World journal of radiology最新文献

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Carbon ion radiation therapy in prostate cancer: The importance of dosage. 碳离子放射治疗前列腺癌:剂量的重要性。
IF 1.4
World journal of radiology Pub Date : 2024-11-28 DOI: 10.4329/wjr.v16.i11.696
Teeradon Treechairusame, Pahnwat T Taweesedt
{"title":"Carbon ion radiation therapy in prostate cancer: The importance of dosage.","authors":"Teeradon Treechairusame, Pahnwat T Taweesedt","doi":"10.4329/wjr.v16.i11.696","DOIUrl":"10.4329/wjr.v16.i11.696","url":null,"abstract":"<p><p>In this article, we comment on the article by Ono <i>et al</i>. We focus specifically on the carbon ion radiotherapy studies and the method to calculate the dosing schedule. While photon hypofractionated radiotherapy in prostate cancer has demonstrated improvement in tumor control with reduced gastrointestinal toxicity compared to conventional radiotherapy, carbon ion radiotherapy (CIRT) offers additional physical and biological advantages. Recent findings, including those from Ono <i>et al</i>, have established new dose constraints of CIRT for prostate cancer treatment and risk factors for rectal bleeding. Due to limited data on CIRT dosing, this study underscores the need for more research to refine dose calculation methods and better understand their effects on clinical outcomes.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"696-699"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between pancreatic morphological changes and diabetes in autoimmune pancreatitis: Multimodal medical imaging assessment has important potential. 自身免疫性胰腺炎胰腺形态改变与糖尿病的关系:多模式医学影像学评估具有重要潜力。
IF 1.4
World journal of radiology Pub Date : 2024-11-28 DOI: 10.4329/wjr.v16.i11.703
Qing-Biao Zhang, Dan Liu, Jun-Bang Feng, Chun-Qi Du, Chuan-Ming Li
{"title":"Relationship between pancreatic morphological changes and diabetes in autoimmune pancreatitis: Multimodal medical imaging assessment has important potential.","authors":"Qing-Biao Zhang, Dan Liu, Jun-Bang Feng, Chun-Qi Du, Chuan-Ming Li","doi":"10.4329/wjr.v16.i11.703","DOIUrl":"10.4329/wjr.v16.i11.703","url":null,"abstract":"<p><p>Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis with clinical symptoms of obstructive jaundice and abdominal discomfort; this condition is caused by autoimmunity and marked by pancreatic fibrosis and dysfunction. Previous studies have revealed a close relationship between early pancreatic atrophy and the incidence rate of diabetes in type 1 AIP patients receiving steroid treatment. Shimada <i>et al</i> performed a long-term follow-up study and reported that the pancreatic volume (PV) of these patients initially exponentially decreased but then slowly decreased, which was considered to be an important factor related to diabetes; moreover, serum IgG4 levels were positively correlated with PV during follow-up. In this letter, regarding the original study presented by Shimada <i>et al</i>, we present our insights and discuss how multimodal medical imaging and artificial intelligence can be used to better assess the relationship between pancreatic morphological changes and diabetes in patients with AIP.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"703-707"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-low-dose chest computed tomography with model-based iterative reconstruction in the analysis of solid pulmonary nodules: A prospective study. 基于模型迭代重建的超低剂量胸部计算机断层扫描在实性肺结节分析中的应用:一项前瞻性研究。
IF 1.4
World journal of radiology Pub Date : 2024-11-28 DOI: 10.4329/wjr.v16.i11.668
Patrick W O'Regan, Antonia Harold-Barry, Alexander T O'Mahony, Claire Crowley, Stella Joyce, Niamh Moore, Owen J O'Connor, Michael T Henry, David J Ryan, Michael M Maher
{"title":"Ultra-low-dose chest computed tomography with model-based iterative reconstruction in the analysis of solid pulmonary nodules: A prospective study.","authors":"Patrick W O'Regan, Antonia Harold-Barry, Alexander T O'Mahony, Claire Crowley, Stella Joyce, Niamh Moore, Owen J O'Connor, Michael T Henry, David J Ryan, Michael M Maher","doi":"10.4329/wjr.v16.i11.668","DOIUrl":"10.4329/wjr.v16.i11.668","url":null,"abstract":"<p><strong>Background: </strong>Incidental pulmonary nodules are an increasingly common finding on computed tomography (CT) scans of the thorax due to the exponential rise in CT examinations in everyday practice. The majority of incidental pulmonary nodules are benign and correctly identifying the small number of malignant nodules is challenging. Ultra-low-dose CT (ULDCT) has been shown to be effective in diagnosis of respiratory pathology in comparison with traditional standard dose techniques. Our hypothesis was that ULDCT chest combined with model-based iterative reconstruction (MBIR) is comparable to standard dose CT (SDCT) chest in the analysis of pulmonary nodules with significant reduction in radiation dose.