Hepatology Forum最新文献

An alternative method in the diagnosis of intrabiliary lesions: Percutaneous endobiliary brush biopsy. 诊断胆道内病变的另一种方法：经皮胆管刷状活检。

IF 1.2

Hepatology Forum Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0073

Mustafa Ozdemir, Tunahan Dertli, Omer Faruk Sevinc, Onur Taydas, Gurkan Danisan, Omer Faruk Ates, Mehmet Halil Ozturk

{"title":"An alternative method in the diagnosis of intrabiliary lesions: Percutaneous endobiliary brush biopsy.","authors":"Mustafa Ozdemir, Tunahan Dertli, Omer Faruk Sevinc, Onur Taydas, Gurkan Danisan, Omer Faruk Ates, Mehmet Halil Ozturk","doi":"10.14744/hf.2023.2023.0073","DOIUrl":"10.14744/hf.2023.2023.0073","url":null,"abstract":"Background and aim: Biliary strictures can occur as a result of various benign or malignant processes. The aim of this study is to evaluate the effectiveness and reliability of percutaneous endobiliary brush biopsy in the diagnosis of intrabiliary lesions.Materials and methods: This retrospective, single-center study was conducted between January 2022 and April 2023, involving a total of 16 patients. Of the patients, 10 were male (62.5%), and 6 were female (37.5%). The average age of the patients was 68.1±8. All patients underwent the procedure using an endobiliary biopsy brush under ultrasound and fluoroscopic guidance.Results: Technical success was achieved in all patients (100%). Cell detection was not observed in biopsy samples from 2 patients (12.5%), resulting in a diagnostic success rate of 87.5%. Access was made to the right biliary system in 14 patients (87.5%) and to the left biliary system in 2 patients (12.5%). Biopsy locations included the common bile duct in 12 patients (75%), hepatic hilum in 2 patients (12.5%), and bilioenteric anastomosis line in 2 patients (12.5%). The mean fluoroscopy time was 16.2±7.1 minutes. The average radiation dose was 660±370 mSv. Pathological diagnosis revealed malignancy in 8 patients (50%) and benign findings in 6 patients (37.5%). Liver abscess requiring drainage developed in 2 patients (12.5%).Conclusion: Percutaneous endobiliary brush biopsy performed under imaging guidance is an effective and reliable method for the diagnosis of biliary lesions.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

D-dimer is a prognostic marker for 1-year mortality in patients with chronic liver failure and hepatic encephalopathy. D 二聚体是慢性肝衰竭和肝性脑病患者 1 年死亡率的预后指标。

IF 1.2

Hepatology Forum Pub Date : 2024-09-11 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0065

Yi-Shan He, Su-Hua Yang, Ze-Yu Huang, Lin Lin, Xue-Cheng Tong, Hong Dai, Yuan Xue

{"title":"D-dimer is a prognostic marker for 1-year mortality in patients with chronic liver failure and hepatic encephalopathy.","authors":"Yi-Shan He, Su-Hua Yang, Ze-Yu Huang, Lin Lin, Xue-Cheng Tong, Hong Dai, Yuan Xue","doi":"10.14744/hf.2023.2023.0065","DOIUrl":"10.14744/hf.2023.2023.0065","url":null,"abstract":"Background and aim: Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver failure with poor outcomes. The present study aimed to evaluate the predictive values of D-dimer in patients with HE.Materials and methods: Patients with chronic liver failure (CLF) and HE were enrolled. Univariate and multivariate logistic analysis was performed to investigate the risk factors for 1-year mortality of HE.Results: During the first year after diagnosis, 39.2% (65/166) of the patients died. D-dimer was significantly higher in non-survivors (Z=2.617, p<0.01). Both D-dimer and international normalized ratio (INR) positively correlated with Child-Pugh and MELD scores, and negatively correlated with sodium (all p<0.01). Moreover, there was a negative relationship between D-dimer and HE grades (r=-0.168, p=0.031), while the relationship between INR and HE grades was not significant (r=0.083, p=0.289). Multivariate analysis showed that age (odds ratio (OR):1.035, 95% CI:1.004-1.067, p=0.03), D-dimer (OR=1.138, 95% CI:1.030-1.258, p=0.01), ALT (OR=1.012, 95% CI:1.001-1.022, p=0.03), and sodium (OR=0.920, 95% CI:0.858-0.986, p=0.02) were independent risk factors for 1-year mortality. Then, a new model Model(Age_DD_ALT_Na) incorporating age, D-dimer, ALT, and sodium was developed. AUROC of Model(Age_DD_ALT_Na) was 0.732, which was significantly higher than MELD and Child-Pugh scores (AUROC: 0.602 and 0.599, p=0.013 and 0.022).Conclusion: D-dimer is a prognostic marker for 1-year mortality in patients with CLF and HE.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leflunomide induced fatal dress syndrome need liver transplantation. 来氟米特诱发的致命着装综合征需要肝移植。

