Advanced Nanobiomed Research最新文献_第10页

Ultrasound-Triggered Release of Anticancer Nanoparticles from Electrospun Fabrics Integrated with Soft Robotic Tentacles 超声波触发释放抗癌纳米粒子的电纺丝织物集成软机器人触手

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-10-12 DOI: 10.1002/anbr.202500052

Samuel C. T. Moorcroft, Benjamin Calmé, Charles Brooker, Pietro Valdastri, Russell Harris, Stephen J. Russell, Giuseppe Tronci

{"title":"Ultrasound-Triggered Release of Anticancer Nanoparticles from Electrospun Fabrics Integrated with Soft Robotic Tentacles","authors":"Samuel C. T. Moorcroft, Benjamin Calmé, Charles Brooker, Pietro Valdastri, Russell Harris, Stephen J. Russell, Giuseppe Tronci","doi":"10.1002/anbr.202500052","DOIUrl":"10.1002/anbr.202500052","url":null,"abstract":"The prompt identification of pancreatic cancer symptoms is an ongoing clinical challenge, often leading to late diagnosis and poor prognosis. Tumor “hijacking” of the pancreatic stromal structure limits the uptake of systemic chemotherapeutics. Localized drug delivery systems (DDS) using endoluminal techniques are widely utilized, with positive early results for improved control over tumor growth. There is a need for technologies that integrate endoluminal resources and intelligent material systems to better control the spatiotemporal delivery of chemotherapeutics. The ultrasound (US)-triggered localized release of therapeutics through the design of solvent traceless drug-loaded vinylbenzyl-functionalized gelatin (gel4vbc) nanoparticles (NPs) integrated with an electrospun fabric is demonstrated. Albumin-loaded NPs encapsulated into a poly(vinyl alcohol) (PVA) coating of a poly(ε-caprolactone) fabric evidence tunable triggered NP delivery controlled by regulating PVA concentration (0–1 wt%) and US intensity (0–3 W cm−2). The fixation of the NP-coated fabric to a magnetic tentacle robot (MTR) enables the automated manipulation into a phantom pancreatic duct before the US-triggered release of NP-loaded albumin and MTR retraction. Albumin release is controlled by varying the surface area of the NP-loaded MTR-coating fabric. Herein a novel DDS capable of facile integration into soft robotics and US-triggered delivery of therapeutic-loaded NPs is designed.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Combining Adipose-Derived Stromal Cell Spheroids and Melt Electrowritten Scaffolds for a 3D Adipose Model Mimicking Structure and Function of Fat Tissue 结合脂肪来源的基质细胞球体和熔融电写支架模拟脂肪组织结构和功能的三维脂肪模型

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-10-06 DOI: 10.1002/anbr.202500172

Franziska Dusi, Tamara Weidemeier, Camilla Mussoni, Sabrina Stecher, Feven Berhanne, Philipp Stahlhut, Taufiq Ahmad, Jürgen Groll, Matthias Becker, Torsten Blunk, Petra Bauer-Kreisel

{"title":"Combining Adipose-Derived Stromal Cell Spheroids and Melt Electrowritten Scaffolds for a 3D Adipose Model Mimicking Structure and Function of Fat Tissue","authors":"Franziska Dusi, Tamara Weidemeier, Camilla Mussoni, Sabrina Stecher, Feven Berhanne, Philipp Stahlhut, Taufiq Ahmad, Jürgen Groll, Matthias Becker, Torsten Blunk, Petra Bauer-Kreisel","doi":"10.1002/anbr.202500172","DOIUrl":"10.1002/anbr.202500172","url":null,"abstract":"Adipose tissue represents an active metabolic and endocrine organ that influences (patho-)physiological processes in metabolism, immune response, or cancer progression. Given the close relationship between morphology and functionality, adipose models that recapitulate the phenotype of mature adipocytes embedded in a tissue-specific matrix are essential for studies on adipose tissue biology. In order to mimic the high cell density and 3D architecture of the native tissue, scaffolds made of ultrathin fibers produced with melt electrowriting (MEW) technology are combined with adipose-derived stromal cell (ASC) spheroids. Fabricated constructs develop an adipose phenotype, demonstrated by storage of triglycerides, expression of adipogenic marker genes, and the development of a tissue-specific extracellular matrix. Upon oleic acid supplementation, differentiated adipocytes significantly increase lipid storage. Tissue functionality is demonstrated by analysis of secreted adipokines and β-adrenergic stimulation of lipolysis. Long-term culture (10 weeks) favors adipocyte maturation to lipid droplet sizes close to those in native tissue, while tissue stability and functionality are unaffected. This hybrid tissue engineering approach, using spheroids as building blocks in tailored MEW scaffolds, provides an adipose model that closely mimics structural and functional characteristics of fat tissue and is therefore an excellent tool for studies on the function and (patho-)physiology of adipose tissue.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06

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Vancomycin-Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds 万古霉素功能化的抗菌组织工程支架纳米递送系统

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-11-17 DOI: 10.1002/anbr.202500145

