World journal of radiology最新文献

{"title":"Contrast-enhanced multidetector computed tomography features and histogram analysis can differentiate ameloblastomas from central giant cell granulomas.","authors":"Adarsh Ghosh,&nbsp;Meyyappan Lakshmanan,&nbsp;Smita Manchanda,&nbsp;Ashu Seith Bhalla,&nbsp;Prem Kumar,&nbsp;Ongkila Bhutia,&nbsp;Asit Ranjan Mridha","doi":"10.4329/wjr.v14.i9.329","DOIUrl":"https://doi.org/10.4329/wjr.v14.i9.329","url":null,"abstract":"<p><strong>Background: </strong>No qualitative or quantitative analysis of contrast-enhanced computed tomography (CT) images has been reported for the differentiation between ameloblastomas and central giant cell granulomas (CGCGs).</p><p><strong>Aim: </strong>To describe differentiating multidetector CT (MDCT) features in CGCGs and ameloblastomas and to compare differences in enhancement of these lesions qualitatively and using histogram analysis.</p><p><strong>Methods: </strong>MDCT of CGCGs and ameloblastomas was retrospectively reviewed to evaluate qualitative imaging descriptors. Histogram analysis was used to compare the extent of enhancement of the soft tissue. Fisher's exact tests and Mann-Whitney <i>U</i> test were used for statistical analysis (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Twelve CGCGs and 33 ameloblastomas were reviewed. Ameloblastomas had a predilection for the posterior mandible with none of the CGCGs involving the angle. CGCGs were multilocular (58.3%), with a mixed lytic sclerotic appearance (75%). Soft tissue component was present in 91% of CGCGs, which showed hyperenhancement (compared to surrounding muscles) in 50% of cases, while the remaining showed isoenhancement. Matrix mineralization was present in 83.3% of cases. Ameloblastomas presented as a unilocular (66.7%), lytic (60.6%) masses with solid components present in 81.8% of cases. However, the solid component showed isoenhancement in 63%. No matrix mineralization was present in 69.7% of cases. Quantitatively, the enhancement of soft tissue in CGCG was significantly higher than in ameloblastoma on histogram analysis (<i>P</i> < 0.05), with a minimum enhancement of > 49.05 HU in the tumour providing 100% sensitivity and 85% specificity in identifying a CGCG.</p><p><strong>Conclusion: </strong>A multilocular, lytic sclerotic lesion with significant hyperenhancement in soft tissue, which spares the angle of the mandible and has matrix mineralization, should indicate prospective diagnosis of CGCG<i>.</i></p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 9","pages":"329-341"},"PeriodicalIF":2.5,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/c1/WJR-14-329.PMC9521432.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmentation of literature review of COVID-19 radiology.","authors":"Suleman Adam Merchant, Prakash Nadkarni, Mohd Javed Saifullah Shaikh","doi":"10.4329/wjr.v14.i9.342","DOIUrl":"10.4329/wjr.v14.i9.342","url":null,"abstract":"<p><p>We suggest an augmentation of the excellent comprehensive review article titled \"Comprehensive literature review on the radiographic findings, imaging modalities, and the role of radiology in the coronavirus disease 2019 (COVID-19) pandemic\" under the following categories: (1) \"Inclusion of additional radiological features, related to pulmonary infarcts and to COVID-19 pneumonia\"; (2) \"Amplified discussion of cardiovascular COVID-19 manifestations and the role of cardiac magnetic resonance imaging in monitoring and prognosis\"; (3) \"Imaging findings related to fluorodeoxyglucose positron emission tomography, optical, thermal and other imaging modalities/devices, including 'intelligent edge' and other remote monitoring devices\"; (4) \"Artificial intelligence in COVID-19 imaging\"; (5) \"Additional annotations to the radiological images in the manuscript to illustrate the additional signs discussed\"; and (6) \"A minor correction to a passage on pulmonary destruction\".</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 9","pages":"342-351"},"PeriodicalIF":1.4,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/1a/WJR-14-342.PMC9521431.