</p><p><strong>Aim: </strong>To prospectively compare ULDCT chest combined with MBIR with SDCT chest in the analysis of solid pulmonary nodules.</p><p><strong>Methods: </strong>A prospective cohort study was conducted on adult patients (<i>n</i> = 30) attending a respiratory medicine outpatient clinic in a tertiary referral university hospital for surveillance of previously detected indeterminate pulmonary nodules on SDCT chest. This study involved the acquisition of a reference SDCT chest followed immediately by an ULDCT chest. Nodule identification, nodule characterisation, nodule measurement, objective and subjective image quality and radiation dose were compared between ULDCT with MBIR and SDCT chest.</p><p><strong>Results: </strong>One hundred solid nodules were detected on ULDCT chest and 98 on SDCT chest. There was no significant difference in the characteristics of correctly identified nodules when comparing SDCT chest to ULDCT chest protocols. Signal-to-noise ratio was significantly increased in the ULDCT chest in all areas except in the paraspinal muscle at the maximum cardiac diameter level (<i>P</i> < 0.001). The mean subjective image quality score for overall diagnostic acceptability was 8.9/10. The mean dose length product, computed tomography volume dose index and effective dose for the ULDCT chest protocol were 5.592 mGy.cm, 0.16 mGy and 0.08 mSv respectively. These were significantly less than the SDCT chest protocol (<i>P</i> < 0.001) and represent a radiation dose reduction of 97.6%.</p><p><strong>Conclusion: </strong>ULDCT chest combined with MBIR is non-inferior to SDCT chest in the analysis of previously identified solid pulmonary nodules and facilitates a large reduction in radiation dose.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"668-677"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of the vertebrae and iliac bone as references for localizing the appendix vermiformis in computed tomography. 利用椎骨和髂骨作为计算机断层定位蚓状阑尾的参考。
IF 1.4
World journal of radiology Pub Date : 2024-11-28 DOI: 10.4329/wjr.v16.i11.629
Muhsin Ozgun Ozturk, Mustafa Resorlu, Sonay Aydin, Kemal Bugra Memis
{"title":"Use of the vertebrae and iliac bone as references for localizing the appendix vermiformis in computed tomography.","authors":"Muhsin Ozgun Ozturk, Mustafa Resorlu, Sonay Aydin, Kemal Bugra Memis","doi":"10.4329/wjr.v16.i11.629","DOIUrl":"10.4329/wjr.v16.i11.629","url":null,"abstract":"<p><strong>Background: </strong>The appendix vermiformis is a part of the gastrointestinal tract, situated in the lower right quadrant of the abdomen. Acute appendicitis, acute inflammation of the appendix vermiformis, is the most common cause of acute abdomen requiring surgical intervention. Although computed tomography (CT) offers high diagnostic efficacy in assessing the appendix across various anatomical positions, it also involves radiation exposure. Reducing exposure factors and narrowing the field of view (FOV) are ways to decrease the radiation dose to the patient. To narrow the FOV, appendix locations within the population must be defined using metric markers.</p><p><strong>Aim: </strong>To determine the location of the appendix vermiformis on CT using the vertebrae and the right iliac bone as anatomical landmarks.</p><p><strong>Methods: </strong>This retrospective study examined 470 patients presenting with abdominal pain who underwent abdominal CT scans between January 01, 2015 and January 01, 2018. Forty-three patients were excluded due to various reasons. The most superior and inferior points and the origin of the appendix were measured separately in relation to the vertebrae and right iliac bone for localization. The population was divided into normal and acute appendicitis groups, and the relationship between appendix location and anthropometric parameters relationship was examined. <i>P</i> values below 0.05 were considered statistically significant.</p><p><strong>Results: </strong>The final analysis included 427 adult patients (206 females and 221 males) with a mean age of 42.1 ± 19.5 years. An ascending appendix course was the most common (90.4%). The appendix ranged from the L2 vertebral body level to the coccygeal vertebral level relative to the vertebrae. The appendix ranged between (-) 140.5 mm and (+) 87.4 mm relative to the right iliac bone. A negative correlation was found between patient age, height, body mass index, and the highest and lowest points of the appendix in regard to the vertebrae.</p><p><strong>Conclusion: </strong>The study's findings unveiled the locations of the appendix in the population in relation to the bony anatomical landmarks. These data can be used as the basis for future research aimed at reducing patient exposure to ionizing radiation.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"629-637"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of small bowel phytobezoar using double balloon enterolithotripsy combined with sequential catharsis: A case report. 双球囊肠内碎石联合序贯泻术治疗小肠植物性牛粪1例。
