Biosensors and Bioelectronics最新文献_第6页

Development of a microarray microfluidic chip mass spectrometry platform based on UV curable 3D hepatocellular sphere bio-ink for rapid screening inhibitors of advanced glycosylation end products from natural compounds 基于UV固化三维肝细胞球生物墨水的微阵列微流控芯片质谱平台的开发，用于快速筛选天然化合物晚期糖基化终产物抑制剂

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-22 DOI: 10.1016/j.bios.2025.117499

Wang Hechen , Xie Yanqiao , Liu Longchan, Zhao Weiman, Gu Lihua, Xiong Aizhen, Wang Zhengtao, Yang Li

{"title":"Development of a microarray microfluidic chip mass spectrometry platform based on UV curable 3D hepatocellular sphere bio-ink for rapid screening inhibitors of advanced glycosylation end products from natural compounds","authors":"Wang Hechen , Xie Yanqiao , Liu Longchan, Zhao Weiman, Gu Lihua, Xiong Aizhen, Wang Zhengtao, Yang Li","doi":"10.1016/j.bios.2025.117499","DOIUrl":"10.1016/j.bios.2025.117499","url":null,"abstract":"<div><div>Advanced glycation end products (AGEs) are the unwanted by-products of excessive sugar intake, and their generation and accumulation promote aging and disease occurrence. However, the lack of robust biology model and platform for fast evaluating AGE generation and accumulation under intervention of drugs hampers AGEs-targeted therapeutic development. This work described a novel biological high AGEs recombinant extracellular matrix 3D human hepatocellular spheres model was built, under the same cell numbers, this 3D hepatocellular spheres expressed more AGEs over an order of magnitude than monolayer culture cells. Combined with UV curable gelatin methacryloyl (GelMA), biological 3D human hepatocellular sphere were made into a extruded type bio-ink with high AGEs, simply encapsulated in a hepatic lobule shaped micro array polymethyl methacrylate (PMMA) microfluidic chip successfully. Due to this biomimetic fluid microreactor environment, our biological microfluidic chip enables effectively determine the inhibition capacity of compounds on endogenous AGE accumulation with a high sensitivity and in a short time, total determination workflow less than 2.5 h, it takes 1/200 of the time required by mainstream methods. The evaluation results showed that alisol B 23-monoacetate and chlorogenic acid were potential natural AGEs inhibitors. Moreover, the integration of high AGEs bio-ink and microfluidic chip provides a promising tool for AGE-related drug discovery and liver disease research.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"284 ","pages":"Article 117499"},"PeriodicalIF":10.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconfigurable acoustic tweezer for precise tracking and in-situ sensing of trace miRNAs in tumor cells 用于肿瘤细胞中痕量mirna的精确跟踪和原位传感的可重构声学镊子

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-22 DOI: 10.1016/j.bios.2025.117505

Jingui Qian , Bowei Zhang , Chuanmin Liu , Yuhang Xue , Hong Zhou , Liang Huang , Shaohui Zheng , Minghui Chen , Yong-Qing Fu

