Advanced Nanobiomed Research最新文献_第9页

Regulation of Antigen-Specific Immunotherapy with Nanomaterials 用纳米材料调节抗原特异性免疫疗法

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-27 DOI: 10.1002/anbr.202300068

Weifan Ye, Yiwen Jia, Hongze Ren, Yujie Xie, Meihua Yu, Yu Chen

{"title":"Regulation of Antigen-Specific Immunotherapy with Nanomaterials","authors":"Weifan Ye, Yiwen Jia, Hongze Ren, Yujie Xie, Meihua Yu, Yu Chen","doi":"10.1002/anbr.202300068","DOIUrl":"https://doi.org/10.1002/anbr.202300068","url":null,"abstract":"Nonspecific immunotherapies often induce general immune activation or suppression. Conversely, antigen-specific immunotherapy, which refers to dampening or augmenting adaptive immunity against a disease-specific antigen, increases T-cell target specificity to pathological tissues, thereby reducing side effects on the rest of the immune system. Advances in engineering strategies for nanomaterials have enabled the feasible modulation of their physicochemical features to incorporate antigens and inherently interact with innate immune cells, which remarkably amplifies the orchestration of antigen-specific immune responses against cancer and autoimmune diseases. From this contemporary perspective, the basic principles of antigen-specific immunotherapy are briefly introduced and we elucidate how the latest nanoengineering paradigms regulate the functions of heterogeneous subsets of immune cells, such as antigen-presenting cells, B cells, and regulatory or cytotoxic T cells, promoting antigen-specific immunotherapy to treat autoimmune diseases and cancer. An outlook on prospects and remaining challenges have been discussed for, translating scientific discoveries of powerful nanomaterials into medical advances in antigen-specific immunotherapy, thus offering new treatment modalities for patients with unmet needs.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore 使用干细胞因子标记的荧光团对胃肠道间质瘤进行 CD117 靶向术中成像

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-27 DOI: 10.1002/anbr.202300063

Shinsuke Nomura, Shinya Yokomizo, Zhidong Wang, Homan Kang, Kai Bao, Chengeng Yang, Brian P. Rubin, Roderick Bronson, Satoshi Kashiwagi, Hak Soo Choi

{"title":"CD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore","authors":"Shinsuke Nomura, Shinya Yokomizo, Zhidong Wang, Homan Kang, Kai Bao, Chengeng Yang, Brian P. Rubin, Roderick Bronson, Satoshi Kashiwagi, Hak Soo Choi","doi":"10.1002/anbr.202300063","DOIUrl":"https://doi.org/10.1002/anbr.202300063","url":null,"abstract":"Complete resection without damaging the capsule is the gold-standard surgical approach for nonmetastatic gastrointestinal stromal tumors (GIST). However, accurately locating tumors during surgery is challenging because GIST is covered by normal mucosal tissue, leading to suboptimal surgeries and increased cancer recurrence rates. To enhance surgical care for GIST, a cutting-edge near-infrared (NIR) fluorescent nanoprobe is presented that enables real-time navigation of GIST by specifically targeting CD117, a protein frequently overexpressed in GIST. By attaching a zwitterionic NIR fluorophore called ZW800-1C to a CD117 ligand, stem cell factor (SCF), precise targeting is achieved while minimizing nonspecific tissue interactions. In in vitro studies, the high affinity of nanoprobe for CD117-positive GIST-T1 cell lines is demonstrated, while exhibiting no binding to CD117-negative cells or GIST-5 R cells. In a xenograft model of GIST-T1 in mice, the nanoprobe produces strong and persistent NIR signals that last over 72 h following a single intravenous injection. Moreover, the nanoprobe successfully detects spontaneous tumors in the cecum of heterozygous Kit K641E mice. In these findings, the promise of CD117-targeted molecular imaging is highlighted as an intraoperative strategy for GIST. Furthermore, this imaging approach holds potential for early diagnosis, as well as monitoring GIST prognosis before and after surgical resection.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The High Potential of ε-Poly-l-Lysine for the Development of Antimicrobial Biomaterials ε-聚赖氨酸在开发抗菌生物材料方面的巨大潜力

