Hepatology Forum最新文献_第3页

Congenital Riedel's lobe of the liver: A case report. 先天性里德尔肝叶：病例报告。

IF 0.8

Hepatology Forum Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0007

Ankoor H Patel, Rajan Amin, George Abdelsayed

引用次数: 0

First two cases of literature: Caustic sclerosing cholangitis due to percutaneous treatment of hydatid liver disease causing liver transplantation. 首两例文献病例：经皮治疗包虫病导致肝移植的苛性硬化性胆管炎。

IF 0.8

Hepatology Forum Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0031

Gokalp Okut, Kutay Saglam, Huseyin Kocaaslan, Cuneyt Kayaalp

引用次数: 0

HBV viral load and tumor and non-tumor factors in patients with HBV-associated HCC. HBV 相关性 HCC 患者的 HBV 病毒载量以及肿瘤和非肿瘤因素。

IF 0.8

Hepatology Forum Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0038

Engin Ataman, Murat Harputluoglu, Brian Irving Carr, Harika Gozukara, Volkan Ince, Sezai Yilmaz

{"title":"HBV viral load and tumor and non-tumor factors in patients with HBV-associated HCC.","authors":"Engin Ataman, Murat Harputluoglu, Brian Irving Carr, Harika Gozukara, Volkan Ince, Sezai Yilmaz","doi":"10.14744/hf.2023.2023.0038","DOIUrl":"10.14744/hf.2023.2023.0038","url":null,"abstract":"Background and aim: Several tumor and non-tumor factors affect the prognosis of hepatocellular carcinoma (HCC) patients. This study aimed to investigate the effects of hepatitis B virus (HBV) viral load on tumor and non-tumor factors in patients with HBV-associated HCC.Materials and methods: Patients with hepatitis B and HCC who presented to the HCC council at the Faculty of Medicine, Marmara University Liver Transplantation Institute, were included in our study. Patients were divided into two groups according to the presence or absence of HBV-DNA, and it was determined whether there were differences between these two groups with respect to tumor and non-tumor parameters.Results: Comparison of serum alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), hepatitis B surface antigen (HBsAg), and C-reactive protein (CRP) levels between HBV-DNA negative and positive patients showed significant differences (respectively p<0.01, p<0.01, p<0.05, and p<0.05). A major finding was a very significant difference between the two patient groups in terms of portal vein invasion (PVI) and venous invasion (p<0.001 and p<0.01, respectively). However, there was no significant difference in metastasis or lymph node involvement between HBV-DNA negative and positive patients.Conclusion: Our findings suggest that HBV viral load plays an important role in PVI in HCC patients, and there is a significant relationship between HBV viral load and inflammation.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between ultrasonography and MR proton density fat fraction techniques in evaluating the severity of liver steatosis. 超声波和磁共振质子密度脂肪分数技术在评估肝脏脂肪变性严重程度中的相关性。

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0046

Betul Kizildag, Murat Baykara, Nursel Yurttutan, Halit Vicdan

{"title":"Correlation between ultrasonography and MR proton density fat fraction techniques in evaluating the severity of liver steatosis.","authors":"Betul Kizildag, Murat Baykara, Nursel Yurttutan, Halit Vicdan","doi":"10.14744/hf.2023.2023.0046","DOIUrl":"10.14744/hf.2023.2023.0046","url":null,"abstract":"Background and aim: To investigate the relationship between ultrasonography (US) and magnetic resonance (MR) proton density fat fraction (PDFF) techniques, using the modified DIXON method, in determining the severity of liver steatosis.Materials and methods: This study included seventy consecutive patients who underwent upper abdominal MRI for various reasons between June 2016 and January 2017. Fatty liver staging was performed using US as indicated.The liver fat percentage was measured and staged according to PDFF values.Results: In the study, of the 70 cases, 36 were male and 34 were female. On US, 18.5% of the cases had stage 0, 32.8% had stage 1, 42.8% had stage 2, and 5.7% had stage 3 liver steatosis. A significant correlation was found between ultrasonographic evaluation and PDFF in determining the percentage of liver fat (r=0.775, p<0.001). When comparing the percentages, MR-evaluated PDFF and ultrasonographic staging were most compatible at grade 3 and least compatible at grade 2. When the PDFF threshold value was set at 8.1%, the sensitivity of US in distinguishing between obvious and indistinct steatosis was 97.1%, and the specificity was 88.9%.Conclusion: Ultrasound continues to be a useful tool for detecting fatty liver disease. However, magnetic resonance (MR) proton density fat fraction (PDFF) imaging is essential for accurately determining the severity and prevalence of steatosis. Our study revealed inconsistencies between US and MR PDFF in grading liver steatosis, showing higher agreement in severe cases and lower agreement in moderate cases. Therefore, we recommend classifying steatosis as either uncertain or apparent rather than using a grading system in US.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha-fetoprotein and albumin inversely relate to each other and to tumor parameters in patients with hepatocellular carcinoma. 甲胎蛋白和白蛋白与肝细胞癌患者的肿瘤参数成反比。

