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Eosinophilic reactive airways disease after immune checkpoint inhibitor treatment. 免疫检查点抑制剂治疗后的嗜酸性粒细胞反应性气道疾病。
IF 0.8
Respirology Case Reports Pub Date : 2024-09-08 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.70022
Parker Cordial, Ian D Bentley, Jeffrey C Horowitz, Kevin Ho
{"title":"Eosinophilic reactive airways disease after immune checkpoint inhibitor treatment.","authors":"Parker Cordial, Ian D Bentley, Jeffrey C Horowitz, Kevin Ho","doi":"10.1002/rcr2.70022","DOIUrl":"https://doi.org/10.1002/rcr2.70022","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICI) are increasingly utilized as first-line treatment for many solid tumour malignancies. One downside of ICI therapy is autoimmune-mediated organ inflammation, or immune-related adverse events (irAE). ICI-related pneumonitis, or non-infectious inflammation of the lung, is a well-described irAE. While guidelines surrounding ICI-related pneumonitis are well established, other ICI-related pulmonary toxicities, including reactive airways disease, are rarely described in the literature. Here, we present a series of patients without pre-existing COPD or asthma who developed reactive airways disease with peripheral eosinophilia after ICI therapy and without radiographic evidence of pneumonitis. The patients were treated with typical therapies for reactive airways disease, including- inhaled steroids, bronchodilators, systemic steroids, and in one instance, dupilumab. All experienced symptomatic improvement with these therapies, enabling some of the patients to continue receiving ICI therapy.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70022"},"PeriodicalIF":0.8,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete removal of a ruptured pulmonary hydatid cyst during conscious sedation bronchoscopy: A case report and literature review. 在有意识镇静支气管镜检查中完全切除破裂的肺包虫囊肿：病例报告和文献综述。
IF 0.8
Respirology Case Reports Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.70002
Kevin Ziyi Wen, Ricky Tanujaya Lim, Andrew Dimitri, Lisa Noonan, Jonathan Williamson
{"title":"Complete removal of a ruptured pulmonary hydatid cyst during conscious sedation bronchoscopy: A case report and literature review.","authors":"Kevin Ziyi Wen, Ricky Tanujaya Lim, Andrew Dimitri, Lisa Noonan, Jonathan Williamson","doi":"10.1002/rcr2.70002","DOIUrl":"10.1002/rcr2.70002","url":null,"abstract":"<p><p>The complete removal of a pulmonary hydatid cyst by bronchoscopy occurs rarely in clinical practice. We describe a 22-year-old male originally from Lebanon, with suspected hydatid cyst rupture on computed tomography chest after experiencing sudden onset fevers and cough whilst taking empiric anthelmintic therapy. Bronchoscopy revealed white gelatinous material in the posterior segment of the left lower lobe. The complete membranes of a hydatid cyst were removed with grasping forceps. Histologic examination confirmed the diagnosis of echinococcosis.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70002"},"PeriodicalIF":0.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A seven-month-old baby presenting excessive crying for pulmonary sequestration with torsion: A case report and literature review. 一名七个月大的婴儿因肺动脉栓塞伴扭转而哭闹不止：病例报告和文献综述。
IF 0.8
Respirology Case Reports Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.70016
Li Li, Yuanxiang Wang, Longwei Sun, Wenjian Wang
{"title":"A seven-month-old baby presenting excessive crying for pulmonary sequestration with torsion: A case report and literature review.","authors":"Li Li, Yuanxiang Wang, Longwei Sun, Wenjian Wang","doi":"10.1002/rcr2.70016","DOIUrl":"10.1002/rcr2.70016","url":null,"abstract":"<p><p>Pulmonary sequestration with torsion is a rare condition. We describe a seven-month-old baby presenting excessive crying for pulmonary sequestration with torsion. Contrast-enhanced chest computed tomography demonstrated an oval-shaped mass in the posteromedial right lower chest, no systemic arterial supply was evident. The edge of the mass showed slight linear reinforcement, and its interior had no reinforcement. Thoracoscopic segmentectomy was carried out and histology confirmed pulmonary sequestration with torsion.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70016"},"PeriodicalIF":0.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pull-up surprise: Chronic foreign body aspiration. 拉起时的惊奇慢性异物吸入
IF 0.8
Respirology Case Reports Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.70011
Dzufar Halim, David Breen
