Advanced Nanobiomed Research最新文献_第2页

Oral Delivery of Chitosan-Rosmarinic Acid Nanoparticles Ameliorates Mucosal Inflammation in a Mouse Model of Colitis 口服壳聚糖-迷迭香酸纳米颗粒改善小鼠结肠炎模型的粘膜炎症

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-30 DOI: 10.1002/anbr.202500068

Afia Tasnim Rahman, Sungyeon Kang, Sangyong Jon

{"title":"Oral Delivery of Chitosan-Rosmarinic Acid Nanoparticles Ameliorates Mucosal Inflammation in a Mouse Model of Colitis","authors":"Afia Tasnim Rahman, Sungyeon Kang, Sangyong Jon","doi":"10.1002/anbr.202500068","DOIUrl":"https://doi.org/10.1002/anbr.202500068","url":null,"abstract":"Inflammatory bowel disease (IBD) is a chronic disorder characterized by intestinal barrier dysfunction, excessive immune activation, and oxidative stress. Current treatment options, such as 5-aminosalicylic acid (5-ASA), exhibit limited therapeutic efficacy due to poor bioavailability and inability to restore intestinal homeostasis. Herein, a novel nanomedicine that can be orally administered, low-molecular-weight chitosan-conjugated rosmarinic acid nanoparticles (LMWC-RANPs), designed to enhance IBD treatment through its mucoadhesive, antioxidant, and immunomodulatory properties, are introduced. LMWC-RANPs exhibit strong mucoadhesion, leading to prolonged retention in the inflamed gastrointestinal tract and efficient ROS scavenging. In a DSS-induced mouse model of colitis, LMWC-RANPs significantly alleviate disease symptoms by reducing body weight loss, preserving colon length, and restoring intestinal barrier integrity. Additionally, LMWC-RANPs effectively modulate the mucosal immune response by promoting macrophage polarization from pro-inflammatory (M1) to anti-inflammatory (M2) phenotypes and reducing Th17 cell populations while enhancing regulatory T cell (Treg) frequencies. Furthermore, oral administration of LMWC-RANPs exhibits no observable systemic toxicity in healthy mice, as confirmed by hematological and histopathological analyses. Collectively, these findings demonstrate the potential of LMWC-RANPs as a safe and effective therapeutic for inflammatory bowel disease, with broader implications for other gut-associated inflammatory diseases.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 10","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery 聚合物刷功能化纳米颗粒用于基因传递

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-27 DOI: 10.1002/anbr.202500063

Carlos E. Neri-Cruz, Julien E. Gautrot

{"title":"Nanoparticles Functionalized with Polymer Brushes for Gene Delivery","authors":"Carlos E. Neri-Cruz, Julien E. Gautrot","doi":"10.1002/anbr.202500063","DOIUrl":"https://doi.org/10.1002/anbr.202500063","url":null,"abstract":"Although the field of gene delivery has made tremendous progress, many obstacles remain to achieve safe, targeted, and controlled delivery and release of nucleic acids. The effective delivery of these therapeutics requires the precise control of physicochemical and biochemical processes regulating a broad range of events, from initial complexation and stabilization in biological fluids, to the crossing of endothelial barriers, internalization, and cytosolic/nuclear release. Polymer brush-functionalized nanoparticles are well suited to control physicochemical parameters that regulate these processes, including the chemical composition of their shell; its grafting density and thickness; as well as the size, shape, and physical properties of its core. In addition, polymer brushes can be designed to display more complex architectures (blocks and mixed brushes), providing further control of the delivery vehicle physicochemistry, size, and hierarchical structure. Here, this study discusses how gene delivery systems can be uniquely engineered, tailoring the physicochemistry of polymer brush-functionalized nanoparticles. In addition, it reviews the impact of brush design on the formation of protein coronas, associated with in vitro transfection, blood circulation, or cytosolic entry. Finally, it discusses how polymer brush engineering enables the design of nanomaterials for theranostics applications.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 10","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection 长循环纳米体可持久预防严重急性呼吸综合征冠状病毒2组粒感染

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-27 DOI: 10.1002/anbr.202400214

Geetha Jyothi Vaskuri, Gang Ye, Fan Bu, Dong Yang, Colleen B. Jonsson, Hailey Turner-Hubbard, Sydney Winecke, Alise Mendoza, Fang Li, Chalet Tan

