World journal of radiology最新文献

{"title":"Role of multi-parametric ultrasonography for the assessment and monitoring of functional status of renal allografts with histopathological correlation.","authors":"Hira Lal, Surojit Ruidas, Raghunandan Prasad, Anuradha Singh, Narayan Prasad, Anupma Kaul, Dharmendra S Bhadauria, Ravi S Kushwaha, Manas R Patel, Manoj Jain, Priyank Yadav","doi":"10.4329/wjr.v16.i12.782","DOIUrl":"10.4329/wjr.v16.i12.782","url":null,"abstract":"<p><strong>Background: </strong>The study focuses on the use of multi-parametric ultrasound [gray scale, color Doppler and shear wave elastography (SWE)] to differentiate stable renal allografts from acute graft dysfunction and to assess time-dependent changes in parenchymal stiffness, thereby assessing its use as an efficient monitoring tool for ongoing graft dysfunction. To date, biopsy is the gold standard for evaluation of acute graft dysfunction. However, because it is invasive, it carries certain risks and cannot be used for follow-up monitoring. SWE is a non-invasive imaging modality that identifies higher parenchymal stiffness values in cases of acute graft dysfunction compared to stable grafts.</p><p><strong>Aim: </strong>To assess renal allograft parenchymal stiffness by SWE and to correlate its findings with functional status of the graft kidney.</p><p><strong>Methods: </strong>This prospective observational study included 71 renal allograft recipients. Multi-parametric ultrasound was performed on all patients, and biopsies were performed in cases of acute graft dysfunction. The study was performed for a period of 2 years at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, a tertiary care center in north India. Independent samples <i>t</i>-test was used to compare the means between two independent groups. Paired-samples <i>t</i>-test was used to test the change in mean value between baseline and follow-up observations.</p><p><strong>Results: </strong>Thirty-one patients had experienced acute graft dysfunction at least once, followed by recovery, but none of them had a history of chronic renal allograft injury. Mean baseline parenchymal stiffness in stable grafts and acute graft dysfunction were 30.21 + 2.03 kPa (3.17 + 0.11 m/s) and 31.07 + 2.88 kPa (3.22 + 0.15 m/s), respectively; however, these differences were not statistically significant (<i>P</i> = 0.305 and 0.252, respectively). There was a gradual decrease in SWE values during the first 3 postoperative months, followed by an increase in SWE values up to one-year post-transplantation. Patients with biopsy-confirmed graft dysfunction showed higher SWE values compared to those with a negative biopsy. However, receiver operating characteristic analysis failed to show statistically significant cut-off values to differentiate between the stable graft and acute graft dysfunction.</p><p><strong>Conclusion: </strong>Acute graft dysfunction displays higher parenchymal stiffness values compared to stable grafts. Therefore, SWE may be useful in monitoring the functional status of allografts to predict any ongoing dysfunction.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 12","pages":"782-793"},"PeriodicalIF":1.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update report on the quality of gliomas radiomics: An integration of bibliometric and radiomics quality score.","authors":"Xu Cao, Ming Xiong, Zhi Liu, Jing Yang, Yu-Bo Kan, Li-Qiang Zhang, Yan-Hui Liu, Ming-Guo Xie, Xiao-Fei Hu","doi":"10.4329/wjr.v16.i12.794","DOIUrl":"10.4329/wjr.v16.i12.794","url":null,"abstract":"<p><strong>Background: </strong>Despite the increasing number of publications on glioma radiomics, challenges persist in clinical translation.</p><p><strong>Aim: </strong>To assess the development and reporting quality of radiomics in brain gliomas since 2019.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted to reveal trends in brain glioma radiomics research. The Radiomics Quality Score (RQS), a metric for evaluating the quality of radiomics studies, was applied to assess the quality of adult-type diffuse glioma studies published since 2019. The total RQS score and the basic adherence rate for each item were calculated. Subgroup analysis by journal type and research objective was performed, correlating the total RQS score with journal impact factors.