Nima Beheshtizadeh, Mahsa Mohammadzadeh, Amir Abbas Seraji, Ali Pirsadeghi, Elham Zendedel, Maliheh Gharibshahian

{"title":"Vancomycin-Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds","authors":"Nima Beheshtizadeh, Mahsa Mohammadzadeh, Amir Abbas Seraji, Ali Pirsadeghi, Elham Zendedel, Maliheh Gharibshahian","doi":"10.1002/anbr.202500145","DOIUrl":"10.1002/anbr.202500145","url":null,"abstract":"Biomaterial-associated infections, particularly those involving methicillin-resistant Staphylococcus aureus, present a significant challenge in tissue engineering, often leading to implant failure. This review examines the strategic development of vancomycin (VAN)-loaded nanoplatforms as an advanced modality to augment antibacterial efficacy within tissue engineering scaffolds. Conventional antibiotic delivery methods are frequently limited by suboptimal drug release kinetics, systemic toxicity, and inadequate penetration of bacterial biofilms. Nanotechnology-based approaches, including polymeric nanoparticles, liposomes, and nanofibers, offer a sophisticated solution by enabling targeted, localized, and sustained release of VAN directly at the implantation site. These systems significantly enhance VAN's bioavailability, reduce requisite dosages, thereby mitigating cytotoxic effects on progenitor cells, and effectively disrupt biofilm matrices. The integration of these nanocarriers into biomaterial matrices, such as hydrogels and electrospun scaffolds, creates a multifunctional environment that concurrently supports tissue regeneration and provides robust prophylactic and therapeutic antimicrobial action.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06

引用次数: 0

Nanobiotechnology-Based Approaches for Targeted Glioma Therapy 基于纳米生物技术的靶向胶质瘤治疗方法

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-09-29 DOI: 10.1002/anbr.202500115

Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang

{"title":"Nanobiotechnology-Based Approaches for Targeted Glioma Therapy","authors":"Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang","doi":"10.1002/anbr.202500115","DOIUrl":"10.1002/anbr.202500115","url":null,"abstract":"Glioma, particularly glioblastoma multiforme, is still one of the most aggressive and chemoresistant forms of brain cancer, in large part attributed to the hindrance of the blood–brain barrier (BBB), tumor heterogeneity, and complicated tumor microenvironment. Recent progress in nanobiotechnology has provided with opportunities to achieve targeted glioma therapy through the delivery of drugs selectively to the tumor through the BBB, thereby enhancing therapeutic efficacy and reducing side effects. In this review, the use of different nanocarrier systems, including lipid nanoparticles, polymeric nanoparticles, and magnetic nanoparticles, for the treatment of glioma, is summarized. These systems can achieve increased drug accumulation in the tumor site, controlled release of the drug, and synergistic influence with immunotherapy, chemotherapy, or radiotherapy. A detailed review of state-of-the-art emerging approaches, including RNA-based nanoparticles, surface-modified nanocarriers, and nanorobots that hold great potential in personalized and precision glioma treatments, is also provided. In addition, the review covers major obstacles to clinical transformation, i.e., nanotoxicity, controlling sustained drug release, and production difficulties. Overcoming these challenges, nanobiotechnology may lead to a paradigm shift in the treatment of glioma and clinical services for patients.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tri-Modal Anticancer Strategies with Doxorubicin-Loaded Iron Oxide Nanoparticles Integrating Chemo and Magneto-Photothermal Therapeutic Effects 阿霉素负载氧化铁纳米颗粒整合化疗和磁光热治疗效果的三模态抗癌策略

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-09-17 DOI: 10.1002/anbr.202500098

Rosalía López-Méndez, Nuria Lafuente-Gómez, Eva Céspedes, Mónica Dhanjani, Marina París-Ogáyar, Francisco José Terán, Aida Serrano, Julio Camarero, Gorka Salas, Claire Wilhelm, Álvaro Somoza, Ana Espinosa

{"title":"Tri-Modal Anticancer Strategies with Doxorubicin-Loaded Iron Oxide Nanoparticles Integrating Chemo and Magneto-Photothermal Therapeutic Effects","authors":"Rosalía López-Méndez, Nuria Lafuente-Gómez, Eva Céspedes, Mónica Dhanjani, Marina París-Ogáyar, Francisco José Terán, Aida Serrano, Julio Camarero, Gorka Salas, Claire Wilhelm, Álvaro Somoza, Ana Espinosa","doi":"10.1002/anbr.202500098","DOIUrl":"10.1002/anbr.202500098","url":null,"abstract":"In this study, the potential of maghemite (γ-Fe2O3) nanoparticles (MNPs) functionalized with doxorubicin (DOX) is explored for chemo-magneto-photothermal therapy in cancer treatment. MNPs are functionalized through electrostatic interactions or disulfide bonds, achieving high drug-loading efficiencies. The trimodal approach combines magnetic hyperthermia (MHT), photothermal therapy (PTT) and local chemotherapy, utilizing low and clinically relevant doses. Thermal treatments induced controlled temperature increases, triggering pH-sensitive DOX release in the acidic environments typical of tumors. Efficient uptake of DOX-loaded MNPs is observed, and their structural integrity is confirmed using advanced synchrotron spectroscopic techniques. Cytotoxicity assays show that MHT and PTT together enhanced therapeutic efficacy compared to free DOX, while minimizing toxicity to healthy cells. This study demonstrates that combining thermal therapies with controlled drug release provides a promising strategy for improving cancer treatment outcomes. The findings highlight the potential clinical application of multifunctional nanoparticle systems for targeted, low-toxicity cancer therapies, advancing the path toward more effective and accessible treatments.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Time-of-Flight Secondary Ion Mass Spectrometry-Partial Least Square Regression for Quantifying Interleukin-8 in Biopolymer Matrices” 对“飞行时间二次离子质谱-偏最小二乘回归定量生物聚合物基质中白细胞介素-8”的修正