IF 1.4
World journal of radiology Pub Date : 2024-11-28 DOI: 10.4329/wjr.v16.i11.683
Bing-Yun Lu, Zhi-Yu Zeng, Dong-Jing Zhang
{"title":"Successful treatment of small bowel phytobezoar using double balloon enterolithotripsy combined with sequential catharsis: A case report.","authors":"Bing-Yun Lu, Zhi-Yu Zeng, Dong-Jing Zhang","doi":"10.4329/wjr.v16.i11.683","DOIUrl":"10.4329/wjr.v16.i11.683","url":null,"abstract":"<p><strong>Background: </strong>Small bowel bezoar obstruction (SBBO) is a rare clinical condition characterized by hard fecal masses in the small intestine, causing intestinal obstruction. It occurs more frequently in the elderly and bedridden patients, but can also affect those with specific gastrointestinal dysfunctions. Diagnosing SBBO is challenging due to its clinical presentation, which mimics other intestinal obstructions. While surgical intervention is the typical treatment for SBBO, advancements in endoscopic techniques have led to increased use of non-surgical methods, such as endoscopic lithotripsy.</p><p><strong>Case summary: </strong>We report a case of small bowel obstruction induced by a phytobezoar. A 49-year-old male with a history of type 2 diabetes and long-term persimmon consumption presented to the hospital with symptoms of vomiting, abdominal distension, and constipation. Computed tomography revealed a small bowel obstruction with foreign bodies. Double balloon enteroscopy identified a phytobezoar blocking the intestinal lumen. The bezoar was successfully fragmented using a snare, and the fragments were treated with 100 mL of paraffin oil to facilitate their passage. This case report aims to enhance the understanding of this rare condition by detailing the clinical presentation, diagnostic process, and treatment outcomes of a patient with SBBO. Special attention is given to the application and effectiveness of non-surgical treatment methods, along with strategies to optimize patient management.</p><p><strong>Conclusion: </strong>Double balloon enteroscopy combined with sequential laxative therapy is an effective approach for the treatment of a breakable phytobezoar.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"683-688"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yttrium-90 radioembolization treatment strategies for management of hepatocellular carcinoma. 治疗肝细胞癌的钇-90放射栓塞治疗策略。
IF 1.4
World journal of radiology Pub Date : 2024-10-28 DOI: 10.4329/wjr.v16.i10.512
Kelly Hao, Andrew J Paik, Lauren H Han, Mina S Makary
{"title":"Yttrium-90 radioembolization treatment strategies for management of hepatocellular carcinoma.","authors":"Kelly Hao, Andrew J Paik, Lauren H Han, Mina S Makary","doi":"10.4329/wjr.v16.i10.512","DOIUrl":"10.4329/wjr.v16.i10.512","url":null,"abstract":"<p><p>As the third leading cause of cancer-related deaths worldwide, hepatocellular carcinoma (HCC) represents a significant global health challenge. This paper provides an introduction and comprehensive review of transarterial radioembolization (TARE) with Yttrium-90 (Y90), a widely performed transcatheter procedure for HCC patients who are not suitable candidates for surgery. TARE involves the targeted delivery of radioactive microspheres to liver tumors, offering a promising treatment option for managing HCC across various stages of the disease. By evaluating Y90 TARE outcomes across early, intermediate, and advanced stages of HCC, the review aims to present a thorough understanding of its efficacy and safety. Additionally, this paper highlights future research directions focusing on the potential of combination therapies with systemic and immunotherapies, as well as personalized treatments. The exploration of these innovative approaches aims to improve treatment outcomes, reduce adverse events, and provide new therapeutic opportunities for HCC patients. The review underscores the importance of ongoing research and clinical trials to optimize TARE further and integrate it into comprehensive HCC treatment paradigms.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 10","pages":"512-527"},"PeriodicalIF":1.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High complex anal fistula managed by the modified transanal opening of the intersphincteric space via the inter-sphincteric approach: A case report. 通过括约肌间入路经肛门打开括约肌间隙的改良方法治疗高位复杂性肛瘘:病例报告。