{"title":"Pull-up surprise: Chronic foreign body aspiration.","authors":"Dzufar Halim, David Breen","doi":"10.1002/rcr2.70011","DOIUrl":"https://doi.org/10.1002/rcr2.70011","url":null,"abstract":"<p><p>Foreign body aspiration is rare in adults but can be life-threatening. This case highlights the subtlety of chronic foreign body aspiration presentation and the importance of judicious use of radiological tool and comprehensive history-taking especially in patients with chronic cough.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70011"},"PeriodicalIF":0.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Escherichia coli community-acquired necrotizing pneumonia, an uncommon presentation of a common pathogen: A case report and literature review. 大肠埃希菌社区获得性坏死性肺炎，一种常见病原体的不常见表现：病例报告和文献综述。
IF 0.8
Respirology Case Reports Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.70015
Alireza Mohammad Hosseini, Parisa Farshchi, Hanieh Hosseini, Fatemeh Zarei
{"title":"<i>Escherichia coli</i> community-acquired necrotizing pneumonia, an uncommon presentation of a common pathogen: A case report and literature review.","authors":"Alireza Mohammad Hosseini, Parisa Farshchi, Hanieh Hosseini, Fatemeh Zarei","doi":"10.1002/rcr2.70015","DOIUrl":"10.1002/rcr2.70015","url":null,"abstract":"<p><p>Community-acquired necrotizing pneumonia is a rare but potentially fatal infection, mainly caused by specific pathogens such as <i>Streptococcus pneumoniae</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Haemophilus influenzae</i>, and <i>Pseudomonas aeruginosa</i>. <i>Escherichia coli</i> is extremely rare as a pathogen for community-acquired necrotizing pneumonia, typically accompanied with bloodstream infection. Here, we report an unusual case of a 60-year-old man with uncontrolled diabetes mellitus and no bloodstream infections, who had severe necrotizing <i>E. coli</i> pneumonia leading to massive hemoptysis and death. Clinicians should be aware of this pathogen in respiratory infections, as it requires immediate pathogen detection and usually aggressive antibiotic treatment.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70015"},"PeriodicalIF":0.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relapsing polychondritis after COVID-19 vaccination. 接种 COVID-19 疫苗后的复发性多软骨炎。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-30 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.70008
Koki Ito, Takunori Ogawa, Shunya Igarashi, Kosuke Miyai, Kimiya Sato, Akihiko Kawana, Yoshifumi Kimizuka
{"title":"Relapsing polychondritis after COVID-19 vaccination.","authors":"Koki Ito, Takunori Ogawa, Shunya Igarashi, Kosuke Miyai, Kimiya Sato, Akihiko Kawana, Yoshifumi Kimizuka","doi":"10.1002/rcr2.70008","DOIUrl":"10.1002/rcr2.70008","url":null,"abstract":"<p><p>Relapsing polychondritis (RP) is a rare inflammatory disorder involving immune-mediated destruction of cartilaginous structures. Herein, we present the first report of a strong association between COVID-19 vaccination and RP development. Clinicians should be aware that RP is among the autoimmune diseases that can develop after mRNA vaccination.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e70008"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsuccessful rechallenge with nivolumab in a patient with advanced non-small cell lung cancer who had a 6-year complete response and treatment-free period: Case report. 一名晚期非小细胞肺癌患者曾在完全应答和无治疗期长达 6 年之久，但重新挑战 nivolumab 治疗未获成功：病例报告。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-29 eCollection Date: 2024-09-01 DOI: 10.1002/rcr2.1401
Toshiaki Takakura, Hiroaki Akamatsu, Atsushi Washioka, Eriko Murakami, Ryota Shibaki, Toshio Shimizu, Yasuhiro Koh, Nobuyuki Yamamoto
{"title":"Unsuccessful rechallenge with nivolumab in a patient with advanced non-small cell lung cancer who had a 6-year complete response and treatment-free period: Case report.","authors":"Toshiaki Takakura, Hiroaki Akamatsu, Atsushi Washioka, Eriko Murakami, Ryota Shibaki, Toshio Shimizu, Yasuhiro Koh, Nobuyuki Yamamoto","doi":"10.1002/rcr2.1401","DOIUrl":"10.1002/rcr2.1401","url":null,"abstract":"<p><p>Several predictive factors of immune checkpoint inhibitor response have been reported, but there has not been sufficient exploration of which patients benefit from immune checkpoint inhibitor rechallenge. We report the case of a patient with non-small cell lung cancer who had 6 years of complete response with initial nivolumab treatment. After relapse, however, rechallenge with nivolumab did not result in tumour shrinkage or long-term response. Even in patients who had an exceptional response to the initial immune checkpoint inhibitor, long-term efficacy may not be achieved by immune checkpoint inhibitor rechallenge. Thorough investigation of biomarkers that predict efficacy of immune checkpoint inhibitor rechallenge is warranted.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 9","pages":"e01401"},"PeriodicalIF":0.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11359703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of upfront triple oral combination therapy with additional pirfenidone in a patient with severe pulmonary hypertension associated with lung diseases. 先期三联口服联合疗法加吡非尼酮对肺部疾病相关重度肺动脉高压患者的疗效。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-26 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70010