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-12-05 DOI: 10.1002/anbr.70085

Ralf Zimmermann, Mirko Nitschke, Marten Samulowitz, Nicholas R. Dennison, Carsten Werner

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Correction to “In-Gel Generated Palladium Nanostructures as Bioorthogonal Uncaging Reactors” 对“凝胶生成的钯纳米结构作为生物正交脱壳反应器”的修正

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-12-12 DOI: 10.1002/anbr.70087

Aisling McGuigan, Víctor Sebastián, Asier Unciti-Broceta, Jesús Santamaría, Ferry Melchels

{"title":"Correction to “In-Gel Generated Palladium Nanostructures as Bioorthogonal Uncaging Reactors”","authors":"Aisling McGuigan, Víctor Sebastián, Asier Unciti-Broceta, Jesús Santamaría, Ferry Melchels","doi":"10.1002/anbr.70087","DOIUrl":"10.1002/anbr.70087","url":null,"abstract":"Adv. NanoBiomed Res., 2025, 5(11), 2500118https://doi.org/10.1002/anbr.202500118Figures 4 and 5 have been updated.The third paragraph under the section “2.3. Release of sequestered dye product from Pd-laden hydrogels” has been updated:The proportion of sequestered dye released from pHEMA–GG discs significantly increased from 12.6% to 17.9% to 21.1% (averaged over both thicknesses and Pd nanoshapes) when exposure time to proresorufin increased from 0.5 to 1 to 2 hours (p < 0.0001). For the pHEMA–co–AM copolymers, the increase from 16.3% after 0.5 hours to 18.3% after 1 hours was smaller but still significant (p = 0.0001), whereas the increase to 18.6% at 2 hours was not (p = 0.8, Figure 5).The section “5.10. Statistics” has been updated.All values are reported as average ± standard deviation unless indicated otherwise. Reported p-values for head-to-head comparisons are obtained from two-tailed homoscedastic Student's T-test (MS Excel). ANOVA with Tukey's post-hoc test was performed between time-points, for pHEMA-GG and pHEMA-co-AM polymers separately (MS Excel). Groups that share a letter (and case) are not statistically significantly different. Decreasing trends were tested for statistical significance using a Mann-Kendall test (XLSTAT).","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Multifunctional Hydrogel-Based wound Dressings for Scar-Free Healing: Design Principles, Therapeutic Mechanisms, and Clinical Translation Challenges 用于无疤痕愈合的多功能水凝胶伤口敷料：设计原则、治疗机制和临床转化挑战

IF 4.4

Advanced Nanobiomed Research Pub Date : 2026-01-06 Epub Date: 2025-11-03 DOI: 10.1002/anbr.202500147

Haonan Chai, Zhenxing Wang, Jingyi Ju, Jiaming Sun

{"title":"Multifunctional Hydrogel-Based wound Dressings for Scar-Free Healing: Design Principles, Therapeutic Mechanisms, and Clinical Translation Challenges","authors":"Haonan Chai, Zhenxing Wang, Jingyi Ju, Jiaming Sun","doi":"10.1002/anbr.202500147","DOIUrl":"10.1002/anbr.202500147","url":null,"abstract":"Pathological scarring imposes a substantial global healthcare burden, affecting over 100 million individuals annually with costs exceeding $20 billion. Current therapies yield suboptimal outcomes due to limited efficacy and recurrence. Hydrogel-based wound dressings have emerged as transformative platforms due to their tunable physicochemical properties, bioactivity, and ability to modulate the wound microenvironment. This review uniquely integrates scar biology with hydrogel-based therapeutic strategies. A phase-specific framework that correlates hydrogel functions is provided with key scar-influencing events, including inflammation regulation, fibroblast reprograming, extracellular matrix remodeling, and skin appendage regeneration. Moreover, cutting-edge innovations are highlighted such as stimuli-responsive hydrogels (pH/temperature/light), nanocomposite systems, and 3D-printed scaffolds that enable spatiotemporal control of drug release and dynamic microenvironment modulation. Furthermore, unresolved clinical translation barriers are critically addressed, including scalability, standardization, biocompatibility, and immune response variability, proposing interdisciplinary solutions. By synthesizing recent advances and persistent limitations, this work provides a translational roadmap for developing next-generation hydrogels to bridge the gap between benchtop innovation and clinical scar-free tissue regeneration.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"6 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0