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-27 DOI: 10.1002/anbr.202300080

Eloïse Lebaudy, Chloé Guilbaud-Chéreau, Benoit Frisch, Nihal Engin Vrana, Philippe Lavalle

{"title":"The High Potential of ε-Poly-l-Lysine for the Development of Antimicrobial Biomaterials","authors":"Eloïse Lebaudy, Chloé Guilbaud-Chéreau, Benoit Frisch, Nihal Engin Vrana, Philippe Lavalle","doi":"10.1002/anbr.202300080","DOIUrl":"https://doi.org/10.1002/anbr.202300080","url":null,"abstract":"ε-poly-l-lysine (ε-PLL) is a natural polypeptide/polycation originating from bacteria. Thanks to its antifungal and antibacterial properties, it is the subject of extensive research in the food and medical industries. ε-PLL is also used to develop biomaterials in a broad range of applications, such as drug delivery, wound healing, or antimicrobial coatings. Indeed, loading ε-PLL inside nanoparticles, functionalizing implant surfaces with ε-PLL, or developing hydrogels based on reactions between ε-PLL and other polymers can improve the materials properties, leading to biocompatible, antibacterial, and antifungal systems. These characteristics are necessary not only for the development of biomaterials, for their integrity in a biological environment, but also for improving the performances of medical devices. Moreover, ε-PLL can be used as an alternative to antibiotics as its mechanism of action reduces the bacterial resistance risk compared with antibiotics. Finally, “smart” systems using ε-PLL may be developed, with controllable material degradation or drug delivery via pH or temperature variations. This review sought to gather the latest research on the development of antimicrobial biomaterials based on the ε-PLL polypeptide.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold Nanoclusters for Tumor Diagnosis and Treatment 用于肿瘤诊断和治疗的纳米金簇

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-23 DOI: 10.1002/anbr.202300082

Shiqun Chen, Shasha Li, Yili Wang, Zuohong Chen, Hao Wang, Xiao-Dong Zhang

{"title":"Gold Nanoclusters for Tumor Diagnosis and Treatment","authors":"Shiqun Chen, Shasha Li, Yili Wang, Zuohong Chen, Hao Wang, Xiao-Dong Zhang","doi":"10.1002/anbr.202300082","DOIUrl":"https://doi.org/10.1002/anbr.202300082","url":null,"abstract":"Nanomedicine shows remarkable potential to improve the efficacy of diagnosis and treatment of tumors, utilizing nanotechnologies and nanomaterials. Gold nanoclusters (AuNCs) have emerged as a highly promising option due to their exceptional optical and enzyme-mimicking catalytic activities as well as good biocompatibility. The renal clearable clusters can enrich in the tumors upon their enhanced permeability and retention properties, which benefits the tumor-related applications. The fluorescence of AuNCs in the second near-infrared region possesses extraordinary penetration depth and high temporal–spatial resolution, enabling excellent in vivo imaging and real-time monitoring of pathological process. AuNC-based nanoplatforms represent a paradigm of integrated, efficient, intelligent, and safe treatment strategy, extending personalized tumor therapy. Meanwhile, the optical and biocatalytic properties can be modulated by adopting the atom/ligand engineering, which further enhances the efficacy of AuNCs. Herein, the advances of AuNCs in the field of diagnosis and treatment of tumors are summarized and the directions to be improved are proposed to promote the clinical translation of the AuNCs.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials 基于生物活性环糊精材料的抗炎纳米疗法

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-21 DOI: 10.1002/anbr.202300106