{"title":"Reconfigurable acoustic tweezer for precise tracking and in-situ sensing of trace miRNAs in tumor cells","authors":"Jingui Qian , Bowei Zhang , Chuanmin Liu , Yuhang Xue , Hong Zhou , Liang Huang , Shaohui Zheng , Minghui Chen , Yong-Qing Fu","doi":"10.1016/j.bios.2025.117505","DOIUrl":"10.1016/j.bios.2025.117505","url":null,"abstract":"<div><div>MicroRNAs (miRNAs) have emerged as critical biomarkers for early cancer diagnosis and monitoring. However, their isolation from clinical samples typically yields only trace amounts, significantly limiting the sensitivity and efficiency of cancer detection. To address this challenge, we present a octangular reconfigurable acoustic tweezer (ORAT) as an integrated platform for precise tumor cell tracking and in-situ detection of trace miRNAs. By simultaneously modulating multidirectional acoustic signals and parameters, the ORAT dynamically reshapes the acoustic field, enabling precise control over manipulation areas, particle spacing, array angles, distribution patterns, and node rotation. This device allows selective particle manipulation across entire regions or specific areas through adaptive adjustments of the microchamber boundary. Notably, the ORAT achieves rapid and accurate localization and labeling of rare tumor cells within a large population of normal cells. Furthermore, it enhances the sensitivity of CRISPR/Cas-based miRNA detection in digital microdroplets by three orders of magnitude, if compared to that of the conventional tube-based method. With its versatile capabilities, the ORAT holds remarkable promise for advancing nucleic acid analysis in a wide range of cancers and related diseases.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"282 ","pages":"Article 117505"},"PeriodicalIF":10.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable electrophoretic lateral flow biosensing for ultra-sensitive human lactate dehydrogenase detection in serum samples 便携式电泳侧流生物传感用于血清样品超灵敏乳酸脱氢酶检测

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-22 DOI: 10.1016/j.bios.2025.117504

Amadeo Sena-Torralba , Yulieth D. Banguera-Ordoñez , Javier Carrascosa , Ángel Maquieira , Sergi Morais

{"title":"Portable electrophoretic lateral flow biosensing for ultra-sensitive human lactate dehydrogenase detection in serum samples","authors":"Amadeo Sena-Torralba , Yulieth D. Banguera-Ordoñez , Javier Carrascosa , Ángel Maquieira , Sergi Morais","doi":"10.1016/j.bios.2025.117504","DOIUrl":"10.1016/j.bios.2025.117504","url":null,"abstract":"<div><div>Lateral flow immunoassays are globally recognized for their simplicity, cost-effectiveness, and rapid qualitative and semiquantitative analyses, making them indispensable as point-of-care screening tools. However, their limited sensitivity restricts their application in clinical settings, requiring the detection of ultralow analyte concentrations in complex sample matrices. To address these challenges, we present a portable biosensing platform integrating battery-powered electrokinetic-driven microfluidics to enhance sensitivity while preserving point-of-care functionality. Our lightweight (151 g), 3D-printed electrophoretic device (€82) supports the simultaneous analysis of three samples and operates with an ultra-low power consumption of 225 mAh<sup>−1</sup>, enabling 44 h of operation on a single charge. By optimizing key parameters such as Joule heating, buffer evaporation, and electroosmotic flow, the device enables iterative incubation and washing steps directly on the nitrocellulose strip, capabilities unattainable with conventional capillarity-driven LFIAs. This advanced biosensing platform achieves a detection limit of 70 pg mL<sup>−1</sup> for human lactate dehydrogenase (h-LDH), a key cancer biomarker, using gold nanoparticles as signal transducers. This result means a 367-fold improvement in sensitivity. Offering rapid, cost-effective, and ultra-sensitive biomarker quantification, this approach holds significant promise for transforming precision medicine, particularly in monitoring LDH-related cancer therapies.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"282 ","pages":"Article 117504"},"PeriodicalIF":10.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging laboratory innovation to translational research and commercialization of extracellular vesicle isolation and detection 连接实验室创新转化研究和商业化的细胞外囊泡分离和检测

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-21 DOI: 10.1016/j.bios.2025.117475

Hyun-Kyung Woo , Yoonho Nam , Hyun Gyu Park , Hakho Lee

引用次数: 0

DNAzyme-driven Z-scheme g-C3N4/V2C heterojunction reactivation for photoelectrochemical assessment of bacterial viability dnazyme驱动的Z-scheme g-C3N4/V2C异质结再激活用于细菌活力的光电化学评估

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-21 DOI: 10.1016/j.bios.2025.117503

Yi Deng , Shuqi Quan , Erkang Tian, Jianwen Dong, Meihong Guo, Juan Li, Hao Yang, Shuangquan Lai

