Advanced Nanobiomed Research最新文献_第2页

Degradation of Mesoporous Silica Materials in Biological Milieu: The Gateway for Therapeutic Applications 介孔二氧化硅材料在生物环境中的降解：治疗应用之门

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Advanced Nanobiomed Research Pub Date : 2024-09-02 DOI: 10.1002/anbr.202400005

Sergio E. Moya, Raquel Ruiz Hernández, Paula C. Angelomé

{"title":"Degradation of Mesoporous Silica Materials in Biological Milieu: The Gateway for Therapeutic Applications","authors":"Sergio E. Moya, Raquel Ruiz Hernández, Paula C. Angelomé","doi":"10.1002/anbr.202400005","DOIUrl":"https://doi.org/10.1002/anbr.202400005","url":null,"abstract":"Since early developments in the field of mesoporous materials, mesoporous silica has attracted large interest in drug delivery, as they display an ordered array of pores with diameters ranging from 2 to 50 nm, which can be loaded with drugs. Mesoporous silica dissolves at physiological pH, triggering the release of loaded drugs. Several studies have focused on determining the key factors that determine the biodistribution, biocompatibility, and toxicity both in vitro or in vivo. However, in vivo studies focused on the degradation of mesoporous silica materials are very scarce, despite its relevance for drug release. In this perspective, recent works addressing mesoporous materials degradation in the context of drug delivery are discussed, first from a physicochemical point of view, and secondly in in vivo settings, in animal models that are the closest conditions to the encountered when the mesoporous materials are administered to humans. Finally, further discussion about the future directions in the design of mesoporous nanomaterials for therapy and for the study of their biological fate are presented.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 10","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progress in the Development of Flexible Wearable Electrodes for Electrocardiogram Monitoring During Exercise 开发用于运动时心电图监测的柔性可穿戴电极的最新进展

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Advanced Nanobiomed Research Pub Date : 2024-08-07 DOI: 10.1002/anbr.202470081

Tae Woog Kang, Jimin Lee, Youngjin Kwon, Yoon Jae Lee, Woon-Hong Yeo

引用次数: 0

DNA Dissipative System for Controlled Release of Immunostimulatory CpG Oligodeoxynucleotides 用于控制释放免疫刺激性 CpG 寡聚氧核苷酸的 DNA 耗散系统

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Advanced Nanobiomed Research Pub Date : 2024-07-30 DOI: 10.1002/anbr.202400082

Aman Ishaqat, Xiaofeng Zhang, Andreas Herrmann

{"title":"DNA Dissipative System for Controlled Release of Immunostimulatory CpG Oligodeoxynucleotides","authors":"Aman Ishaqat, Xiaofeng Zhang, Andreas Herrmann","doi":"10.1002/anbr.202400082","DOIUrl":"https://doi.org/10.1002/anbr.202400082","url":null,"abstract":"Herein, a dissipative system tailored for the controlled loading and release of CpG oligodeoxynucleotides (CpG ODNs), known for their pharmacological immunostimulatory properties, is reported. The approach involves multiple cycles of deactivation and activation of the CpG ODNs via its hybridization with a complementary fuel strand, followed by its selective release mediated by the enzymatic activity of T7 exonuclease. The autonomous and temporal behavior of this dissipative system can be tuned by three factors: the design of the fuel strand and its concentration that governs the kinetics of the forward hybridization reaction, as well as the concentration of T7 exonuclease, which regulates the backward energy dissipation reaction. Furthermore, the enzyme's tolerance toward waste accumulation is demonstrated, and the system's robust performance when utilizing various fuel strands in alternating fashion is showcased. The findings underscore the potential of this approach for precise and programmable delivery of therapeutic nucleic acids in multiple cycles, with implications for enhancing immunotherapeutic strategies in which controlled kinetics of the nucleic acid is highly desired.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 11","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring of Electrophysiological Functions in Brain-on-a-Chip and Brain Organoids 监测脑芯片和脑器官组织的电生理功能

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Advanced Nanobiomed Research Pub Date : 2024-07-23 DOI: 10.1002/anbr.202400052

