Respirology Case Reports最新文献_第9页

Palivizumab for Donor-Derived RSV Infection in an Adult Bilateral Lung Transplant Recipient: A Case Report. 帕利珠单抗治疗成人双侧肺移植受者供体来源的RSV感染：一例报告

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Respirology Case Reports Pub Date : 2026-07-29 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70706

Rosemary Meharry, Cassandra Vale, John Mackintosh

{"title":"Palivizumab for Donor-Derived RSV Infection in an Adult Bilateral Lung Transplant Recipient: A Case Report.","authors":"Rosemary Meharry, Cassandra Vale, John Mackintosh","doi":"10.1002/rcr2.70706","DOIUrl":"10.1002/rcr2.70706","url":null,"abstract":"Respiratory syncytial virus (RSV) causes significant morbidity in immunocompromised adults. We describe a post-operative bilateral lung transplant recipient with donor-derived RSV who developed increasing viral load and progressive respiratory failure despite conventional therapy (enteral ribavirin, methylprednisolone, IVIG) and was ultimately administered palivizumab. By day 42, the patient remained ventilator-dependent with low RSV PCR cycle threshold (Ct) values on bronchoalveolar lavage. Transbronchial biopsies showed mixed inflammatory appearances, indicating either acute RSV infection or possible rejection. Following administration of single dose intramuscular palivizumab (10 mg/kg) we observed an improving clinical trajectory and increasing Ct values. RSV became undetectable by day 64, with follow-up biopsies revealing no rejection. The patient was successfully discharged on day 87 and continues to show stable allograft function. This case demonstrates safe use of single dose palivizumab to augment conventional therapy for life-threatening RSV in the profoundly immunocompromised lung transplant recipient.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70706"},"PeriodicalIF":0.7,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Diagnostic Confirmation of Malignant Pleural Mesothelioma With Extensive Pleural Adhesions Using Pleural Cryobiopsy Under Local Anaesthesia. 局部麻醉下胸膜冷冻活检成功诊断恶性胸膜间皮瘤伴广泛胸膜粘连。

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Respirology Case Reports Pub Date : 2026-07-29 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70704

Shotaro Otaki, Mikito Suzuki, Kaito Yano, Tomohiro Imoto, Reiko Shimizu, Tsunekazu Hishima, Kazuo Nakagawa

{"title":"Successful Diagnostic Confirmation of Malignant Pleural Mesothelioma With Extensive Pleural Adhesions Using Pleural Cryobiopsy Under Local Anaesthesia.","authors":"Shotaro Otaki, Mikito Suzuki, Kaito Yano, Tomohiro Imoto, Reiko Shimizu, Tsunekazu Hishima, Kazuo Nakagawa","doi":"10.1002/rcr2.70704","DOIUrl":"10.1002/rcr2.70704","url":null,"abstract":"Local anaesthesia thoracoscopy using flex-rigid thoracoscope is useful for diagnosing pleural lesions, but it is generally not indicated in cases with extensive pleural adhesions. We report a case of malignant pleural mesothelioma (MPM) with extensive pleural adhesions that was safely diagnosed using pleural cryobiopsy under local anaesthesia. A 65-year-old man with a history of asbestos exposure presented with chest pain and significant weight loss. A very small amount of pleural effusion, narrowing of the left lower intercostal spaces on chest computed tomography (CT) and negative lung sliding sign on transthoracic echocardiography (TTE) indicated significant pleural adhesions. Considering the high risk of general anaesthesia, biopsy under minimally invasive local anaesthesia was chosen. Precise localization of the lesions using positron emission tomography-CT and TTE enables making the incision over the tumour. After minimal adhesion dissection, pleural cryobiopsy was performed and a definitive diagnosis of epithelial MPM was made.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70704"},"PeriodicalIF":0.7,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Breath Sound Changes During Erythromycin Therapy in Paediatric Diffuse Panbronchiolitis. 红霉素治疗小儿弥漫性泛细支气管炎时纵向呼吸音的变化。

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Respirology Case Reports Pub Date : 2026-07-27 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70685

Katsuhito Iikura, Hideshi Fujinaga, Haruka Tokoro, Junichi Koinuma, Yuji Takizawa, Shinji Oana