</p><p><strong>Results: </strong>The radiomics research in glioma was initiated in 2011 and has witnessed a surge since 2019. Among the 260 original studies, the median RQS score was 11, correlating with a basic compliance rate of 46.8%. Subgroup analysis revealed significant differences in domain 1 and its subitems (multiple segmentations) across journal types (<i>P</i> = 0.039 and <i>P</i> = 0.03, respectively). The Spearman correlation coefficients indicated that the total RQS score had a negative correlation with the Journal Citation Report category (-0.69) and a positive correlation with the five-year impact factors (0.318) of journals.</p><p><strong>Conclusion: </strong>Glioma radiomics research quality has improved since 2019 but necessitates further advancement with higher publication standards.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 12","pages":"794-805"},"PeriodicalIF":1.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed computed tomography severity index for the evaluation of invasive fungal sinusitis: Preliminary results.","authors":"Smita Manchanda, Ashu S Bhalla, Ankita D Nair, Kapil Sikka, Hitesh Verma, Alok Thakar, Aanchal Kakkar, Maroof A Khan","doi":"10.4329/wjr.v16.i12.771","DOIUrl":"10.4329/wjr.v16.i12.771","url":null,"abstract":"<p><strong>Background: </strong>Invasive fungal sinusitis (IFS) can present as a mild disease to life-threatening infection. A recent surge in cases was seen due to the coronavirus disease 2019 (COVID-19) pandemic. Many patients require surgical debridement and hence imaging [contrast-enhanced computed tomography (CECT) of the paranasal sinuses (PNS)] to document the extent of the disease. However, there was no scoring system using CECT to describe the severity of IFS. This study proposes a computed tomography (CT) severity index (CTSI) to describe the severity of rhino-orbital-cerebral involvement in symptomatic COVID-19 patients and hypothesizes that higher CTSI correlates with disease severity and thus slow response/non-response to treatment.</p><p><strong>Aim: </strong>To propose a scoring system using CECT to describe the severity of IFS and correlate it with clinical outcomes.</p><p><strong>Methods: </strong>A prospective study on 66 COVID-19 positive patients with CECT PNS done for IFS was performed. Split-bolus single-phase CT technique was used. Based on the extent of involvement, a CTSI was designed. Disease in four major subsite areas was assessed. Each subsite involvement was given points according to this model and then summated. Based on the final summated CTSI, the disease was classified as mild, moderate, or severe. Two subsets were subsequently analyzed including survival and death; and responders and non-responders.</p><p><strong>Results: </strong>The study cohort was 66 COVID-19-positive patients with suspected IFS with a median age of 48.5 years. Mild disease was noted in 34 (51.52%), moderate in 28 (42.42%), and severe disease in 4 (6.06%) patients. There was a significant association of mortality and poor clinical response (<i>P</i> = 0.02) with disease bilaterality. Laterality and CTSI were significant predictors of response to treatment. The mean CTSI of responders was 6.3, of non-responders was 12.9 and the response to treatment was significantly associated with CTSI (<i>t</i>-test, <i>P</i> < 0.001). Receiver operating characteristic curve analysis (Liu method) to distinguish between responders and non-responders showed that the cut-off value for CTSI of 11 had a sensitivity of 78.26% and a specificity of 95.35% to predict response assessment.</p><p><strong>Conclusion: </strong>CTSI can help in quantification of the disease burden, mapping out disease extent, triaging patients, and response assessment; especially patients with underlying comorbidities. A higher score would alert the clinician to initiate aggressive treatment, as severe disease correlates with slow response/non-response to the treatment.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 12","pages":"771-781"},"PeriodicalIF":1.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic intracranial hypertension: Imaging and clinical fundamentals.","authors":"Nikolaos-Achilleas Arkoudis, Efstathia Davoutis, Manos Siderakis, Georgia Papagiannopoulou, Nikolaos Gouliopoulos, Ilianna Tsetsou, Evgenia Efthymiou, Ornella Moschovaki-Zeiger, Dimitrios Filippiadis, Georgios Velonakis","doi":"10.4329/wjr.v16.i12.722","DOIUrl":"10.4329/wjr.v16.i12.722","url":null,"abstract":"<p><p>Neuroimaging is a paramount element for the diagnosis of idiopathic intracranial hypertension, a condition characterized by signs and symptoms of raised intracranial pressure without the identification of a mass or hydrocephalus being recognized. The primary purpose of this review is to deliver an overview of the spectrum and the specific role of the various imaging findings associated with the condition while providing imaging examples and educational concepts. Clinical perspectives and insights into the disease, including treatment options, will also be discussed.