Respirology Case Reports最新文献_第8页

Bronchoscopic Localization of a Post-Surgical Persistent Air Leak Facilitating Successful Treatment With a Hybrid Imaging-Guided Percutaneous Sealing of Fistula and Autologous Blood Patch Technique. 支气管镜定位术后持续性气漏，促进了成像引导下经皮瘘封堵和自体血液贴片技术的成功治疗。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-07 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70711

Ivory Ching Yee Yeo, Carrie Kah-Lai Leong, Eugene MingJin Gan

{"title":"Bronchoscopic Localization of a Post-Surgical Persistent Air Leak Facilitating Successful Treatment With a Hybrid Imaging-Guided Percutaneous Sealing of Fistula and Autologous Blood Patch Technique.","authors":"Ivory Ching Yee Yeo, Carrie Kah-Lai Leong, Eugene MingJin Gan","doi":"10.1002/rcr2.70711","DOIUrl":"10.1002/rcr2.70711","url":null,"abstract":"Post-surgical persistent air leak (PAL) poses significant management challenges in patients with high surgical risk and complex anatomy. A 58-year-old female with advanced thymoma underwent extensive thoracic resection and developed PAL refractory to conservative management with pleural drain insertion. Chest Computed Tomography (CT) suggested a possible broncho-pleural fistula at the left lower lobe superior segment. Sequential bronchoscopic balloon occlusion under general anaesthesia localized the fistula to the LB6 lateral subsegment with the aid of a digital chest drain system. This was confirmed by methylene blue instillation via bronchoscopy and observation of colour change in the pleural drain fluid. Interventional radiology (IR) subsequently performed CT-fluoroscopy guided percutaneous sealing of fistula using Histoacryl-lipiodol mixture, followed by autologous blood and thrombin instillation via the pleural drain, resulting in obliteration of fistula and complete resolution of PAL. We highlight a unique case of multi-disciplinary collaboration between Pulmonology and IR to successfully treat PAL via a combination of minimally invasive techniques.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70711"},"PeriodicalIF":0.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatable Traits-Oriented Management in Pre-COPD With Severe Obstructive Sleep Apnea: A Case Report of Symptomatic and Spirometric Improvement After Integrated Therapy. 以治疗特征为导向的copd前伴严重阻塞性睡眠呼吸暂停的治疗：综合治疗后症状和肺量改善1例报告。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-07 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70710

Norifumi Kudeken

{"title":"Treatable Traits-Oriented Management in Pre-COPD With Severe Obstructive Sleep Apnea: A Case Report of Symptomatic and Spirometric Improvement After Integrated Therapy.","authors":"Norifumi Kudeken","doi":"10.1002/rcr2.70710","DOIUrl":"10.1002/rcr2.70710","url":null,"abstract":"Pre-chronic obstructive pulmonary disease (pre-COPD) is an early disease state characterised by respiratory symptoms and/or structural abnormalities without established airflow limitation. We report a woman in her 40s with cough, exertional dyspnoea, preserved spirometry, mild emphysematous change and severe obstructive sleep apnea (apnea-hypopnea index, 88.1 events/h). Integrated management with inhaled fluticasone furoate/umeclidinium/vilanterol and continuous positive airway pressure was initiated. After 12 weeks, FEV1 increased from 2.27 to 2.73 L and FEV1/FVC from 82.5% to 86.9%, while the COPD Assessment Test score decreased from 12 to 3. The patient continued smoking and body weight remained essentially stable. Systemic inflammatory markers showed no clear overall improvement. Eosinophilic asthma was considered less likely because bronchodilator responsiveness was negative, blood eosinophils and total IgE were low, sputum eosinophils were negative, and sputum cytology showed neutrophilic inflammation. This case is hypothesis-generating and suggests that selected pre-COPD patients may benefit from multifactorial trait-oriented management.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70710"},"PeriodicalIF":0.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociated Biologic Responses Across the United Airway: A Case Report of Severe Asthma With Chronic Rhinosinusitis With Nasal Polyps and Eosinophilic Otitis Media. 跨联合气道的分离生物学反应：重度哮喘合并慢性鼻窦炎合并鼻息肉和嗜酸性中耳炎1例报告。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-06 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70715

Tomoko Tajiri, Naoki Takemoto, Toshiya Minakata, Motohiko Suzuki, Yoshiyuki Ozawa, Hirotsugu Ohkubo