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0023

Brian Carr, Vito Guerra, Volkan Ince, Burak Isik, Sezai Yilmaz

{"title":"Alpha-fetoprotein and albumin inversely relate to each other and to tumor parameters in patients with hepatocellular carcinoma.","authors":"Brian Carr, Vito Guerra, Volkan Ince, Burak Isik, Sezai Yilmaz","doi":"10.14744/hf.2023.2023.0023","DOIUrl":"10.14744/hf.2023.2023.0023","url":null,"abstract":"Background and aim: Alpha-fetoprotein (AFP), an oncofetal protein and biomarker in hepatocellular carcinoma (HCC), has unclear roles and actions.To evaluate the relationships between AFP, liver function tests, and HCC aggressiveness.Materials and methods: A retrospective analysis of an HCC patient database was conducted to examine the relationships between baseline serum AFP values, liver function tests, and tumor characteristics.Results: Statistically significant positive trends were observed between AFP levels and both AST and bilirubin, along with negative trends between AFP and albumin. Significant correlations were also found between AFP and MTD, multifocality, and PVT. Increases in MTD, multifocality, and PVT were noted even at low AFP levels, indicating both AFP-independent and AFP-dependent processes. However, these parameter changes were minimal compared to the substantial changes in AFP levels. Relationships between AFP-related liver and tumor characteristics were found to be similar but inverse to those for albumin, with normal albumin levels associated with more favorable tumor characteristics. Additionally, serum levels of albumin and AFP were inversely related.Conclusion: AFP and albumin levels significantly, but inversely, correlate with tumor parameters, suggesting that albumin may suppress HCC functions and could serve as a potential prognostic marker.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vibration-controlled transient elastography for non-invasive screening of liver fibrosis and steatosis in Turkish patients with psoriasis: A cross-sectional study. 振动控制瞬态弹性成像技术用于无创筛查土耳其银屑病患者的肝纤维化和脂肪变性：一项横断面研究。

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0017

Ahsen Nihal Aksoy, Burak Hanci, Mehmet Furkan Baskent, Emine Gul Umutlu, Eda Nur Kumas, Suleyman Umit Emanet, Mehmet Oguz Yalcin, Zeynep Duzyol, Ayse Gulsen Teker, Yusuf Yilmaz

{"title":"Vibration-controlled transient elastography for non-invasive screening of liver fibrosis and steatosis in Turkish patients with psoriasis: A cross-sectional study.","authors":"Ahsen Nihal Aksoy, Burak Hanci, Mehmet Furkan Baskent, Emine Gul Umutlu, Eda Nur Kumas, Suleyman Umit Emanet, Mehmet Oguz Yalcin, Zeynep Duzyol, Ayse Gulsen Teker, Yusuf Yilmaz","doi":"10.14744/hf.2023.2023.0017","DOIUrl":"10.14744/hf.2023.2023.0017","url":null,"abstract":"Background and aim: The prevalence of fibrosis and steatosis in patients with psoriasis, as determined by vibration-controlled transient elastography (VCTE), has not been evaluated in Turkiye to date. The present cross-sectional study aims to present the first systematic screening results, focusing on two primary objectives: 1) establishing the prevalence of fibrosis and steatosis, and 2) identifying independent predictors for liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) values in this patient population.Materials and methods: Patients were eligible for inclusion if they had a confirmed diagnosis of psoriasis by a qualified dermatologist based on characteristic signs and symptoms and histopathological examination, and had undergone VCTE for LSM and CAP measurements.Results: The diagnosis of severe fibrosis and cirrhosis - identified by LSM values of 10.0-13.9 and ≥14.0 kPa, respectively - was significantly prevalent (7.0% and 10.1%, respectively) among a sizeable cohort of relatively young Turkish patients with psoriasis (n=328; mean age: 49.5±12.7 years). Additionally, severe steatosis, as diagnosed by VCTE and characterized by a CAP value exceeding 290 dB/m, was identified in up to 43.3% of patients. Although body mass index (BMI) was the only variable found to be an independently associated with LSM, multivariable linear regression analysis failed to identify any statistically independent predictor of CAP values.Conclusion: The prevalence of hepatic fibrosis and steatosis in Turkish patients with psoriasis is far from negligible, with BMI identified as an independent risk factor for fibrosis.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal testing strategies for incidental anti-mitochondrial M2 antibody-positive patients. 针对偶发性抗线粒体 M2 抗体阳性患者的最佳检测策略。