{"title":"Long-Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection","authors":"Geetha Jyothi Vaskuri, Gang Ye, Fan Bu, Dong Yang, Colleen B. Jonsson, Hailey Turner-Hubbard, Sydney Winecke, Alise Mendoza, Fang Li, Chalet Tan","doi":"10.1002/anbr.202400214","DOIUrl":"10.1002/anbr.202400214","url":null,"abstract":"Breakthrough infections in vaccinated population and continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants make it imperative to develop more efficacious medical countermeasures. Previously, an anti-SARS-CoV-2 nanobody, Nanosota-3A, that neutralizes the infection of live Omicron BA.1 with picomolar potency, is identified. Herein, Nanosota-3A is fused with the crystallizable fragment (Fc) domain of human IgG1 that contains M252Y/S254T/T256E (YTE) substitutions, named Nanosota-3A-Fc-YTE. Compared to Nanosota-3A-Fc, Nanosota-3A-Fc-YTE exhibits identical binding to the SARS-CoV-2 spike protein yet displays eightfold higher binding affinity for human neonatal Fc receptor (hFcRn) at pH 6.0. In hFcRn transgenic mice, the half-life of Nanosota-3A-Fc and Nanosota-3A-Fc-YTE is 5.1 days and 24.8 days, respectively. The mice are challenged with intranasal exposure of Omicron B.1.1.529 virus 55 days after a single dose of Nanosota-3A fusions (20 mg kg−1) is administered. Compared to the untreated controls, the lung viral titers in mice receiving Nanosota-3A-Fc-YTE are reduced by 104.7-fold (p = 0.007) with 50% of the mice free of detectable virus. By contrast, Nanosota-3A-Fc-treated mice show only 3.5-fold reduction in the viral titers (p = 0.41). The durable protection conferred by a single dose of Nanosota-3A-Fc-YTE administered nearly 2 months prior to the virus exposure demonstrates the promise of long-circulating nanobodies as powerful prophylactics against SARS-CoV-2.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 8","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Antimicrobial Properties of Sodium Borate and Carbonate and their Perborate and Percarbonate Counterparts 硼酸钠和碳酸钠及其过硼酸钠和过碳酸钠的抗菌性能比较

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-26 DOI: 10.1002/anbr.202500045

Ayden Watt, Dario Job, Justin Matta, Nitin Chandra Teja Dadi, Cat-Thy Dang, Yara Raphael, Joshua Vorstenbosch, Geraldine Merle, Jake Barralet

{"title":"Comparative Antimicrobial Properties of Sodium Borate and Carbonate and their Perborate and Percarbonate Counterparts","authors":"Ayden Watt, Dario Job, Justin Matta, Nitin Chandra Teja Dadi, Cat-Thy Dang, Yara Raphael, Joshua Vorstenbosch, Geraldine Merle, Jake Barralet","doi":"10.1002/anbr.202500045","DOIUrl":"10.1002/anbr.202500045","url":null,"abstract":"Antimicrobial resistance (AMR) poses a significant challenge in wound management, particularly in ischemic and chronic wounds, which are prone to infection and where traditional treatments often fall short. In response to this need, the antibacterial activity of polycaprolactone (PCL) films, composited with sodium perborate and sodium percarbonate to provide controlled release of oxygen and reactive oxygen species, is compared in vitro and in vivo. Sustained antimicrobial action against both Gram-positive and Gram-negative bacteria is measured in vitro that allowed lower quantities to be used compared with the borate and carbonate counterparts sodium borate and carbonate. This effect is also observed in vivo, such that perborate formulations are effective at wound treatment using one-tenth the borate concentration required in sodium borate formulations. Overall, sodium perborate-loaded films significantly accelerate wound closure, reduce bacterial load, and enhance early-phase wound healing, outperforming borate equivalent counterparts at equivalent loading levels. In addition to effectively inhibiting bacterial growth, these composites prevent biofilm formation in vitro. These findings suggest that perborate-loaded polymeric films could be a powerful tool in advanced wound care, offering both potent antimicrobial effects and promotion of wound healing in complex clinical settings.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 8","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Strategies for Platelet-Modified Nanoparticles in Targeted Tumor Therapy 靶向肿瘤治疗中血小板修饰纳米颗粒的新策略

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-25 DOI: 10.1002/anbr.202500082

