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Can FDG-PET after neoadjuvant chemotherapy plus nivolumab predict residual disease in non-small cell lung cancer? 新辅助化疗加 nivolumab 后的 FDG-PET 能否预测非小细胞肺癌的残留疾病？
IF 0.8
Respirology Case Reports Pub Date : 2024-08-19 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70007
Hideto Iguchi, Hiroaki Akamatsu, Yoshimitsu Hirai, Takahito Nakaya, Aya Fusamoto, Yumi Yata, Takahiro Nagai, Daiki Kitahara, Toshiaki Takakura, Yoshiharu Nishimura, Nobuyuki Yamamoto
{"title":"Can FDG-PET after neoadjuvant chemotherapy plus nivolumab predict residual disease in non-small cell lung cancer?","authors":"Hideto Iguchi, Hiroaki Akamatsu, Yoshimitsu Hirai, Takahito Nakaya, Aya Fusamoto, Yumi Yata, Takahiro Nagai, Daiki Kitahara, Toshiaki Takakura, Yoshiharu Nishimura, Nobuyuki Yamamoto","doi":"10.1002/rcr2.70007","DOIUrl":"10.1002/rcr2.70007","url":null,"abstract":"<p><p>Neoadjuvant therapy with nivolumab improves event-free survival (EFS) in patients with resectable non-small cell lung cancer, and a pathological complete response is a predictor of longer EFS. We assessed metabolic responses using 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) before and after neoadjuvant treatment to explore its surrogacy for pathological complete response (pCR). We describe three patients with squamous cell lung carcinoma who underwent neoadjuvant therapy with nivolumab plus chemotherapy, followed by surgery. In Cases 1 and 2, preoperative tumour response were PR per RECIST and demonstrated marked metabolic response on FDG-PET after neoadjuvant therapy, with both resected tumours showing a pCR. On the other hand, Case 3 showed a tumour response before surgery (PR per RECIST), however, the tumour, maintained FDG uptake (19.5 → 15.1), and the resected tumour remained residual cells (RVT, 15%). Thus, reduction of FDG uptake on FDG-PET can predict the pathological response to neoadjuvant therapy with nivolumab.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70007"},"PeriodicalIF":0.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benralizumab-resistant mucus plugs in severe asthma complicated by eosinophilic chronic rhinosinusitis. 严重哮喘并发嗜酸性粒细胞慢性鼻窦炎患者的抗苯拉利单抗粘液栓。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-15 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70009
Masamitsu Hamakawa, Tadashi Ishida
{"title":"Benralizumab-resistant mucus plugs in severe asthma complicated by eosinophilic chronic rhinosinusitis.","authors":"Masamitsu Hamakawa, Tadashi Ishida","doi":"10.1002/rcr2.70009","DOIUrl":"10.1002/rcr2.70009","url":null,"abstract":"<p><p>It is an absolute necessity to achieve complete control of comorbidities to obtain optimal asthma control. Importantly, type 2 asthma and ECRS share the same inflammatory pathophysiology and are common co-morbidities. If the initial biologic is insufficiently effective, it is worth considering an alternative biologic.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70009"},"PeriodicalIF":0.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empyema necessitans. 肺脓肿
IF 0.8
Respirology Case Reports Pub Date : 2024-08-15 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.1393
Anu Menon, David Wisa, Chenyang Zhan, Mohit Chawla, Or Kalchiem-Dekel
{"title":"Empyema necessitans.","authors":"Anu Menon, David Wisa, Chenyang Zhan, Mohit Chawla, Or Kalchiem-Dekel","doi":"10.1002/rcr2.1393","DOIUrl":"10.1002/rcr2.1393","url":null,"abstract":"<p><p>Empyema necessitans should be suspected in any patient presenting with constitutional symptoms, pleural effusion, and a subcutaneous chest wall mass. Thoracic sonography is a readily available tool, which can expedite diagnosis and timely management.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e01393"},"PeriodicalIF":0.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of type B2 thymoma with steroid and radiotherapy. 用类固醇和放射疗法成功治疗 B2 型胸腺瘤。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-13 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70006
Miho Fujiwara, Hiromi Watanabe, Yuki Takigawa, Mayu Goda, Keisuke Shiraha, Tomoyoshi Inoue, Suzuka Matsuoka, Kenichiro Kudo, Akiko Sato, Ken Sato, Keiichi Fujiwara, Takuo Shibayama