IF 1.2

Hepatology Forum Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.0010

Ali Riza Caliskan, Mehmet Ali Erdogan

引用次数: 0

Intrabiliary pressure in the pathophysiology of extra hepatic biliary obstruction. 肝外胆道梗阻病理生理学中的胆道内压。

IF 1.2

Hepatology Forum Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0066

Dhananjay Saxena, Shridhar Vasantrao Sasturkar, Amar Mukund, Yashwant Patidar, Ashok Kumar Choudhury, Ragini Kilambi, Pratibha Kale

{"title":"Intrabiliary pressure in the pathophysiology of extra hepatic biliary obstruction.","authors":"Dhananjay Saxena, Shridhar Vasantrao Sasturkar, Amar Mukund, Yashwant Patidar, Ashok Kumar Choudhury, Ragini Kilambi, Pratibha Kale","doi":"10.14744/hf.2023.2023.0066","DOIUrl":"10.14744/hf.2023.2023.0066","url":null,"abstract":"Background and aim: The aim of this study was to evaluate the role of intrabiliary pressure (IBP) in the pathophysiology of extrahepatic biliary obstruction (EHBO) during percutaneous transhepatic biliary drainage (PTBD).Materials and methods: Adult patients with EHBO who underwent PTBD were prospectively enrolled. IBP was recorded during primary PTBD. The parameters of interest were age, gender, etiology of EHBO, baseline and post-PTBD liver function tests, duration for resolution of jaundice (decrease in total serum bilirubin ≥30% of baseline or <2 mg/dL), cholangitis, bile cultures, and serum albumin levels. The level of EHBO was divided into three types: Type 1 - secondary biliary confluence involved; Type 2 - primary biliary confluence involved; Type 3 - mid and distal common bile duct obstruction.Results: IBP was measured in 102 patients, and finally, 87 patients, including 52 (59.77%) females, were analyzed. The mean age of the patients was 56.1±11.6 years. The most common etiology of EHBO was carcinoma of the gallbladder in 44 (50.6%) patients. The mean IBP was 18.41±3.91 mmHg. IBP was significantly higher in Type 3 EHBO compared to Type 1 and 2 (p=0.012). A significant correlation was seen between IBP and baseline total serum bilirubin (p<0.01). There was a negative correlation between IBP and baseline serum albumin (p=0.017). In 56.3% of patients, resolution of jaundice was observed by day 3, but this was not significantly associated with IBP (p=0.19). There was no correlation between IBP and cholangitis (p=0.97) or bacterial cultures (p=0.21).Conclusion: IBP was significantly associated with the type of EHBO, baseline serum bilirubin, and albumin levels. IBP could not predict cholangitis or the resolution of jaundice after PTBD.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Action of melatonin and physical exercise on the liver of cirrhotic rats: Study of oxidative stress and the inflammatory process. 褪黑激素和体育锻炼对肝硬化大鼠肝脏的作用：氧化应激和炎症过程研究

IF 1.2

Hepatology Forum Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0037

Gabriela S Martins, Carlos Gustavo S Rosa, Elizangela G Schemitt, Josieli R Colares, Sandielly Rb Fonseca, Marilda S Brasil, Millena O Engeroff, Norma P Marroni