IF 1.4
World journal of radiology Pub Date : 2024-10-28 DOI: 10.4329/wjr.v16.i10.552
Ya-Qun Wang, Yan Wang, Xiao-Feng Jia, Qiao-Jing Yan, Xue-Ping Zheng
{"title":"High complex anal fistula managed by the modified transanal opening of the intersphincteric space <i>via</i> the inter-sphincteric approach: A case report.","authors":"Ya-Qun Wang, Yan Wang, Xiao-Feng Jia, Qiao-Jing Yan, Xue-Ping Zheng","doi":"10.4329/wjr.v16.i10.552","DOIUrl":"10.4329/wjr.v16.i10.552","url":null,"abstract":"<p><strong>Background: </strong>High complex anal fistulas are epithelialized tunnels, with the main fistula piercing above the deep external sphincter and the internal opening approaching the dentate line. Conventional surgical procedures for high complex anal fistulas remove most of the external sphincter and damage the anorectal ring. Postoperative loss of anal function can cause physical and mental damage. Transanal opening of the intersphincteric space (TROPIS) is an effective procedure that completely preserves the external anal sphincter. However, its clinical application is limited by challenges in the localization of the internal opening of a fistula and the high risk of complications. On the basis of our clinical experience, we modified the TROPIS procedure for the treatment of treating high complex anal fistulas.</p><p><strong>Case summary: </strong>A patient with a high complex anal fistula located above the anorectal ring underwent modified TROPIS, which involved sepsis drainage and identification of the internal opening in the intersphincteric space. The patient with the high complex anal fistula recovered well postoperatively, without any postoperative complications or anal dysfunction. Anal function returned to normal after 17 months of follow-up.</p><p><strong>Conclusion: </strong>The modified TROPIS procedure is the most minimally invasive surgery for anal fistulas that minimally impairs anal function. It allows the complete removal of infected anal glands and reduces the risk of postoperative complications. Modified TROPIS <i>via</i> the intersphincteric approach is an alternative sphincter-preserving treatment for high complex anal fistulas.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 10","pages":"552-560"},"PeriodicalIF":1.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-resolution magnetic resonance imaging in the diagnosis and management of vertebral artery dissection: A case report. 高分辨率磁共振成像在椎动脉夹层诊断和治疗中的应用:病例报告。
IF 1.4
World journal of radiology Pub Date : 2024-10-28 DOI: 10.4329/wjr.v16.i10.593
Hai-Bin Zhang, Yong-Hong Duan, Min Zhou, Ri-Chu Liang
{"title":"High-resolution magnetic resonance imaging in the diagnosis and management of vertebral artery dissection: A case report.","authors":"Hai-Bin Zhang, Yong-Hong Duan, Min Zhou, Ri-Chu Liang","doi":"10.4329/wjr.v16.i10.593","DOIUrl":"10.4329/wjr.v16.i10.593","url":null,"abstract":"<p><strong>Background: </strong>Vertebral artery dissection (VAD) is a rare but life-threatening condition characterized by tearing of the intimal layer of the vertebral artery, leading to stenosis, occlusion or rupture. The clinical presentation of VAD can be heterogeneous, with common symptoms including headache, dizziness and balance problems. Timely diagnosis and treatment are crucial for favorable outcomes; however, VAD is often missed due to its variable clinical presentation and lack of robust diagnostic guidelines. High-resolution magnetic resonance imaging (HRMRI) has emerged as a reliable diagnostic tool for VAD, providing detailed visualization of vessel wall abnormalities.</p><p><strong>Case summary: </strong>A young male patient presented with an acute onset of severe headache, vomiting, and seizures, followed by altered consciousness. Imaging studies revealed bilateral VAD, basilar artery thrombosis, multiple brainstem and cerebellar infarcts, and subarachnoid hemorrhage. Digital subtraction angiography (DSA) revealed vertebral artery stenosis but failed to detect the dissection, potentially because intramural thrombosis obscured the VAD. In contrast, HRMRI confirmed the diagnosis by revealing specific signs of dissection. The patient was managed conservatively with antiplatelet therapy and other supportive measures, such as blood pressure control and pain management. After 5 mo of rehabilitation, the patient showed significant improvement in swallowing and limb strength.</p><p><strong>Conclusion: </strong>HR-MRI can provide precise evidence for the identification of VAD.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 10","pages":"593-599"},"PeriodicalIF":1.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenteric venous thrombosis in a young adult: A case report and review of the literature. 一名年轻成年人的肠系膜静脉血栓形成:病例报告和文献综述。
