Respirology Case ReportsPub Date : 2025-03-25eCollection Date: 2025-03-01DOI: 10.1002/rcr2.70158
Kan Zhang, Jie Gao, Xiaofei Liu, Dingyun Song, Tiemei Zhao
{"title":"Pulmonary Light Chain Deposition With Sjögren Syndrome: A Case Report and Literature Review.","authors":"Kan Zhang, Jie Gao, Xiaofei Liu, Dingyun Song, Tiemei Zhao","doi":"10.1002/rcr2.70158","DOIUrl":"10.1002/rcr2.70158","url":null,"abstract":"<p><p>The incidence of light chain deposition disease (LCDD) is relatively low and difficult to diagnose, while cases of PLCDD combined with Sjogren's syndrome are more rare. A case of pulmonary light chain deposit disease combined with Sjogren's syndrome admitted to our department is reported as follows, and the relevant literature is reviewed in order to improve clinicians' understanding of rare diseases and early diagnosis and treatment.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70158"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Malignant Airway Obstruction Mimicking Bronchial Asthma.","authors":"Yuka Matsuo, Yuki Takigawa, Ken Sato, Kenichiro Kudo, Hiromi Watanabe, Akiko Sato, Keiichi Fujiwara, Takuo Shibayama","doi":"10.1002/rcr2.70169","DOIUrl":"10.1002/rcr2.70169","url":null,"abstract":"<p><p>Asthma and central airway stenosis are often misdiagnosed due to overlapping clinical features, leading to delayed diagnosis and inappropriate management. A comprehensive diagnostic approach is crucial for accurate differentiation and improving patient outcomes.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70169"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-03-25eCollection Date: 2025-03-01DOI: 10.1002/rcr2.70168
Qiang-Zhong Pi, Hu Luo
{"title":"A Rare Case of Plasmacytoma Presenting as Pulmonary Mass.","authors":"Qiang-Zhong Pi, Hu Luo","doi":"10.1002/rcr2.70168","DOIUrl":"10.1002/rcr2.70168","url":null,"abstract":"<p><p>Plasmacytoma can manifest as a solitary pulmonary mass, which can be accurately diagnosed through a combination of Bone scan, serum protein electrophoresis, computed tomography (CT)-guided biopsy and bone marrow biopsy. Notably, this case diagnosed with multiple myeloma (MM) with extramedullary plasmacytoma (EMP) demonstrated an exceptional treatment response to radiotherapy and proteasome inhibitor-based chemotherapy.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70168"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pembrolizumab-Induced Anti-Yo-Antibody-Positive Cerebellitis: A Case Report.","authors":"Takafumi Yamano, Toshihide Yokoyama, Tadashi Ishida","doi":"10.1002/rcr2.70160","DOIUrl":"10.1002/rcr2.70160","url":null,"abstract":"<p><p>We report a rare case of pembrolizumab-induced anti-Yo-antibody-positive cerebellitis in a patient with stage IV lung adenocarcinoma. Following two cycles of combination therapy, the patient developed nystagmus and ataxia. Despite tumour regression and normal magnetic resonance imaging (MRI) findings, cerebrospinal fluid analysis revealed lymphocyte-dominant hypercellularity, increased protein, and oligoclonal bands. Immune checkpoint inhibitor (ICI)-related cerebellitis was diagnosed after excluding infectious causes, metastases, and cancerous meningitis coupled with a positive anti-Yo antibody. Methylprednisolone pulse was ineffective, but high-dose intravenous immunoglobulin therapy resolved symptoms. To the best of our knowledge, this is the first case report of ICI-related cerebellitis with anti-Yo-antibody in lung adenocarcinoma. This case highlights the importance of paraneoplastic antibody testing in diagnosing ICI-related encephalitis, especially in cases of normal MRI findings.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70160"},"PeriodicalIF":0.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-03-24eCollection Date: 2025-03-01DOI: 10.1002/rcr2.70164
Martin Boussuges, Mathilde Cadic, Gaelle Peret, Aurélie Kienlen