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple rule-out computed tomography angiography: Evaluation of acute chest pain in COVID-19 patients in the emergency department.","authors":"Suzan Bahadir,&nbsp;Sonay Aydın,&nbsp;Mecit Kantarci,&nbsp;Edhem Unver,&nbsp;Erdal Karavas,&nbsp;Düzgün Can Şenbil","doi":"10.4329/wjr.v14.i8.311","DOIUrl":"https://doi.org/10.4329/wjr.v14.i8.311","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to define clinical evidence supporting that triple rule-out computed tomography angiography (TRO CTA) is a comprehensive and feasible diagnostic tool in patients with novel coronavirus disease 2019 (COVID-19) who were admitted to the emergency department (ED) for acute chest pain. Optimizing diagnostic imaging strategies in COVID-19 related thromboembolic events, will help for rapid and noninvasive diagnoses and results will be effective for patients and healthcare systems in all aspects.</p><p><strong>Aim: </strong>To define clinical evidence supporting that TRO CTA is a comprehensive and feasible diagnostic tool in COVID-19 patients who were admitted to the ED for acute chest pain, and to assess outcomes of optimizing diagnostic imaging strategies, particularly TRO CTA use, in COVID-19 related thromboembolic events.</p><p><strong>Methods: </strong>TRO CTA images were evaluated for the presence of coronary artery disease, pulmonary thromboembolism (PTE), or acute aortic syndromes. Statistical analyses were used for evaluation of significant association between the variables. A two tailed <i>P</i>-value <i><</i> 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Fifty-three patients were included into the study. In 31 patients (65.9%), there was not any pathology, while PTE was diagnosed in 11 patients. There was no significant relationship between the rates of pathology on CTA and history of hypertension. On the other hand, the diabetes mellitus rate was much higher in the acute coronary syndrome group, particularly in the PTE group (8/31 = 25.8% <i>vs</i> 6/16 = 37.5%, <i>P</i> = 0.001). The rate of dyslipidemia was significantly higher in the group with pathology on CTA while compared to those without pathology apart from imaging findings of the pneumonia group (62.5% <i>vs</i> 38.7%, <i>P <</i> 0.001). Smoking history rates were similar in the groups. Platelets, D-dimer, fibrinogen, C-reactive protein, and erythrocyte sedimentation rate values were higher in COVID-19 cases with additional pathologies.</p><p><strong>Conclusion: </strong>TRO CTA is an effective imaging method in evaluation of all thoracic vascular systems at once and gives accurate results in COVID-19 patients.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 8","pages":"311-318"},"PeriodicalIF":2.5,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/71/WJR-14-311.PMC9453316.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amebic liver abscess: Clinico-radiological findings and interventional management.","authors":"Rajeev Nayan Priyadarshi,&nbsp;Ramesh Kumar,&nbsp;Utpal Anand","doi":"10.4329/wjr.v14.i8.272","DOIUrl":"https://doi.org/10.4329/wjr.v14.i8.272","url":null,"abstract":"<p><p>In its classic form, amebic liver abscess (ALA) is a mild disease, which responds dramatically to antibiotics and rarely requires drainage. However, the two other forms of the disease, <i>i.e.</i>, acute aggressive and chronic indolent usually require drainage. These forms of ALA are frequently reported in endemic areas. The acute aggressive disease is particularly associated with serious complications, such as ruptures, secondary infections, and biliary communications. Laboratory parameters are deranged, with signs of organ failure often present. This form of disease is also associated with a high mortality rate, and early drainage is often required to control the disease severity. In the chronic form, the disease is characterized by low-grade symptoms, mainly pain in the right upper quadrant. Ultrasound and computed tomography (CT) play an important role not only in the diagnosis but also in the assessment of disease severity and identification of the associated complications. Recently, it has been shown that CT imaging morphology can be classified into three patterns, which seem to correlate with the clinical subtypes. Each pattern depicts its own set of distinctive imaging features. In this review, we briefly outline the clinical and imaging features of the three distinct forms of ALA, and discuss the role of percutaneous drainage in the management of ALA.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 8","pages":"272-285"},"PeriodicalIF":2.5,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/3c/WJR-14-272.PMC9453321.