对 pH 值敏感的智能单体可预防口腔癌进展

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2024-04-10 DOI:10.1002/anbr.202470041

Shiyu Liu, Jing Chen, Xuedong Zhou, Yu Hao, Yawen Zong, Yangyang Shi, Xiao Guo, Qi Han, Mingyun Li, Bolei Li, Lei Cheng

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引用次数: 0

摘要

癌症治疗口腔癌的肿瘤微环境呈酸性。我们设计了一种对 pH 值敏感的叔胺单体甲基丙烯酸十二烷基甲基氨基乙酯（DMAEM），它能根据 pH 值的变化发生可逆的质子化和去质子化反应。在酸性微环境中，DMAEM 可质子化为具有强细胞毒性的季铵单体--甲基丙烯酸二甲基氨基十二烷基酯（DMADDM）。通过这种方法，DMAEM 可抑制口腔癌的发展。更多详情，请参阅李博磊、程磊及合作者发表的第 2300119 号文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A pH-Sensitive Smart Monomer Prevents Oral Cancer Progression

查看原文本刊更多论文

A pH-Sensitive Smart Monomer Prevents Oral Cancer Progression

Cancer Treatment

Oral cancer shows an acidic tumor microenvironment. A pH-sensitive tertiary amine monomer dodecylmethylaminoethyl methacrylate (DMAEM) has been designed, which displays reversible protonation and deprotonation reactions according to the pH changes. In the acidic microenvironment DMAEM could be protonated into strong cytotoxic quaternary ammonium monomers - Dimethylaminododecyl methacrylate (DMADDM). By this means, DMAEM inhibits the progression of oral cancer. More details can be found in article number 2300119 by Bolei Li, Lei Cheng, and co-workers.

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.