{"title":"Two Cases of Tracheal Diverticulum Closure in Bronchoscopy by Argon Plasma Coagulation.","authors":"Martin Boussuges, Mathilde Cadic, Gaelle Peret, Aurélie Kienlen","doi":"10.1002/rcr2.70164","DOIUrl":"10.1002/rcr2.70164","url":null,"abstract":"<p><p>We describe two cases of patients who benefited from closure of symptomatic tracheal diverticulum with argon plasma coagulation by bronchoscopy. When the communication openings between the diverticulum and the trachea are millimetre-sized, the technique is safe and effective. In our experience, two sessions, 1 month apart, are required to achieve complete closure of the diverticulum-related openings.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70164"},"PeriodicalIF":0.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-03-24eCollection Date: 2025-03-01DOI: 10.1002/rcr2.70146
Sona Vekaria, Grace Kavanagh, Siobhain Mulrennan
{"title":"Personalised CFTR Modulator Treatment Initiation and Monitoring in CF-Related Liver Disease: When Less Is More.","authors":"Sona Vekaria, Grace Kavanagh, Siobhain Mulrennan","doi":"10.1002/rcr2.70146","DOIUrl":"10.1002/rcr2.70146","url":null,"abstract":"<p><p>Hepatotoxicity due to Elexacaftor/Tezacaftor/Ivacaftor (ETI) use has been well documented. There are no dose adjustments or increased-frequency monitoring algorithms recommended for people who experience elevated transaminases without cirrhosis, only suggested treatment interruption or withdrawal depending on the severity of the derangement. Here we describe a patient with non-cirrhotic hepatic steatosis who experienced persistently elevated liver function tests due to modulator therapy but demonstrated a remarkable response to a notably low dose of ETI.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70146"},"PeriodicalIF":0.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Allergic Bronchopulmonary Mycosis Caused by <i>Schizophyllum commune</i> Successfully Treated With Mepolizumab.","authors":"Mitsuki Kakiuchi, Yuki Takigawa, Ken Sato, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Keiichi Fujiwara, Takuo Shibayama","doi":"10.1002/rcr2.70161","DOIUrl":"10.1002/rcr2.70161","url":null,"abstract":"<p><p>Allergic bronchopulmonary mycosis (ABPM) is a complication of bronchial asthma (BA) and can lead to lung damage and respiratory failure. The standard treatment for ABPM is steroid therapy. Nonetheless, this treatment increases the risk of infections and osteoporosis. Alternative therapies include immunomodulatory biologics and mucus plug removal by bronchoscopy. This report describes a case of a 70-year-old man diagnosed with BA in 2014 and treated with inhaled corticosteroids/long-acting beta-agonists, which were later discontinued for unknown reasons. He was presented to our department with a BA attack, including wheezing and desaturation. Computed tomography and laboratory examinations suggested ABPM; the patient underwent mucus plug removal. The final diagnosis was ABPM, and steroids and itraconazole were initiated. However, BA symptoms did not improve, and the mucus plug and desaturation persisted. Mepolizumab (100 mg/month) subcutaneously cleared the plug and improved BA. This case demonstrates that mepolizumab can treat patients with ABPM and refractory BA.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70161"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-03-20eCollection Date: 2025-03-01DOI: 10.1002/rcr2.70163
Ali Gohar, Bilal Ahmed, Asim Ali, Maryam Ilyas, Momina Masroor, Ayesha Ayman, Masab Ali, Muhammad Husnain Ahmad
{"title":"Primary Ciliary Dyskinesia Complicated by Stroke in an Elderly Male: A Case Report.","authors":"Ali Gohar, Bilal Ahmed, Asim Ali, Maryam Ilyas, Momina Masroor, Ayesha Ayman, Masab Ali, Muhammad Husnain Ahmad","doi":"10.1002/rcr2.70163","DOIUrl":"10.1002/rcr2.70163","url":null,"abstract":"<p><p>Kartagener syndrome (KS) is an uncommon hereditary disorder, featuring situs inversus, chronic sinusitis, and bronchiectasis. Our case report presents a 60-year-old Asian male with KS who was incidentally diagnosed with KS upon presenting with an ischemic cerebrovascular accident (CVA). The patient had a longstanding history of poorly