{"title":"Magnetically Actuated Nanomaterials in Biomedical Applications","authors":"Jiaxiang Xiao, Qian Dong, Yiting Xu, Changwen Li, Jiayu Zeng, Xin Xia, Xiangxian Meng, Zhuo Chen","doi":"10.1002/anbr.202300136","DOIUrl":"10.1002/anbr.202300136","url":null,"abstract":"<p>Magnetic nanomaterials, distinguished by their unique magnetic phenomena, particularly their magnetically actuated capabilities, have found widespread application in the field of nanomedicine. Compared with alternative driving mechanisms, magnetic actuation as a remote, highly permeable, and precisely controllable driving strategy endows nanomaterials with temporal and spatia mobility, making it possible to initiate and cease multiple forms of movement in vivo at will. When coupled with cutting-edge diagnostic and treating techniques including but not limited to magnetic resonance imaging, magnetothermal therapy, and magnetoelectric stimulation, magnetically actuated nanomaterials offer the potential for visual analysis, provision of reliable molecular information, and effective disease or tissue damage intervention. This review comprehensively outlines the synthesis methodologies, functional strategies, and biomedical applications of magnetically actuated nanomaterials within nanomedicine. Additionally, the future developments and applications of biocompatible magnetically actuated nanomaterials, especially in response to time-varying magnetic fields, are anticipated.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 8","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moon Sung Kang, Hee Jeong Jang, Jeong Min Kim, Hyo Jung Jo, Kyung Min Park, Young-Hwa Chung, Dong-Wook Han
{"title":"Evaluation of Anti-inflammatory Activity of Garlic Extracts in 3D Bioprinted Skin Equivalents","authors":"Moon Sung Kang, Hee Jeong Jang, Jeong Min Kim, Hyo Jung Jo, Kyung Min Park, Young-Hwa Chung, Dong-Wook Han","doi":"10.1002/anbr.202470071","DOIUrl":"https://doi.org/10.1002/anbr.202470071","url":null,"abstract":"<p><b>3D Bioprinting</b>\u0000 </p><p>This study introduces a 3D bioprinted skin model to evaluate the anti-inflammatory effects of garlic extracts (N-Benzyl-N-methyl-dodecan-1-amine, BMDA). The cover art of the article 2400007 by Young-Hwa Chung, Dong-Wook Han, and co-workers highlights advanced drug screening as an alternative for preclinical research in future pharmaceutical and cosmetic industries.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 7","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202470071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multifunctional MXene Nanosheets and Their Applications in Antibacterial Therapy","authors":"Xuyang Lai, Yuting Tang, Yuanhao Dong, Yankun Luo, Xiaodong Yang, Qiang Peng","doi":"10.1002/anbr.202400033","DOIUrl":"10.1002/anbr.202400033","url":null,"abstract":"<p>\u0000Bacterial infections are a great threat to human health, and the irrational use of antibiotics has largely compromised the efficacy of antibiotic therapy due to the emergence of drug-resistant pathogens. It is known that synthesizing new antibiotics is difficult and time-consuming. In this case, developing antibiotics-independent antibacterial approaches is of great importance and significance. In the past decade, various functional nanomaterials have shown great potentials in the treatment of bacterial infections. Among these nanomaterials, transition metal carbides or nitrides, namely MXene, have attracted much attention. As the novel 2D nanosheets, MXene can serve either as a direct antibacterial agent due to its intrinsic antibacterial activity and photothermal effect, or as an efficient carrier to load photosensitizers and photocatalysts for photodynamic and photocatalytic therapy. In recent few years, the number of literatures regarding MXene-based antibacterial therapy has increased rapidly. Thus, it is the time to systematically summarize the applications of MXene in the treatment of bacteria, especially those with drug resistance. Herein, it is aimed to summarize the preparation methods for MXene and provide a comprehensive understanding of its properties and applications in antibacterial therapy. Also, its use for bacterial detection and the challenges for practical use are discussed.