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in interventional radiology treatment of pulmonary embolism: A brief review.","authors":"Alessandro Posa,&nbsp;Pierluigi Barbieri,&nbsp;Giulia Mazza,&nbsp;Alessandro Tanzilli,&nbsp;Roberto Iezzi,&nbsp;Riccardo Manfredi,&nbsp;Cesare Colosimo","doi":"10.4329/wjr.v14.i8.286","DOIUrl":"https://doi.org/10.4329/wjr.v14.i8.286","url":null,"abstract":"<p><p>Pulmonary embolism represents a common life-threatening condition. Prompt identification and treatment of this pathological condition are mandatory. In cases of massive pulmonary embolism and hemodynamic instability or right heart failure, interventional radiology treatment for pulmonary embolism is emerging as an alternative to medical treatment (systemic thrombolysis) and surgical treatment. Interventional radiology techniques include percutaneous endovascular catheter directed therapies as selective thrombolysis and thrombus aspiration, which can prove useful in cases of failure or infeasibility of medical and surgical approaches.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 8","pages":"286-292"},"PeriodicalIF":2.5,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/a7/WJR-14-286.PMC9453319.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced magnetic resonance imaging findings in salivary gland tumors.","authors":"Erkan Gökçe,&nbsp;Murat Beyhan","doi":"10.4329/wjr.v14.i8.256","DOIUrl":"https://doi.org/10.4329/wjr.v14.i8.256","url":null,"abstract":"<p><p>Salivary gland tumors (SGTs) make up a small portion (approximately 5%) of all head and neck tumors. Most of them are located in the parotid glands, while they are less frequently located in the submandibular glands, minor salivary glands or sublingual gland. The incidence of malignant or benign tumors (BTs) in the salivary glands varies according to the salivary gland from which they originate. While most of those detected in the parotid gland tend to be benign, the incidence of malignancy increases in other glands. The use of magnetic resonance imaging (MRI) in the diagnosis of SGTs is increasing every day. While conventional sequences provide sufficient data on the presence, localization, extent and number of the tumor, they are insufficient for tumor specification. With the widespread use of advanced techniques such as diffusion-weighted imaging, semi-quantitative and quantitative perfusion MRI, studies and data have been published on the differentiation of malignant or BTs and the specificity of their subtypes. With diffusion MRI, differentiation can be made by utilizing the cellularity and microstructural properties of tumors. For example, SGTs such as high cellular Warthin's tumor (WT) or lymphoma on diffusion MRI have been reported to have significantly lower apparent diffusion values than other tumors. Contrast agent uptake and wash-out levels of tumors can be detected with semi-quantitative perfusion MRI. For example, it is reported that almost all of the pleomorphic adenomas show an increasing enhancement time intensity curve and do not wash-out. On quantitative perfusion MRI studies using perfusion parameters such as Ktrans, Kep, and Ve, it is reported that WTs can show higher Kep and lower Ve values than other tumors. In this study, the contribution of advanced MRI to the diagnosis and differential diagnosis of SGTs will be reviewed.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 8","pages":"256-271"},"PeriodicalIF":2.5,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/cd/WJR-14-256.PMC9453317.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmenting prostate magnetic resonance imaging reporting to incorporate diagnostic recommendations based upon clinical risk calculators.","authors":"Karisma Gupta,&nbsp;Jordan D Perchik,&nbsp;Andrew M Fang,&nbsp;Kristin K Porter,&nbsp;Soroush Rais-Bahrami","doi":"10.4329/wjr.v14.i8.249","DOIUrl":"https://doi.org/10.4329/wjr.v14.i8.249","url":null,"abstract":"<p><p>Risk calculators have offered a viable tool for clinicians to stratify patients at risk of prostate cancer (PCa) and to mitigate the low sensitivity and specificity of screening prostate specific antigen (PSA). While initially based on clinical and demographic data, incorporation of multiparametric magnetic resonance imaging (MRI) and the validated prostate imaging reporting and data system suspicion scoring system has standardized and improved risk stratification beyond the use of PSA and patient parameters alone. Biopsy-naïve patients with lower risk profiles for harboring clinically significant PCa are often subjected to uncomfortable, invasive, and potentially unnecessary prostate biopsy procedures. Incorporating risk calculator data into prostate MRI reports can broaden the role of radiologists, improve communication with clinicians primarily managing these patients, and help guide clinical care in directing the screening, detection, and risk stratification of PCa.