Fumihiro Kashizaki, Sachiko Matsumoto, Atsushi Miyasaka, Nanami Tsuchiya, Reeko Osada, Mai Kaneko, Kentaro Yumoto, Hao Chen, Kenji Konishi, Harumi Koizumi, Kenichi Takahashi, Takeshi Kaneko
{"title":"Effectiveness of upfront triple oral combination therapy with additional pirfenidone in a patient with severe pulmonary hypertension associated with lung diseases.","authors":"Fumihiro Kashizaki, Sachiko Matsumoto, Atsushi Miyasaka, Nanami Tsuchiya, Reeko Osada, Mai Kaneko, Kentaro Yumoto, Hao Chen, Kenji Konishi, Harumi Koizumi, Kenichi Takahashi, Takeshi Kaneko","doi":"10.1002/rcr2.70010","DOIUrl":"10.1002/rcr2.70010","url":null,"abstract":"<p><p>Diagnosis and treatment of pulmonary hypertension (PH) in patients with lung diseases (PH-LD) remain unestablished and pose significant challenges. In this report, we present a case of a 77-year-old patient with an indeterminate for usual interstitial pneumonia pattern along with chronic obstructive pulmonary disease, who developed groups 1 and 3 PH. Following diagnosis, upfront triple oral combination therapy (UTOCT) with macitentan, sildenafil, and selexipag was initiated. Stability in disease progression was achieved over 4 years with the addition of pirfenidone to address interstitial lung disease progression. To the best of our knowledge, this represents the first reported case of PH-LD, where disease control was maintained with the addition of pirfenidone to UTOCT. This case suggests that some patients with PH-LD, presenting with groups 1 and 3 PH, may benefit from combined UTOCT and antifibrotic agents, potentially improving symptoms and extending their prognosis.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70010"},"PeriodicalIF":0.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revamping hemothorax management: The promise of low-dose intrapleural fibrinolytic therapy as an alternative. 重塑血气胸治疗：低剂量胸膜腔内纤维蛋白溶解疗法有望成为一种替代疗法。
IF 0.8
Respirology Case Reports Pub Date : 2024-08-26 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70012
Mas Fazlin Mohamad Jailaini, Yusra Hashim, Mohamed Faisal Abdul Hamid
{"title":"Revamping hemothorax management: The promise of low-dose intrapleural fibrinolytic therapy as an alternative.","authors":"Mas Fazlin Mohamad Jailaini, Yusra Hashim, Mohamed Faisal Abdul Hamid","doi":"10.1002/rcr2.70012","DOIUrl":"10.1002/rcr2.70012","url":null,"abstract":"<p><p>Surgical evacuation has long been the standard treatment for hemothorax. However, some patients are not suitable candidates for surgery. Intrapleural fibrinolytic therapy (IPFT) has recently emerged as an effective alternative for managing retained hemothorax. This case report describes two patients with retained hemothorax who were unfit for surgery and were successfully treated with IPFT at our centre. Both patients were deemed unsuitable for surgery due to comorbidities and their overall functional status. They received three cycles of IPFT, each consisting of 2.5 mg of alteplase. This treatment effectively evacuated the retained hemothorax, achieving complete radiological resolution without immediate or delayed complications up to 3 months post-discharge.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70012"},"PeriodicalIF":0.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval. 来自肾脏的孤立复发性转移性肺结节：超长的间隔期
IF 0.8
Respirology Case Reports Pub Date : 2024-08-26 eCollection Date: 2024-08-01 DOI: 10.1002/rcr2.70005
Cheong Kim, Hwan Jin Lee, Kyu Yun Jang, Jun Hyung Park, Jae Seok Jeong, Yong Chul Lee
{"title":"Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval.","authors":"Cheong Kim, Hwan Jin Lee, Kyu Yun Jang, Jun Hyung Park, Jae Seok Jeong, Yong Chul Lee","doi":"10.1002/rcr2.70005","DOIUrl":"10.1002/rcr2.70005","url":null,"abstract":"<p><p>Our case highlights the importance of follow-up. Previous meta-analysis has shown that patients with sub-centimetre nodules may have extended follow-up intervals before requiring intervention, unlike those with larger nodules exceeding 1 cm. However, referring to our case, we can see the importance of regular and dense follow-up.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"12 8","pages":"e70005"},"PeriodicalIF":0.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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