{"title":"Longitudinal Breath Sound Changes During Erythromycin Therapy in Paediatric Diffuse Panbronchiolitis.","authors":"Katsuhito Iikura, Hideshi Fujinaga, Haruka Tokoro, Junichi Koinuma, Yuji Takizawa, Shinji Oana","doi":"10.1002/rcr2.70685","DOIUrl":"10.1002/rcr2.70685","url":null,"abstract":"Diffuse panbronchiolitis (DPB) is a chronic inflammatory lung disease of unknown aetiology predominantly affecting middle-aged adults, characterized by chronic sinusitis, productive cough and exertional dyspnea. DPB is rare in children, and its clinical course remains poorly understood. We report a case of DPB in a 13-year-old girl in whom breath sounds were recorded throughout the treatment course using an electronic stethoscope. The patient was treated with low-dose macrolide therapy, which led to improvement in clinical symptoms and pulmonary function, accompanied by parallel changes in abnormal breath sounds. Breath sound analysis revealed that coarse crackles resolved first, followed by sequential amelioration of adventitious continuous sounds from the peripheral to the central airways. Furthermore, a treatment duration of at least 6 months was suggested to be necessary. Breath sound analysis may provide objective information regarding respiratory function and contribute to a deeper understanding of the pathophysiology of this rare disease.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 7","pages":"e70685"},"PeriodicalIF":0.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13407016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Association of Interstitial Lung Disease in Ankylosing Spondylitis: A Case Report and Review of Early Detection and Multidisciplinary Management. 强直性脊柱炎中罕见的间质性肺疾病：一个病例报告及早期发现和多学科治疗的回顾。

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Respirology Case Reports Pub Date : 2026-07-27 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70672

Stefani Larasati, Awalia

{"title":"A Rare Association of Interstitial Lung Disease in Ankylosing Spondylitis: A Case Report and Review of Early Detection and Multidisciplinary Management.","authors":"Stefani Larasati, Awalia","doi":"10.1002/rcr2.70672","DOIUrl":"10.1002/rcr2.70672","url":null,"abstract":"Ankylosing spondylitis (AS) is a chronic inflammatory disorder of the axial skeleton, occasionally complicated by uncommon but increasingly recognized pulmonary involvement such as interstitial lung disease (ILD). We report a 35-year-old woman with a year-long history of inflammatory back pain and peripheral arthritis who fulfilled clinical and radiologic criteria for AS. Despite partial response to cDMARDs, she developed a productive cough. High-resolution CT revealed right upper-lobe ground-glass opacities consistent with early cellular ILD, supported by spirometry showing a moderate restrictive defect and negative autoimmune serology excluding overlapping connective tissue diseases. Conservative pulmonary monitoring and escalation to secukinumab resulted in marked improvement in both musculoskeletal and respiratory symptoms. This case highlights clinically under-recognized pulmonary involvement in AS, including early inflammatory (cellular) ILD, emphasizing diagnostic challenges and the importance of timely imaging and multidisciplinary management.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 7","pages":"e70672"},"PeriodicalIF":0.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemoptysis Secondary to Right Pulmonary Artery Aneurysm in Behçet's Disease: A Case Report and Literature Review. 右肺动脉瘤继发咯血1例并文献复习。

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Respirology Case Reports Pub Date : 2026-07-24 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70695

Dua Nori, Suha Nori, Dania A Ashoor, Lana M Dweekat, Reem Shihab

引用次数: 0

Mediastinal Extrapleural Air Mimicking a Bulla in a Non-Expandable Lung. 非膨胀性肺的纵隔胸膜外空气模拟大泡。

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Respirology Case Reports Pub Date : 2026-07-22 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70693

Hidenori Takahashi, Kota Taguchi, Mio Toyama-Kousaka, Shinichiro Ota, Masaharu Shinkai

引用次数: 0

Endovascular Coil Embolization of Ruptured Idiopathic Multiple Bilateral Pulmonary Artery Aneurysms: A Case Report. 血管内线圈栓塞治疗特发性双侧多发肺动脉动脉瘤1例。

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Respirology Case Reports Pub Date : 2026-07-20 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70691

Abdullah S Almawi, Mohammed S Almasri, Fahad A Almejrad, Mohammed N Almusaad, Maher Alanazi

引用次数: 0

A Rare Case of Scrofuloderma Presenting as Recurrent Tuberculosis in a Young Patient. 一例罕见的黑囊皮病表现为复发结核的年轻患者。

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Respirology Case Reports Pub Date : 2026-07-20 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70694

Yoshihiro Okada, Asuka Okada, Shin Miyagawa, Ami Arimoto, Taisei Furumuro, Masanori Izuka, Yuma Watabe, Izumi Sato, Yusuke Inui, Masahide Ueda, Takahiro Ibaraki, Hideaki Takenaka, Sumito Choh

