Advanced Nanobiomed Research最新文献_第8页

Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold 用植物提取的玉米蛋白替代动物提取的明胶用作组织工程支架

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-22 DOI: 10.1002/anbr.202300104

Apurva Limaye, Venkatesan Perumal, Courtney M. Karner, Treena Livingston Arinzeh

{"title":"Plant-Derived Zein as an Alternative to Animal-Derived Gelatin for Use as a Tissue Engineering Scaffold","authors":"Apurva Limaye, Venkatesan Perumal, Courtney M. Karner, Treena Livingston Arinzeh","doi":"10.1002/anbr.202300104","DOIUrl":"10.1002/anbr.202300104","url":null,"abstract":"Natural biomaterials are commonly used as tissue engineering scaffolds due to their biocompatibility and biodegradability. Plant-derived materials have also gained significant interest due to their abundance and as a sustainable resource. This study evaluates the corn-derived protein zein as a plant-derived substitute for animal-derived gelatin, which is widely used for its favorable cell adhesion properties. Limited studies exist evaluating pure zein for tissue engineering. Herein, fibrous zein scaffolds are evaluated in vitro for cell adhesion, growth, and infiltration into the scaffold in comparison to gelatin scaffolds and are further studied in a subcutaneous model in vivo. Human mesenchymal stem cells (MSCs) on zein scaffolds express focal adhesion kinase and integrins such as α\u0000 v\u0000 β\u0000 3, α\u0000 4, and β\u0000 1 similar to gelatin scaffolds. MSCs also infiltrate zein scaffolds with a greater penetration depth than cells on gelatin scaffolds. Cells loaded onto zein scaffolds in vivo show higher cell proliferation and CD31 expression, as an indicator of blood vessel formation. Findings also demonstrate the capability of zein scaffolds to maintain the multipotent capability of MSCs. Overall, findings demonstrate plant-derived zein may be a suitable alternative to the animal-derived gelatin and demonstrates zein's potential as a scaffold for tissue engineering.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Adhesion to Detachment: Strategies to Design Tissue-Adhesive Hydrogels 从粘附到剥离：设计组织粘性水凝胶的策略

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-22 DOI: 10.1002/anbr.202300090

Minh Hieu Ho, Quinn van Hilst, Xiaolin Cui, Yogambha Ramaswamy, Tim Woodfield, Jelena Rnjak-Kovacina, Steven G. Wise, Khoon S. Lim

{"title":"From Adhesion to Detachment: Strategies to Design Tissue-Adhesive Hydrogels","authors":"Minh Hieu Ho, Quinn van Hilst, Xiaolin Cui, Yogambha Ramaswamy, Tim Woodfield, Jelena Rnjak-Kovacina, Steven G. Wise, Khoon S. Lim","doi":"10.1002/anbr.202300090","DOIUrl":"10.1002/anbr.202300090","url":null,"abstract":"The use of tissue adhesives dates to 1940s when surgical glues were introduced for wound closure applications. However, current clinically used tissue adhesives (fibrin and cyanoacrylate glues) have limited adhesion strength and biocompatibility issues which restrict their performance in targeted applications. Due to this unmet clinical challenge, there is a need to develop next-generation tissue adhesives to expand the current limited available options. Another factor that is often overlooked in the field is the consequence of when these tissue adhesives fail while in use in specific applications. In this review, the complications arising from tissue adhesives that have insufficient adhesion strength are covered, where unintentional loosening and detachment can lead to serious complications depending on both the applications and scenarios in which the adhesives are used. Next, the current methodologies employed to design tissue-adhesive hydrogels targeting specific applications are also collated. Finally, the different strategies to engineer on-demand removal property of these tissue-adhesive hydrogels are consolidated, including some perspectives on current challenges and outlooks in this field.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Rolling Circle Amplification (RCA)-Based DNA-Functional Materials for Cancer Diagnosis and Therapy 用于癌症诊断和治疗的基于滚圆放大（RCA）的 DNA 功能材料的研究进展

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-21 DOI: 10.1002/anbr.202300108

