Advanced Nanobiomed Research最新文献

Laponite Nanoclay-Loaded Microgel Suspensions as Supportive Matrices for Osteogenesis 皂石纳米粘土负载微凝胶悬浮液作为骨形成的支持性基质

IF 4

Advanced Nanobiomed Research Pub Date : 2024-09-11 DOI: 10.1002/anbr.202400024

Gagan K. Jalandhra, Tzong-tyng Hung, Kristopher A. Kilian

{"title":"Laponite Nanoclay-Loaded Microgel Suspensions as Supportive Matrices for Osteogenesis","authors":"Gagan K. Jalandhra, Tzong-tyng Hung, Kristopher A. Kilian","doi":"10.1002/anbr.202400024","DOIUrl":"https://doi.org/10.1002/anbr.202400024","url":null,"abstract":"Microscale carriers have emerged as promising materials for nurturing cell growth and as delivery vehicles for regenerative therapies. Carriers based on granular hydrogels have proved advantageous, where “microgels” can be formulated to have a broad range of properties to guide the behavior of adherent cells. Herein, the fabrication of osteogenic microgel matrices through the incorporation of laponite nanoclays is demonstrated. Forming a jammed suspension provides a scaffolding where cells can adhere to the surface of the microgels, with pathways for migration and proliferation fostered by the interstitial volume. By varying the content and type of laponite—RD and XLG—the degree of osteogenesis can be tuned in embedded populations of adipose-derived stem cells. The nano- and microstructured composite materials enhance osteogenesis at the transcript and protein level, leading to increased deposition of bone minerals and an increase in the compressive modulus of the assembled scaffold. Together, these microgel suspensions are promising materials for encouraging osteogenesis with scope for delivery via injection and stabilization to bone-mimetic mechanical properties after matrix deposition.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioreactors: A Regenerative Approach to Skeletal Muscle Engineering for Repair and Replacement 生物反应器：用于修复和替代的骨骼肌工程再生方法

IF 4

Advanced Nanobiomed Research Pub Date : 2024-09-11 DOI: 10.1002/anbr.202400030

Alysha Williamson, Khashayar Khoshmanesh, Elena Pirogova, Peiqi Yang, Finn Snow, Richard Williams, Anita Quigley, Rob M. I. Kapsa

引用次数: 0

Monitoring of Electrophysiological Functions in Brain-on-a-Chip and Brain Organoids 监测脑芯片和脑器官组织的电生理功能

IF 4

Advanced Nanobiomed Research Pub Date : 2024-09-09 DOI: 10.1002/anbr.202470091

Jiyoung Song, Hoon Eui Jeong, Andrew Choi, Hong Nam Kim

引用次数: 0

Phototactic Biohybrid Microrobot Using Peptide Nanotubes-Coated Microalgae for pH-Responsive Active Drug Delivery 利用肽纳米管包覆微藻的光触媒生物杂交微型机器人实现 pH 值响应型活性药物递送

IF 4

Advanced Nanobiomed Research Pub Date : 2024-09-03 DOI: 10.1002/anbr.202400042

Laura Ha, Hyunsik Choi, Ashmeet Singh, Bolam Kim, Byung-Kwon Kaang, You-Kwan Oh, Sei Kwang Hahn, Dong-Pyo Kim

{"title":"Phototactic Biohybrid Microrobot Using Peptide Nanotubes-Coated Microalgae for pH-Responsive Active Drug Delivery","authors":"Laura Ha, Hyunsik Choi, Ashmeet Singh, Bolam Kim, Byung-Kwon Kaang, You-Kwan Oh, Sei Kwang Hahn, Dong-Pyo Kim","doi":"10.1002/anbr.202400042","DOIUrl":"https://doi.org/10.1002/anbr.202400042","url":null,"abstract":"Despite the recent wide investigation on active cancer drug delivery, there are still strong medical unmet needs for active tumor-environment responsive cancer drug delivery in terms of spatiotemporal control. Herein, a biohybrid system of pH-responsive peptide nanotubes (PNTs)-coated microalgae for active cancer drug delivery in response to the tumor-environment is developed. The amphiphilic PNTs are effectively used to encapsulate cancer drugs and coat the living microalgae of C. reinhardtii by electrostatic interactions. The drug-loaded PNTs-based biohybrid microalgae maintain agile movement with phototaxis behavior. After in vitro characterization and cytotoxicity assessment, it is shown that the biohybrid microalgae could be phototactically localized to the cancer cells and pH-responsively disassembled to release cancer drugs in a controlled manner. Finally, with the encapsulation of paclitaxel, the statistically significant suppression of tumor growth in xenograft tumor model animals is successfully demonstrated. Taken together, the feasibility of the multifunctional microrobotic platform for advanced cancer therapy is confirmed.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation of Mesoporous Silica Materials in Biological Milieu: The Gateway for Therapeutic Applications 介孔二氧化硅材料在生物环境中的降解：治疗应用之门