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 8","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"State-of-the-Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment","authors":"Sabine Szunerits, Rabah Boukherroub","doi":"10.1002/anbr.202400040","DOIUrl":"https://doi.org/10.1002/anbr.202400040","url":null,"abstract":"<p>The slow healing process of diabetic wound due to persisting infections in wound bed, owing to hyperglycemia, makes the search for efficient treatments pending. While it is complicated to increase the wound closure rate in diabetic-related wounds due to the complex pathology, the treatment of such wound with hydrogels is seen as a promising approach and pursued over the years. However, where is this research currently standing in terms of clinical translation of these different multifunctional and stimuli-responsive hydrogel bandages to accelerate diabetic foot ulcer healing and help to improve the life of the patients and the future of diabetic wound management? This perspective article will review some of the most important advancements in the field and will conclude with some perspectives, considered as relevant in the clinical context.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 9","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yijun Han, Xinyue Yu, Zeinab Marfavi, Yumo Chen, Linxuan Zhang, Jing Chu, Kang Sun, Mingda Li, Ke Tao
{"title":"A Perspective on Ultrasound-Triggered Production of Reactive Oxygen Species by Inorganic Nano/Microparticles","authors":"Yijun Han, Xinyue Yu, Zeinab Marfavi, Yumo Chen, Linxuan Zhang, Jing Chu, Kang Sun, Mingda Li, Ke Tao","doi":"10.1002/anbr.202400060","DOIUrl":"https://doi.org/10.1002/anbr.202400060","url":null,"abstract":"<p>Ultrasound can activate nano/microparticles to induce reactive oxygen species (ROS). The advantages of deep penetration and precise spatiotemporal control are demonstrated for multiple applications, such as sonodynamic therapy, chemical industry, and environmental treatment. Meanwhile, a toolbox of inorganic particles is developed to enhance ROS production via cavitation enhancement, sonoluminescence, and piezocatalytic effect. Nonetheless, sophisticated influences of ultrasonic parameters hamper further exploration of novel sonosensitized materials. In this perspective, the influential parameters in different mechanisms are reviewed, emphasizing the relationship between ultrasound frequency and catalytic activity, and outlooks are provided on the study of inorganic sonosensitizers.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 9","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthetic Immunology—Building Immunity from the Bottom-Up with Synthetic Cells","authors":"Oskar Staufer","doi":"10.1002/anbr.202400037","DOIUrl":"10.1002/anbr.202400037","url":null,"abstract":"<p>Synthetic cells can advance immunotherapy, offering innovative approaches to understanding and enhancing immune responses. This review article delves into the advancements and potential of synthetic cell technologies in immunology, emphasizing their role in understanding and manipulating immune functions. Recent progress in understanding vertebrate immune systems and the challenges posed by diseases highlight the need for innovative research methods, complementing the analysis of multidimensional datasets and genetic engineering. Synthetic immune cell engineering aims to simplify the complexity of immunological systems by reconstructing them in a controlled setting. This approach, alongside high-throughput strategies, facilitates systematic investigations into immunity and the development of novel treatments. The article reviews synthetic cell technologies, focusing on their alignment with the three laws of immunity: universality, tolerance, and appropriateness. It explores the integration of synthetic cell modules to mimic processes such as controlled T-cell activation, bacteria engulfment and elimination, or cellular maturation into desirable phenotypes. Together, such advancements expand the toolbox for understanding and manipulating immune functions. Synthetic cell technologies stand at the innovation crossroads in immunology, promising to illuminate fundamental immune system principles and open new avenues for research and therapy.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 9","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141367351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lamyaa Albakr, Hongyuan Du, Xiyuan Zhang, Himanshu Kathuria, Ahmed Fahmi Anwar-Fadzil, Nial J. Wheate, Lifeng Kang