IF 1.4
World journal of radiology Pub Date : 2024-10-28 DOI: 10.4329/wjr.v16.i10.569
Jiao-Jiao Yuan, Hai-Fu Zhang, Jian Zhang, Jun-Zhi Li
{"title":"Mesenteric venous thrombosis in a young adult: A case report and review of the literature.","authors":"Jiao-Jiao Yuan, Hai-Fu Zhang, Jian Zhang, Jun-Zhi Li","doi":"10.4329/wjr.v16.i10.569","DOIUrl":"10.4329/wjr.v16.i10.569","url":null,"abstract":"<p><strong>Background: </strong>Acute mesenteric vein thrombosis (MVT) accounts for only 2%-10% of all cases of acute mesenteric ischaemia, with an incidence rate of ~0.1% in Europe and the United States. It represents < 10% of mesenteric infarction cases and is seen predominantly in older adults. In younger individuals, MVT is uncommon, with 36% of cases having unidentified mechanisms and causes.</p><p><strong>Case summary: </strong>A 27-year-old man presented to the emergency department on February 29, 2024, with a chief complaint of intermittent abdominal pain for 3 day. He was previously in good health. As the abdominal pain was not alleviated by conventional treatment, an abdominal computed tomography (CT) scan was performed, which showed increased density in the portal and mesenteric veins. Further imaging, including portal vein ultrasound, mesenteric CT angiography, and enhanced abdominal CT, revealed widespread thrombosis of the portal vein system (including the main portal vein, left and right branches, proximal mesenteric vein, and splenic vein). After 10 day of thrombectomy and anticoagulation therapy, the patient's abdominal pain had improved significantly. Follow-up assessments indicated that portal venous blood flow had largely returned to normal. He was discharged on March 9, 2024. During a follow-up exam 2 months later, repeat abdominal enhanced CT showed that the previously detected thrombi were no longer visible.</p><p><strong>Conclusion: </strong>Clinicians should remain vigilant for acute MVT in young patients presenting with abdominal pain, to prevent misdiagnosis of this fatal condition.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 10","pages":"569-578"},"PeriodicalIF":1.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of infection and macrophage activation syndrome patient using low-dose etoposide: A case report. 使用小剂量依托泊苷成功治疗感染和巨噬细胞活化综合征患者:病例报告
IF 1.4
World journal of radiology Pub Date : 2024-10-28 DOI: 10.4329/wjr.v16.i10.579
Shu-Pei Gao, Xiao-Fang Luo, Mohammadreza Kosari, Wen-Juan Li, Liu Yang, Wei Tu, Ji-Xin Zhong
{"title":"Successful management of infection and macrophage activation syndrome patient using low-dose etoposide: A case report.","authors":"Shu-Pei Gao, Xiao-Fang Luo, Mohammadreza Kosari, Wen-Juan Li, Liu Yang, Wei Tu, Ji-Xin Zhong","doi":"10.4329/wjr.v16.i10.579","DOIUrl":"10.4329/wjr.v16.i10.579","url":null,"abstract":"<p><strong>Background: </strong>Macrophage activation syndrome (MAS), a sub-type of hemophagocytic lymphohistiocytosis (HLH) secondary to autoimmune rheumatic diseases, is a critical and potentially fatal condition characterized by an excessive inflammatory response. Despite the established efficacy of the HLH-2004 guideline in diagnosing and treating HLH over the years, ongoing discussion persists regarding its application, especially for HLH secondary to complicated conditions, such as autoimmune rheumatic diseases combined with severe infection. Etoposide (VP-16), a topoisomerase II inhibitor that effectively induces DNA damage and subsequent apoptosis in hyperactivated immune cells, has been widely used for the treatment of HLH. However, its suppressive effect on immune system may also cause potential exacerbation of infection in autoimmune rheumatic disease-induced HLH patients complicated with severe infection. Therefore, the use of VP-16 in such cases was inconclusive.</p><p><strong>Case summary: </strong>In this case study, we propose a potentially effective strategy for managing a patient diagnosed with secondary HLH complicated with systemic lupus erythematosus (SLE) and chronic coronavirus disease 2019 infection. Our approach involves early administration of low-dose VP-16 (100 mg twice a week, 300 mg in total), combined with methylprednisolone, cyclophosphamide, and cyclosporine A. The administration of etoposide effectively led to improvements in various indices of HLH.</p><p><strong>Conclusion: </strong>Low dose etoposide proves to be an effective approach in alleviating HLH while mitigating the risk of infection.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 10","pages":"579-585"},"PeriodicalIF":1.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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