{"title":"DNAzyme-driven Z-scheme g-C3N4/V2C heterojunction reactivation for photoelectrochemical assessment of bacterial viability","authors":"Yi Deng , Shuqi Quan , Erkang Tian, Jianwen Dong, Meihong Guo, Juan Li, Hao Yang, Shuangquan Lai","doi":"10.1016/j.bios.2025.117503","DOIUrl":"10.1016/j.bios.2025.117503","url":null,"abstract":"<div><div>Assessment of bacterial viability is vital for food and clinical biosafety, as it reveals pathogen survival and metabolic state, helping predict their potential to persist and cause illness. Herein, we presented a visible light-driven photoelectrochemical assay (termed DzPEC) designed for signal-on detection of live pathogenic bacteria. The DzPEC assay was fabricated using a DNAzyme-functionalized Z-scheme g-C<sub>3</sub>N<sub>4</sub>/V<sub>2</sub>C bio-heterojunction as a photoresposive material and SiO<sub>2</sub> as a photoquencher. The DzPEC assay, which utilizes DNAzyme to target the metabolic endoprotein RNase H2 that is secreted into the extracellular matrix, allows for bacterial viability assessment. Leveraging the Z-scheme heterojunction with high photoactive performance, the DzPEC assay for <em>Salmonella enterica</em> (<em>S. enterica</em>), used as a bacteria model, exhibited a detection limit of 141 CFU/mL and the ability to detect live bacterial abundnace as low as 0.1 %. The DzPEC assay demonstrated a strong correlation with RT-qPCR in the detection of <em>S. enterica</em> contamination in complex food and clinical matrices. These findings highlighted the potential of the DzPEC assay in bacterial viability phenotyping and live bacteria-associated biosafety monitoring.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"282 ","pages":"Article 117503"},"PeriodicalIF":10.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile and programmable dual-mode logic gold nanoflares for intracellular correlated DNA repair enzymes imaging 用于细胞内相关DNA修复酶成像的通用和可编程双模式逻辑金纳米耀斑

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-21 DOI: 10.1016/j.bios.2025.117501

Liannishang Li , Lei Huang , Mingxi Li , Shaoying He , Huo Xu , Chunhua Lu , Chao Xing

{"title":"Versatile and programmable dual-mode logic gold nanoflares for intracellular correlated DNA repair enzymes imaging","authors":"Liannishang Li , Lei Huang , Mingxi Li , Shaoying He , Huo Xu , Chunhua Lu , Chao Xing","doi":"10.1016/j.bios.2025.117501","DOIUrl":"10.1016/j.bios.2025.117501","url":null,"abstract":"<div><div>In situ monitoring of correlated DNA repair enzyme activities in living cells is crucial for clinical and biomedical research. Here, we introduce a versatile, programmable dual-mode logic gold nanoflares strategy for OR/AND gate logic imaging the activity of apurinic/apyrimidinic endonuclease 1 (APE1) and flap endonuclease 1 (FEN1) within cells. The logic gold nanoflares were designed via conjugating enzyme-activatable sites modified branched double-stranded DNA structures to gold nanoparticles. These meticulously engineered nanoflares specifically respond to APE1 and FEN1 in living cells through logic biocomputing, emitting a fluorescent signal that allows for the sensitive monitor of APE1 and FEN1 activities. In vitro experiments demonstrate that the nanoflares are highly biocompatible and can make effectively and sensitively judgments on the two enzyme targets across various cancer cell lines. This OR/AND dual-mode logic gold nanoflare strategy offers a straightforward tool for the comprehensive analysis of multiple DNA repair enzymes, presenting promising applications in disease diagnosis, drug efficacy evaluation, and programmable therapeutics.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"282 ","pages":"Article 117501"},"PeriodicalIF":10.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated and confinable paper-based chip biosensor for all-in-one colorimetric detection of aflatoxin B1 用于黄曲霉毒素B1综合比色检测的集成、受限的纸质芯片生物传感器

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-19 DOI: 10.1016/j.bios.2025.117500