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 12","pages":"722-748"},"PeriodicalIF":1.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute respiratory distress syndrome caused by demulsifier poisoning: A case report.","authors":"Kai-Ying Yang, Zhi-Xin Cui","doi":"10.4329/wjr.v16.i11.689","DOIUrl":"10.4329/wjr.v16.i11.689","url":null,"abstract":"<p><strong>Background: </strong>This case report emphasizes the potential pulmonary toxicity of demulsifier gas, which is a widely used chemical. To our knowledge, this is the first documented instance of acute respiratory distress syndrome (ARDS) induced by inhalation of demulsifier gas. This report underscores the need for increased workplace safety and awareness regarding health risks associated with demulsifiers, particularly in industrial settings. Timely diagnosis and management of ARDS are crucial for improving patient outcomes, thus making this report significant for clinical practice and occupational health literature.</p><p><strong>Case summary: </strong>We present a rare case of acute demulsifier poisoning leading to ARDS in a previously healthy 69-year-old man. He presented with chest discomfort, shortness of breath, and dyspnea following a 30-minute exposure to demulsifier fumes in a poorly ventilated area. Chest computed tomography revealed bilateral diffuse infiltrative shadows. Based on his exposure history and clinical findings, a diagnosis of ARDS due to demulsifier poisoning was confirmed. The patient required high-flow oxygen and intravenous norepinephrine upon admission and was subsequently intubated for mechanical ventilation. Following timely and effective multidisciplinary treatment interventions including emergency care, intensive care, and respiratory medicine, he achieved positive outcomes and was ultimately discharged.</p><p><strong>Conclusion: </strong>This case underscores the critical importance of recognizing chemical exposure risks and their potential to cause severe respiratory complications.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"689-695"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Afferent loop syndrome of a patient with recurrent fever: A case report.","authors":"Jing Yuan, Ying-Jie Zhang, Wu Wen, Xiao-Cong Liu, Feng-Lin Chen, Ye Yang","doi":"10.4329/wjr.v16.i11.678","DOIUrl":"10.4329/wjr.v16.i11.678","url":null,"abstract":"<p><strong>Background: </strong>Afferent loop syndrome (ALS) is a rare complication, Aoki <i>et al</i> reported that the incidence of distal gastrectomy in Billroth-II is 0.3%-1.0%. The clinical manifestations of ALS are atypical, which can manifest as severe abdominal pain, vomiting, obstructive jaundice, malnutrition, <i>etc.</i></p><p><strong>Case summary: </strong>The patient was a 58-year-old man who complained of recurrent high fever for more than 1 week. Laboratory tests showed an increase in neutrophil ratio, procalcitonin, C-reactive protein, and abnormal liver function. Enhanced computed tomography scan of the abdomen showed small intestinal obstruction between the anastomosis of the gastrojejunum, bile duct, and pancreaticoduodenum. Gastroscopy revealed significant narrowing of the lumen 15 cm from the anastomosis into the afferent loop. After performing balloon dilation and placement of the nutrition tube, the patient did not experience further fever.</p><p><strong>Conclusion: </strong>ALS is relatively rare after pancreaticoduodenectomy, and the treatment depends on the nature of the obstructive lesion. The traditional treatment method is surgery, and in recent years, endoscopy has provided a new treatment method for ALS.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"678-682"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right-to-left shunt detection <i>via</i> synchronized contrast transcranial Doppler combined with contrast transthoracic echocardiography: A preliminary study.","authors":"Man-Juan Yao, Ying-Ying Zhao, Shui-Ping Deng, Hua-Hua Xiong, Jing Wang, Li-Jie Ren, Li-Ming Cao","doi":"10.4329/wjr.v16.i11.657","DOIUrl":"10.4329/wjr.v16.i11.657","url":null,"abstract":"<p><strong>Background: </strong>Patent foramen ovale (PFO)-related right-to-left shunts (RLSs) have been implicated in cryptogenic stroke and migraine, with larger shunts posing a higher risk. When used individually to detect RLS, contrast transcranial Doppler (cTCD) and contrast transthoracic echocardiography (cTTE) may yield false-negative results. Further, the literature exposes gaps regarding the understanding of the limitations of cTCD and cTTE, presents conflicting recommendations on their exclusive use, and highlights inefficiencies associated with nonsynchronous testing.