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 8","pages":"249-255"},"PeriodicalIF":2.5,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/0f/WJR-14-249.PMC9453318.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging volumes during COVID-19: A Victorian health service experience.","authors":"Jo-Anne Pinson,&nbsp;My Linh Diep,&nbsp;Vinay Krishnan,&nbsp;Caroline Aird,&nbsp;Cassie Cooper,&nbsp;Christopher Leong,&nbsp;Jeff Chen,&nbsp;Nicholas Ardley,&nbsp;Eldho Paul,&nbsp;Mohamed Khaldoun Badawy","doi":"10.4329/wjr.v14.i8.293","DOIUrl":"https://doi.org/10.4329/wjr.v14.i8.293","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organisation declared the coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020. While globally, the relative caseload has been high, Australia's has been relatively low. During the pandemic, radiology services have seen significant changes in workflow across modalities and a reduction in imaging volumes.</p><p><strong>Aim: </strong>To investigate differences in modality imaging volumes during the COVID-19 pandemic across a large Victorian public health network.</p><p><strong>Methods: </strong>A retrospective analysis from January 2019 to December 2020 compared imaging volumes across two periods corresponding to the pandemic's first and second waves. Weekly volumes across patient class, modality and mobile imaging were summed for periods: wave 1 (weeks 11 to 16 for 2019; weeks 63 to 68 for 2020) and wave 2 (weeks 28 to 43 for 2019; weeks 80 to 95 for 2020). Microsoft Power Business Intelligence linked to the radiology information system was used to mine all completed examinations.</p><p><strong>Results: </strong>Summed weekly data during the pandemic's first wave showed the greatest decrease of 29.8% in adult outpatient imaging volumes and 46.3% in paediatric emergency department imaging volumes. Adult nuclear medicine demonstrated the greatest decrease of 37.1% for the same period. Paediatric nuclear medicine showed the greatest decrease of 47.8%, with angiography increasing by 50%. The pandemic's second wave demonstrated the greatest decrease of 23.5% in adult outpatient imaging volumes, with an increase of 18.2% in inpatient imaging volumes. The greatest decrease was 28.5% in paediatric emergency department imaging volumes. Nuclear medicine showed the greatest decrease of 37.1% for the same period. Paediatric nuclear medicine showed the greatest decrease of 36.7%. Mobile imaging utilisation increased between 57.8% and 135.1% during the first and second waves. A strong correlation was observed between mobile and non-mobile imaging in the emergency setting (Spearman's correlation coefficient = -0.743, <i>P =</i> 0.000). No correlation was observed in the inpatient setting (Spearman's correlation coefficient = -0.059, <i>P =</i> 0.554).</p><p><strong>Conclusion: </strong>Nuclear medicine was most impacted, while computed tomography and angiography were the least affected by the pandemic. The impact was less during the pandemic's second wave. Mobile imaging shows continuous growth during both waves.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 8","pages":"293-310"},"PeriodicalIF":2.5,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/7d/WJR-14-293.PMC9453320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of X-radiation in the management of COVID-19 disease.","authors":"Divya K Mohan,&nbsp;K Nandhini,&nbsp;Venkateswarlu Raavi,&nbsp;Venkatachalam Perumal","doi":"10.4329/wjr.v14.i7.219","DOIUrl":"https://doi.org/10.4329/wjr.v14.i7.219","url":null,"abstract":"<p><p>Coronaviruses are a diverse group of viruses that infect both animals and humans. Even though the existence of coronavirus and its infection to humans is not new, the 2019-novel coronavirus (nCoV) caused a major burden to individuals and society <i>i.e.