{"title":"Successful treatment of type B2 thymoma with steroid and radiotherapy.","authors":"Miho Fujiwara, Hiromi Watanabe, Yuki Takigawa, Mayu Goda, Keisuke Shiraha, Tomoyoshi Inoue, Suzuka Matsuoka, Kenichiro Kudo, Akiko Sato, Ken Sato, Keiichi Fujiwara, Takuo Shibayama","doi":"10.1002/rcr2.70006","DOIUrl":"10.1002/rcr2.70006","url":null,"abstract":"<p><p>An 86-year-old woman with leg edema and dyspnea on exertion was admitted to our hospital. Chest computed tomography (CT) revealed a mass in the anterior mediastinum with pericardial invasion. Histological examination with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) led to the diagnosis of Masaoka stage IVa type B2 thymoma. For palliation, radiotherapy (32 Gy/16 fractions) and prednisolone (30 mg/day) were administered and tapered. After treatment, both the pericardial effusion and tumour size decreased. Combination therapy with steroids and radiotherapy may be effective for treating thymomas.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70006"},"PeriodicalIF":0.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osimertinib-induced BRAF mutation in a single metastatic lesion among multiple pulmonary lesions in a case of lung cancer with EGFR exon 19 deletion. 一例表皮生长因子受体19外显子缺失肺癌患者的多个肺部病灶中，单个转移病灶出现奥希替尼诱导的BRAF突变。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-13 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70003
Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto
{"title":"Osimertinib-induced BRAF mutation in a single metastatic lesion among multiple pulmonary lesions in a case of lung cancer with EGFR exon 19 deletion.","authors":"Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto","doi":"10.1002/rcr2.70003","DOIUrl":"10.1002/rcr2.70003","url":null,"abstract":"<p><p>One of the resistant mechanisms of EGFR-TKIs is BRAF V600E mutation. Herein, we present the case of a 54-year-old Japanese female who underwent a right middle lobectomy for pathological stage IIB lung adenocarcinoma. One year and nine months after the surgery, she developed multiple intrapulmonary metastases. Osimertinib was administered due to EGFR exon 19 deletion. Although all intrapulmonary metastases had shrunk, the nodule at the superior segment of left lung enlarged after postoperative 4 years. The tumour was resected and BRAF V600E mutation and exon 19 deletion were detected. Three months after treatment with dabrafenib and trametinib instead of osimertinib, the remaining intrapulmonary metastases increased again. The continued growth of the metastatic foci even after EGFR-TKI may indicate an acquired resistance. Thus, a repeat biopsy will aid in confirming the new gene expression. It should have been necessary to administer an additional dose of dabrafenib and trametinib without discontinuing osimertinib.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70003"},"PeriodicalIF":0.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modified two-scope technique for transbronchial lung cryobiopsy of peripheral pulmonary lesions. 经支气管肺冷冻生物切片检查周围肺部病变的改良双镜技术。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-11 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.1450
Sze Shyang Kho, Chan Sin Chai, Adam Malik Ismail
{"title":"Modified two-scope technique for transbronchial lung cryobiopsy of peripheral pulmonary lesions.","authors":"Sze Shyang Kho, Chan Sin Chai, Adam Malik Ismail","doi":"10.1002/rcr2.1450","DOIUrl":"10.1002/rcr2.1450","url":null,"abstract":"<p><p>Bleeding mitigation is an important part of any transbronchial lung cryobiopsy (TBLC) procedure, either for interstitial lung disease (ILD) or peripheral pulmonary lesions (PPL). The two-scope technique has been previously described for ILD and PPL-TBLC, but it has its own limitations and technical and logistical complexities. In this case series, we describe a modified two-scope technique that enhances the conventional two-scope technique by maintaining a small equipment footprint and longer bronchoscopic vision without the need for intra-procedure switching of bronchoscopes. Three cases of PPLs were navigated by standard radial endobronchial ultrasound and biopsied with the 1.1 mm flexible ultrathin cryoprobe. All cases achieved a conclusive diagnosis with adequate specimens for immunohistochemical staining and molecular analysis; only Grade 1 bleeding reported in two cases. The challenges and limitations of this modified two-scope technique were also explored in this series.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e01450"},"PeriodicalIF":0.8,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffuse large B-cell lymphoma presenting with pulmonary artery compression symptoms, case reports. 出现肺动脉压迫症状的弥漫大 B 细胞淋巴瘤病例报告。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-11 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.1441