{"title":"Dissociated Biologic Responses Across the United Airway: A Case Report of Severe Asthma With Chronic Rhinosinusitis With Nasal Polyps and Eosinophilic Otitis Media.","authors":"Tomoko Tajiri, Naoki Takemoto, Toshiya Minakata, Motohiko Suzuki, Yoshiyuki Ozawa, Hirotsugu Ohkubo","doi":"10.1002/rcr2.70715","DOIUrl":"10.1002/rcr2.70715","url":null,"abstract":"Asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and eosinophilic otitis media (EOM) share type 2 inflammatory pathways. Although type 2-targeted biologic therapies have shown efficacy for these diseases, some patients exhibit dissociated responses to a single biologic. A case of severe asthma with CRSwNP and EOM that showed dissociated responses to biologic therapies and was successfully managed by biologic switching is reported. A 55-year-old man with asthma, recurrent CRSwNP requiring multiple surgeries and oral corticosteroid-dependent EOM was referred to our hospital. Nineteen months after starting dupilumab, EOM and endoscopic and radiological findings of CRSwNP improved partially. However, his nasal symptoms and olfactory dysfunction persisted, and asthma remained uncontrolled. After switching from dupilumab to mepolizumab, asthma control, nasal symptoms and olfactory dysfunction improved, and EOM remained well controlled. Careful monitoring of disease activity and consideration of biologic switching may help achieve optimal control in patients with type 2 united airway diseases.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70715"},"PeriodicalIF":0.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Suspected Case of Allergic Bronchopulmonary Mycosis Associated With Exophiala dermatitidis. 疑似过敏性支气管肺真菌病合并外生性皮炎1例。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-06 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70700

Toshiyuki Yonezawa, Saori Onishi, Daisuke Sunakawa, Yasutaka Kato, Satoru Ito

{"title":"A Suspected Case of Allergic Bronchopulmonary Mycosis Associated With Exophiala dermatitidis.","authors":"Toshiyuki Yonezawa, Saori Onishi, Daisuke Sunakawa, Yasutaka Kato, Satoru Ito","doi":"10.1002/rcr2.70700","DOIUrl":"10.1002/rcr2.70700","url":null,"abstract":"Exophiala dermatitidis is a black fungus that can colonize the airways, but allergic bronchopulmonary mycosis (ABPM) associated with E. dermatitidis is rare. An 83-year-old former smoker without asthma presented with exertional dyspnea. Chest CT showed bronchiectasis and a mucus plug in the left B3 bronchus. One month after discharge for acute cholecystitis, he returned with cough. Chest CT showed enlargement of the mucus plug and an infiltrative shadow in the left upper lobe. Despite piperacillin/tazobactam therapy for suspected bacterial pneumonia, cough and radiological findings persisted. Laboratory findings showed eosinophilia of 546/μL and total IgE of 823 IU/mL. Bronchoscopy on hospital day 4 revealed the mucus plug, and cultures yielded E. dermatitidis. ABPM associated with E. dermatitidis was suspected. Corticosteroid and voriconazole therapy improved cough, radiological findings and eosinophilia. This case suggests E. dermatitidis may be involved in ABPM, even without cystic fibrosis.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70700"},"PeriodicalIF":0.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Solitary Soft Tissue Mass in the Thigh as the First Manifestation of Occult Lung Squamous Cell Carcinoma: A Case Report. 大腿单发软组织肿块为隐匿性肺鳞状细胞癌的首发表现：1例报告。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-06 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70713

Jian Gao, MengWei Zhang, YuYing Li

引用次数: 0

Endovascular Stent-Graft Exclusion for the Treatment of Haemoptysis Caused by Central Pulmonary Artery Pseudoaneurysm: A Case Report. 血管内支架排除治疗中央肺动脉假性动脉瘤所致咯血1例。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-04 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70714

Dongjun Su, Shuangxi Li, Fenqiang Li

{"title":"Endovascular Stent-Graft Exclusion for the Treatment of Haemoptysis Caused by Central Pulmonary Artery Pseudoaneurysm: A Case Report.","authors":"Dongjun Su, Shuangxi Li, Fenqiang Li","doi":"10.1002/rcr2.70714","DOIUrl":"10.1002/rcr2.70714","url":null,"abstract":"Pulmonary artery pseudoaneurysm (PAP) is a rare lethal disease; central tuberculous PAP carries a mortality rate of 50%-90% and often responds poorly to conventional embolization. We report a 59-year-old tuberculous woman with recurrent haemoptysis secondary to left main PAP. Covered stent-graft exclusion was conducted after failed conservative treatment and bronchial artery embolization, with complete haemostasis and no recurrence at 1-year follow-up. Most existing literature adopts vessel-occlusive embolization for PAP, which may cause pulmonary infarction. Moreover, stent-graft implantation for main pulmonary artery lesions is seldom reported due to dimensional mismatch between large native main pulmonary arteries and commercially available covered stent-grafts (maximum diameter 12 mm). Our case uniquely confirms that precise preoperative vascular measurement allows successful deployment of a 12 mm stent-graft within the 11 mm proximal arterial segment, providing rare long-term follow-up evidence of durable haemostasis and preserved pulmonary patency via this vessel-preserving intervention strategy for central PAP.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70714"},"PeriodicalIF":0.7,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review. 小细胞肺癌伴囊性空腔1例报告及文献复习。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-02 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70709

Hiroyuki Shimada, Yukihisa Inoue, Osamu Matsubara, Mio Yamamoto, Shohei Yamashita, Tetsu Hara, Kazuki Yamanaka, Yasuto Jinn