IF 4

Advanced Nanobiomed Research Pub Date : 2024-09-02 DOI: 10.1002/anbr.202400005

Sergio E. Moya, Raquel Ruiz Hernández, Paula C. Angelomé

{"title":"Degradation of Mesoporous Silica Materials in Biological Milieu: The Gateway for Therapeutic Applications","authors":"Sergio E. Moya, Raquel Ruiz Hernández, Paula C. Angelomé","doi":"10.1002/anbr.202400005","DOIUrl":"https://doi.org/10.1002/anbr.202400005","url":null,"abstract":"Since early developments in the field of mesoporous materials, mesoporous silica has attracted large interest in drug delivery, as they display an ordered array of pores with diameters ranging from 2 to 50 nm, which can be loaded with drugs. Mesoporous silica dissolves at physiological pH, triggering the release of loaded drugs. Several studies have focused on determining the key factors that determine the biodistribution, biocompatibility, and toxicity both in vitro or in vivo. However, in vivo studies focused on the degradation of mesoporous silica materials are very scarce, despite its relevance for drug release. In this perspective, recent works addressing mesoporous materials degradation in the context of drug delivery are discussed, first from a physicochemical point of view, and secondly in in vivo settings, in animal models that are the closest conditions to the encountered when the mesoporous materials are administered to humans. Finally, further discussion about the future directions in the design of mesoporous nanomaterials for therapy and for the study of their biological fate are presented.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progress in the Development of Flexible Wearable Electrodes for Electrocardiogram Monitoring During Exercise 开发用于运动时心电图监测的柔性可穿戴电极的最新进展

IF 4

Advanced Nanobiomed Research Pub Date : 2024-08-07 DOI: 10.1002/anbr.202470081

Tae Woog Kang, Jimin Lee, Youngjin Kwon, Yoon Jae Lee, Woon-Hong Yeo

引用次数: 0

Monitoring of Electrophysiological Functions in Brain-on-a-Chip and Brain Organoids 监测脑芯片和脑器官组织的电生理功能

IF 4

Advanced Nanobiomed Research Pub Date : 2024-07-23 DOI: 10.1002/anbr.202400052

Jiyoung Song, Hoon Eui Jeong, Andrew Choi, Hong Nam Kim

{"title":"Monitoring of Electrophysiological Functions in Brain-on-a-Chip and Brain Organoids","authors":"Jiyoung Song, Hoon Eui Jeong, Andrew Choi, Hong Nam Kim","doi":"10.1002/anbr.202400052","DOIUrl":"10.1002/anbr.202400052","url":null,"abstract":"Though animal models are still the gold standard for fundamental biological studies and drug evaluation for brain diseases, concerns arise from an apparent lack of reflecting the human genetics and pathophysiology. Recently, human avatars such as brain-on-a-chip and brain organoids which are generated in a 3D manner using multiple types of human-originated cells have risen as alternative testing models. Particularly in monitoring the functional neuronal cells that express action potentials in brain-on-a-chip or brain organoids, various methods of measuring their electrophysiological function have been suggested for the study of brain-related disease. Recent methodologies for analyzing the electrophysiology of different types of cells in brain-on-a-chip and brain organoids are summarized in this review. We first emphasize the inherent features of brain-on-a-chip and brain organoids from the perspective of the cell culture environment and accessibility to cells in the deep layer. The applicable monitoring techniques are then overviewed based on these features. Finally, we discuss the unmet needs for electrophysiology monitoring in advanced human brain avatar models.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postembedding Iodine Staining for Contrast-Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam-Scanning Electron Microscopy 利用聚焦离子束扫描电子显微镜对骨组织进行对比度增强型三维成像的包埋后碘染色技术

