Phytochemistry Letters最新文献_第3页

Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-28 DOI: 10.1016/S1874-3900(25)01076-6

引用次数: 0

Three new methylene-bridged bisflavonoid glycosides with cardioprotective activity from Suaeda glauca 三种具有保护心脏活性的新亚桥双黄酮苷

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-21 DOI: 10.1016/j.phytol.2025.102994

Xianrui Ding , Jia Jia , Xianjun Fu , Zhengwei Gu , Kuo Xu

{"title":"Three new methylene-bridged bisflavonoid glycosides with cardioprotective activity from Suaeda glauca","authors":"Xianrui Ding , Jia Jia , Xianjun Fu , Zhengwei Gu , Kuo Xu","doi":"10.1016/j.phytol.2025.102994","DOIUrl":"10.1016/j.phytol.2025.102994","url":null,"abstract":"<div><div>A comprehensive phytochemical and pharmacological investigation of the n-BuOH fraction derived from an aqueous ethanol extract of Suaeda glauca (Bunge) Bunge led to the identification of twenty-two compounds. These include five methylene-bridged dimeric flavonol glycosides (1–5), three mono-flavonol glycosides (6–8), three phenylacrylic acids (9–11), three benzoic acids (12–15), and seven alkaloids (16–22). Notably, compounds 1–3 are newly reported. Furthermore, compounds 4, 5, 9–12, and 16–22 are reported for the first time from the genus Suaeda, with compounds 4 and 16 identified as new natural products. Compounds 1–9 and 16–20 demonstrated the ability to ameliorate pericardial edema and venous congestion in zebrafish embryos induced by verapamil hydrochloride (VH) at a concentration of 50 μM. In contrast, other compounds at this concentration exhibited lethal or teratogenic effects. Importantly, compounds 3 and 4 displayed superior efficacy in alleviating venous congestion in zebrafish embryos compared to the positive control, digoxin. These findings provide a theoretical foundation for the high-value utilization of the constituents of S. glauca.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102994"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new alkaloids from the roots of Stemona parviflora 从小檗根中提取的两个新的生物碱

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-19 DOI: 10.1016/j.phytol.2025.102993

Si-Wei Luo, Qi-Fan Xu, Zhi-Qi Yin, Ke Pan

引用次数: 0

(±)-Laevigiol A, a pair of new enantiomeric phenylpropanoids from the leaves and twigs of Croton laevigatus Vahl. and their anti-Alzheimer’s disease activities （±）-Laevigiol A是一种新的对映体苯丙素，从Croton laevigatus Vahl的叶和枝中分离得到。以及抗阿尔茨海默病的活动

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-17 DOI: 10.1016/j.phytol.2025.102982

Yu-Bin Lu, Mi-Na Yang, Hui-Jie Li, Li-Jia Ye, Le-Le Guo, Miao Zhang, Chun-Min Liu, Xin Wang, Yi-Nan Yang, Zhan-Xin Zhang, Dong-Qing Fei

{"title":"(±)-Laevigiol A, a pair of new enantiomeric phenylpropanoids from the leaves and twigs of Croton laevigatus Vahl. and their anti-Alzheimer’s disease activities","authors":"Yu-Bin Lu, Mi-Na Yang, Hui-Jie Li, Li-Jia Ye, Le-Le Guo, Miao Zhang, Chun-Min Liu, Xin Wang, Yi-Nan Yang, Zhan-Xin Zhang, Dong-Qing Fei","doi":"10.1016/j.phytol.2025.102982","DOIUrl":"10.1016/j.phytol.2025.102982","url":null,"abstract":"<div><div>(+)-Laevigiol A (1a) and (−)-Laevigiol A (1b), a pair of new enantiomeric phenylpropanoids, together with ten known compounds (2–11), were isolated from the ethanol extract of the leaves and twigs of Croton laevigatus. The racemic mixture 1 was separated through chiral HPLC. Their structures with absolute configurations were established by analysis of spectroscopic data (IR, HRESIMS, 1D and 2D NMR) and quantum chemical calculations of electronic circular dichroism (ECD) curves. Furthermore, all compounds were evaluated for their in vivo anti-Alzheimer’s disease (AD) activities by using Caenorhabditis elegans AD pathological model. Among them, compounds 1, 6, and 9–11 could delay AD-like symptoms of worm paralysis phenotype, indicating their potential anti-AD bioactivities.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102982"},"PeriodicalIF":1.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diaporolide, a new 10-membered lactone derivative from the endophytic Diaporthe sp. RYF-Br-5 associated with the rare conifer Keteleeria pubescens 来自稀有针叶油杉内生植物Diaporthe sp. RYF-Br-5的一个新的10元内酯衍生物

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-16 DOI: 10.1016/j.phytol.2025.102981

Li-Hong Yan , Hao-Wei Chen , Peng Hu , Jiyang Li , Juan Xiong , Ze-Xin Jin , Jin-Feng Hu

引用次数: 0

Antifungal naphthalenes and related polyketides from the cranberry (Vaccinium macrocarpon) endophyte Protoventuria sp. 蔓越莓（Vaccinium macrocarpon）内生菌原venturia sp.的抗真菌萘和相关聚酮。