引用次数: 0

Bronchoscopic Removal of Aspergilloma in a 26-Year-Old Man. 支气管镜下曲菌瘤切除一例26岁男性。

IF 0.7

Respirology Case Reports Pub Date : 2026-08-02 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70696

Chun-Hao Wang, Lih-Yu Chang, Jann-Yuan Wang

引用次数: 0

Intravascular Pulmonary Artery Tumour Mimicking Nodal Recurrence and Inadvertently Sampled by EBUS-TBNA: A Case Report. 模拟淋巴结复发的肺动脉血管内肿瘤和EBUS-TBNA无意取样：1例报告。

IF 0.7

Respirology Case Reports Pub Date : 2026-07-30 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70708

Shoichiro Harada, Yasuto Ueda, Shinsuke Oda, Shino Arita, Yuri Shibata, Takashi Sumikawa, Yasuyuki Hasegawa, Mizuho Matsushita, Hiroki Chikumi, Akira Yamasaki

{"title":"Intravascular Pulmonary Artery Tumour Mimicking Nodal Recurrence and Inadvertently Sampled by EBUS-TBNA: A Case Report.","authors":"Shoichiro Harada, Yasuto Ueda, Shinsuke Oda, Shino Arita, Yuri Shibata, Takashi Sumikawa, Yasuyuki Hasegawa, Mizuho Matsushita, Hiroki Chikumi, Akira Yamasaki","doi":"10.1002/rcr2.70708","DOIUrl":"10.1002/rcr2.70708","url":null,"abstract":"Pulmonary artery tumours are rare and may mimic thromboembolism or nodal recurrence on imaging. We report a woman in her 70s with a history of resected stage IB lung adenocarcinoma who underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for a mediastinal lesion suspected to be nodal recurrence. During the second needle pass, synchronous lesion movement and increased bleeding were observed. Histopathology revealed high-grade sarcomatous cells with weak focal thyroid transcription factor-1 (TTF-1) positivity and h-caldesmon/myogenin expression, unlike the primary adenocarcinoma. Subsequent imaging confirmed that the lesion was intravascular within the pulmonary artery. EBUS-TBNA may inadvertently sample a pulmonary artery tumour when it mimics nodal recurrence during post-resection surveillance. Synchronous lesion movement and unexpected bleeding may indicate pulmonary artery puncture. Sarcomatoid transformation of adenocarcinoma and primary intimal sarcoma remained competing diagnoses because tissue was insufficient for molecular confirmation.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70708"},"PeriodicalIF":0.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muddy Water Pneumonitis: An Emerging Occupational Lung Disease in Professional Divers. 浑水肺炎：职业潜水员中一种新出现的职业性肺病。

IF 0.7

Respirology Case Reports Pub Date : 2026-07-29 eCollection Date: 2026-08-01 DOI: 10.1002/rcr2.70697

Sadia Sultana Resma, Dewan Azmal Hussain, Rashedul Hasan Ripon, Fazle Rabbi

{"title":"Muddy Water Pneumonitis: An Emerging Occupational Lung Disease in Professional Divers.","authors":"Sadia Sultana Resma, Dewan Azmal Hussain, Rashedul Hasan Ripon, Fazle Rabbi","doi":"10.1002/rcr2.70697","DOIUrl":"10.1002/rcr2.70697","url":null,"abstract":"Chronic occupational exposure to contaminated aquatic environments is an underrecognized cause of progressive lung injury. Recurrent aspiration of sediment-rich river water can lead to chronic inflammatory lung injury with possible environmental pathogen colonization and destructive lung disease, even in immunocompetent individuals. A 35-year-old non-smoking professional diver in a tropical mangrove region of the Sundarban, Bangladesh, with 17 years of exposure performing 10-15 daily dives in muddy saline mangrove water, presented with 1 year of progressive exertional dyspnea and intermittent cough. Water aspiration during mud collection was frequent; four coworkers reported similar symptoms. SpO2 was 93% at rest, dropping to 89% after 700 m on a 6-min walk test, indicating exercise-induced desaturation despite preserved walking distance. Digital clubbing and bilateral coarse crepitations were present. HRCT showed diffuse nodules and a left upper lobe cavitary lesion; Mantoux and Interferon gamma release assay were negative. Pulmonary function revealed severe restrictive defect (TLC 39%, FVC 25%, DLCO 36%, RV/TLC 48%). BAL grew Acinetobacter sensitive to meropenem and amikacin. After 7 days of IV therapy, symptoms improved, but domiciliary oxygen was not feasible. The patient died 1 month later. Muddy water pneumonitis can cause progressive necrotizing lung injury in divers, likely representing a multifactorial process involving environmental particulate exposure with superimposed infection. It was worsened by socioeconomic constraints and highlights the need for occupational protection and early recognition.","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70697"},"PeriodicalIF":0.7,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0