</i>, anxiety, fear of infection, extreme competition for hospitalization, and more importantly financial liability. The nCoV infection/disease diagnosis was based on non-specific signs and symptoms, biochemical parameters, detection of the virus using reverse-transcription polymerase chain reaction (RT-PCR), and X-ray-based imaging. This review focuses on the consolidation of potentials of X-ray-based imaging modality [chest-X radiography (CXR) and chest computed tomography (CT)] and low-dose radiation therapy (LDRT) for screening, severity, and management of COVID-19 disease. Reported studies suggest that CXR contributed significantly toward initial rapid screening/diagnosis and CT- imaging to monitor the disease severity. The chest CT has high sensitivity up to 98% and low specificity for diagnosis and severity of COVID-19 disease compared to RT-PCR. Similarly, LDRT compliments drug therapy in the early recovery/Less hospital stays by maintaining the physiological parameters better than the drug therapy alone. All the results undoubtedly demonstrated the evidence that X-ray-based technology continues to evolve and play a significant role in human health care even during the pandemic.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 7","pages":"219-228"},"PeriodicalIF":2.5,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/1e/WJR-14-219.PMC9350611.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33499573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular imaging as a tool for evaluation of COVID-19 sequelae - A review of literature.","authors":"Kunal R Chandekar,&nbsp;Swayamjeet Satapathy,&nbsp;Harmandeep Singh,&nbsp;Anish Bhattacharya","doi":"10.4329/wjr.v14.i7.194","DOIUrl":"https://doi.org/10.4329/wjr.v14.i7.194","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) is caused by the novel viral pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 primarily involves the lungs. Nucleic acid testing based on reverse-transcription polymerase chain reaction of respiratory samples is the current gold standard for the diagnosis of SARS-CoV-2 infection. Imaging modalities have an established role in triaging, diagnosis, evaluation of disease severity, monitoring disease progression, extra-pulmonary involvement, and complications. As our understanding of the disease improves, there has been substantial evidence to highlight its potential for multi-systemic involvement and development of long-term sequelae. Molecular imaging techniques are highly sensitive, allowing non-invasive visualization of physiological or pathological processes at a cellular or molecular level with potential for detection of functional changes earlier than conventional radiological imaging. The purpose of this review article is to highlight the evolving role of molecular imaging in evaluation of COVID-19 sequelae. Though not ideal for diagnosis, the various modalities of molecular imaging play an important role in assessing pulmonary and extra-pulmonary sequelae of COVID-19. Perfusion imaging using single photon emission computed tomography fused with computed tomography (CT) can be utilized as a first-line imaging modality for COVID-19 related pulmonary embolism. ¹⁸F-fluorodeoxyglucose positron emission tomography (PET)/CT is a sensitive tool to detect multi-systemic inflammation, including myocardial and vascular inflammation. PET in conjunction with magnetic resonance imaging helps in better characterization of neurological sequelae of COVID-19. Despite the fact that the majority of published literature is retrospective in nature with limited sample sizes, it is clear that molecular imaging provides additional valuable information (complimentary to anatomical imaging) with semi-quantitative or quantitative parameters to define inflammatory burden and can be used to guide therapeutic strategies and assess response. However, widespread clinical applicability remains a challenge owing to longer image acquisition times and the need for adoption of infection control protocols.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"14 7","pages":"194-208"},"PeriodicalIF":2.5,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/22/WJR-14-194.PMC9350609.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33499575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}