of regorafenib administration, a chest computed tomography scan revealed bilateral ground-glass opacities, a characteristic finding in interstitial lung disease. This case illustrates a relatively rapid progression of regorafenib-induced interstitial lung disease following its radiographic manifestation. Clinicians should remain vigilant for this potential pulmonary toxicity in patients receiving regorafenib, even with an apparently short latency period after treatment commencement. Early recognition and prompt intervention are crucial in managing this adverse event.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 8","pages":"e70286"},"PeriodicalIF":0.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}