{"title":"Transbronchial lung cryobiopsy under real-time radial EBUS: First report on a novel twist of the classical technique.","authors":"Nektarios Anagnostopoulos, Simone Petrarulo, Claudia Ravaglia, Alessandra Dubini, Sara Piciucchi, Grigoris Stratakos, Venerino Poletti","doi":"10.1002/rcr2.1435","DOIUrl":"10.1002/rcr2.1435","url":null,"abstract":"<p><p>Transbronchial lung cryobiopsy (TBLC) is a relatively new technique for obtaining lung biopsies, known for being the least invasive method while offering a high diagnostic yield, a favourable safety profile, and a significant reduction in morbidity, mortality, and hospital stay length compared to surgical lung biopsy. Radial-EBUS (r-EBUS) represent a cornerstone modality for accessing 'invisible' peripheral pulmonary lesions. However, a major drawback of these techniques is the lack of 'real-time' visualization of the biopsy being obtained. In this case report, we present a young woman who was referred to us with a cough, haemoptysis, and a non-resolving lung consolidation. She underwent TBLC under real-time rEBUS guidance. This clinical case demonstrates that, in specific clinical scenarios, TBLC with real-time rEBUS is an excellent diagnostic tool.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01435"},"PeriodicalIF":0.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hoa Do Thanh, Duc Vu Anh, Ghi Nguyen Hai, Duong Le Xuan
{"title":"Community-acquired necrotizing pneumonia caused by methicillin-resistant <i>Staphylococcus aureus</i> in a healthy pregnant woman after being infected with influenza A: A case report for early warning.","authors":"Hoa Do Thanh, Duc Vu Anh, Ghi Nguyen Hai, Duong Le Xuan","doi":"10.1002/rcr2.1396","DOIUrl":"10.1002/rcr2.1396","url":null,"abstract":"<p><p>A previously healthy woman, 5 weeks pregnant, was admitted to the intensive care unit in critical condition for septic shock and acute respiratory distress syndrome due to methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) after being infected with Influenza for 3 days. The patient in this case suffered from severe sequelae due to necrotizing pneumonia and later died on the 20th day after admission. We would like to remind clinicians to be aware of this rare but serious diagnosis. The key is to begin appropriate treatment immediately because MRSA necrotizing pneumonia is mediated by toxins and once the toxins are released they cannot be limited by antibiotic treatments. Necrotizing pneumonia related to MRSA should be considered in young patients with pneumonia, sepsis, and neutropenia following seasonal influenza infection with rapidly progressive symptoms.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01396"},"PeriodicalIF":0.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hwan Jin Lee, Jun Hyung Park, Ae Ri Ahn, Jae Seok Jeong, Yong Chul Lee
{"title":"A rare occurrence of paragonimiasis accompanied by cryptococcal pneumonia.","authors":"Hwan Jin Lee, Jun Hyung Park, Ae Ri Ahn, Jae Seok Jeong, Yong Chul Lee","doi":"10.1002/rcr2.1424","DOIUrl":"10.1002/rcr2.1424","url":null,"abstract":"<p><p>Pulmonary paragonimiasis may be accompanied by a rare infectious disease, such as cryptococcal pneumonia. To our knowledge, this is the first case ever reported in the English literature.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01424"},"PeriodicalIF":0.8,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11258439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alma Rose Devasia, Surya Krishnan, S Swathi Krishna, Aravind Perathur, Jyotsna Yesodharan, Keechilat Pavithran
{"title":"Diffuse pleural metastasis from atypical meningioma.","authors":"Alma Rose Devasia, Surya Krishnan, S Swathi Krishna, Aravind Perathur, Jyotsna Yesodharan, Keechilat Pavithran","doi":"10.1002/rcr2.1430","DOIUrl":"10.1002/rcr2.1430","url":null,"abstract":"<p><p>Meningioma is the most common benign primary brain tumour and does not usually metastasise. We report the case of a 69-year-old male patient with a history of meningioma who presented respiratory symptoms. He was found to have diffuse pleural metastasis from meningioma, which occurred 10 years after surgical management of recurrent meningioma. This case study provides insights into the clinical profile, workup and management of metastatic meningioma.