Chunyu Bai, Lan Sun, Yimin Cui, Huan Meng, Jiulong Li, Qian Xiang

{"title":"Emerging Strategies for Platelet-Modified Nanoparticles in Targeted Tumor Therapy","authors":"Chunyu Bai, Lan Sun, Yimin Cui, Huan Meng, Jiulong Li, Qian Xiang","doi":"10.1002/anbr.202500082","DOIUrl":"https://doi.org/10.1002/anbr.202500082","url":null,"abstract":"Platelets play a crucial role in tumor development through a bidirectional interaction with cancer cells. On one hand, platelets promote tumor proliferation, metastasis, and immune evasion; on the other, tumors can activate platelets, creating a feedback loop that accelerates disease progression. Disrupting this interaction by targeting platelets has emerged as a promising strategy to control tumor growth and dissemination. However, traditional antiplatelet drugs often lack tumor specificity, limiting their therapeutic efficacy and increasing the risk of adverse effects such as bleeding. To overcome these limitations, researchers have turned to nanotechnology to design platelet-modified nanoparticles that enhance tumor targeting and improve treatment precision. This review summarizes recent advances in the development of these nanoparticles, including those aimed at modulating platelet-tumor interactions, directly treating tumors, or improving radiotherapy outcomes. The distinct advantages of platelet-modified nanoparticles are also discussed, such as enhanced drug delivery, minimized off-target effects, and superior biocompatibility. Finally, their potential clinical applications and implications for cancer therapy is explored, highlighting how these innovations could transform the treatment landscape for malignant tumors. This review underscores the significance of platelet-targeting strategies in advancing cancer nanomedicine and addresses current challenges in the field.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 10","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges 外泌体在椎间盘再生中的作用、机遇和挑战

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-21 DOI: 10.1002/anbr.202500074

Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong

引用次数: 0

Nanostructured Biomaterial-Based Approaches to Support Induced Pluripotent Stem Cell Differentiation 纳米结构生物材料支持诱导多能干细胞分化的方法

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-21 DOI: 10.1002/anbr.202500072

Beatriz A. B. R. Passos, Matteo Battaglini, Gianni Ciofani

{"title":"Nanostructured Biomaterial-Based Approaches to Support Induced Pluripotent Stem Cell Differentiation","authors":"Beatriz A. B. R. Passos, Matteo Battaglini, Gianni Ciofani","doi":"10.1002/anbr.202500072","DOIUrl":"https://doi.org/10.1002/anbr.202500072","url":null,"abstract":"The possibility to control the proliferation of stem cells and guide their differentiation toward specific cellular lineages holds great promise as a potential therapeutic approach for regenerating and substituting damaged tissues, and in the treatment of several human diseases. In recent years, developing strategies for obtaining induced pluripotent stem cells (iPSCs) from adult tissues has been a groundbreaking scientific discovery; the rationale behind the exploitation of iPSCs in therapy consists in the isolation of adult cells, their reprogramming into iPSCs, and the subsequent differentiation into somatic cells. However, traditional differentiation procedures usually cannot finely tune and control the differentiation of iPSCs, leading to undesired cellular subpopulations and potentially adverse effects in the case of cellular grafting in adult tissues. In this context, nanostructured biomaterial-based approaches for the guided differentiation of iPSCs represent a promising tool for overcoming the limitations of traditional protocols. This review aims to provide the current state of the art concerning the exploitation of nanostructured biomaterials (scaffolds or nanocarriers) to control and tune the differentiation processes of iPSCs. With this work, it is hoped to provide new insights and perspectives into biomaterial designing and application strategies in the context of iPSC-based studies.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 10","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic Nanoparticles Mitigate Chemotherapy-Induced Peripheral Neuropathy 阳离子纳米颗粒减轻化疗诱导的周围神经病变

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-16 DOI: 10.1002/anbr.202500002

Divya Bhansali, Rocco Latorre, Raquel Tonello, David Poolman, Suwan Ding, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong

