Bwalya Angel Witika, Aaron Hutton, Pedzisai A. Makoni, Ryan F. Donnelly
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A State-of-the-Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines
Nanomaterial-loaded microneedles are a novel development in the fields of medicine and vaccines. Researchers have created extremely effective systems for the targeted and controlled delivery of a variety of bioactive agents by fusing nanomaterials with microneedle platforms. The design and manufacturing processes of nanomaterial-loaded microneedles are covered herein, along with applications to improve drug stability, bioavailability, and patient adherence. Important preclinical and clinical studies that demonstrate the efficiency of these systems in delivering small molecules, biologics, and vaccines are also covered in the review. In order to direct ongoing research and expedite the clinical translation of this promising technology, important challenges and future directions are identified. This review offers a thorough evaluation of the most recent developments in this quickly developing field of technology.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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