{"title":"Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery","authors":"Lamyaa Albakr, Hongyuan Du, Xiyuan Zhang, Himanshu Kathuria, Ahmed Fahmi Anwar-Fadzil, Nial J. Wheate, Lifeng Kang","doi":"10.1002/anbr.202470061","DOIUrl":"https://doi.org/10.1002/anbr.202470061","url":null,"abstract":"<p><b>Nanocarrier</b>\u0000 </p><p>Overview of the most used nanocarriers for therapeutics delivery via skin, covering the lipid-based such as liposomes and the inorganic such as carbon nanotubes. The review article focuses on their applications and the challenges that limit their clinical adoptions. More details can be found in article 2400003 by Lifeng Kang and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202470061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transdermal Delivery of Polymeric Nanoparticles Containing Aconite Root for the Treatment of Chemotherapy-Induced Peripheral Neuropathy","authors":"Tae Eon Park, Man-Suk Hwang, Ki Su Kim","doi":"10.1002/anbr.202470051","DOIUrl":"https://doi.org/10.1002/anbr.202470051","url":null,"abstract":"<p><b>Transdermal Nanomedicine</b>\u0000 </p><p>The chemotherapy-induced peripheral neuropathy (CIPN) caused by anticancer drugs results in severe pain for patients. In article number 2400006, Tae Eon Park, Man-Suk Hwang, and Ki Su Kim have developed hyaluronic acid-based polymeric nanoparticles containing natural herb extracts to alleviate neuropathic pain caused by CIPN. These particles are delivered non-invasively through the skin, contributing to nerve regeneration.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202470051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nimeet Desai, Vishakha Tambe, Prasad Pofali, Lalitkumar K. Vora
{"title":"Cell Membrane-Coated Nanoparticles: A New Frontier in Immunomodulation","authors":"Nimeet Desai, Vishakha Tambe, Prasad Pofali, Lalitkumar K. Vora","doi":"10.1002/anbr.202400012","DOIUrl":"https://doi.org/10.1002/anbr.202400012","url":null,"abstract":"<p>Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, the immune system's inability to discern and eliminate abnormal cells leads to uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, the immune system encounters challenges in clearance and neutralization. Achieving a delicate balance of pro-inflammatory and anti-inflammatory signals is essential in managing a range of disorders and diseases. Like in other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among the plethora of nanotechnology-based interventions, the concept of cell membrane-coated nanoparticles holds significant potential for immunomodulatory applications owing to their biomimetic properties that allow for precise interaction with the compromised immune system. This review thoroughly examines the potential of novel nanosystems for immune modulation. The exploration covers crucial elements, including the origins and characteristics of cell membranes, the methods employed for their procurement and coating, physicochemical/biological characterization techniques, and enhancement of their therapeutic efficacy via functionalization. Subsequently, case studies-based analysis of utilizing these bioinspired nanosystems in tackling different conditions caused by immune disturbance has been comprehensively discussed.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 8","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis","authors":"Yongyuan Kang, Xiaowei Liu, Xiping Chen, Yiyuan Duan, Jie Wang, Changyou Gao","doi":"10.1002/anbr.202400008","DOIUrl":"https://doi.org/10.1002/anbr.202400008","url":null,"abstract":"<p>Skin pathological fibrosis conditions, such as hypertrophic scars (HS) and keloids, where the scar tissue is raised and extends beyond the original wound boundary, are aesthetically unappealing and sometimes painful or itchy, significantly impacting the life quality of patients. In this review, the advances of nanobiomaterials in treating skin pathological fibrosis are summarized and discussed. The focus is on the therapeutic approaches to cellular and molecular targets of HS, highlighting the potential of nanotechnology in scar management. The biofunctional nanomaterials can modulate inflammation, regulate angiogenesis, and promote fibroblast apoptosis. The nanotechnology-based drug delivery systems such as liposomes, ethosomes, and dendritic macromolecules can improve the solubility, stability, and efficacy of drugs, and enhance precise delivery, resulting in better outcomes in HS therapy. Integrating nanomaterials or nanostructures into hydrogels, nanofibers, and microneedles can enhance the biological functionality and maximize the therapeutic effect of nanoparticles (NPs) at the wound site. The important potential of nanotechnology-based scar treatment should be further explored to overcome the current challenges and promote its application in clinical practice.</p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 8","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202400008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}