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01430"},"PeriodicalIF":0.8,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Allergic bronchopulmonary mycosis in <i>Schizophyllum commune</i> with positive <i>Aspergillus</i>-specific IgE antibodies: A case report.","authors":"Hiroshi Takahashi, Masamitsu Hamakawa, Tadashi Ishida, Akira Watanabe","doi":"10.1002/rcr2.1433","DOIUrl":"10.1002/rcr2.1433","url":null,"abstract":"<p><p><i>Schizophyllum commune</i> is the third most common causative fungus of allergic bronchopulmonary mycosis(ABPM). Two-thirds of ABPM caused by <i>S. commune</i> can be positive for <i>Aspergillus fumigatus</i>-specific IgE, which can be difficult to diagnose. Our patient presented to our hospital with wet cough for 3 months and chest pain for 3 days. Blood tests showed IgE 1522 IU/mL, eosinophils 688/mm<sup>3</sup>, <i>A. fumigatus</i> -specific IgE 2.24 UA/mL, and chest computed tomography showed high-attenuation mucus. Bronchoscopy showed mucus plugs and speculum examination showed filamentous fungi, but various culture tests did not detect <i>A. fumigatus</i>, Asp f 1-specific IgE was negative, and <i>S. commune</i> was detected in the culture of bronchial washing. Since he was positive for <i>S. commune</i>-specific IgE and IgG, he diagnosed ABPM caused by <i>S. commune</i>. These findings demonstrate the importance of identifying the causative fungus in ABPM by detailed examination.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01433"},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141628057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Donnan, Miranda Siemienowicz, Hui Sien Tay, Catriona McLean, Steve Philpot, Chris Mason, Greg Snell, Ian Glaspole, Rob G Stirling
{"title":"Trimethoprim-sulfamethoxazole acute respiratory distress syndrome requiring lung transplantation.","authors":"Matthew Donnan, Miranda Siemienowicz, Hui Sien Tay, Catriona McLean, Steve Philpot, Chris Mason, Greg Snell, Ian Glaspole, Rob G Stirling","doi":"10.1002/rcr2.1434","DOIUrl":"10.1002/rcr2.1434","url":null,"abstract":"<p><p>Trimethoprim-sulfamethoxazole (TMP-SMX) acute respiratory distress syndrome (ARDS) is a rare, but severe complication of a commonly prescribed antibiotic. TMP-SMX typically affects young, otherwise well patients with a specific human leukocyte antigen type (HLA-B*07:02 and HLA-C*07:02). The condition is poorly understood with a unique pathological appearance and mechanism that remains unclear. Mortality rate is greater than one third. We describe the case of a previously well 18-year-old woman treated with a prolonged course of TMP-SMX for a complex urinary tract infection who developed rapidly progressive respiratory failure requiring prolonged intensive care admission, extra-corporeal membranous oxygenation, and eventual lung transplantation. No targeted treatment exists, further research is required to better understand disease pathogenetic mechanisms and potential therapeutic interventions.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01434"},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141628058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<sup>18</sup>F-FDG accumulation at the early onset of acute exacerbation of idiopathic interstitial pneumonia on <sup>18</sup>F-FDG PET/CT: A case report.","authors":"Kimitaka Akaike, Koichi Saruwatari, Shinya Sakata, Seitaro Oda, Shinya Shiraishi, Shinji Iyama, Aiko Masunaga, Yusuke Tomita, Hidenori Ichiyasu, Takuro Sakagami","doi":"10.1002/rcr2.1427","DOIUrl":"10.1002/rcr2.1427","url":null,"abstract":"<p><p>Acute exacerbation of idiopathic interstitial pneumonias (AE-IIPs) is a disease associated with a poor prognosis in patients with IIPs. However, the specific characteristics of fluorine-18 2-fluoro-2-deoxy-d-glucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) imaging for AE-IIPs remain unclear. Herein, we present the case of a patient with lung cancer combined with IIPs who underwent <sup>18</sup>F-FDG PET/CT at the early onset of AE-IIPs. The scan, conducted 18 days post-bronchoscopy for lung cancer evaluation, revealed AE-IIPs before the onset of respiratory failure. New ground-glass opacities appeared, accompanied by significant <sup>18</sup>F-FDG accumulation extending beyond these regions. To the best of our knowledge, this report represents the first assessment of <sup>18</sup>F-FDG PET/CT images at the early onset of AE-IIPs before respiratory failure in humans. The observed features in this PET image could potentially contribute to our understanding of the pathophysiology of AE-IIPs.