Advanced Nanobiomed Research最新文献_第6页

Advances in Pulmonary Protein Delivery Systems 肺蛋白输送系统的进展

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-03-08 DOI: 10.1002/anbr.202300176

Yuanyuan Zhao, Shuai Liu, Xueguang Lu

引用次数: 0

Monitoring the Intracellular Fate of Molecular Beacons: The Challenge of False Positive Signals 监测分子信标的细胞内命运：假阳性信号的挑战

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-03-08 DOI: 10.1002/anbr.202300147

Diogo Volpati, Pedro H. B. Aoki, Therese B. Johansson, Roberto Munita, Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Charlotte Ling, Christelle N. Prinz

{"title":"Monitoring the Intracellular Fate of Molecular Beacons: The Challenge of False Positive Signals","authors":"Diogo Volpati, Pedro H. B. Aoki, Therese B. Johansson, Roberto Munita, Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Charlotte Ling, Christelle N. Prinz","doi":"10.1002/anbr.202300147","DOIUrl":"10.1002/anbr.202300147","url":null,"abstract":"Molecular beacons (MBs) have been used on surfaces for detecting oligonucleotides. Attempts to use them intracellularly for monitoring mRNA content have been made, however, without any clear conclusion regarding the reliability of the method, mainly due to false positive signals. To reach an understanding of the intracellular fate of MBs, a critical question remains: how long after MB delivery and where in the cell does a false positive signal appear? To answer that question, the MB delivery method should allow for a time-stamped synchronized delivery of MBs to multiple cells, resulting in MBs being distributed in the cytosol immediately after delivery. Herein, nanostraws are used to inject MBs targeting insulin (Ins1) mRNA directly in the cytosol of clonal beta-cells, and the evolution of the MB fluorescence in time and space is monitored. The results show an MB translocation to the nucleus, where MBs are degraded or where they open nonspecifically, before the fluorophore alone is expelled back from the nucleus to the cytosol. The signal translocation to the nucleus and back to the cytosol is faster when scrambled MBs are used. The results shed light on the intracellular fate of MBs and highlight the short time scales before false positive signals become predominant.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine-Enabled Mild Photothermal Therapy Strategies for Enhanced Antitumor Treatment 增强抗肿瘤治疗的纳米药物温和光热疗法策略

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-03-07 DOI: 10.1002/anbr.202470031

Yongjuan Li, Xinran Zhu, Ya Dong, Yang Yang, Danyang Shen, Zhenzhen Li, Rui Li, Xiaowei Dang, Zhihai Qin, Kelong Fan

引用次数: 0

Advances of Structural Design and Biomedical Applications of Tobacco Mosaic Virus Coat Protein 烟草花叶病毒外壳蛋白的结构设计和生物医学应用进展

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-03-07 DOI: 10.1002/anbr.202300135

Jialun Zhang, Haobo He, Fanmeng Zeng, Mingming Du, Dehua Huang, Guangcun Chen, Qiangbin Wang

{"title":"Advances of Structural Design and Biomedical Applications of Tobacco Mosaic Virus Coat Protein","authors":"Jialun Zhang, Haobo He, Fanmeng Zeng, Mingming Du, Dehua Huang, Guangcun Chen, Qiangbin Wang","doi":"10.1002/anbr.202300135","DOIUrl":"10.1002/anbr.202300135","url":null,"abstract":"Recognized as the primary RNA virus to be categorized and extensively studied, the tobacco mosaic virus (TMV) is foundational to advancements in virology, molecular biology, and biomaterials. Over the past few decades, the deep comprehension of the TMV coat protein (TMVcp) molecular structure and assembly principles has stimulated a surge in research on TMVcp structural design using genetic engineering and chemical modification techniques. The unique characteristics of TMVcp, including its nanoscale orderly structure, ease of modification, and considerable drug loading capacity, have enabled significant progress in its biomedical applications. This review summarizes the advanced strategies deployed for TMVcp design and multidimensional assembly and underscores the prototypical applications of TMVcp-based biomaterials in bioimaging, drug delivery, tissue engineering, and biosensing. Ultimately, the future prospects of TMVcp research in structural design and biomedical applications are explored, which encompass artificial intelligence-guided structural and functional design, the development of stimulus-responsive biomaterials, and potential clinical translation.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-Edge Achievements of Inner Ear Drug Delivery Systems 内耳给药系统的尖端成果

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-03-01 DOI: 10.1002/anbr.202400004

Hui Zhang, Dongyu Xu, Huan Wang, Renjie Chai, Yuanjin Zhao

引用次数: 0

Natural Polymer-Based Materials for Wound Healing Applications 用于伤口愈合的天然聚合物基材料

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-02-22 DOI: 10.1002/anbr.202300131

Trinh Thi-Phuong Ho, Hien A. Tran, Vinh Khanh Doan, Joanneke Maitz, Zhe Li, Steven G. Wise, Khoon S. Lim, Jelena Rnjak-Kovacina

