Advanced Nanobiomed Research最新文献_第7页

Block Copolymer-Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy 嵌段共聚物稳定的金属有机框架杂化物负载钯纳米粒子，可通过近红外光热疗法缓解肿瘤症状

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-01-14 DOI: 10.1002/anbr.202470011

Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabral

引用次数: 0

Machine Learning-Based Prediction of Immunomodulatory Properties of Polymers: Toward a Faster and Easier Development of Anti-Inflammatory Biomaterials 基于机器学习的聚合物免疫调节特性预测：更快更简便地开发抗炎生物材料

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-01-08 DOI: 10.1002/anbr.202300085

Aghilas Akkache, Lisa Clavier, Oleh Mezhenskyi, Kateryna Andriienkova, Thibaut Soubrié, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova

{"title":"Machine Learning-Based Prediction of Immunomodulatory Properties of Polymers: Toward a Faster and Easier Development of Anti-Inflammatory Biomaterials","authors":"Aghilas Akkache, Lisa Clavier, Oleh Mezhenskyi, Kateryna Andriienkova, Thibaut Soubrié, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova","doi":"10.1002/anbr.202300085","DOIUrl":"10.1002/anbr.202300085","url":null,"abstract":"In biomaterials development, creating materials with desirable properties can be a time-consuming and resource-intensive process, often relying on serendipitous discoveries. A potential route to accelerate this process is to employ artificial intelligence methodologies such as machine learning (ML). Herein, the possibility to predict anti-inflammatory properties of the polymers by using a simplified model of inflammation and a restrained dataset is explored. Cellular assays with 50 different polymers are conducted using the murine macrophage cell line RAW 264.7 as a model. These experiments generate a dataset which is used to develop a ML model based on Bayesian logistic regression. After conducting a Bayesian logistic regression analysis, two ML models, K-nearest neighbors (KNN) and Naïve Bayes, are employed to predict anti-inflammatory polymers properties. The study finds that the probability of a polymer having anti-inflammatory properties is multiplied by three if it is a polycation, and that nitric oxide secretion is a good indicator in determining the anti-inflammatory properties of a polymer, which in this work are defined by tumor necrosis factor alpha expression decrease. Overall, the study suggests that with appropriate dataset design, ML techniques can provide valuable information on functional polymer properties, enabling faster and more efficient biomaterial development.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimuli-Responsive Nanocarriers for Transcytosis-Based Cancer Drug Delivery 基于刺激响应的纳米载体用于癌症药物的转囊输送

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-01-08 DOI: 10.1002/anbr.202300125

Zhehao Wang, Yuji Sun, Youqing Shen, Zhuxian Zhou

引用次数: 0

Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold 用植物提取的玉米蛋白替代动物提取的明胶用作组织工程支架

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-22 DOI: 10.1002/anbr.202300104

Apurva Limaye, Venkatesan Perumal, Courtney M. Karner, Treena Livingston Arinzeh

{"title":"Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold","authors":"Apurva Limaye, Venkatesan Perumal, Courtney M. Karner, Treena Livingston Arinzeh","doi":"10.1002/anbr.202300104","DOIUrl":"10.1002/anbr.202300104","url":null,"abstract":"Natural biomaterials are commonly used as tissue engineering scaffolds due to their biocompatibility and biodegradability. Plant-derived materials have also gained significant interest due to their abundance and as a sustainable resource. This study evaluates the corn-derived protein zein as a plant-derived substitute for animal-derived gelatin, which is widely used for its favorable cell adhesion properties. Limited studies exist evaluating pure zein for tissue engineering. Herein, fibrous zein scaffolds are evaluated in vitro for cell adhesion, growth, and infiltration into the scaffold in comparison to gelatin scaffolds and are further studied in a subcutaneous model in vivo. Human mesenchymal stem cells (MSCs) on zein scaffolds express focal adhesion kinase and integrins such as α\u0000 v\u0000 β\u0000 3, α\u0000 4, and β\u0000 1 similar to gelatin scaffolds. MSCs also infiltrate zein scaffolds with a greater penetration depth than cells on gelatin scaffolds. Cells loaded onto zein scaffolds in vivo show higher cell proliferation and CD31 expression, as an indicator of blood vessel formation. Findings also demonstrate the capability of zein scaffolds to maintain the multipotent capability of MSCs. Overall, findings demonstrate plant-derived zein may be a suitable alternative to the animal-derived gelatin and demonstrates zein's potential as a scaffold for tissue engineering.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Adhesion to Detachment: Strategies to Design Tissue-Adhesive Hydrogels 从粘附到剥离：设计组织粘性水凝胶的策略