{"title":"Cationic Nanoparticles Mitigate Chemotherapy-Induced Peripheral Neuropathy","authors":"Divya Bhansali, Rocco Latorre, Raquel Tonello, David Poolman, Suwan Ding, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong","doi":"10.1002/anbr.202500002","DOIUrl":"10.1002/anbr.202500002","url":null,"abstract":"Chemotherapy-induced peripheral neuropathy (CIPN) is a major clinical challenge, particularly for patients treated with paclitaxel (PTX), a highly effective yet neurotoxic chemotherapeutic agent. PTX often causes debilitating neuropathic pain, including mechanical and cold allodynia, driven by neuroinflammation and altered peripheral neuron excitability. This study investigates PTX-loaded cationic PAMAM-Chol nanoparticles (PTX NPs) as a novel strategy to mitigate CIPN. PTX NPs exhibit high drug loading efficiency (99%), sustained release, and reduced neurotoxicity in neuronal cell models. In a murine CIPN model, PTX NPs produce an 85% overall reduction in cold allodynia with a peak inhibition of 90% at day 8 and accelerate the recovery of mechanical allodynia, restoring withdrawal thresholds to baseline levels by day 14, compared to persistent nociception with unencapsulated PTX. PTX NPs also suppress dorsal root ganglia inflammation, reducing the expression of proinflammatory cytokines TNFα and IL-1β. Furthermore, as indicated by phosphorylated ERK, neuronal activation is prevented in PTX NP-treated mice, suggesting a reduction in central sensitization. Importantly, PTX NPs demonstrate no observable toxicity in liver or kidney function. These findings establish a proof of concept that nanomedicine-mediated delivery can alleviate CIPN effectively, offering a promising approach to refine PTX-based chemotherapy regimens.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 9","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reshaping Protein-Based Nanoparticles: Innovative Artificial Intelligence-Driven Strategies for Structural Design and Applications 重塑蛋白质纳米颗粒：结构设计和应用的创新人工智能驱动策略

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-05 DOI: 10.1002/anbr.202500017

Mohammad Mahmoudi Gomari, Mehdi Alidadi, Neda Rostami, Sidi A. Bencherif

{"title":"Reshaping Protein-Based Nanoparticles: Innovative Artificial Intelligence-Driven Strategies for Structural Design and Applications","authors":"Mohammad Mahmoudi Gomari, Mehdi Alidadi, Neda Rostami, Sidi A. Bencherif","doi":"10.1002/anbr.202500017","DOIUrl":"10.1002/anbr.202500017","url":null,"abstract":"Nanoparticles (NPs) have become a pivotal technology in biomedical research due to their unique physicochemical properties and nanoscale size, allowing for targeted applications. Among NP materials, proteins and their derivatives stand out for their biocompatibility, engineering flexibility, and inherent biological functions, making them especially attractive for NP design. However, the structural and biochemical complexity of proteins has historically presented challenges in NP development. Recent advancements in artificial intelligence (AI) have transformed this field. Neural network models such as AlphaFold, ProteinMPNN, and RoseTTAFold, along with protein language models like evolutionary scale modeling, enable the design of protein-based NPs (PNPs) with diverse symmetries, shapes, and functionalities. These AI-driven approaches address traditional limitations, unlocking new possibilities in nanomedicine. This review explores the transformative role of AI in PNP design, emphasizing its potential to broaden applications, solve challenges, and drive innovative solutions in biotechnology and medical research.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 9","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202500017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Multifunctional Nanoparticles for Effective Targeted Cancer Therapy 磁性多功能纳米颗粒有效靶向治疗癌症

IF 4.4

Advanced Nanobiomed Research Pub Date : 2025-06-04 DOI: 10.1002/anbr.202400176

Yao Miao, Qing Bao, Tao Yang, Mingying Yang, Chuanbin Mao

{"title":"Magnetic Multifunctional Nanoparticles for Effective Targeted Cancer Therapy","authors":"Yao Miao, Qing Bao, Tao Yang, Mingying Yang, Chuanbin Mao","doi":"10.1002/anbr.202400176","DOIUrl":"https://doi.org/10.1002/anbr.202400176","url":null,"abstract":"Due to the lack of targeting specificity, rapid clearance, and high toxicity associated with small molecule drugs in tumor treatment, the design of an effective drug delivery system is crucial. To better overcome physiological barriers and achieve prolonged tumor retention, nanoparticles (Fe3O4@SiO2@Au, termed FSA-NPs), made of core–shell NPs (Fe3O4@SiO2), consisting of a Fe3O4 core and a mesoporous silica (SiO2) shell, and with their surfaces decorated with gold NPs, are constructed. The FSA-NPs have a size range of 60–80 nm and a mildly negative surface charge. The magnetic Fe3O4 core imparts magnetic targeting capabilities to FSA-NPs, while the high porosity of the mesoporous silica shell enables efficient drug loading. Additionally, the gold NPs can convert light into heat. As a result, after being internalized by A549 lung cancer cells, FSA-NPs exhibit potent cytotoxic effects against the cancer cells under an applied magnetic field, making them a promising theranostic agent for integrated cancer diagnosis and therapy.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"5 10","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0