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0043

Kristina Emsell-Needham, Sujoy Khan

引用次数: 0

Prevalence of hepatic steatosis and fibrosis in apparently healthy airline pilots: A transient elastography study. 表面健康的飞行员肝脏脂肪变性和纤维化的发生率：瞬态弹性成像研究

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0050

Piercarlo Minoretti, Andrés S Santiago Sáez, Ángel F García Martín, Miryam Liaño Riera, Manuel Gómez Serrano, Enzo Emanuele

{"title":"Prevalence of hepatic steatosis and fibrosis in apparently healthy airline pilots: A transient elastography study.","authors":"Piercarlo Minoretti, Andrés S Santiago Sáez, Ángel F García Martín, Miryam Liaño Riera, Manuel Gómez Serrano, Enzo Emanuele","doi":"10.14744/hf.2023.2023.0050","DOIUrl":"10.14744/hf.2023.2023.0050","url":null,"abstract":"Background and aim: Airline pilots (APs) are often characterized by a sedentary lifestyle, predisposing them to adverse cardiometabolic consequences. In this cross-sectional study, we used transient elastography (TE) to investigate the prevalence of hepatic steatosis and fibrosis among apparently healthy APs.Materials and methods: The study cohort consisted of 137 male APs of Caucasian descent who voluntarily underwent TE. To evaluate the extent and severity of hepatic steatosis and fibrosis, we employed established cutoff values for the controlled attenuation parameter (CAP) and liver stiffness measurement (LSM).Results: Of the APs, 34 (24.8%) were diagnosed with TE-defined steatosis. Specifically, 25 APs (18.2%) exhibited mild steatosis, 6 (4.4%) moderate steatosis, and 3 (2.2%) severe steatosis. The majority of participants (80 APs or 58.4%) showed no signs of liver fibrosis based on LSM values. However, 49 APs (35.8%) were diagnosed with mild fibrosis (F1), 7 (5.1%) with significant fibrosis (F2), and one (0.7%) with advanced fibrosis (F3). None of the pilots had F4 (cirrhosis). In multivariable linear regression analysis, BMI was the sole independent predictor of both CAP (β=0.34, p<0.001) and LSM (β=0.41, p<0.001) values in our sample of male APs.Conclusion: TE is a straightforward and convenient non-invasive method for detecting hepatic steatosis and fibrosis in high-risk occupational groups such as APs.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scotch pine-induced liver injury: A case report. 苏格兰松引起的肝损伤：病例报告

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2022.2022.0046

Kadir Intas

引用次数: 0

Safety and hemostatic effect of Achillea millefolium L. in localized bleeding. Achillea millefolium L.对局部出血的安全性和止血效果。

IF 1.2

Hepatology Forum Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2022.2022.0041

Amin Bagheri, Gholamreza Amin, Seyed Mohammad Tavangar, Matineh Heidari, Jamshid Bagheri

{"title":"Safety and hemostatic effect of Achillea millefolium L. in localized bleeding.","authors":"Amin Bagheri, Gholamreza Amin, Seyed Mohammad Tavangar, Matineh Heidari, Jamshid Bagheri","doi":"10.14744/hf.2022.2022.0041","DOIUrl":"10.14744/hf.2022.2022.0041","url":null,"abstract":"Background and aim: This study aims to demonstrate the hemostatic effect of the hydroalcoholic extract of Achillea millefolium L. in localized bleeding and to assess the safety of its topical application on rat liver.Materials and methods: The aerial parts of A. millefolium were macerated in methanol for two days. Twelve female Wistar rats, weighing 120-220 g, underwent anesthesia and laparotomy. The liver was exposed, and two incisions were made to induce bleeding. One incision was treated with a sponge soaked in A. millefolium extract, while the other served as a control. The animals were divided into two groups: in one, A. millefolium (150 mg/kg) was applied to the first incision, and in the other, to the second incision. Liver biopsies were collected after 4, 6, and 8 weeks.Results: Application of A. millefolium to liver incisions, whether first or second, significantly reduced bleeding time (by 36.1% and 31.9%, respectively). Histopathological analysis showed no signs of toxicity or hepatic damage after 4, 6, and 8 weeks in the female rats.Conclusion: The study confirms the hemostatic effect of the hydroalcoholic extract of A. millefolium in localized bleeding and establishes its safety for topical use.","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0