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-22 DOI: 10.1002/anbr.202300090

Minh Hieu Ho, Quinn van Hilst, Xiaolin Cui, Yogambha Ramaswamy, Tim Woodfield, Jelena Rnjak-Kovacina, Steven G. Wise, Khoon S. Lim

{"title":"From Adhesion to Detachment: Strategies to Design Tissue-Adhesive Hydrogels","authors":"Minh Hieu Ho, Quinn van Hilst, Xiaolin Cui, Yogambha Ramaswamy, Tim Woodfield, Jelena Rnjak-Kovacina, Steven G. Wise, Khoon S. Lim","doi":"10.1002/anbr.202300090","DOIUrl":"10.1002/anbr.202300090","url":null,"abstract":"The use of tissue adhesives dates to 1940s when surgical glues were introduced for wound closure applications. However, current clinically used tissue adhesives (fibrin and cyanoacrylate glues) have limited adhesion strength and biocompatibility issues which restrict their performance in targeted applications. Due to this unmet clinical challenge, there is a need to develop next-generation tissue adhesives to expand the current limited available options. Another factor that is often overlooked in the field is the consequence of when these tissue adhesives fail while in use in specific applications. In this review, the complications arising from tissue adhesives that have insufficient adhesion strength are covered, where unintentional loosening and detachment can lead to serious complications depending on both the applications and scenarios in which the adhesives are used. Next, the current methodologies employed to design tissue-adhesive hydrogels targeting specific applications are also collated. Finally, the different strategies to engineer on-demand removal property of these tissue-adhesive hydrogels are consolidated, including some perspectives on current challenges and outlooks in this field.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Rolling Circle Amplification (RCA)-Based DNA-Functional Materials for Cancer Diagnosis and Therapy 用于癌症诊断和治疗的基于滚圆放大（RCA）的 DNA 功能材料的研究进展

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-21 DOI: 10.1002/anbr.202300108

Xun You, Jing Wang, Xiaocui Guo, Dayong Yang

{"title":"Advances in Rolling Circle Amplification (RCA)-Based DNA-Functional Materials for Cancer Diagnosis and Therapy","authors":"Xun You, Jing Wang, Xiaocui Guo, Dayong Yang","doi":"10.1002/anbr.202300108","DOIUrl":"10.1002/anbr.202300108","url":null,"abstract":"Developing biocompatible material systems with accurate functional designability and powerful integration capability is the urgent demand of efficient cancer diagnosis and therapy. Deoxyribonucleic acids (DNAs) as biomacromolecules are characterized with sequence programmability, rich biological activity, and molecular recognition, and show great performance in the fabrication of biomedical materials. Rolling circle amplification (RCA) is an efficient isothermal enzymatic amplification strategy for production of ultralong single-stranded DNA (ssDNA) with defined repeat sequences and structures. By virtue of rational design of the RCA templates sequences, the produced ssDNA enables to integrate and amplify the required function modules, which endows RCA-based DNA materials with extraordinary performance in cancer therapeutics. In this review, RCA-based strategies for integration of functional modules are systematically summarized; construction of RCA-based functional DNA materials and their recent progress in cancer therapeutics including detection, bioimaging, and therapy are overviewed; and finally the opportunities and challenges of RCA-based assembly strategy in terms of material construction and applications in cancer diagnosis and therapy are discussed. It is envisioned that RCA-based DNA-functional materials will provide typical paradigms for the application of DNA-functional materials in the field of cancer therapeutics, and hopefully provide more possibilities for precision medicine.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age-Related Macular Degeneration 具有高度清除活性氧特性的介孔氧化铈纳米粒子用于治疗老年性黄斑变性症