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-15 DOI: 10.1016/j.phytol.2025.102974

Irbaz Rehman , Alexandra King , Joey B. Tanney , Mark W. Sumarah , David R. McMullin

{"title":"Antifungal naphthalenes and related polyketides from the cranberry (Vaccinium macrocarpon) endophyte Protoventuria sp.","authors":"Irbaz Rehman , Alexandra King , Joey B. Tanney , Mark W. Sumarah , David R. McMullin","doi":"10.1016/j.phytol.2025.102974","DOIUrl":"10.1016/j.phytol.2025.102974","url":null,"abstract":"<div><div>Ericaceous plants, including high-value fruit crops, harbor phylogenetically diverse fungal endophytes. A collection of ∼350 fungal endophytes from Canadian fruit-bearing plants was generated to investigate the taxonomic and secondary metabolite diversity of these poorly studied fungi. A putatively novel species of Protoventuria was isolated as an endophyte from a cranberry (Vaccinium macrocarpon) leaf in Central Ontario promoting an investigation of its secondary metabolites. From this fungus, two new naphthalenes, protoventurenes A and B (1–2), were characterized by LC-HRMS and NMR spectroscopy. Two additional structurally similar metabolites were also identified, the naphtalenone fragranone (3), previously reported from a shrub in Thailand, and the phenalenone derivative lamellicolic anhydride (4) originally from Verticillium lamellicola. Metabolites 1–4 inhibited the growth of the plant pathogen Botrytis cinerea with a 100-µg dose, and protoventurene B (2) inhibited Colletotrichum gloeosporioides at the same concentration. The investigation of ericaceous endophytes continues to reveal ecologically unique fungi and their new secondary metabolites.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102974"},"PeriodicalIF":1.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new phenolic derivatives with neuroprotective activities from the fruits of Magnolia denudata 白玉兰果实中两种具有神经保护活性的新酚类衍生物

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-14 DOI: 10.1016/j.phytol.2025.102980

Lin-Fen Ding , Xiang-Yue Zhang , Qiu-Hua Wang , Qiu-Ye Zhao , Shi-Huan Yin , Liu-Dong Song , Xing-De Wu

引用次数: 0

Two new ursane type triterpenoids from adult leaves of Cyclocarya paliurus

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-14 DOI: 10.1016/j.phytol.2025.102976

Shan-Xuan Zhang , Meng-Fei Liu , Yu-Ling Tan , Jin-Long Duan , Qiao-Lin Xu , Jian-Wen Tan

{"title":"Two new ursane type triterpenoids from adult leaves of Cyclocarya paliurus","authors":"Shan-Xuan Zhang , Meng-Fei Liu , Yu-Ling Tan , Jin-Long Duan , Qiao-Lin Xu , Jian-Wen Tan","doi":"10.1016/j.phytol.2025.102976","DOIUrl":"10.1016/j.phytol.2025.102976","url":null,"abstract":"<div><div>A phytochemical study on the adult leaves of Cyclocarya paliurus led to the isolation of two new ursane type triterpenoids 2α,3β,23-trihydroxy-taraxastan-28,20β-olide (1) and 3β,11α,19α,24,30-pentahydroxy-20β,28-epoxy-28β-ethoxy-ursane (2), along with four known analogs, 2α,3α-23-trihydroxyurs-12-en-28-oic acid (3), hederagenin (4), quinatic acid (5) and arjunolic acid (6). Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D, 2D NMR and MS techniques. These triterpenoids were tested for their in vitro α-glucosidase inhibitory activity with acarbose and corosolic acid as references. All of these compounds, except 2, were found to show obvious in vitro α-glucosidase inhibitory activity with MIC values ranging from 0.017 to 0.106 mM, which were much stronger than acarbose (IC50 0.408 mM). Especially, 3, 4 and 6 showed in vitro α-glucosidase inhibitory activity with MIC values (IC50 0.034, 0.017 and 0.041 mM) close or even more potent than corosolic acid (IC50 0.033 mM). The present result supported that the adult leaves of C. paliurus was also a rich resource for potential anti-diabetic chemicals worthy of further investigation.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102976"},"PeriodicalIF":1.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new alkamides and a new polyacetylene glucoside from Achillea alpina L. 从山茱萸中分离出两个新的烷酰胺和一个新的聚乙炔糖苷。

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-14 DOI: 10.1016/j.phytol.2025.102968

Ang Li , Xiu-Wei Li , Huan Guo, Qiang Guo, Xia Wu, Xiao-Qing Chen

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Isolation of macrocarpene-type sesquiterpenes from stigma maydis (Zea mays) 从玉米柱头中分离巨木型倍半萜

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-05-14 DOI: 10.1016/j.phytol.2025.102977

Dan Wang , Ming Zhao , Xiaoxue Li , Shujun Zhang , Liqiu Sun , Jinlan Wang , Zhichun Shi , Jun Li , Yingnan Zhao

引用次数: 0