Xun You, Jing Wang, Xiaocui Guo, Dayong Yang

{"title":"Advances in Rolling Circle Amplification (RCA)-Based DNA-Functional Materials for Cancer Diagnosis and Therapy","authors":"Xun You, Jing Wang, Xiaocui Guo, Dayong Yang","doi":"10.1002/anbr.202300108","DOIUrl":"10.1002/anbr.202300108","url":null,"abstract":"Developing biocompatible material systems with accurate functional designability and powerful integration capability is the urgent demand of efficient cancer diagnosis and therapy. Deoxyribonucleic acids (DNAs) as biomacromolecules are characterized with sequence programmability, rich biological activity, and molecular recognition, and show great performance in the fabrication of biomedical materials. Rolling circle amplification (RCA) is an efficient isothermal enzymatic amplification strategy for production of ultralong single-stranded DNA (ssDNA) with defined repeat sequences and structures. By virtue of rational design of the RCA templates sequences, the produced ssDNA enables to integrate and amplify the required function modules, which endows RCA-based DNA materials with extraordinary performance in cancer therapeutics. In this review, RCA-based strategies for integration of functional modules are systematically summarized; construction of RCA-based functional DNA materials and their recent progress in cancer therapeutics including detection, bioimaging, and therapy are overviewed; and finally the opportunities and challenges of RCA-based assembly strategy in terms of material construction and applications in cancer diagnosis and therapy are discussed. It is envisioned that RCA-based DNA-functional materials will provide typical paradigms for the application of DNA-functional materials in the field of cancer therapeutics, and hopefully provide more possibilities for precision medicine.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age-Related Macular Degeneration 具有高度清除活性氧特性的介孔氧化铈纳米粒子用于治疗老年性黄斑变性症

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-13 DOI: 10.1002/anbr.202370121

Seung Woo Choi, Ye Eun Kim, Jaeyun Kim

引用次数: 0

Micro/Nanomotors for Oral Delivery of Drugs: From Design to Application 用于口服给药的微型/纳米马达：从设计到应用

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-05 DOI: 10.1002/anbr.202300057

Chen Xie, Qiansha Luo, Yuxuan Zhang, Fang Qin, Yingfeng Tu, Kun Liu

{"title":"Micro/Nanomotors for Oral Delivery of Drugs: From Design to Application","authors":"Chen Xie, Qiansha Luo, Yuxuan Zhang, Fang Qin, Yingfeng Tu, Kun Liu","doi":"10.1002/anbr.202300057","DOIUrl":"10.1002/anbr.202300057","url":null,"abstract":"Oral administration, as a traditional approach of taking therapeutic drugs, is easily accepted by patients due to its convenience and compliance. However, the harsh digestive environment and mucosa-epithelial cell barriers limit the absorption of drugs through the oral route, particularly for biomacromolecules such as protein, peptide, or nucleic acid drugs. To address this issue, active carriers such as micro/nanomotors and mechanical devices have been engineered as novel delivery systems that are capable of converting various energy into mechanical force. The active delivery of these carriers holds promise for overcoming absorptive barriers and improving drug delivery efficiency, making them an attractive option for precision medicine applications that include drug delivery, gene and cell therapy, biopsy, tissue penetration, intracellular delivery, and biosensing. This article presents an overview of the progress and challenges associated with orally delivering macromolecular drugs, as well as strategies to enhance drug absorption. Additionally, it discusses recent developments and potential applications of active carriers in drug delivery and related fields, which may provide inspiration for future research.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shortwave-Infrared-Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer 用于乳腺癌 CD8 靶向和体内细胞毒性 T 细胞成像的短波激发纳米探针

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-05 DOI: 10.1002/anbr.202300092

Jay V. Shah, Jake N. Siebert, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Edmund C. Lattime, Vidya Ganapathy, Prabhas V. Moghe

{"title":"Shortwave-Infrared-Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer","authors":"Jay V. Shah, Jake N. Siebert, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Edmund C. Lattime, Vidya Ganapathy, Prabhas V. Moghe","doi":"10.1002/anbr.202300092","DOIUrl":"10.1002/anbr.202300092","url":null,"abstract":"Checkpoint immunotherapy has made great strides in the treatment of solid tumors, but many patients do not respond to immune checkpoint inhibitors. Identification of tumor-infiltrating cytotoxic T cells (CTLs) has the potential to stratify patients and monitor immunotherapy responses. In this study, the design of cluster of differentiation (CD8+) T cell-targeted nanoprobes that emit shortwave infrared (SWIR) light in the second tissue-transparent window for noninvasive, real-time imaging of CTLs in murine models of breast cancer is presented. SWIR-emitting rare-earth nanoparticles encapsulated in human serum albumin are conjugated with anti-CD8α to target CTLs with high specificity. CTL targeting is validated in vitro through binding of nanoprobes to primary mouse CTLs. The potential for the use of SWIR fluorescence intensity to determine CTL presence is validated in two syngeneic mammary fat pad tumor models, EMT6 and 4T1, which differ in immune infiltration. SWIR imaging using CD8-targeted nanoprobes successfully identifies the presence of CTLs in the more immunogenic EMT6 model, while imaging confirms the lack of substantial immune infiltration in the nonimmunogenic 4T1 model. In this work, the opportunity for SWIR imaging using CD8-targeted nanoprobes to assess CTL infiltration in tumors for the stratification and monitoring of responders to checkpoint immunotherapy is highlighted.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Biomimetic Mineralization of Viruses: More than Calcium 病毒的人工仿生矿化：不仅仅是钙

