Advanced Nanobiomed Research最新文献_第8页

A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy 将基本金属离子作为纳米药物用于癌症治疗的简要回顾

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300069

Lin Weng, Xin Chen

{"title":"A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy","authors":"Lin Weng, Xin Chen","doi":"10.1002/anbr.202300069","DOIUrl":"10.1002/anbr.202300069","url":null,"abstract":"In this review, the latest progress in essential metal-ion-based nanomedicines for tumor therapy is summarized, existing challenges are addressed, and possible directions are proposed for such therapeutic strategies. Essential metal ions are critical for the metabolic activity of organisms. Their abnormal spatial and temporal distribution in biological systems, particularly inside the cell, disrupts biochemical processes and leads to irreversible physicochemical damage to cells. Thus, they can function as the foundation of targeted cancer therapies for tumor inhibition and eradication. Over the last decade, numerous essential metal-ion-based cancer therapies have been developed to fight a wide spectrum of cancers with improved efficiency and minor drug resistance. Triggering biocatalysis, affecting protein metabolism, interfering with signal transduction, damaging DNA, and initiating biomineralization are the main mechanisms underlying these therapies. In this study, it is aimed to provide readers with general implications for future research for an increased interest in future clinical applications of these advanced cancer therapies.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoformed Parylene-C Cuff Electrodes for Small Nerve Interfacing 用于小神经接口的热成型聚对二甲苯袖带电极

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300102

Francisco Zurita, Sebastian Freko, Lukas Hiendlmeier, Fulvia Del Duca, Tanja Groll, Olga Seelbach, Katja Steiger, Bernhard Wolfrum

{"title":"Thermoformed Parylene-C Cuff Electrodes for Small Nerve Interfacing","authors":"Francisco Zurita, Sebastian Freko, Lukas Hiendlmeier, Fulvia Del Duca, Tanja Groll, Olga Seelbach, Katja Steiger, Bernhard Wolfrum","doi":"10.1002/anbr.202300102","DOIUrl":"10.1002/anbr.202300102","url":null,"abstract":"Peripheral nerve interfacing plays a crucial role in various healthcare applications. Generally, interfacing peripheral nerves results in a compromise between selectivity and invasiveness. In particular, large nerves carry many axonal fibers, which are difficult to address selectively without penetrating the nerve. Higher selectivity without nerve penetration can be achieved by targeting small nerves with extraneural cuff electrodes. However, in practice, small nerves are challenging to interface appropriately. Herein, a new multielectrode device is presented that can selectively interface small nerves (<200 μm). The device is fabricated using rapid laser-based processing with biocompatible materials such as parylene-C and Pt/Ir alloy. Furthermore, the cuff electrode is prefolded via a stick-and-roll thermoforming process, which simplifies the interfacing procedure. It is shows that the device is capable of selectively stimulating the nerve of a locust in vivo. Moreover, the subjects show no increased mortality 2 weeks after the implantation of the device.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous Noble Metal-Based Nanomaterials in Biomedical Applications 生物医学应用中的多孔贵金属纳米材料

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300078

Ziyue Zhang, Shouzhi Yang, Haiyang Su, Kun Qian

{"title":"Porous Noble Metal-Based Nanomaterials in Biomedical Applications","authors":"Ziyue Zhang, Shouzhi Yang, Haiyang Su, Kun Qian","doi":"10.1002/anbr.202300078","DOIUrl":"10.1002/anbr.202300078","url":null,"abstract":"Noble metal-based nanomaterials have attracted tremendous attention in biomedical applications due to their unique electrical, optical, and chemical properties, playing crucial roles in the ultrasensitive detection of biomarkers, bioimaging, cancer therapy, etc. Especially, porous noble metal-based nanomaterials show superior performance due to the large specific area and multiple active sites. Platforms constructed from porous noble metal-based nanomaterials are emerging as highly promising tools for various biomedical applications. Herein, the properties and synthesis strategies of porous noble metal-based nanomaterials are briefly introduced. Then the recent progress of porous noble metal-based nanomaterials in the biomedical field is highlighted, focusing primarily on their applications in optics, electrochemistry, and mass spectrometry. Finally, the challenges related to fabrication and biocompatibility for their applications while also providing an outlook on their widespread use in clinical situations are discussed. This review aims to provide further insights into the design of porous noble metal-based nanomaterials and expand their applications in the biomedical field.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parallelized Immunomagnetic Isolation of Basophils Directly from Whole Blood 直接从全血中平行免疫磁分离嗜碱性粒细胞