IF 4

Advanced Nanobiomed Research Pub Date : 2024-07-17 DOI: 10.1002/anbr.202400035

Mahdi Ayoubi, Richard Weinkamer, Alexander F. van Tol, Maximilian Rummler, Paul Roschger, Peter C. Brugger, Andrea Berzlanovich, Luca Bertinetti, Andreas Roschger, Peter Fratzl

{"title":"Postembedding Iodine Staining for Contrast-Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam-Scanning Electron Microscopy","authors":"Mahdi Ayoubi, Richard Weinkamer, Alexander F. van Tol, Maximilian Rummler, Paul Roschger, Peter C. Brugger, Andrea Berzlanovich, Luca Bertinetti, Andreas Roschger, Peter Fratzl","doi":"10.1002/anbr.202400035","DOIUrl":"10.1002/anbr.202400035","url":null,"abstract":"For a better understanding of living tissues and materials, it is essential to study the intricate spatial relationship between cells and their surrounding tissue on the nanoscale, with a need for 3D, high-resolution imaging techniques. In the case of bone, focused ion beam-scanning electron microscopy (FIB-SEM) operated in the backscattered electron (BSE) mode proves to be a suitable method to image mineralized areas with a nominal resolution of 5 nm. However, as clinically relevant samples are often resin-embedded, the lack of atomic number (Z) contrast makes it difficult to distinguish the embedding material from unmineralized parts of the tissue, such as osteoid, in BSE images. Staining embedded samples with iodine vapor has been shown to be effective in revealing osteoid microstructure by 2D BSE imaging. Based on this idea, an iodine (Z = 53) staining protocol is developed for 3D imaging with FIB-SEM, investigating how the amount of iodine and exposure time influences the imaging outcome. Bone samples stained with this protocol also remain compatible with confocal laser scanning microscopy to visualize the lacunocanalicular network. The proposed protocol can be applied for 3D imaging of tissues exhibiting mineralized and nonmineralized regions to study physiological and pathological biomineralization.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically Actuated Nanomaterials in Biomedical Applications 生物医学应用中的磁动纳米材料

IF 4

Advanced Nanobiomed Research Pub Date : 2024-07-17 DOI: 10.1002/anbr.202300136

Jiaxiang Xiao, Qian Dong, Yiting Xu, Changwen Li, Jiayu Zeng, Xin Xia, Xiangxian Meng, Zhuo Chen

{"title":"Magnetically Actuated Nanomaterials in Biomedical Applications","authors":"Jiaxiang Xiao, Qian Dong, Yiting Xu, Changwen Li, Jiayu Zeng, Xin Xia, Xiangxian Meng, Zhuo Chen","doi":"10.1002/anbr.202300136","DOIUrl":"10.1002/anbr.202300136","url":null,"abstract":"Magnetic nanomaterials, distinguished by their unique magnetic phenomena, particularly their magnetically actuated capabilities, have found widespread application in the field of nanomedicine. Compared with alternative driving mechanisms, magnetic actuation as a remote, highly permeable, and precisely controllable driving strategy endows nanomaterials with temporal and spatia mobility, making it possible to initiate and cease multiple forms of movement in vivo at will. When coupled with cutting-edge diagnostic and treating techniques including but not limited to magnetic resonance imaging, magnetothermal therapy, and magnetoelectric stimulation, magnetically actuated nanomaterials offer the potential for visual analysis, provision of reliable molecular information, and effective disease or tissue damage intervention. This review comprehensively outlines the synthesis methodologies, functional strategies, and biomedical applications of magnetically actuated nanomaterials within nanomedicine. Additionally, the future developments and applications of biocompatible magnetically actuated nanomaterials, especially in response to time-varying magnetic fields, are anticipated.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Anti-inflammatory Activity of Garlic Extracts in 3D Bioprinted Skin Equivalents 在三维生物打印皮肤等效物中评估大蒜提取物的抗炎活性

IF 4

Advanced Nanobiomed Research Pub Date : 2024-07-07 DOI: 10.1002/anbr.202470071

Moon Sung Kang, Hee Jeong Jang, Jeong Min Kim, Hyo Jung Jo, Kyung Min Park, Young-Hwa Chung, Dong-Wook Han

引用次数: 0