Lanlan Li, Bingyu Chen, Gang Li, Sheng Chen, Jianxiang Zhang

{"title":"Anti-Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials","authors":"Lanlan Li, Bingyu Chen, Gang Li, Sheng Chen, Jianxiang Zhang","doi":"10.1002/anbr.202300106","DOIUrl":"https://doi.org/10.1002/anbr.202300106","url":null,"abstract":"Despite remarkable advances in understanding the mechanisms underlying inflammation, the currently available anti-inflammatory therapies have many limitations, such as poor efficacies, low selectivity, and severe adverse effects. Bioactive materials with intrinsically anti-inflammatory activities have emerged as promising drug candidates for the treatment of inflammatory disorders. Among them, nanotherapies based on bioactive cyclodextrin (CD) materials have attracted much attention, owing to their multiple advantages, including broad availability, well-controlled structures, easy functionalization, good processibility, high cost-effectiveness, and excellent biocompatibility. This review provides a comprehensive overview of the recent advancements in the development and applications of anti-inflammatory nanoparticles (NPs) based on bioactive CD materials, with special focus on reactive oxygen species-scavenging NPs and NPs capable of regulating inflammatory cell recruitment and activation. In addition, the applications of these anti-inflammatory nanotherapies in the treatment of different acute/chronic inflammatory diseases are highlighted. Furthermore, major challenges in the clinical translation of these new generation anti-inflammatory therapies derived from bioactive CD materials are discussed.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age-Related Macular Degeneration 具有高度清除活性氧特性的介孔氧化铈纳米粒子用于治疗老年性黄斑变性症

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-21 DOI: 10.1002/anbr.202300062

Seung Woo Choi, Ye Eun Kim, Jaeyun Kim

{"title":"Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age-Related Macular Degeneration","authors":"Seung Woo Choi, Ye Eun Kim, Jaeyun Kim","doi":"10.1002/anbr.202300062","DOIUrl":"https://doi.org/10.1002/anbr.202300062","url":null,"abstract":"Age-related macular degeneration (AMD), the leading cause of vision loss among older individuals, is characterized by damage to photoreceptors and retinal pigment epithelial cells (RPEs). Oxidative stress and chronic inflammation in the retina play notable roles in AMD pathogenesis, rendering them attractive therapeutic targets. Cerium oxide nanoparticles (CeNPs) have shown promise in scavenging reactive oxygen species (ROS) by mimicking antioxidant enzymes, whereas mesoporous materials have emerged as versatile drug carriers. Herein, mesoporous CeNPs (mCeNPs) that integrate the advantages of CeNPs and mesoporous materials are presented. The mCeNPs can be synthesized using 1,1′-carbonyldiimidazole and imidazole in acetone without heating and pressurization. The resulting mCeNPs exhibit mesoporous structures comprising assembled small CeNPs, exerting excellent ROS-scavenging capabilities, biocompatibility, and cytoprotective and anti-inflammatory effects against H2O2-induced damage in RPEs. Using a sodium iodate-induced AMD mouse model, it is demonstrated that intravitreal mCeNP administration can exhibit disease-preventive effects. These findings indicate the therapeutic potential of mCeNPs against AMD.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Point-of-Care Testing (POCT) Devices for DNA Detection: A Comprehensive Review 用于DNA检测的即时检测(POCT)设备:全面综述

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-20 DOI: 10.1002/anbr.202370111

Ignasia Handipta Mahardika, Sarida Naorungroj, Wisarut Khamcharoen, Sarath Kin, Nadnudda Rodthongkum, Orawon Chailapakul, Kwanwoo Shin

引用次数: 0

Smart Nanomedicine Targeting Endocytosis Mediated by Cancer Cell Surface Neuraminidase-1 针对癌细胞表面神经氨酸酶-1 介导的内吞作用的智能纳米药物

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-08 DOI: 10.1002/anbr.202300076

Ken Murakami, Daiki Kambe, Yasuhiro Yokoi, Hajime Wakui, Shun Hayakawa, Nozomi Hirane, Ryosuke Koide, Michiru Otaki, Noriko Nagahori, Shin-Ichiro Nishimura