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01427"},"PeriodicalIF":0.8,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lymphoid follicular hyperplasia arising from the chest wall presenting as a substantial mass.","authors":"Naoya Kitamura, Keitaro Tanabe, Toshihiro Ojima, Koichiro Shimoyama, Akira Noguchi, Kenichi Hirabayashi, Tomoshi Tsuchiya","doi":"10.1002/rcr2.1417","DOIUrl":"10.1002/rcr2.1417","url":null,"abstract":"<p><p>Lymphoid follicular hyperplasia (LFH) is a benign lymphoproliferative disease. Although it can occur within the thoracic cavity, LFH originating from the chest wall has not been reported. A 79-year-old woman was incidentally found to have a well-defined mass on the left posterior chest wall during a preoperative examination for aortic valve replacement. The mass had slowly grown over 6 years. Thoracoscopic surgical resection was performed without complications. Pathological examination ruled out lymphoproliferative diseases, such as Castleman disease or malignant lymphoma, and a diagnosis of LFH was made. Although LFH generally has a good prognosis, surgical resection is recommended for diagnostic and therapeutic purposes owing to the possibility of malignancy masquerading as a reactive lesion. This is the first report of an LFH arising from the chest wall with imaging findings similar to other benign tumours. Its potential as a differential diagnosis for tumours with similar imaging findings is highlighted.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01417"},"PeriodicalIF":0.8,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eosinophilic granulomatosis with polyangiitis developed during treatment with benralizmab for severe asthma: A case report and literature review.","authors":"Mitsukuni Sakabe, Kazunori Tobino, Yumi Obata, Shota Sogabe, Kazuki Uchida, Yosuke Murakami","doi":"10.1002/rcr2.1431","DOIUrl":"10.1002/rcr2.1431","url":null,"abstract":"<p><p>Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare autoimmune disorder characterized by necrotizing vasculitis, asthma, and eosinophilia. We report a case of EGPA that developed during benralizumab treatment for severe asthma and provide a literature review. A 79-year-old Japanese male with severe asthma presented with generalized purpura 4 months after initiating benralizumab treatment. He had reduced his oral prednisolone dose from 7.5 to 2 mg/day. Laboratory tests revealed eosinophilia, and skin biopsy showed vasculitis with eosinophilic infiltration. He was diagnosed with EGPA and treated with corticosteroids, azathioprine, and mepolizumab, which led to rapid improvement and sustained remission. Five cases of EGPA developing during benralizumab treatment have been reported, with onset ranging from 14 to 36 weeks after initiation. Clinicians should monitor for EGPA development in patients receiving benralizumab, particularly during oral corticosteroid reduction.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01431"},"PeriodicalIF":0.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryuta Onozato, Jun Miyata, Takanori Asakura, Ho Namkoong, Koichiro Asano, Naoki Hasegawa, Koichi Fukunaga
{"title":"Development of allergic bronchopulmonary aspergillosis in a patient with nontuberculous mycobacterial-pulmonary disease successfully treated with dupilumab: A case report and literature review.","authors":"Ryuta Onozato, Jun Miyata, Takanori Asakura, Ho Namkoong, Koichiro Asano, Naoki Hasegawa, Koichi Fukunaga","doi":"10.1002/rcr2.1432","DOIUrl":"10.1002/rcr2.1432","url":null,"abstract":"<p><p>Pulmonary manifestations in patients with allergic bronchopulmonary aspergillosis (ABPA) and nontuberculous mycobacterial-pulmonary disease (NTM-PD) include bronchiectasis and mucus plugging. A 68-year-old woman, treated with antibiotics and inhaled corticosteroids for NTM-PD and asthma, presented with fever and wheezing. ABPA was diagnosed based on laboratory findings (elevated peripheral blood eosinophil counts and serum total IgE levels and positive <i>Aspergillus</i>-specific IgE and IgG) and imaging observation of a high-attenuation mucus plug. Systemic prednisolone was avoided to prevent NTM-PD progression. Dupilumab, a monoclonal antibody that blocks IL-4/13, was introduced to improve the clinical findings. Herein, we discuss the pathophysiological mechanisms underlying this rare comorbidity.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 7","pages":"e01432"},"PeriodicalIF":0.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}