Hepatology Forum最新文献_第2页

Is high AFP associated with liver diseases in ataxia-telangiectasia and ataxia-oculomotor apraxia? 高AFP与共济失调-毛细血管扩张和共济失调-动眼肌失用症的肝脏疾病相关吗？

IF 1.2

Hepatology Forum Pub Date : 2024-11-28 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2023.2023.0070

Rashad Ismayilov, Tugba Ozum, Ece Ersal, Sabir Israfilov, Najmaddin Abdurrahimli, Gul Yalcin Cakmakli, Bulent Elibol, Hatice Yasemin Balaban

{"title":"Is high AFP associated with liver diseases in ataxia-telangiectasia and ataxia-oculomotor apraxia?","authors":"Rashad Ismayilov, Tugba Ozum, Ece Ersal, Sabir Israfilov, Najmaddin Abdurrahimli, Gul Yalcin Cakmakli, Bulent Elibol, Hatice Yasemin Balaban","doi":"10.14744/hf.2023.2023.0070","DOIUrl":"https://doi.org/10.14744/hf.2023.2023.0070","url":null,"abstract":"Background and aim: Ataxia-telangiectasia (AT) and ataxia-oculomotor apraxia type 2 (AOA2) are both autosomal recessive cerebellar ataxias characterized by elevated serum alpha-fetoprotein (AFP) levels. However, the source and clinical implications of this increase, as well as its relationship with liver diseases are unknown. In this study, we investigated the frequency of liver diseases and their relationship with high AFP in patients with AT and AOA2.Materials and methods: The study involved 19 adult patients (13 patients with AT and 6 patients with AOA2) who were followed between January 1992 and March 2023. The demographic and clinical characteristics, serum levels of liver enzymes and AFP, liver imaging, and survival data were retrospectively reviewed.Results: The mean age of patients was 26.8±5.1 years (11 men and 8 women).While 69% (9/13) of AT patients had elevated liver enzymes and 56% (5/9) had abnormal liver imaging, both were normal in all AOA2 patients.Liver enzyme elevation was associated with the presence of comorbid disease (p=0.007), but not with AFP level (p=0.33) in AT patients. Hepatosteatosis was not associated neither with comorbidity (p=0.524) nor AFP level (p=0.905) in this group. During a median follow-up of 17 (1-29) years, 5 AT patients passed away due to cancer (4 patients) and sepsis (1 patient). AFP level was not associated with the occurrence of cancer (p=0.382).Conclusion: This study found a high prevalence of liver disease (69%) in AT, unlike in AOA, independent of AFP levels. Since comorbid diseases, especially cancer, were associated with elevated liver enzymes, adult AT patients with abnormal liver functions should be screened for the development of cancers.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"6 1","pages":"11-15"},"PeriodicalIF":1.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety analysis of different ıntensities of elf-pemf in terms of apoptotic, inflammatory, and transcription factor NF-Κb expression levels in rat liver. 不同浓度的 elf-pemf 对大鼠肝脏中细胞凋亡、炎症和转录因子 NF-Κb 表达水平的安全性分析。

IF 1.2

Hepatology Forum Pub Date : 2024-11-09 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.0005

Yasin Gokce, Ugur Seker, Merve Pekince Ozoner

{"title":"Safety analysis of different ıntensities of elf-pemf in terms of apoptotic, inflammatory, and transcription factor NF-Κb expression levels in rat liver.","authors":"Yasin Gokce, Ugur Seker, Merve Pekince Ozoner","doi":"10.14744/hf.2024.2024.0005","DOIUrl":"https://doi.org/10.14744/hf.2024.2024.0005","url":null,"abstract":"Background and aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats.Materials and methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Control, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the device was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field application was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed.Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group.Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apoptosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 4","pages":"178-183"},"PeriodicalIF":1.2,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of Yersinia pseudotuberculosis liver abscess and bacteremia in a heterozygous carrier of HFE1 H63D and MPEG1 mutations in Turkiye. 一例罕见的假结核耶尔森氏菌肝脓肿和菌血症在土耳其HFE1 H63D和MPEG1突变杂合携带者。

IF 1.2

Hepatology Forum Pub Date : 2024-10-25 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2023.2023.0041

Muhammed Alper Ozarslan, Hasan Selcuk Ozkan, Mert Pekerbas, Bartu Cetin, Mustafa Mustafayev, Fulya Gunsar, Asude Durmaz, Ayca Aykut, Sohret Aydemir