Jiyoung Song, Hoon Eui Jeong, Andrew Choi, Hong Nam Kim

{"title":"Monitoring of Electrophysiological Functions in Brain-on-a-Chip and Brain Organoids","authors":"Jiyoung Song, Hoon Eui Jeong, Andrew Choi, Hong Nam Kim","doi":"10.1002/anbr.202400052","DOIUrl":"10.1002/anbr.202400052","url":null,"abstract":"Though animal models are still the gold standard for fundamental biological studies and drug evaluation for brain diseases, concerns arise from an apparent lack of reflecting the human genetics and pathophysiology. Recently, human avatars such as brain-on-a-chip and brain organoids which are generated in a 3D manner using multiple types of human-originated cells have risen as alternative testing models. Particularly in monitoring the functional neuronal cells that express action potentials in brain-on-a-chip or brain organoids, various methods of measuring their electrophysiological function have been suggested for the study of brain-related disease. Recent methodologies for analyzing the electrophysiology of different types of cells in brain-on-a-chip and brain organoids are summarized in this review. We first emphasize the inherent features of brain-on-a-chip and brain organoids from the perspective of the cell culture environment and accessibility to cells in the deep layer. The applicable monitoring techniques are then overviewed based on these features. Finally, we discuss the unmet needs for electrophysiology monitoring in advanced human brain avatar models.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 9","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postembedding Iodine Staining for Contrast-Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam-Scanning Electron Microscopy 利用聚焦离子束扫描电子显微镜对骨组织进行对比度增强型三维成像的包埋后碘染色技术

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Advanced Nanobiomed Research Pub Date : 2024-07-17 DOI: 10.1002/anbr.202400035

Mahdi Ayoubi, Richard Weinkamer, Alexander F. van Tol, Maximilian Rummler, Paul Roschger, Peter C. Brugger, Andrea Berzlanovich, Luca Bertinetti, Andreas Roschger, Peter Fratzl

{"title":"Postembedding Iodine Staining for Contrast-Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam-Scanning Electron Microscopy","authors":"Mahdi Ayoubi, Richard Weinkamer, Alexander F. van Tol, Maximilian Rummler, Paul Roschger, Peter C. Brugger, Andrea Berzlanovich, Luca Bertinetti, Andreas Roschger, Peter Fratzl","doi":"10.1002/anbr.202400035","DOIUrl":"10.1002/anbr.202400035","url":null,"abstract":"For a better understanding of living tissues and materials, it is essential to study the intricate spatial relationship between cells and their surrounding tissue on the nanoscale, with a need for 3D, high-resolution imaging techniques. In the case of bone, focused ion beam-scanning electron microscopy (FIB-SEM) operated in the backscattered electron (BSE) mode proves to be a suitable method to image mineralized areas with a nominal resolution of 5 nm. However, as clinically relevant samples are often resin-embedded, the lack of atomic number (Z) contrast makes it difficult to distinguish the embedding material from unmineralized parts of the tissue, such as osteoid, in BSE images. Staining embedded samples with iodine vapor has been shown to be effective in revealing osteoid microstructure by 2D BSE imaging. Based on this idea, an iodine (Z = 53) staining protocol is developed for 3D imaging with FIB-SEM, investigating how the amount of iodine and exposure time influences the imaging outcome. Bone samples stained with this protocol also remain compatible with confocal laser scanning microscopy to visualize the lacunocanalicular network. The proposed protocol can be applied for 3D imaging of tissues exhibiting mineralized and nonmineralized regions to study physiological and pathological biomineralization.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 10","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically Actuated Nanomaterials in Biomedical Applications 生物医学应用中的磁动纳米材料

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Advanced Nanobiomed Research Pub Date : 2024-07-17 DOI: 10.1002/anbr.202300136

Jiaxiang Xiao, Qian Dong, Yiting Xu, Changwen Li, Jiayu Zeng, Xin Xia, Xiangxian Meng, Zhuo Chen