{"title":"Smart Nanomedicine Targeting Endocytosis Mediated by Cancer Cell Surface Neuraminidase-1","authors":"Ken Murakami, Daiki Kambe, Yasuhiro Yokoi, Hajime Wakui, Shun Hayakawa, Nozomi Hirane, Ryosuke Koide, Michiru Otaki, Noriko Nagahori, Shin-Ichiro Nishimura","doi":"10.1002/anbr.202300076","DOIUrl":"10.1002/anbr.202300076","url":null,"abstract":"Human neuraminidase-1 (NEU1) plays a much more profound function in human cancers than previously considered. It is demonstrated that cancer cell surface NEU1 is a desired gatekeeper for an innovative anticancer therapeutic nanomedicine enabling active drug-targeting delivery by specific endocytosis into the cytoplasm. Nanosome, an antiadhesive nanoparticular shuttle, carrying multiple suicide substrates for NEU1 confers potent and universal inhibitory effects on the proliferation of human cancer cells, such as hepatocellular carcinoma (HCC) (HepG2, IC50 = 13.5 nM), lung cancer (A549, IC50 = 9.57 nM), and colon cancer (HT-29, IC50 = 11.1 nM), in which irreversible inactivation of cell surface NEU1 is essential for the intracellular trafficking and subsequent lysosomal membrane permeabilization by nanosomal aggregation due to the formation of “sialidase corona” through irreversible inactivation of NEU1–NEU4 residing in lysosome. Nanomedicine targeting membrane-tethered NEU1 allows efficient delivery of hydrophobic sorafenib (Nexavar), a RAF family kinase inhibitor for the treatment of advanced renal cell carcinoma and unresectable HCC at the recommended dose of 400 mg orally twice daily, into endolysosome, resulting in a potent and sustainable inhibition (IC50 = 3.1–6.2 nM at 24–96 h after coincubation) against HepG2 cell growth.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135340525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment 可注射多孔硅纳米粒子作为血浆细胞因子清除剂用于增强细胞因子风暴综合征的治疗

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-10-16 DOI: 10.1002/anbr.202370101

Ruogu Qi, Shengliang Li, Feng Li, Junhua Mai, Yu Wang, Guixian Zhu, Dechen Zhang, Zheng Li, Haifa Shen, Jianliang Shen, Xuewu Liu

引用次数: 0

Point-of-Care Testing (POCT) Devices for DNA Detection: A Comprehensive Review DNA检测点检测(POCT)设备:全面综述

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-10-15 DOI: 10.1002/anbr.202300058

Ignasia Handipta Mahardika, Sarida Naorungroj, Wisarut Khamcharoen, Sarath Kin, Nadnudda Rodthongkum, Orawon Chailapakul, Kwanwoo Shin

{"title":"Point-of-Care Testing (POCT) Devices for DNA Detection: A Comprehensive Review","authors":"Ignasia Handipta Mahardika, Sarida Naorungroj, Wisarut Khamcharoen, Sarath Kin, Nadnudda Rodthongkum, Orawon Chailapakul, Kwanwoo Shin","doi":"10.1002/anbr.202300058","DOIUrl":"10.1002/anbr.202300058","url":null,"abstract":"DNA chips play a crucial role in point-of-care diagnostics by enabling rapid and accurate detection of genetic information. These chips offer high sensitivity and selectivity, allowing for the identification of specific DNA sequences associated with diseases and pathogens. Integration into lab-on-chip platforms streamlines and miniaturizes diagnostic workflows, paving the way for cost-effective, portable, and user-friendly testing devices that can revolutionize healthcare delivery. In this review, a comprehensive description of the platforms utilized in DNA analysis, including microfluidic devices and integrated DNA chips, is provided. It explores the selection and immobilization of DNA probes for improved selectivity. Additionally, it covers diverse detection techniques such as optical detection (colorimetry and fluorescence) and electrochemical techniques. In these discussions, it is aimed to provide a thorough understanding of the current state of the art in DNA biosensor-integrated lab-on-chip technology for point-of-care testing. The continued advancements in DNA chip technology hold immense promise for the development of next-generation point-of-care diagnostics, where integrated sample preparation and rapid results generation can further enhance patient outcomes and contribute to the effective management of diseases.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"3 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135758496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0