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300064

Pan-Deng Shi, Yan-Peng Xu, Hui Zhao, Cheng-Feng Qin

引用次数: 0

A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy 将基本金属离子作为纳米药物用于癌症治疗的简要回顾

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300069

Lin Weng, Xin Chen

{"title":"A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy","authors":"Lin Weng, Xin Chen","doi":"10.1002/anbr.202300069","DOIUrl":"10.1002/anbr.202300069","url":null,"abstract":"In this review, the latest progress in essential metal-ion-based nanomedicines for tumor therapy is summarized, existing challenges are addressed, and possible directions are proposed for such therapeutic strategies. Essential metal ions are critical for the metabolic activity of organisms. Their abnormal spatial and temporal distribution in biological systems, particularly inside the cell, disrupts biochemical processes and leads to irreversible physicochemical damage to cells. Thus, they can function as the foundation of targeted cancer therapies for tumor inhibition and eradication. Over the last decade, numerous essential metal-ion-based cancer therapies have been developed to fight a wide spectrum of cancers with improved efficiency and minor drug resistance. Triggering biocatalysis, affecting protein metabolism, interfering with signal transduction, damaging DNA, and initiating biomineralization are the main mechanisms underlying these therapies. In this study, it is aimed to provide readers with general implications for future research for an increased interest in future clinical applications of these advanced cancer therapies.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoformed Parylene-C Cuff Electrodes for Small Nerve Interfacing 用于小神经接口的热成型聚对二甲苯袖带电极

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300102

Francisco Zurita, Sebastian Freko, Lukas Hiendlmeier, Fulvia Del Duca, Tanja Groll, Olga Seelbach, Katja Steiger, Bernhard Wolfrum

{"title":"Thermoformed Parylene-C Cuff Electrodes for Small Nerve Interfacing","authors":"Francisco Zurita, Sebastian Freko, Lukas Hiendlmeier, Fulvia Del Duca, Tanja Groll, Olga Seelbach, Katja Steiger, Bernhard Wolfrum","doi":"10.1002/anbr.202300102","DOIUrl":"10.1002/anbr.202300102","url":null,"abstract":"Peripheral nerve interfacing plays a crucial role in various healthcare applications. Generally, interfacing peripheral nerves results in a compromise between selectivity and invasiveness. In particular, large nerves carry many axonal fibers, which are difficult to address selectively without penetrating the nerve. Higher selectivity without nerve penetration can be achieved by targeting small nerves with extraneural cuff electrodes. However, in practice, small nerves are challenging to interface appropriately. Herein, a new multielectrode device is presented that can selectively interface small nerves (<200 μm). The device is fabricated using rapid laser-based processing with biocompatible materials such as parylene-C and Pt/Ir alloy. Furthermore, the cuff electrode is prefolded via a stick-and-roll thermoforming process, which simplifies the interfacing procedure. It is shows that the device is capable of selectively stimulating the nerve of a locust in vivo. Moreover, the subjects show no increased mortality 2 weeks after the implantation of the device.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous Noble Metal-Based Nanomaterials in Biomedical Applications 生物医学应用中的多孔贵金属纳米材料

IF 3.4

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI: 10.1002/anbr.202300078

Ziyue Zhang, Shouzhi Yang, Haiyang Su, Kun Qian

{"title":"Porous Noble Metal-Based Nanomaterials in Biomedical Applications","authors":"Ziyue Zhang, Shouzhi Yang, Haiyang Su, Kun Qian","doi":"10.1002/anbr.202300078","DOIUrl":"10.1002/anbr.202300078","url":null,"abstract":"Noble metal-based nanomaterials have attracted tremendous attention in biomedical applications due to their unique electrical, optical, and chemical properties, playing crucial roles in the ultrasensitive detection of biomarkers, bioimaging, cancer therapy, etc. Especially, porous noble metal-based nanomaterials show superior performance due to the large specific area and multiple active sites. Platforms constructed from porous noble metal-based nanomaterials are emerging as highly promising tools for various biomedical applications. Herein, the properties and synthesis strategies of porous noble metal-based nanomaterials are briefly introduced. Then the recent progress of porous noble metal-based nanomaterials in the biomedical field is highlighted, focusing primarily on their applications in optics, electrochemistry, and mass spectrometry. Finally, the challenges related to fabrication and biocompatibility for their applications while also providing an outlook on their widespread use in clinical situations are discussed. This review aims to provide further insights into the design of porous noble metal-based nanomaterials and expand their applications in the biomedical field.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138605454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0