{"title":"A rare case of Yersinia pseudotuberculosis liver abscess and bacteremia in a heterozygous carrier of HFE1 H63D and MPEG1 mutations in Turkiye.","authors":"Muhammed Alper Ozarslan, Hasan Selcuk Ozkan, Mert Pekerbas, Bartu Cetin, Mustafa Mustafayev, Fulya Gunsar, Asude Durmaz, Ayca Aykut, Sohret Aydemir","doi":"10.14744/hf.2023.2023.0041","DOIUrl":"https://doi.org/10.14744/hf.2023.2023.0041","url":null,"abstract":"Yersinia pseudotuberculosis is a rare pathogenic organism in humans and is encountered mostly in patients with acquired or hereditary iron overload. This case report presents such a case with no known risk factors for iron overload, except heterozygous mutations in MPEG1 and HFE genes, while presenting the first patient with Y. pseudotuberculosis liver abscess in Turkiye. Here we present a 63-years-old male with known long-standing hypertension, type 2 diabetes, peripheral artery disease and chronic kidney disease presenting with right upper quadrant pain, nausea, vomiting and fever, whose imaging studies revealed multiple liver abscesses. While investigating the etiology, Yersinia pseudotuberculosis growth was observed in his abscess aspiration material and blood culture. Genetic analysis conducted after the detection of a ferritin level of 13725 µg/L, showed a heterozygous H63D mutation in HFE. Consequent whole-exon-sequencing reported an additional heterozygous p. Thr73Ala mutation in MPEG1. Even though, Y. pseudotuberculosis is detected mostly in patients with primary hemochromatosis, even heterozygous carriers of hemochromatosis may present clinically if concomitant comorbidities exist and may pose a challenge not only to clinicians but also to laboratory diagnosticians.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"6 1","pages":"22-25"},"PeriodicalIF":1.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of functional liver imaging scores derived on gadoxetic acid-enhanced MRI in hepatocellular carcinoma patients. 肝细胞癌患者肝功能影像学评分的验证：加多西酸增强MRI。

IF 1.2

Hepatology Forum Pub Date : 2024-10-11 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2023.2023.0024

Duygu Ozgul, Ferhat Can Piskin, Sinan Sozutok, Huseyin Tugsan Balli

{"title":"Validation of functional liver imaging scores derived on gadoxetic acid-enhanced MRI in hepatocellular carcinoma patients.","authors":"Duygu Ozgul, Ferhat Can Piskin, Sinan Sozutok, Huseyin Tugsan Balli","doi":"10.14744/hf.2023.2023.0024","DOIUrl":"https://doi.org/10.14744/hf.2023.2023.0024","url":null,"abstract":"Background and aim: To investigate the correlation of the functional liver imaging scores (FLIS) and the scoring system in hepatocellular carcinoma (HCC) patients.Materials and methods: Between April 2015 and December 2022, the HCC patients who underwent gadoxetic acid-enhanced MRI were analyzed. Three parameters on hepatobiliary phase images were evaluated for FLIS: liver parenchymal enhancement, biliary excretion, and signal intensity of the portal vein. The correlation between Child-Turcotte-Pugh (CTP) classification, the albumin-bilirubin (ALBI) grade, and Fibrosis-4 (F-4) score, and FLIS were analyzed. Receiver operating characteristic curve analysis was performed to demonstrate the cut-off value of FLIS for differentiating between CTP classification and ALBI grade.Results: We retrospectively analyzed 178 HCC patients (144 men, 34 women; mean age, 65.9 years). A moderate negative correlation was present between CTP classification and ALBI grade, and FLIS (r=-0.596 and r=-0.513, respectively). FLIS ≤3 was determined as the most optimal criterion for differentiating CTP A or B patients from CTP C patients.Conclusion: This study showed that the FLIS is a simple, non-invasive imaging marker for the assessment of liver function in HCC patients.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"6 2","pages":"41-46"},"PeriodicalIF":1.2,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An alternative method in the diagnosis of intrabiliary lesions: Percutaneous endobiliary brush biopsy. 诊断胆道内病变的另一种方法：经皮胆管刷状活检。

IF 1.2

Hepatology Forum Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0073

Mustafa Ozdemir, Tunahan Dertli, Omer Faruk Sevinc, Onur Taydas, Gurkan Danisan, Omer Faruk Ates, Mehmet Halil Ozturk

