用于治疗糖尿病足溃疡的智能伤口敷料的最新技术和未来挑战

IF 4 Q2 ENGINEERING, BIOMEDICAL
Sabine Szunerits, Rabah Boukherroub
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引用次数: 0

摘要

由于高血糖导致伤口床持续感染,糖尿病伤口愈合过程缓慢,因此需要寻找有效的治疗方法。由于病理复杂,要提高糖尿病相关伤口的愈合率十分复杂,而使用水凝胶治疗此类伤口则被视为一种前景广阔的方法,多年来一直在研究之中。然而,就这些不同的多功能和刺激响应型水凝胶绷带的临床转化而言,这项研究目前的进展如何,能否加速糖尿病足溃疡的愈合,帮助改善患者的生活和糖尿病伤口管理的未来?本视角文章将回顾该领域最重要的一些进展,最后提出一些与临床相关的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

State-of-the-Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment

State-of-the-Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment

The slow healing process of diabetic wound due to persisting infections in wound bed, owing to hyperglycemia, makes the search for efficient treatments pending. While it is complicated to increase the wound closure rate in diabetic-related wounds due to the complex pathology, the treatment of such wound with hydrogels is seen as a promising approach and pursued over the years. However, where is this research currently standing in terms of clinical translation of these different multifunctional and stimuli-responsive hydrogel bandages to accelerate diabetic foot ulcer healing and help to improve the life of the patients and the future of diabetic wound management? This perspective article will review some of the most important advancements in the field and will conclude with some perspectives, considered as relevant in the clinical context.

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来源期刊
Advanced Nanobiomed Research
Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-
CiteScore
5.00
自引率
5.90%
发文量
87
审稿时长
21 weeks
期刊介绍: Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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