Sareh Sadat Moshirian-Farahi , Hamidreza Rahmanian , Jianxiong Wu , Qiao Huang , Yuxin Sun , Tongtong Ma , Huajun Wu , Yingchun Fu , Kejun Cheng , Jinming Pan

{"title":"Integrated and confinable paper-based chip biosensor for all-in-one colorimetric detection of aflatoxin B1","authors":"Sareh Sadat Moshirian-Farahi , Hamidreza Rahmanian , Jianxiong Wu , Qiao Huang , Yuxin Sun , Tongtong Ma , Huajun Wu , Yingchun Fu , Kejun Cheng , Jinming Pan","doi":"10.1016/j.bios.2025.117500","DOIUrl":"10.1016/j.bios.2025.117500","url":null,"abstract":"<div><div>This study presents the development of a rapid and highly sensitive colorimetric biosensor for the detection of aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), utilizing a peroxidase-mimetic nanozyme in combination with a membrane-confined signal amplification strategy. The biosensor platform incorporates AFB<sub>1</sub>-specific aptamer-labeled Fe<sup>3+</sup>-doped mesoporous carbon nanospheres, which hybridize with a complementary strand immobilized on paper nanofibers. Upon binding with AFB<sub>1</sub>, the nanozyme detaches and is subsequently removed through a washing step. The remaining nanozyme catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine in the presence of H<sub>2</sub>O<sub>2</sub>, generating a blue-colored signal. To facilitate real-time, quantitative signal analysis, a smartphone-based imaging strategy is employed. In contrast to conventional open-solution detection methods, this approach confines the catalytic reaction and its products within the membrane, thereby enhancing the signal intensity. The integration of the nanozyme's high catalytic efficiency with the signal amplification enabled by membrane confinement results in superior sensitivity, stability, and operational simplicity. The biosensor demonstrates a broad detection range from 0.01 to 1000 ng mL<sup>−1</sup> and an exceptionally low detection limit of 3.9 pg mL<sup>−1</sup>, outperforming most analogous systems. Additionally, the biosensor exhibits excellent performance in complex sample matrices, such as chicken feed and traditional Chinese medicinal herbs. Through the combination of smartphone imaging for quantitative analysis and rapid, visual detection, this platform provides a versatile, user-friendly tool for real-time, on-site food safety monitoring and health surveillance.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"282 ","pages":"Article 117500"},"PeriodicalIF":10.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivalent aptamer-linked tetrahedron DNA assisted catalytic hairpin assembly for accurate SERS assay of cancer-derived exosomes in clinical blood 多价适体连接四面体DNA辅助催化发夹组装用于临床血液中癌症来源外泌体的精确SERS测定

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-18 DOI: 10.1016/j.bios.2025.117497

Jingjing Zhang, Chenlong Yan, Lijie Xie, Qingzhong Ding, Xiyu He, Jian Liu, Tingxiao Wang, Xinyue Gu, Lianhui Wang, Chunyuan Song

