Validation of functional liver imaging scores derived on gadoxetic acid-enhanced MRI in hepatocellular carcinoma patients.

IF 2.1 Q4 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Forum Pub Date : 2024-10-11 eCollection Date: 2025-01-01 DOI:10.14744/hf.2023.2023.0024

Duygu Ozgul, Ferhat Can Piskin, Sinan Sozutok, Huseyin Tugsan Balli

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Abstract

Background and aim: To investigate the correlation of the functional liver imaging scores (FLIS) and the scoring system in hepatocellular carcinoma (HCC) patients.

Materials and methods: Between April 2015 and December 2022, the HCC patients who underwent gadoxetic acid-enhanced MRI were analyzed. Three parameters on hepatobiliary phase images were evaluated for FLIS: liver parenchymal enhancement, biliary excretion, and signal intensity of the portal vein. The correlation between Child-Turcotte-Pugh (CTP) classification, the albumin-bilirubin (ALBI) grade, and Fibrosis-4 (F-4) score, and FLIS were analyzed. Receiver operating characteristic curve analysis was performed to demonstrate the cut-off value of FLIS for differentiating between CTP classification and ALBI grade.

Results: We retrospectively analyzed 178 HCC patients (144 men, 34 women; mean age, 65.9 years). A moderate negative correlation was present between CTP classification and ALBI grade, and FLIS (r=-0.596 and r=-0.513, respectively). FLIS ≤3 was determined as the most optimal criterion for differentiating CTP A or B patients from CTP C patients.

Conclusion: This study showed that the FLIS is a simple, non-invasive imaging marker for the assessment of liver function in HCC patients.

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肝细胞癌患者肝功能影像学评分的验证：加多西酸增强MRI。

背景与目的：探讨肝细胞癌（HCC）患者肝功能影像学评分（FLIS）与评分系统的相关性。材料与方法：对2015年4月至2022年12月期间行加多辛酸增强MRI检查的HCC患者进行分析。评估FLIS的肝胆期图像的三个参数：肝实质增强、胆汁排泄和门静脉信号强度。分析Child-Turcotte-Pugh （CTP）分级、白蛋白-胆红素（ALBI）分级、纤维化-4 （F-4）评分与FLIS的相关性。进行受试者工作特征曲线分析，以证明FLIS在区分CTP分级和ALBI分级时的截止值。结果：我们回顾性分析178例HCC患者(144例男性，34例女性；平均年龄65.9岁)。CTP分型与ALBI分级、FLIS呈中度负相关（r=-0.596、r=-0.513）。FLIS≤3被确定为区分CTP A或B与CTP C的最佳标准。结论：本研究表明FLIS是评估HCC患者肝功能的一种简单、无创的影像学标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Forum

CiteScore

1.90

自引率

12.50%

发文量