</p><p><strong>Aim: </strong>To investigate the accuracy of multimodal ultrasound to improve diagnostic efficiency in detecting PFO-related RLSs.</p><p><strong>Methods: </strong>We prospectively enrolled four patients with cryptogenic stroke (<i>n</i> = 1), migraine (<i>n</i> = 2), and unexplained dizziness (<i>n</i> = 1) who underwent synchronized cTCD combined with cTTE. The participants were monitored and followed-up for 24 months.</p><p><strong>Results: </strong>cTTE identified moderate and large RLSs in patients with recurrent cryptogenic stroke and migraines, whereas cTCD revealed only small RLSs. Moderate and large RLS were confirmed on combined cTTE and cTCD. After excluding other causes, both patients underwent PFO occlusion. At 21- and 24-month follow-up examinations, neither stroke nor migraine had recurred. cTTE revealed a small RLS in a third patient with unexplained dizziness and a fourth patient with migraines; however, simultaneous cTCD detected a large RLS. These patients did not undergo interventional occlusion, and dizziness and headache recurred at the 17- and 24-month follow-up examinations.</p><p><strong>Conclusion: </strong>Using cTTE or cTCD may underestimate RLS, impairing risk assessments. Combining synchronized cTCD with cTTE could enhance testing accuracy and support better diagnostic and therapeutic decisions.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"657-667"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing clinical decision-making for ruptured intracranial aneurysms: Current applications and future directions of computed tomography angiography.","authors":"Xing-Yan Le, Jin-Rui Zhang, Jun-Bang Feng, Chuan-Ming Li","doi":"10.4329/wjr.v16.i11.700","DOIUrl":"10.4329/wjr.v16.i11.700","url":null,"abstract":"<p><p>Ruptured intracranial aneurysms (RIAs) are a leading cause of subarachnoid haemorrhage (SAH) and are associated with a poor prognosis and high mortality rate. Computed tomography angiography (CTA) is the preferred imaging modality for the diagnosis of RIAs, as it is considered to be a fast, economical, and less invasive method. In this letter, regarding an original study presented by Elmokadem <i>et al</i>, we present our insights and discuss how CTA can better assist in clinical decision-making for patients with RIAs complicated by SAH.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"700-702"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectra of intracranial diseases in Chinese military pilots (cadets) unqualified for transfer to pilot modified high performance aircraft.","authors":"Yao Zhao, Di Gao, Yan-Bing Liu, Jing-Jing Xue, Xiang Lu, Jing-Jing Dong, Yan Zhang, Jia Zeng","doi":"10.4329/wjr.v16.i11.638","DOIUrl":"10.4329/wjr.v16.i11.638","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;With very high mortality and disability rates, cerebrovascular diseases and intracranial tumors severely threaten the health and fighting strength of flying personnel, requiring great concern and intensive screening in clinic, early warning in an early and accurate manner and early intervention of diseases possibly resulting in inflight incapacitation are key emphases of aeromedical support in clinic.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To probe into the spectra of intracranial diseases, flight factors and medical imaging characteristics of military pilots (cadets) in the physical examination for transfer to pilot modified high performance aircraft, thus rendering theoretical references for clinical aeromedical support of pilots.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 554 military pilots (cadets) undergoing physical examination for transfer to pilot modified high performance aircraft from December 2020 to April 2024 in a military medical center were enrolled in this study. Then, a retrospective study was carried out on intracranial disease spectra and head magnetic resonance imaging (MRI) data of 36 pilots (cadets) who were unqualified for transfer to pilot modified high performance aircraft. Besides, a descriptive statistical analysis was conducted on the clinical data, age, fighter type and head MRI data of such pilots (cadets).