{"title":"Multivalent aptamer-linked tetrahedron DNA assisted catalytic hairpin assembly for accurate SERS assay of cancer-derived exosomes in clinical blood","authors":"Jingjing Zhang, Chenlong Yan, Lijie Xie, Qingzhong Ding, Xiyu He, Jian Liu, Tingxiao Wang, Xinyue Gu, Lianhui Wang, Chunyuan Song","doi":"10.1016/j.bios.2025.117497","DOIUrl":"10.1016/j.bios.2025.117497","url":null,"abstract":"<div><div>Exosome-based liquid biopsy plays an increasingly important role in non-invasive cancer diagnosis. However, due to their small size and low abundance, sensitive and accurate detection of cancer-derived exosomes in complex biological samples still faces great challenges. Herein, an ultrasensitive SERS assay based on the multivalent aptamer-linked tetrahedron DNA (MATD) assisted catalytic hairpin assembly (CHA) was developed for accurate detection of cancer-derived exosomes, including MATD-modified SERS sensing chip, identification SERS tags (IS), and assist SERS tags (AS). Taking SGC-7901 cell-derived exosomes as a test model, the exosomes can be captured onto the SERS sensing chip by the specific binding of multivalent aptamers to CD63 proteins, and then the MUC1 aptamers on the IS bind to the highly expressed MUC1 proteins on the SGC-7901 cell-derived exosomes to release the patch strands (P), further triggering the CHA-induced assembly of AuNP network structures between IS and AS with rich hotspots on SERS sensing chip. The proposed SERS assay can achieve ultra-high sensitivity low to 2.98 × 10<sup>3</sup> particles mL<sup>−1</sup> (i.e., approximately 6 exosome particles can be detected from 2 μL of biological sample) within 40 min, high specificity for identifying SGC-7901 cell-derived exosomes, and can accurately distinguish gastric cancer patients from healthy people, which shows the potential applications in clinical diagnosis.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"282 ","pages":"Article 117497"},"PeriodicalIF":10.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterojunction nanofluidic memristors based on peptide chain valves for neuromorphic applications 神经形态应用中基于肽链阀的异质结纳米流控忆阻器

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-18 DOI: 10.1016/j.bios.2025.117496

Honglin Lv , Yin Zhang

引用次数: 0

Engineered ratiometric Sensory electrospun fibers for oxygen mapping in complex cultures and tumor microenvironment 用于复杂培养物和肿瘤微环境中氧定位的工程比例传感电纺丝纤维

IF 10.7 1区生物学

Biosensors and Bioelectronics Pub Date : 2025-04-17 DOI: 10.1016/j.bios.2025.117481

Giuliana Grasso , Stefania Forciniti , Valentina Onesto , Lara Pierantoni , David Caballero , Eliana D'Amone , Giuseppe Gigli , Rui L. Reis , Joaquim M. Oliveira , Loretta L. del Mercato

{"title":"Engineered ratiometric Sensory electrospun fibers for oxygen mapping in complex cultures and tumor microenvironment","authors":"Giuliana Grasso , Stefania Forciniti , Valentina Onesto , Lara Pierantoni , David Caballero , Eliana D'Amone , Giuseppe Gigli , Rui L. Reis , Joaquim M. Oliveira , Loretta L. del Mercato","doi":"10.1016/j.bios.2025.117481","DOIUrl":"10.1016/j.bios.2025.117481","url":null,"abstract":"<div><div>Monitoring the hypoxic microenvironment is fundamental due to its implication in tumor aggressiveness and progression. In this work, we propose the fabrication of ratiometric fluorescent fibers via electrospinning of poly(trimethylsylil)propine (PTMSP) polymer, an optically clear and gas permeable polymer, for oxygen (O<sub>2</sub>) sensing in a melanoma tumor model. The ratiometric sensing configuration was obtained by entrapping tris(4,7-diphenyl-1,10-phenanthroline) ruthenium (II) dichloride, capable of detecting dissolved O<sub>2</sub> variations, together with rhodamine B isothiocyanate, serving as a reference dye, within the polymer matrix. The fibers were characterized to point out morphology, porosity, and hydrophilicity. The sensing ability of the fibrous mat was deeply investigated by means of microplate reader and confocal imaging, showing a strict correlation between the fluorescent ratiometric read-out and the increasing concentration of dissolved O<sub>2</sub> in aqueous-based media. Moreover, the fibers exhibited high photostability, reversibility and excellent cytocompatibility, allowing monitoring O<sub>2</sub> gradients over time and space in <em>vitro</em> melanoma co-cultures. Overall, the optimized micrometric sensing system holds potential for real-time assessments of dissolved O<sub>2</sub> levels in <em>vitro</em> complex cell systems and heterogeneous tumour microenvironments, and can open up new engineering possibilities by means of using O<sub>2</sub>-sensitive dyes in tissue engineering scaffolding strategies.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"283 ","pages":"Article 117481"},"PeriodicalIF":10.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0