{"title":"Natural Polymer-Based Materials for Wound Healing Applications","authors":"Trinh Thi-Phuong Ho, Hien A. Tran, Vinh Khanh Doan, Joanneke Maitz, Zhe Li, Steven G. Wise, Khoon S. Lim, Jelena Rnjak-Kovacina","doi":"10.1002/anbr.202300131","DOIUrl":"10.1002/anbr.202300131","url":null,"abstract":"Skin injuries pose significant health challenges, with conditions like burns and diabetic, venous, and pressure ulcers presenting complex wound management scenarios. Effective wound care strategies for these injuries encompass a range of interventions, from simple wound dressings to bioactive materials and surgical procedures involving skin substitutes and skin grafting. This review explores the potential of natural polymers, including silk, collagen, gelatin, elastin, cellulose, chitosan, alginate, and hyaluronic acid, in wound management. Natural polymers offer several advantages, including abundance, biodegradability, and compatibility with traditional and modern material fabrication techniques, and have demonstrated safety and efficacy in clinical applications, modulating various facets of the wound healing process. Highlighting preclinical and clinical studies, along with commercial products, this review showcases the versatility and utility of natural polymers in wound management and provides insights into emerging developments, such as 3D bioprinting and stimuli-responsive materials, which hold promise for personalized wound treatments. Additionally, we discuss the importance of the material format and morphology in engineering the next generation of wound dressings and skin substitutes, offering a pathway to optimize natural polymers for enhanced wound healing outcomes.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Challenges in Cerebral Organoids Research 脑有机体研究的进展与挑战

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-02-17 DOI: 10.1002/anbr.202300126

Dandan Luo, Jiaqi Xu, Fuyao Liu, Zhen Gu

引用次数: 0

Dendrimer-Based Nanodrugs for Chemodynamic Therapy of Tumors 用于肿瘤化学动力疗法的树枝状聚合物纳米药物

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-02-17 DOI: 10.1002/anbr.202300149

Caiyun Zhang, Yunqi Guo, Mingwu Shen, Xiangyang Shi

引用次数: 0

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications 装载响应性纳米粒子的微针贴片的多功能平台：合成与前景广阔的生物医学应用

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-02-15 DOI: 10.1002/anbr.202300142

Rixin Xie, Wenjing Li, Kexin Shi, Li Yang, Hongzhong Chen, Shaoyun Jiang, Xiaowei Zeng

{"title":"Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications","authors":"Rixin Xie, Wenjing Li, Kexin Shi, Li Yang, Hongzhong Chen, Shaoyun Jiang, Xiaowei Zeng","doi":"10.1002/anbr.202300142","DOIUrl":"https://doi.org/10.1002/anbr.202300142","url":null,"abstract":"\u0000Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneedle transdermal drug delivery eliminates the need to pass through the gastrointestinal tract and liver, reducing the metabolic consumption of drugs by first-pass effect. While compared with intravenous drug delivery, microneedle transdermal drug delivery reduces patient discomfort and does not require professional administration. However, there are few review articles on microneedles loaded with responsive nanoparticles. Herein, the current researches on microneedles loaded with specific responsive nanoparticles such as glucose-responsive, pH-responsive, enzyme-responsive, light-responsive, magnetic-responsive, ultrasound-responsive, and multiresponsive, and the biomedical application of these microneedle array systems are summarized. In addition, the challenges and prospects of microneedle strategies loaded with responsive nanoparticles are briefly discussed, which will facilitate the development of such versatile drug-delivery strategy.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140544425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cutting-Edge Progress in Covalent Organic Framework-Based Nanomedicine 共价有机框架纳米医学的前沿进展

IF 3.4

Advanced Nanobiomed Research Pub Date : 2024-02-08 DOI: 10.1002/anbr.202300163

Huaijuan Guo, Yang Liu, Chao Fang, Xuebing Yan, Kun Zhang, Huali Gao

{"title":"The Cutting-Edge Progress in Covalent Organic Framework-Based Nanomedicine","authors":"Huaijuan Guo, Yang Liu, Chao Fang, Xuebing Yan, Kun Zhang, Huali Gao","doi":"10.1002/anbr.202300163","DOIUrl":"10.1002/anbr.202300163","url":null,"abstract":"Covalent organic frameworks (COFs) are a class of porous crystalline materials with exceptional properties, constructed through covalently linked organic units. COFs are extensively applied in the field of biomedicine, particularly in the context of anticancer treatments. First, this review summarizes the diverse synthetic methods of COFs, including solvothermal synthesis, microwave-assisted synthesis, room temperature synthesis, interface synthesis, ionothermal techniques, mechanical grinding, and electrochemical methods, and their impacts on the material's structure and performance. Second, COFs exhibit tremendous potential in the field of cancer therapy because of their orderly lattice structure, tunable pore sizes, high surface area, and excellent thermal and chemical stability. Therefore, the article deeply explores the applications of COFs in diverse cancer treatment modalities, encompassing early diagnostic bioimaging, drug delivery, various phototherapies, chemodynamic therapy, sonodynamic therapy, radiation therapy, and their combined therapeutic strategies. Finally, the article points out current research challenges and future directions in this field.","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202300163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139853497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0