{"title":"An alternative method in the diagnosis of intrabiliary lesions: Percutaneous endobiliary brush biopsy.","authors":"Mustafa Ozdemir, Tunahan Dertli, Omer Faruk Sevinc, Onur Taydas, Gurkan Danisan, Omer Faruk Ates, Mehmet Halil Ozturk","doi":"10.14744/hf.2023.2023.0073","DOIUrl":"10.14744/hf.2023.2023.0073","url":null,"abstract":"Background and aim: Biliary strictures can occur as a result of various benign or malignant processes. The aim of this study is to evaluate the effectiveness and reliability of percutaneous endobiliary brush biopsy in the diagnosis of intrabiliary lesions.Materials and methods: This retrospective, single-center study was conducted between January 2022 and April 2023, involving a total of 16 patients. Of the patients, 10 were male (62.5%), and 6 were female (37.5%). The average age of the patients was 68.1±8. All patients underwent the procedure using an endobiliary biopsy brush under ultrasound and fluoroscopic guidance.Results: Technical success was achieved in all patients (100%). Cell detection was not observed in biopsy samples from 2 patients (12.5%), resulting in a diagnostic success rate of 87.5%. Access was made to the right biliary system in 14 patients (87.5%) and to the left biliary system in 2 patients (12.5%). Biopsy locations included the common bile duct in 12 patients (75%), hepatic hilum in 2 patients (12.5%), and bilioenteric anastomosis line in 2 patients (12.5%). The mean fluoroscopy time was 16.2±7.1 minutes. The average radiation dose was 660±370 mSv. Pathological diagnosis revealed malignancy in 8 patients (50%) and benign findings in 6 patients (37.5%). Liver abscess requiring drainage developed in 2 patients (12.5%).Conclusion: Percutaneous endobiliary brush biopsy performed under imaging guidance is an effective and reliable method for the diagnosis of biliary lesions.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 4","pages":"167-170"},"PeriodicalIF":1.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced liver injury: Diagnosis, management and the role of liver transplantation. 药物性肝损伤：诊断、治疗和肝移植的作用。

IF 1.2

Hepatology Forum Pub Date : 2024-09-11 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2024.2024.0003

Nazli Begum Ozturk, Eren Uskudar, Merih Deniz Toruner, Cem Simsek, Ahmet Gurakar

引用次数: 0

D-dimer is a prognostic marker for 1-year mortality in patients with chronic liver failure and hepatic encephalopathy. D 二聚体是慢性肝衰竭和肝性脑病患者 1 年死亡率的预后指标。

IF 1.2

Hepatology Forum Pub Date : 2024-09-11 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0065

Yi-Shan He, Su-Hua Yang, Ze-Yu Huang, Lin Lin, Xue-Cheng Tong, Hong Dai, Yuan Xue

{"title":"D-dimer is a prognostic marker for 1-year mortality in patients with chronic liver failure and hepatic encephalopathy.","authors":"Yi-Shan He, Su-Hua Yang, Ze-Yu Huang, Lin Lin, Xue-Cheng Tong, Hong Dai, Yuan Xue","doi":"10.14744/hf.2023.2023.0065","DOIUrl":"10.14744/hf.2023.2023.0065","url":null,"abstract":"Background and aim: Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver failure with poor outcomes. The present study aimed to evaluate the predictive values of D-dimer in patients with HE.Materials and methods: Patients with chronic liver failure (CLF) and HE were enrolled. Univariate and multivariate logistic analysis was performed to investigate the risk factors for 1-year mortality of HE.Results: During the first year after diagnosis, 39.2% (65/166) of the patients died. D-dimer was significantly higher in non-survivors (Z=2.617, p<0.01). Both D-dimer and international normalized ratio (INR) positively correlated with Child-Pugh and MELD scores, and negatively correlated with sodium (all p<0.01). Moreover, there was a negative relationship between D-dimer and HE grades (r=-0.168, p=0.031), while the relationship between INR and HE grades was not significant (r=0.083, p=0.289). Multivariate analysis showed that age (odds ratio (OR):1.035, 95% CI:1.004-1.067, p=0.03), D-dimer (OR=1.138, 95% CI:1.030-1.258, p=0.01), ALT (OR=1.012, 95% CI:1.001-1.022, p=0.03), and sodium (OR=0.920, 95% CI:0.858-0.986, p=0.02) were independent risk factors for 1-year mortality. Then, a new model Model(Age_DD_ALT_Na) incorporating age, D-dimer, ALT, and sodium was developed. AUROC of Model(Age_DD_ALT_Na) was 0.732, which was significantly higher than MELD and Child-Pugh scores (AUROC: 0.602 and 0.599, p=0.013 and 0.022).Conclusion: D-dimer is a prognostic marker for 1-year mortality in patients with CLF and HE.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 4","pages":"193-197"},"PeriodicalIF":1.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatopulmonary syndrome unveiled: Exploring pathogenesis, diagnostic approaches, and therapeutic strategies. 肝肺综合征揭秘：探索发病机制、诊断方法和治疗策略。

IF 1.2

Hepatology Forum Pub Date : 2024-09-10 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2024.2024.0001