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Abnormal head images were found in 36 out of 554 pilots (cadets) participating in the physical examination for transfer to pilot modified high performance aircraft, including arachnoid cyst in 17 (3.1%) military pilots (cadets), suspected very small aneurysm in 11 (2.0%), cavernous hemangioma in 4 (0.7%), vascular malformation in 2 (0.4%), and pituitary tumor in 3 (0.5%, one of which developed cavernous hemangioma simultaneously). Among the 17 pilots (cadets) with arachnoid cyst, 4 were identified as unqualified for transfer to pilot modified high performance aircraft because the marginal brain tissues were compressed by the cyst &gt; 6 cm in length and diameter. The 11 pilots (cadets) with suspected very small aneurysms identified by 3.0T MRI consisted of 6 diagnosed with conus arteriosus by digital subtraction angiography and qualified for transfer to pilot modified high performance aircraft, and 5 identified as very small intracranial aneurysms with diameter &lt; 3 mm and unqualified for transfer to pilot modified high performance aircraft. No symptoms and signs were observed in the 4 military pilots (cadets) with cavernous hemangioma, and the results of MRI revealed bleeding. The 1 of the 4 had the lesion located in pons and developed Rathke cyst in pituitary gland at the same time, and unqualified for transfer to pilot modified high performance aircraft. The 2 of the 4 were unqualified for flying, and 2 transferred to air combat service division. The 2 pilots (cadets) with vascular malformation were identified as unqualified for transfer to pilot modified high p","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"638-643"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic volume change using three dimensional-computed tomography volumetry and its relationships with diabetes on long-term follow-up in autoimmune pancreatitis.","authors":"Ryuichi Shimada, Yasunari Yamada, Kazuhisa Okamoto, Kazunari Murakami, Mitsuteru Motomura, Hajime Takaki, Kengo Fukuzawa, Yoshiki Asayama","doi":"10.4329/wjr.v16.i11.644","DOIUrl":"10.4329/wjr.v16.i11.644","url":null,"abstract":"<p><strong>Background: </strong>Several studies found that early pancreatic atrophy detected by computed tomography (CT) within 6 months was associated with a high incidence of diabetes in patients with type-1 autoimmune pancreatitis (AIP) receiving steroid therapy; however, no long-term follow-up studies have been performed.</p><p><strong>Aim: </strong>To investigate pancreatic volume (PV) changes using three dimensional (3D)-CT volumetry and their relationship with IgG4 and diabetes in patients with AIP.</p><p><strong>Methods: </strong>This retrospective study included 33 patients with type-1 AIP receiving steroid therapy. Patients were divided into diffuse (D-type) and mass-forming type (M-type) AIP. PV was determined by semi-automated 3D-CT volumetry, and changes between initial and follow-up values were calculated. The relationship between PV and serum IgG4 levels was analyzed by Spearman's rank correlation. The PV atrophy ratio compared with the presumed normal PV at the time of last follow-up CT and its relationship with diabetes were investigated.</p><p><strong>Results: </strong>There were 16 D-type and 17 M-type patients with long-term follow-up (mean, 95.8 months). The regression curve of mean relative PV change reduced exponentially and rapidly during the first 25 months and then more slowly in both groups. The overall cumulative pancreas re-enlargement rates at 1, 3, 5, 7 and 10 years were 6.1%, 12.2%, 29.2%, 47.5% and 55.0%, respectively. There was a moderate-to-very strong positive correlation (<i>ρ</i> ≥ 0.4) between PV and serum IgG4 levels in nine (9/13, 69.2%) patients. All 33 patients showed pancreatic atrophy (mean 59.3%) after long-term follow-up. Patients with D-type AIP had a significantly higher atrophy rate and higher incidence of diabetes than M-type patients (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>PV change initially reduced exponentially and then more slowly and is considered an important factor associated with diabetes. Serum IgG4 levels were positively correlated with PV during follow-up.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 11","pages":"644-656"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}