Mhd Baraa Habib, Khaled Ali, Mohamad Fael, Bana Sabbagh, Mohamad Talal Basrak, Osama Alkhalaila, Awni Alshurafa
{"title":"Diffuse large B-cell lymphoma presenting with pulmonary artery compression symptoms, case reports.","authors":"Mhd Baraa Habib, Khaled Ali, Mohamad Fael, Bana Sabbagh, Mohamad Talal Basrak, Osama Alkhalaila, Awni Alshurafa","doi":"10.1002/rcr2.1441","DOIUrl":"10.1002/rcr2.1441","url":null,"abstract":"<p><p>Mediastinal diffuse large B-cell lymphoma (DLBC) may manifest in different presentations including systemic symptoms and local mass symptoms. We report two cases of diffuse large B-cell lymphoma presenting with pulmonary artery compression symptoms. The first case is of a 38-year-old Asian man which mimicked pulmonary embolism, and the second one is of a 27-year-old Asian woman who presented with fainting and respiratory symptoms due to local mass effect. Both cases were significantly improved after treatment. Local mass effect symptoms may be the first clinical presentation in DLBC lymphoma and should not be overlooked.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e01441"},"PeriodicalIF":0.8,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A potential prospect: The novel treatment of intrapleural saline irrigation with intrapleural tyloxapol in treating thoracic empyema. 一个潜在的前景：胸腔内生理盐水灌注配合胸腔内泰乐菌素治疗胸腔积液的新疗法。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-10 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70000
Mas Fazlin Mohamad Jailaini, Noor Amirah Saini, Mohd Jazman Che Rahim, Mohamed Faisal Abdul Hamid
{"title":"A potential prospect: The novel treatment of intrapleural saline irrigation with intrapleural tyloxapol in treating thoracic empyema.","authors":"Mas Fazlin Mohamad Jailaini, Noor Amirah Saini, Mohd Jazman Che Rahim, Mohamed Faisal Abdul Hamid","doi":"10.1002/rcr2.70000","DOIUrl":"10.1002/rcr2.70000","url":null,"abstract":"<p><p>The treatment for empyema thoracis has been evolving over the years, including the usage of intrapleural fibrinolytic therapy (IPFT), for example, alteplase with intrapleural deoxyribonuclease (DNase) to enhance the drainage of pleural effusion. Here, we report two cases of thoracic empyema that were successfully treated with intrapleural saline irrigation and intrapleural tyloxapol apart from parenteral antibiotics as the pillar of the treatment. Both patients averted surgical procedure (decortication) and were discharged well. Upon follow-up, both cases showed clinical cure, biochemical recovery, and radiological improvement, indicating a good treatment outcome. This is the first reported cases on combination of saline irrigation with tyloxapol as alternative treatment for pleural infection.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70000"},"PeriodicalIF":0.8,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of overlapping self-expandable covered stents in the management of long-segment tracheobronchomalacia: A case report. 在治疗长段气管支气管畸形中使用重叠式自膨式覆盖支架：病例报告。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-10 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.1451
Therese Pauline F Yap, Wen-Jue Soong
{"title":"The use of overlapping self-expandable covered stents in the management of long-segment tracheobronchomalacia: A case report.","authors":"Therese Pauline F Yap, Wen-Jue Soong","doi":"10.1002/rcr2.1451","DOIUrl":"10.1002/rcr2.1451","url":null,"abstract":"<p><p>Tracheomalacia is a condition where the tracheal wall is abnormally soft and prone to collapse during increased respiratory efforts. Airway malacia can manifest as segmental conditions like laryngomalacia, tracheomalacia and bronchomalacia, or as diffuse conditions such as tracheobronchomalacia (TBM). Unlike long-segment congenital tracheal stenosis, where surgery may be the preferred treatment, the management of long-segment TBM remains controversial.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e01451"},"PeriodicalIF":0.8,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Miliary sarcoidosis. 纤毛性肉瘤病。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-06 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.1448
Atif Saleem Siddiqui
{"title":"Miliary sarcoidosis.","authors":"Atif Saleem Siddiqui","doi":"10.1002/rcr2.1448","DOIUrl":"10.1002/rcr2.1448","url":null,"abstract":"<p><p>Miliary patterns on chest imaging of the lung can be associated with sarcoidosis.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e01448"},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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