Advanced Nanobiomed Research最新文献_第7页

Zinc and Strontium-Doped Titania Nanotube Surfaces Enhance Antibacterial Activity and Increase Osteogenic Differentiation of Mesenchymal Stem Cells 锌和锶掺杂二氧化钛纳米管表面增强间充质干细胞的抗菌活性和促进成骨分化

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-12-05 DOI: 10.1002/anbr.202500161

Abhishek Bhattacharjee, Aniruddha Vijay Savargaonkar, Bruno L. Pereira, Paulo Soares, Ketul C. Popat

{"title":"Zinc and Strontium-Doped Titania Nanotube Surfaces Enhance Antibacterial Activity and Increase Osteogenic Differentiation of Mesenchymal Stem Cells","authors":"Abhishek Bhattacharjee, Aniruddha Vijay Savargaonkar, Bruno L. Pereira, Paulo Soares, Ketul C. Popat","doi":"10.1002/anbr.202500161","DOIUrl":"https://doi.org/10.1002/anbr.202500161","url":null,"abstract":"Bone is one of the critical tissues in the body as injury to it determines the quality of life for the patients. Orthopedic implants are surgical interventions which aid in maintaining the quality of life; however, bacterial infections and poor osseointegration result in implant failure which lead to revision surgeries and complications. Implant surface modifications prevent implant failures by preventing bacteria adhesion on the surfaces and encouraging cell adhesion and growth, hence leading to improved osseointegration. In this study, titanium surfaces are modified to fabricate titania nanotubes on the surfaces, and then these nanotube surfaces are doped simultaneously with zinc and strontium. Biocompatibility and antibacterial activity for these surfaces is evaluated through osteogenic differentiation of adipose derived stem cells and growth inhibition of gram-positive and gram-negative bacteria, respectively. The results show that these modified titanium surfaces demonstrate significantly reduced bacterial adhesion and biofilm formation as compared with unmodified titanium and enhance the osteogenic differentiation of adipose derived stem cells despite lower cell adhesion.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox-Responsive Mitochondrial Delivery from Functionalized Vascular Stent Surfaces 功能化血管支架表面氧化还原反应线粒体递送

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-11-16 DOI: 10.1002/anbr.202500202

Fang Tang, Brandon C. Applewhite, Bowen Wang, Bin Jiang

{"title":"Redox-Responsive Mitochondrial Delivery from Functionalized Vascular Stent Surfaces","authors":"Fang Tang, Brandon C. Applewhite, Bowen Wang, Bin Jiang","doi":"10.1002/anbr.202500202","DOIUrl":"https://doi.org/10.1002/anbr.202500202","url":null,"abstract":"Mitochondrial dysfunction and oxidative stress are key contributors to impaired vascular healing following stent implantation. Although drug-eluting stents reduce restenosis, they do not promote tissue regeneration or correct cellular metabolic deficits. A redox-responsive mitochondrial delivery system is developed for localized therapeutic release from vascular stent surfaces. Intact mitochondria are immobilized onto Nitinol substrates through a stepwise surface modification strategy incorporating a reactive oxygen species (ROS)-cleavable linker. Upon exposure to elevated ROS levels, mitochondria are released in a dose-dependent manner and internalized by human endothelial cells and vascular smooth muscle cells. Transmission electron microscopy confirms the integrity of isolated mitochondria, and X-ray photoelectron spectroscopy and secondary ion mass spectrometry validate successful surface functionalization and grafting. The modified surfaces demonstrate high biocompatibility, with minimal cytotoxicity and reduced platelet adhesion. Released mitochondria restore mitochondrial membrane potential, oxygen consumption rate and enhance cell viability under oxidative stress. Ex vivo assessment in rat aortic tissue provides visual confirmation of mitochondrial uptake in a physiologically relevant context. This platform establishes a stimulus-responsive, organelle-based therapeutic strategy that targets mitochondrial dysfunction at the biomaterial–tissue interface and offers potential to enhance vascular regeneration in oxidative microenvironments following endovascular interventions.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Applications of Black and Violet Phosphorus-Based Biomaterials 黑色和紫色磷基生物材料的抗菌应用

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-11-21 DOI: 10.1002/anbr.202500203

Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding

{"title":"Antibacterial Applications of Black and Violet Phosphorus-Based Biomaterials","authors":"Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding","doi":"10.1002/anbr.202500203","DOIUrl":"https://doi.org/10.1002/anbr.202500203","url":null,"abstract":"The accelerating emergence of antibiotic-resistant bacteria has intensified the need for innovative antimicrobial strategies. Among promising candidates, black phosphorus (BP) and violet phosphorus (VP) nanosheets have garnered significant attention due to their unique 2D structure, large specific surface area, tunable bandgap, and exceptional biocompatibility and biodegradability. This review systematically discusses recent advances in the synthesis of phosphorus nanosheets, elaborates on their fundamental physical, chemical, and optical properties, and critically evaluates their biosafety profiles. Special focus is given to the multifaceted antimicrobial mechanisms of BP and VP, including physical disruption of bacterial membranes, light-driven photothermal and photodynamic effects, and their superior capacity for efficient delivery of antibacterial agents. Additionally, composite strategies, such as polymer modification and metal doping, are highlighted that further enhance the antibacterial performance of phosphorus-based materials. The review also explores the latest progress in clinical and preclinical applications of BP and VP nanomaterials, spanning the treatment of infectious bone defects, skin and soft tissue infections, respiratory system infections, dental and ocular infections, and sepsis. Collectively, these insights underscore the potential of phosphorus-based nanomaterials as next-generation antimicrobial platforms, providing both a theoretical basis and practical guidance for their further research and clinical translation in combating bacterial infections.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03

引用次数: 0

3D Hydrogel Cell Cultures and Their Biomedical Applications 三维水凝胶细胞培养及其生物医学应用

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-12-08 DOI: 10.1002/anbr.202500133

Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic-Crook, Jeremy M. Crook, Brett Paull

{"title":"3D Hydrogel Cell Cultures and Their Biomedical Applications","authors":"Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic-Crook, Jeremy M. Crook, Brett Paull","doi":"10.1002/anbr.202500133","DOIUrl":"https://doi.org/10.1002/anbr.202500133","url":null,"abstract":"In recent years, research into 3D cell cultures has grown remarkably, supporting significant advances in biomedical applications and drug development. Numerous studies have demonstrated their importance for controlling the cellular environment to better emulate natural tissue conditions and provide new insights into cell–cell and cell–matrix interactions for cell growth, differentiation, and migration. This review explores how 3D cell cultures outperform traditional planar/2D culture systems, detailing their key characteristics along with the strengths and limitations of different hydrogel biomaterials and platforms used for their formation, housing, and studying such cell-in-hydrogel cultures, including microfluidic and 3D printed arrangements. Finally, the review showcases recent cutting-edge applications of 3D hydrogel models and their essential roles in biomedical research and translation, including tissue engineering, drug discovery, cancer research, and neuroscience.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro/Nanorobot for Drug Delivery—A Review of Material Selections 用于给药的微纳米机器人——材料选择综述

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2026-01-21 DOI: 10.1002/anbr.202500080

Xiaozhuo Wu, Bingyun Li, Malcolm Xing

{"title":"Micro/Nanorobot for Drug Delivery—A Review of Material Selections","authors":"Xiaozhuo Wu, Bingyun Li, Malcolm Xing","doi":"10.1002/anbr.202500080","DOIUrl":"https://doi.org/10.1002/anbr.202500080","url":null,"abstract":"The concept of utilizing micro/nanorobot (MNR) for drug delivery in vivo was raised decades ago, and numerous prototypes have been created ever since. Other than the application of delivering drugs, nanorobots are also widely researched for noninvasive surgery, cell stimulation, bioimaging, diagnostics and monitoring, sensing, photocatalysis, and environmental remediation. The design of drug-delivering MNR requires the robot to 1) consist of bio-friendly materials, 2) be able to propel itself or be propelled by external force, 3) be able to self-direct or be directed by external control to the target location, and 4) have a basic drug load and release function. However, even though many prototypes can perform all these different nanoscaled functions, they are always staying on the prototype stage instead of leaping into the practical stage. This review aims to explain the latest MNR designs from the perspective of material selection. From the prototypes listed in this review, there are a wide range of materials that can be adopted into design to fulfill various tasks with considerations into biocompatibility, motion, navigation, and drug load and release.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation 生物打印可兴奋组织与促进功能和成熟的多重刺激系统

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-11-17 DOI: 10.1002/anbr.202500107

