Oxygen-Releasing Hydrogels for Tissue Regeneration

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2024-03-31 DOI:10.1002/anbr.202300133

Shengxi Jiang, Yujia Zheng, Hao Xia, Zexin Liu, Shuquan Rao, Yingbo Wang, Hongyu Sun, Xiong Lu, Chaoming Xie

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Abstract

Hydrogels have emerged as a focal point of research in the biomedical field due to their applications in tissue repair. However, the majority of hydrogels lack the capability to release oxygen, constraining their therapeutic outcomes in environments with hypoxic tissues. In recent years, oxygen-releasing hydrogels have garnered extensive attention in the field of tissue engineering, owing to their ability to modulate oxygen release and meet the diverse oxygenation requirements of various tissues. These hydrogels can enhance repair efficiency and promote tissue regeneration in hypoxic tissue environments. The design of oxygen-releasing hydrogels primarily involves the utilization of diverse oxygen sources, such as algae, perfluorocarbons, and peroxides, to achieve optimal tissue oxygenation. This review provides a comprehensive summary of the design and fabrication strategies of oxygen-releasing hydrogels, discusses deeply into their underlying oxygen-releasing mechanisms, and their myriad applications in tissue repair along with the prospective challenges.

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用于组织再生的释氧水凝胶

水凝胶因其在组织修复方面的应用而成为生物医学领域的研究焦点。然而，大多数水凝胶缺乏释放氧气的能力，这限制了它们在缺氧组织环境中的治疗效果。近年来，释放氧的水凝胶因其能够调节氧的释放并满足各种组织的不同氧合需求而在组织工程领域受到广泛关注。这些水凝胶可以提高修复效率，促进缺氧组织环境中的组织再生。氧释放水凝胶的设计主要涉及利用不同的氧源，如藻类、全氟化碳和过氧化物，以实现最佳的组织氧合。本综述全面总结了析氧水凝胶的设计和制造策略，深入探讨了其潜在的析氧机制、在组织修复中的大量应用及其面临的挑战。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.