{"title":"Action of melatonin and physical exercise on the liver of cirrhotic rats: Study of oxidative stress and the inflammatory process.","authors":"Gabriela S Martins, Carlos Gustavo S Rosa, Elizangela G Schemitt, Josieli R Colares, Sandielly Rb Fonseca, Marilda S Brasil, Millena O Engeroff, Norma P Marroni","doi":"10.14744/hf.2023.2023.0037","DOIUrl":"10.14744/hf.2023.2023.0037","url":null,"abstract":"Background and aim: Cirrhosis is characterized by structural and functional alterations of the liver. Melatonin (MLT) has antioxidant properties. Physical exercise (EX) can reverse muscle loss in cirrhotic patients. The objective was to evaluate the action of MLT and EX on the liver of rats subjected to the experimental model of bile duct ligation (BLD).Materials and methods: 48 male Wistar rats were used, divided into groups: Control (CO), CO+MLT, CO+EX, CO+MLT+EX, BDL, BDL+MLT, BDL+EX, and BDL+MLT+EX. The treatments occurred from the 15th to the 28th day. The dose of MLT was 20 mg/kg via I.p (1x/day), and the EX was performed 10 min/day. Blood and liver were collected for analysis.Results: The liver integrity enzymes AST, ALT, and ALP showed a significant reduction in the groups treated with MLT and EX. Histological analyses showed reorganization of the liver parenchyma, reduction of inflammatory infiltrate, and fibrotic nodules. Lipoperoxidation (LPO), the activity of antioxidant enzymes, and nitric oxide metabolites showed a significant reduction in the groups treated with MLT and EX. The expression of TNF-α and NF-kB decreased in the treated groups.Conclusion: Melatonin and physical exercise seem to be effective in restoring the parameters evaluated in this model of experimental cirrhosis.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of triglyceride-glucose index and anthropometric obesity indices in predicting severe grades of hepatic steatosis in nonalcoholic fatty liver disease among non-diabetic obese individuals. 甘油三酯-葡萄糖指数与人体测量肥胖指数在预测非糖尿病肥胖者非酒精性脂肪肝肝脂肪变性严重程度方面的比较。

IF 1.2

Hepatology Forum Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0049

Huseyin Karaaslan, Hasan Inan, Alper Tunga Turkmen, Ismail Altintas, Nida Uyar, Mehmet Ali Eren

{"title":"Comparison of triglyceride-glucose index and anthropometric obesity indices in predicting severe grades of hepatic steatosis in nonalcoholic fatty liver disease among non-diabetic obese individuals.","authors":"Huseyin Karaaslan, Hasan Inan, Alper Tunga Turkmen, Ismail Altintas, Nida Uyar, Mehmet Ali Eren","doi":"10.14744/hf.2023.2023.0049","DOIUrl":"10.14744/hf.2023.2023.0049","url":null,"abstract":"Background and aim: The triglyceride glucose index (TyG) has been proposed as a promising indicator of both insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). However, the efficacy of the TyG index in predicting NAFLD has not been adequately studied, particularly in obese individuals.Materials and methods: We analyzed 190 morbidly obese individuals. The TyG index, anthropometric obesity indices, homeostatic model assessment (HOMA-IR), and biochemical parameters were compared. NAFLD was diagnosed by hepatic ultrasonography and classified into four grades (0, 1, 2, and 3). Individuals in grades 2 and 3 are considered to have severe steatosis, while those in grades 0 and 1 do not.Results: The area under the curve (AUC) values of the TyG index, body mass index, neck circumferences, waist-to-hip ratio, and HOMA-IR did not differ significantly in predicting severe steatosis (0.640, 0.742, 0.725, 0.620, and 0.624 respectively). However, the AUC values of waist circumference and alanine aminotransferase provided better predictions than the TyG index (0.782, 0.744, and 0.640 respectively).Conclusion: The TyG index is highly effective in predicting both the presence and severity of NAFLD. However, it did not outperform simple obesity indices in predicting NAFLD and its severity in obese patients.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal testing strategies for incidental anti-mitochondrial M2 antibody-positive patients. 针对偶发性抗线粒体 M2 抗体阳性患者的最佳检测策略。

IF 1.2

Hepatology Forum Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.0007

Ilkay Ergenc, Busra Gozaydinoglu, Caglayan Keklikkiran, Yusuf Yilmaz

引用次数: 0

From NAFLD to MASLD: Meta-analysis and systematic review of NAFLD patients in Turkiye in terms of metabolic profile and MASLD potential. 从 NAFLD 到 MASLD：对土耳其 NAFLD 患者的代谢概况和 MASLD 潜力进行 Meta 分析和系统回顾。