Anusha Alam, Nazli Begum Ozturk, Filiz Akyuz

引用次数: 0

Liver disorders in substance abusers. 药物滥用者的肝脏疾病。

IF 1.2

Hepatology Forum Pub Date : 2024-09-10 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2024.2024.0012

George Sarin Zacharia, Anu Jacob

{"title":"Liver disorders in substance abusers.","authors":"George Sarin Zacharia, Anu Jacob","doi":"10.14744/hf.2024.2024.0012","DOIUrl":"https://doi.org/10.14744/hf.2024.2024.0012","url":null,"abstract":"Substance use disorders are a global health problem with detrimental effects on one's health, wealth, and stealth. It includes the use of prescribed medications or the use of illicit drugs in excess amounts or for excess durations associated with complex neuropsychiatric and/or physical manifestations. It affects every organ in the body, and the liver is no exception to the deleterious effects of substance abuse. The mechanism of liver injury varies from agent to agent and may include direct toxic effects, oxidative stress, and inflammatory responses. The hepatic involvement ranges from asymptomatic liver enzyme elevation and fatty liver disease to hepatitis, liver failure, and cirrhosis. Alcohol, the most frequent agent implicated in substance use disorder, is also a prototype hepatotoxin, capable of inducing the whole spectrum of liver diseases. Cigarette smoke contains numerous harmful chemicals, including carcinogens, which can induce liver injury, fibrosis, and HCC. Cocaine, particularly in acute overdose, can result in ischemic hepato-necrosis, while it can also result in clinically inapparent transaminasemia. Marijuana and opiates, despite being associated with numerous deleterious effects, are rarely implicated in clinically apparent liver injury. Individuals with substance use disorder are also prone to viral hepatitis and hepatic insults secondary to hypotension, hypoxia, and other systemic ailments. Liver transplant candidacy in individuals with substance use disorder is a highly complex arena, with guidelines balancing abstinence requirements against evolving evidence on outcomes. This review article provides a thorough analysis of the hepatotoxic repercussions stemming from the agents commonly implicated in substance abuse disorders.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"6 1","pages":"34-40"},"PeriodicalIF":1.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of hepatorenal syndrome incidence and outcomes using previous and current diagnostic criteria in cirrhotic patients. 肝硬化患者肝肾综合征发生率和预后的比较。

IF 1.2

Hepatology Forum Pub Date : 2024-09-10 eCollection Date: 2025-01-01 DOI: 10.14744/hf.2023.2023.0067

Muhammet Mikdat Akbas, Mehmet Uzunlulu, Cundullah Torun, Ozgur Bahadir

{"title":"Comparison of hepatorenal syndrome incidence and outcomes using previous and current diagnostic criteria in cirrhotic patients.","authors":"Muhammet Mikdat Akbas, Mehmet Uzunlulu, Cundullah Torun, Ozgur Bahadir","doi":"10.14744/hf.2023.2023.0067","DOIUrl":"https://doi.org/10.14744/hf.2023.2023.0067","url":null,"abstract":"Background and aim: Hepatorenal syndrome (HRS) is a severe complication of liver cirrhosis with evolving diagnostic criteria. This study aimed to examine HRS prevalence, subtypes, and outcomes while comparing previous and current diagnostic criteria.Materials and methods: This is a retrospective observational clinical study conducted on hospitalized patients with decompensated cirrhosis. Demographic characteristics, comorbidities, disease duration, disease severity, length of hospitalization, number of rehospitalizations, cirrhosis etiologies, laboratory data, and clinical outcomes were reviewed. The criteria from 2007 by the International Club of Ascites were the previous ones, with the 2015 criteria being the current criteria for diagnosing HRS. The incidence of HRS and its subtypes was determined, and the clinical characteristics of patients with and without HRS were compared using the Mann-Whitney U test.Results: The study enrolled 212 patients, with a male predominance (57.5%) and a mean age of 63.4±14.5 years. A total of 32.1% of patients developed acute kidney injury (AKI), with prerenal azotemia being the most common type (76.5%), followed by intrinsic renal AKI (23.5%). Under the current criteria, 27 patients (12.7%) received an HRS diagnosis, while under the previous criteria, 16 patients (7.5%) received an HRS diagnosis, and the difference in diagnostic frequencies was statistically significant (p=0.046). In HRS cases, the MELD score (p=0.001), being classified as Child-Pugh C (p=0.043), rehospitalization (p=0.011), requiring intensive care (p=0.001), and creatinine levels (p<0.001) were higher.Conclusion: AKI is common in hospitalized cirrhotic patients. The current HRS criteria identify more cases that need close monitoring compared to the previous criteria.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"6 1","pages":"5-10"},"PeriodicalIF":1.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0