{"title":"A Rare Case of Scrofuloderma Presenting as Recurrent Tuberculosis in a Young Patient.","authors":"Yoshihiro Okada, Asuka Okada, Shin Miyagawa, Ami Arimoto, Taisei Furumuro, Masanori Izuka, Yuma Watabe, Izumi Sato, Yusuke Inui, Masahide Ueda, Takahiro Ibaraki, Hideaki Takenaka, Sumito Choh","doi":"10.1002/rcr2.70694","DOIUrl":"10.1002/rcr2.70694","url":null,"abstract":"A 23-year-old Indonesian man was referred to our institution due to a skin ulcer with white exudate on the right chest wall. He had undergone treatment for pulmonary tuberculosis (TB) in Indonesia 3 years prior to the consultation. Chest ultrasonography and computed tomography revealed multiple intercostal abscesses and a thickened right pleura with calcification. Histological findings from a skin biopsy of the ulcer and a positive polymerase chain reaction for Mycobacterium tuberculosis in the exudate indicated the involvement of TB. Based on these findings, the patient was diagnosed with scrofuloderma and multiple intercostal abscesses. Recurrent TB may result from either the regrowth of residual strains or reinfection with a different strain. This report highlights that recurrent TB can manifest as scrofuloderma through contiguous spread from underlying intercostal abscesses. In cases of skin ulcers with an unclear aetiology, thorough histopathological and bacteriological assessments facilitate a prompt and accurate diagnosis.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 7","pages":"e70694"},"PeriodicalIF":0.7,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13384745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Documented Case of Congenital Drug-Resistant Tuberculosis in Indonesia: A Case Report. 印度尼西亚首例记录在案的先天性耐药结核病例：一例报告。

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Respirology Case Reports Pub Date : 2026-07-20 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70680

Cynthia Centauri, Srisadono Fauzi Adiprabowo, Putri Maharani Tristanita Marsubrin, Irandi Putra Pratomo

{"title":"The First Documented Case of Congenital Drug-Resistant Tuberculosis in Indonesia: A Case Report.","authors":"Cynthia Centauri, Srisadono Fauzi Adiprabowo, Putri Maharani Tristanita Marsubrin, Irandi Putra Pratomo","doi":"10.1002/rcr2.70680","DOIUrl":"10.1002/rcr2.70680","url":null,"abstract":"Congenital drug-resistant tuberculosis (DR-TB) is a rare condition with no standardized treatment. Congenital TB itself is a life-threatening condition. The clinical manifestations can be nonspecific, particularly in preterm infants, which can further reduce diagnostic awareness. We report a case of a 32-week preterm baby with rifampicin-resistant TB. She was born with respiratory distress and early-onset jaundice, initially suspected of sepsis and admitted to the NICU. The infant initially showed clinical improvement at 3 days of life, but at 23 days of life, the clinical condition worsened despite a sterile blood culture. The mother was subsequently diagnosed with miliary TB with rifampicin-resistant Xpert sputum. The infant's gastric lavage Xpert MTB/RIF confirmed rifampicin-resistant TB. At 32 days of life, she received a five-drug regimen, including bedaquiline. She completed 12 months of treatment with a favourable outcome. This case highlights the challenges of early recognition and treatment selection in congenital DR-TB.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 7","pages":"e70680"},"PeriodicalIF":0.7,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nocardia cyriacigeorgica Identified by Bronchial Washing During Evaluation of Radiologic Progression in a Patient With Prior Nontuberculous Mycobacterial Diseases. 既往非结核性分枝杆菌疾病患者放射学进展评估中经支气管清洗发现的cyriacigeorgica诺卡菌。

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Respirology Case Reports Pub Date : 2026-07-19 eCollection Date: 2026-07-01 DOI: 10.1002/rcr2.70654

Hidenori Takahashi, Kanako Furukawa, Yugo Satake, Natsuko Nakano, Shinichiro Ota, Masaharu Shinkai

{"title":"Nocardia cyriacigeorgica Identified by Bronchial Washing During Evaluation of Radiologic Progression in a Patient With Prior Nontuberculous Mycobacterial Diseases.","authors":"Hidenori Takahashi, Kanako Furukawa, Yugo Satake, Natsuko Nakano, Shinichiro Ota, Masaharu Shinkai","doi":"10.1002/rcr2.70654","DOIUrl":"10.1002/rcr2.70654","url":null,"abstract":"Pulmonary nocardiosis may occur in immunocompetent patients with structural lung disease and may resemble the progression of nontuberculous mycobacterial pulmonary disease. We report an 81-year-old immunocompetent woman with chronic bronchiectasis and prior Mycobacterium kansasii, M. intracellulare, and M. abscessus infections. Despite persistently negative sputum mycobacterial cultures, chest computed tomography (CT) revealed progressive nodular bronchiectatic changes. Bronchial washing from the right B5 bronchus yielded Nocardia cyriacigeorgica; mycobacterial studies were negative. Trimethoprim-sulfamethoxazole was stopped shortly after initiation because of drug eruption, and minocycline monotherapy led to transient symptomatic and radiologic improvement. However, follow-up CT at 6 months revealed radiologic progression. Repeat bronchoscopy was culture-negative, but bronchial washing cytology revealed filamentous organisms suggestive of persistent nocardial infection. Minocycline monotherapy was continued for 12 months. Chest CT at 12 months revealed new contralateral left upper lobe bronchocentric abnormalities. This case highlights the importance of bronchial washing and longitudinal reassessment when radiologic progression remains unexplained by sputum evaluation.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 7","pages":"e70654"},"PeriodicalIF":0.7,"publicationDate":"2026-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13381721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0