controlled type 2 diabetes mellitus and hypertension, presenting with acute right-sided weakness and speech impairment. His history of recurrent respiratory infections and infertility, combined with family findings of dextrocardia and male infertility, suggested KS. On physical examination, the patient exhibited signs of dextrocardia. Imaging confirmed situs inversus and dextrocardia, while neurological evaluation revealed an embolic stroke in the left middle cerebral artery territory. Certain cardiovascular anomalies in KS may affect stroke risk; however, their co-occurrence in the patient appears to be coincidental, given the patient's baseline risk for stroke. A high-resolution chest CT demonstrated bronchiectasis and carotid Doppler ultrasound identified atherosclerotic plaques, likely contributing to the stroke. This case highlights the need for heightened awareness of neurological events, such as stroke, in patients with KS. Cardiovascular risk factors, compounded by the complexity of the syndrome, require prompt evaluation and multidisciplinary care to prevent severe complications.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70163"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respirology Case ReportsPub Date : 2025-03-20eCollection Date: 2025-03-01DOI: 10.1002/rcr2.70134
Jose Carlos Fraga, Felipe Colombo Holanda, Natalia Zanini Silva, Maria Fernanda Oliveira, Paola Santis Isolan, Elenara Fonseca Procianoy
{"title":"Bronchopleural Fistula Following COVID-19 and Necrotizing Pneumonia in Childhood: Treatment With Intrapleural Vacuum-Assisted Closure Therapy.","authors":"Jose Carlos Fraga, Felipe Colombo Holanda, Natalia Zanini Silva, Maria Fernanda Oliveira, Paola Santis Isolan, Elenara Fonseca Procianoy","doi":"10.1002/rcr2.70134","DOIUrl":"10.1002/rcr2.70134","url":null,"abstract":"<p><p>Bronchopleural fistula is an abnormal communication between the bronchial tree and the pleural space. Necrotizing pneumonia is a catastrophic infection of the lungs characterised by necrosis of the interstitial tissue. Although rarely reported, it has been described as a complication of COVID-19. The usual treatment for bronchopleural fistula involves endoscopic or surgical procedures. We present the case of a 5-year-old girl admitted with necrotizing pneumonia and difficult-to-control bronchopleural fistula, with a report of flu-like illness and a positive PCR test for COVID-19 2 months earlier. Over 38 days, several procedures were performed, including left-side tube drainage, thoracotomy, segmental resection, open window thoracotomy, and finally vacuum-assisted closure (VAC) therapy. Twenty days after the start of VAC therapy, complete closure of the bronchopleural fistula was achieved. At 26 months of follow-up, the child remained asymptomatic, with radiological examinations showing pulmonary expansion and absence of intrapleural air.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70134"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aspergillus Bronchitis at Localised Mucus Plug in an Immunocompetent Patient.","authors":"Kai Yamazaki, Yukihiro Horio, Kazuhito Hatanaka, Takashi Yaguchi, Kozaburo Sadahiro, Kohei Umemoto, Shigeaki Hattori, Katsuyoshi Tomomatsu, Naoki Hayama, Yoko Ito, Tsuyoshi Oguma, Koichiro Asano","doi":"10.1002/rcr2.70104","DOIUrl":"10.1002/rcr2.70104","url":null,"abstract":"<p><p>Aspergillus tracheobronchitis is a form of invasive aspergillosis that primarily occurs in immunocompromised patients. We report a case of Aspergillus bronchitis in an immunocompetent 55-year-old woman with a mucus plug at the site of localised bronchiectasis. The mucus plug gradually enlarged over 9 years, when the patient exhibited submissive haemoptysis. Bronchial artery embolization, followed by partial lung resection was performed. Pathological and mycological examinations led to the diagnosis of AT caused by <i>Aspergillus udagawae</i>.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"13 3","pages":"e70104"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}