Uijung Yong, Jinseon Park, Jinah Jang

{"title":"Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation","authors":"Uijung Yong, Jinseon Park, Jinah Jang","doi":"10.1002/anbr.202500107","DOIUrl":"https://doi.org/10.1002/anbr.202500107","url":null,"abstract":"Bioprinted excitable tissues, including cardiac, skeletal muscle, and neural constructs, have emerged as promising platforms for modeling physiological function and disease. Alongside advances in bioprinting resolution and bioink formulation, structurally complex tissues have been fabricated with increasing anatomical fidelity. However, their functional performance has remained limited compared to native tissues. To address this gap, a broad range of stimulation strategies, including electrical, mechanical, optical, magnetic, ultrasound, and hybrid modalities, have been explored to replicate the dynamic physiological cues found in vivo. These approaches have contributed to improvements in tissue-specific maturation metrics, such as contractility, conduction velocity, and network activity. This review summarizes the current landscape of stimulation-based strategies applied to bioprinted excitable tissues and examines how key parameters influence biological outcomes across tissue types. It outlines shared principles and tissue-specific requirements that may guide future platform development. By positioning stimulation not as an auxiliary element but as a central design component, this review aims to support the creation of more mature, responsive, and physiologically relevant engineered tissue systems.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Applications of Black and Violet Phosphorus-Based Biomaterials 黑色和紫色磷基生物材料的抗菌应用

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-11-21 DOI: 10.1002/anbr.202500203

Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding

{"title":"Antibacterial Applications of Black and Violet Phosphorus-Based Biomaterials","authors":"Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding","doi":"10.1002/anbr.202500203","DOIUrl":"https://doi.org/10.1002/anbr.202500203","url":null,"abstract":"The accelerating emergence of antibiotic-resistant bacteria has intensified the need for innovative antimicrobial strategies. Among promising candidates, black phosphorus (BP) and violet phosphorus (VP) nanosheets have garnered significant attention due to their unique 2D structure, large specific surface area, tunable bandgap, and exceptional biocompatibility and biodegradability. This review systematically discusses recent advances in the synthesis of phosphorus nanosheets, elaborates on their fundamental physical, chemical, and optical properties, and critically evaluates their biosafety profiles. Special focus is given to the multifaceted antimicrobial mechanisms of BP and VP, including physical disruption of bacterial membranes, light-driven photothermal and photodynamic effects, and their superior capacity for efficient delivery of antibacterial agents. Additionally, composite strategies, such as polymer modification and metal doping, are highlighted that further enhance the antibacterial performance of phosphorus-based materials. The review also explores the latest progress in clinical and preclinical applications of BP and VP nanomaterials, spanning the treatment of infectious bone defects, skin and soft tissue infections, respiratory system infections, dental and ocular infections, and sepsis. Collectively, these insights underscore the potential of phosphorus-based nanomaterials as next-generation antimicrobial platforms, providing both a theoretical basis and practical guidance for their further research and clinical translation in combating bacterial infections.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147567890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Hydrogel Cell Cultures and Their Biomedical Applications 三维水凝胶细胞培养及其生物医学应用

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03 Epub Date: 2025-12-08 DOI: 10.1002/anbr.202500133

Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic-Crook, Jeremy M. Crook, Brett Paull

{"title":"3D Hydrogel Cell Cultures and Their Biomedical Applications","authors":"Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic-Crook, Jeremy M. Crook, Brett Paull","doi":"10.1002/anbr.202500133","DOIUrl":"https://doi.org/10.1002/anbr.202500133","url":null,"abstract":"In recent years, research into 3D cell cultures has grown remarkably, supporting significant advances in biomedical applications and drug development. Numerous studies have demonstrated their importance for controlling the cellular environment to better emulate natural tissue conditions and provide new insights into cell–cell and cell–matrix interactions for cell growth, differentiation, and migration. This review explores how 3D cell cultures outperform traditional planar/2D culture systems, detailing their key characteristics along with the strengths and limitations of different hydrogel biomaterials and platforms used for their formation, housing, and studying such cell-in-hydrogel cultures, including microfluidic and 3D printed arrangements. Finally, the review showcases recent cutting-edge applications of 3D hydrogel models and their essential roles in biomedical research and translation, including tissue engineering, drug discovery, cancer research, and neuroscience.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-03-03

引用次数: 0