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-13 DOI: 10.1002/anbr.202370121

Seung Woo Choi, Ye Eun Kim, Jaeyun Kim

引用次数: 0

Micro/Nanomotors for Oral Delivery of Drugs: From Design to Application 用于口服给药的微型/纳米马达：从设计到应用

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-05 DOI: 10.1002/anbr.202300057

Chen Xie, Qiansha Luo, Yuxuan Zhang, Fang Qin, Yingfeng Tu, Kun Liu

{"title":"Micro/Nanomotors for Oral Delivery of Drugs: From Design to Application","authors":"Chen Xie, Qiansha Luo, Yuxuan Zhang, Fang Qin, Yingfeng Tu, Kun Liu","doi":"10.1002/anbr.202300057","DOIUrl":"10.1002/anbr.202300057","url":null,"abstract":"Oral administration, as a traditional approach of taking therapeutic drugs, is easily accepted by patients due to its convenience and compliance. However, the harsh digestive environment and mucosa-epithelial cell barriers limit the absorption of drugs through the oral route, particularly for biomacromolecules such as protein, peptide, or nucleic acid drugs. To address this issue, active carriers such as micro/nanomotors and mechanical devices have been engineered as novel delivery systems that are capable of converting various energy into mechanical force. The active delivery of these carriers holds promise for overcoming absorptive barriers and improving drug delivery efficiency, making them an attractive option for precision medicine applications that include drug delivery, gene and cell therapy, biopsy, tissue penetration, intracellular delivery, and biosensing. This article presents an overview of the progress and challenges associated with orally delivering macromolecular drugs, as well as strategies to enhance drug absorption. Additionally, it discusses recent developments and potential applications of active carriers in drug delivery and related fields, which may provide inspiration for future research.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shortwave-Infrared-Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer 用于乳腺癌 CD8 靶向和体内细胞毒性 T 细胞成像的短波激发纳米探针

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-05 DOI: 10.1002/anbr.202300092

Jay V. Shah, Jake N. Siebert, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Edmund C. Lattime, Vidya Ganapathy, Prabhas V. Moghe

{"title":"Shortwave-Infrared-Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer","authors":"Jay V. Shah, Jake N. Siebert, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Edmund C. Lattime, Vidya Ganapathy, Prabhas V. Moghe","doi":"10.1002/anbr.202300092","DOIUrl":"10.1002/anbr.202300092","url":null,"abstract":"Checkpoint immunotherapy has made great strides in the treatment of solid tumors, but many patients do not respond to immune checkpoint inhibitors. Identification of tumor-infiltrating cytotoxic T cells (CTLs) has the potential to stratify patients and monitor immunotherapy responses. In this study, the design of cluster of differentiation (CD8+) T cell-targeted nanoprobes that emit shortwave infrared (SWIR) light in the second tissue-transparent window for noninvasive, real-time imaging of CTLs in murine models of breast cancer is presented. SWIR-emitting rare-earth nanoparticles encapsulated in human serum albumin are conjugated with anti-CD8α to target CTLs with high specificity. CTL targeting is validated in vitro through binding of nanoprobes to primary mouse CTLs. The potential for the use of SWIR fluorescence intensity to determine CTL presence is validated in two syngeneic mammary fat pad tumor models, EMT6 and 4T1, which differ in immune infiltration. SWIR imaging using CD8-targeted nanoprobes successfully identifies the presence of CTLs in the more immunogenic EMT6 model, while imaging confirms the lack of substantial immune infiltration in the nonimmunogenic 4T1 model. In this work, the opportunity for SWIR imaging using CD8-targeted nanoprobes to assess CTL infiltration in tumors for the stratification and monitoring of responders to checkpoint immunotherapy is highlighted.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Biomimetic Mineralization of Viruses: More than Calcium 病毒的人工仿生矿化：不仅仅是钙

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300064

Pan-Deng Shi, Yan-Peng Xu, Hui Zhao, Cheng-Feng Qin

引用次数: 0