{"title":"Magnetically Actuated Nanomaterials in Biomedical Applications","authors":"Jiaxiang Xiao, Qian Dong, Yiting Xu, Changwen Li, Jiayu Zeng, Xin Xia, Xiangxian Meng, Zhuo Chen","doi":"10.1002/anbr.202300136","DOIUrl":"10.1002/anbr.202300136","url":null,"abstract":"Magnetic nanomaterials, distinguished by their unique magnetic phenomena, particularly their magnetically actuated capabilities, have found widespread application in the field of nanomedicine. Compared with alternative driving mechanisms, magnetic actuation as a remote, highly permeable, and precisely controllable driving strategy endows nanomaterials with temporal and spatia mobility, making it possible to initiate and cease multiple forms of movement in vivo at will. When coupled with cutting-edge diagnostic and treating techniques including but not limited to magnetic resonance imaging, magnetothermal therapy, and magnetoelectric stimulation, magnetically actuated nanomaterials offer the potential for visual analysis, provision of reliable molecular information, and effective disease or tissue damage intervention. This review comprehensively outlines the synthesis methodologies, functional strategies, and biomedical applications of magnetically actuated nanomaterials within nanomedicine. Additionally, the future developments and applications of biocompatible magnetically actuated nanomaterials, especially in response to time-varying magnetic fields, are anticipated.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 8","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Anti-inflammatory Activity of Garlic Extracts in 3D Bioprinted Skin Equivalents 在三维生物打印皮肤等效物中评估大蒜提取物的抗炎活性

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Advanced Nanobiomed Research Pub Date : 2024-07-07 DOI: 10.1002/anbr.202470071

Moon Sung Kang, Hee Jeong Jang, Jeong Min Kim, Hyo Jung Jo, Kyung Min Park, Young-Hwa Chung, Dong-Wook Han

引用次数: 0

Multifunctional MXene Nanosheets and Their Applications in Antibacterial Therapy 多功能 MXene 纳米片及其在抗菌治疗中的应用

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Advanced Nanobiomed Research Pub Date : 2024-07-02 DOI: 10.1002/anbr.202400033

Xuyang Lai, Yuting Tang, Yuanhao Dong, Yankun Luo, Xiaodong Yang, Qiang Peng

{"title":"Multifunctional MXene Nanosheets and Their Applications in Antibacterial Therapy","authors":"Xuyang Lai, Yuting Tang, Yuanhao Dong, Yankun Luo, Xiaodong Yang, Qiang Peng","doi":"10.1002/anbr.202400033","DOIUrl":"10.1002/anbr.202400033","url":null,"abstract":"\u0000Bacterial infections are a great threat to human health, and the irrational use of antibiotics has largely compromised the efficacy of antibiotic therapy due to the emergence of drug-resistant pathogens. It is known that synthesizing new antibiotics is difficult and time-consuming. In this case, developing antibiotics-independent antibacterial approaches is of great importance and significance. In the past decade, various functional nanomaterials have shown great potentials in the treatment of bacterial infections. Among these nanomaterials, transition metal carbides or nitrides, namely MXene, have attracted much attention. As the novel 2D nanosheets, MXene can serve either as a direct antibacterial agent due to its intrinsic antibacterial activity and photothermal effect, or as an efficient carrier to load photosensitizers and photocatalysts for photodynamic and photocatalytic therapy. In recent few years, the number of literatures regarding MXene-based antibacterial therapy has increased rapidly. Thus, it is the time to systematically summarize the applications of MXene in the treatment of bacteria, especially those with drug resistance. Herein, it is aimed to summarize the preparation methods for MXene and provide a comprehensive understanding of its properties and applications in antibacterial therapy. Also, its use for bacterial detection and the challenges for practical use are discussed.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 8","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

State-of-the-Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment 用于治疗糖尿病足溃疡的智能伤口敷料的最新技术和未来挑战

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Advanced Nanobiomed Research Pub Date : 2024-06-23 DOI: 10.1002/anbr.202400040

Sabine Szunerits, Rabah Boukherroub

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A Perspective on Ultrasound-Triggered Production of Reactive Oxygen Species by Inorganic Nano/Microparticles 透视无机纳米/微粒在超声波触发下产生的活性氧物种

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Advanced Nanobiomed Research Pub Date : 2024-06-20 DOI: 10.1002/anbr.202400060

Yijun Han, Xinyue Yu, Zeinab Marfavi, Yumo Chen, Linxuan Zhang, Jing Chu, Kang Sun, Mingda Li, Ke Tao

引用次数: 0