IF 1.2

Hepatology Forum Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0042

Sevginur Akdas, Nuray Yazihan

{"title":"From NAFLD to MASLD: Meta-analysis and systematic review of NAFLD patients in Turkiye in terms of metabolic profile and MASLD potential.","authors":"Sevginur Akdas, Nuray Yazihan","doi":"10.14744/hf.2023.2023.0042","DOIUrl":"10.14744/hf.2023.2023.0042","url":null,"abstract":"Non-alcoholic Fatty Liver Disease (NAFLD) is both a cause and a consequence of metabolic disturbances. Consequently, the disease term has recently changed to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Turkiye is one of the leading countries with high incidences of diseases such as diabetes, obesity, metabolic syndrome, and fatty liver. This study aims to identify the metabolic parameters and MASLD potential of NAFLD in Turkiye. All NAFLD studies conducted in Turkiye were systematically searched using the keywords \"fatty liver disease\" AND \" Turkiye \" on PubMed, Scopus, and Web of Science databases. A total of 2653 articles were scanned, and 120 studies were eligible for meta-analysis. The metabolic parameters were meta-analyzed from a broad perspective. According to the meta-analysis results, there were significant increases in waist circumferences (mean difference: 10.90, p<0.00001), HOMA-IR (mean difference: 2.13, p<0.00001), aspartate aminotransferase (AST) (mean difference: 17.82, p<0.00001), systolic blood pressure (SBP) (mean difference: 5.86, p<0.00001), and C-reactive protein (CRP) levels (mean difference: 0.95, p<0.00001). These parameters are representative biochemical findings of disturbed glucose metabolism, lipid profile, blood pressure, and acute phase response mechanisms. Furthermore, the analysis of all related parameters commonly found among the articles confirmed these metabolic dysfunctions. NAFLD is a metabolic disease that encompasses multiple pathways related to glucose and lipid metabolism, vascular function, inflammation, and acute phase responses. Additionally, our results suggest that Turkish NAFLD patients identified in previous studies mostly have MASLD. This is the first meta-analysis study indicating changes in metabolism-related parameters with a cumulative meta-analysis of all Turkish NAFLD studies.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolution and revolution of artificial intelligence in hepatology: From current applications to future paradigms. 人工智能在肝病学中的演变与革命：从当前应用到未来范例。

IF 1.2

Hepatology Forum Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.ed0001

Cem Simsek

引用次数: 0

Cross talk between genetics and biochemistry in the pathogenesis of hepatocellular carcinoma. 遗传学和生物化学在肝细胞癌发病机制中的交叉对话。

IF 1.2

Hepatology Forum Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0028

Mete Ucdal, Ayse Burus, Basak Celtikci

{"title":"Cross talk between genetics and biochemistry in the pathogenesis of hepatocellular carcinoma.","authors":"Mete Ucdal, Ayse Burus, Basak Celtikci","doi":"10.14744/hf.2023.2023.0028","DOIUrl":"10.14744/hf.2023.2023.0028","url":null,"abstract":"The liver is a crucial organ in the regulation of metabolism, signaling, and homeostasis. Using recent advanced sequencing technologies, several mutations of genes in major metabolic and signaling pathways have been discovered in the pathogenesis of hepatocellular carcinoma (HCC). These gene signatures alter expression and ultimately affect biochemical pathways by modifying enzyme/protein levels, resulting in numerous clinical outcomes related to HCC. It comes with varying forms of genetic and biochemical alterations, associated with carbohydrate, lipid, nucleic acid, and amino acid metabolism, as well as signaling pathways linked to tumorigenesis. Here, we aim to summarize the main components and mechanisms involved in the progression of HCC with a special focus on the metabolic regulation of key effectors of tumorigenesis, through the crosstalk between genetics and biochemistry. This paper provides an overview of hepatocellular carcinoma, underlying the fundamental effect of gene variations on metabolic and signaling pathways. Since there is still an unmet need for biomarkers and novel therapeutic targets, some of these signature genes or proteins can be used as novel biomarkers for diagnosis, prognosis, and novel potential therapeutic targets for the treatment of HCC.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0