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300122

Justin Myles, Nicolas Castaño, Sungu Kim, Zhenyun Zhu, Sindy K.Y. Tang

{"title":"Parallelized Immunomagnetic Isolation of Basophils Directly from Whole Blood","authors":"Justin Myles, Nicolas Castaño, Sungu Kim, Zhenyun Zhu, Sindy K.Y. Tang","doi":"10.1002/anbr.202300122","DOIUrl":"10.1002/anbr.202300122","url":null,"abstract":"Basophils are the rarest circulating white blood cells (WBCs), but they play important roles in allergic disorders and other diseases. To enhance diagnostic capabilities, it would be desirable to isolate and analyze basophils efficiently from small blood samples. In 100 μL of whole blood, there are typically ≈103 basophils, outnumbered by ≈105 WBCs and ≈108 red blood cells (RBCs). Basophils’ low abundance has therefore presented a significant challenge in their isolation from whole blood. Conventional in-bulk basophil isolation methods require lengthy processing steps and cannot work with small volumes of blood. Herein, a parallelized integrated basophil isolation device (pi-BID) is reported for the negative immunomagnetic selection of basophils directly from four samples of 100 μL of whole blood, in parallel, within 14 min including sample preparation time. The pi-BID interfaces directly with standard sample tubes, and uses a single pressure source to drive the flow in parallel microfluidic channels. Compared with conventional in-bulk basophil isolation, the pi-BID is >3× faster, and has higher purity (≈93%) and similar recovery (≈67%). Compared with other microfluidic devices for the immunomagnetic isolation of WBC subtypes, the pi-BID achieves 10× higher enrichment of target cells from whole blood, with no prior removal of RBCs necessary.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Block Copolymer-Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy 嵌段共聚物稳定的金属有机框架杂化物负载钯纳米粒子，可通过近红外光热疗法缓解肿瘤症状

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300107

Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabral

{"title":"Block Copolymer-Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy","authors":"Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabral","doi":"10.1002/anbr.202300107","DOIUrl":"10.1002/anbr.202300107","url":null,"abstract":"Metal–organic frameworks (MOFs), such as the magnetic resonance imaging-fit MIL-100 based on Fe, are gaining significant attention as versatile theranostics with high-loading capability. Moreover, as MOFs can be engineered to target tumors, there is much interest in applying them for precise pin-point treatment of cancer. Herein, Pd nanoparticles within MIL-100(Fe) are generated to create MOFs with remarkable photothermal conversion properties for cancer therapy. The Pd-loaded MIL-100(Fe) (Pd@MIL-100(Fe)) are stabilized with biocompatible block copolymers to generate MOFs with PEGylated surfaces. This is achieved by directly mixing poly(ethylene glycol)-poly(L-aspartic acid) (PEG-p(Asp)) or dopamine-modified PEG-p(Asp) (PEG-p(Asp-Dopa)) block copolymers with the MOFs in aqueous conditions. The resulting block copolymer-stabilized MOF hybrids are stable in physiological conditions. Particularly, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids show enhanced blood circulation and increased accumulation in B16F10 melanoma. Furthermore, when irradiated with 808 nm light, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids rapidly increase the temperature to 50 °C, enabling tumor remission. The surface-stabilized Pd@MIL-100(Fe)/polymer hybrids open viable opportunities for innovating MOF/polymer hybrid-based approaches for drug delivery.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It Takes Two to Tango: Controlling Human Mesenchymal Stromal Cell Response via Substrate Stiffness and Surface Topography 探戈需要两个人通过基底硬度和表面形貌控制人类间充质基质细胞反应

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300042

Sofia Ribeiro, Alexandre Watigny, Yves Bayon, Manus Biggs, Dimitrios I. Zeugolis

引用次数: 0

Emerging Sensing and In Situ Detection Technologies for the Analysis of Extracellular Vesicle miRNAs 用于分析细胞外囊泡 miRNA 的新兴传感和原位检测技术

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300067

Jixuan Han, Chen Wang, Ling Zhu, Yanlian Yang

{"title":"Emerging Sensing and In Situ Detection Technologies for the Analysis of Extracellular Vesicle miRNAs","authors":"Jixuan Han, Chen Wang, Ling Zhu, Yanlian Yang","doi":"10.1002/anbr.202300067","DOIUrl":"10.1002/anbr.202300067","url":null,"abstract":"Liquid biopsy has received increasing attention as a new disease detection modality because of its noninvasive, simple sampling, and reproducible assay advantages. Among the markers of liquid biopsy, extracellular vesicles (EVs) are considered as promising disease biomarkers because they contain a large amount of biological information and have a significant role in physiological activities. The emergence and progression of some of these diseases are associated with miRNAs carried by EVs (EV-miRNAs). Therefore, high-sensitive detection of EV-miRNAs is essential in clinical applications. A growing number of strategies, including biosensors, in situ detection methods, and microfluidics have been developed for the detection of EV-miRNA and have been applied in the diagnosis of diseases such as cancer. This review summarizes the probes, signal amplification, and detection methods for EV-miRNA detection, as well as the application of membrane fusion-based in situ detection and integrated microfluidic chips for EV-miRNA detection. The challenges of these materials and techniques in clinical diagnostic applications are also discussed.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Nanoparticles and Nanoclusters as a Theranostics and Symptoms Disappearing Agent for Traumatic Brain Injury 作为创伤性脑损伤的治疗和症状消失剂的多功能纳米粒子和纳米团簇

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-28 DOI: 10.1002/anbr.202300010

Fong LaiGuan Zoey, Krishna Kanta Ghosh, Mathangi Palanivel, Balázs Gulyás, Parasuraman Padmanabhan

引用次数: 0

2D Materials for Combination Therapy to Address Challenges in the Treatment of Cancer 用于联合疗法的二维材料应对癌症治疗中的挑战

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-28 DOI: 10.1002/anbr.202300070

Ava Self, Megan Farell, Laximicharan Samineni, Manish Kumar, Esther W. Gomez

引用次数: 0

Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment 通过重组肿瘤微环境提高免疫疗法的疗效

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-11-28 DOI: 10.1002/anbr.202300061

Bokai Gong, Wenfeng Jia, Yang Zhou, Yanyan Xu, Ya Wei, Huile Gao

引用次数: 0