Phytochemistry Letters最新文献

{"title":"Vibrational spectroscopic techniques and variable selection in Linear Discriminant Analysis to geographical origin discrimination of Jatropha mollissima sap","authors":"Caroline Lins Fernandes ,&nbsp;Tiago Santos Silva ,&nbsp;Caike Lobo Rodrigues de Lima ,&nbsp;Isabel Cristina Vicente dos Santos ,&nbsp;Djair Araújo Fialho ,&nbsp;Marcus Vinicius Lia Fook ,&nbsp;Paulo Henrique Gonçalves Dias Diniz ,&nbsp;José Filipe Bacalhau Rodrigues ,&nbsp;Simone da Silva Simões","doi":"10.1016/j.phytol.2024.09.007","DOIUrl":"10.1016/j.phytol.2024.09.007","url":null,"abstract":"<div><div>This study aimed at the geographical origin discrimination of <em>Jatropha mollissima</em> saps using mid- and near-infrared spectroscopies (MIR and NIR, respectively) and Linear Discriminant Analysis (LDA). For this purpose, a total of 108 sap samples were collected in 3 different geographical regions over 12 months, and their content of total polyphenols, flavonoids, and tannins were quantified. Overall, samples from region C had consistently lower levels of these secondary metabolites throughout most of the months studied. In contrast, samples from regions A and B displayed relatively stable metabolite concentrations over the collection period. Since raw sap samples are subject to deterioration during storage, lyophilization was employed to remove moisture and consequently increase their shelf-life. Thus, MIR spectroscopy was applied to both raw and lyophilized sap samples, while NIR spectroscopy was only applied to lyophilized samples. Then, Principal Component Analysis from the secondary metabolites and spectral data indicated a trend of separation between the region C (located in <em>Sertão</em>) and the regions A and B (located in <em>Agreste</em>). Next, the Successive Projection Algorithm (SPA), Genetic Algorithm (GA), and Ant Colony Optimization (ACO) were used for variable selection in LDA. As a result, all constructed models achieved a sensitivity, specificity, and accuracy of 100 %, or very close to it, in both the training and test sets. However, the SPA-LDA models were more parsimonious, selecting fewer variables and presenting reproductive results as it is a deterministic technique. Hence, the proposed analytical methodologies align with the principles of Green Chemistry by requiring a simple sample preparation, avoiding the use of reagents and solvents, and reducing waste generation. Moreover, special attention can be given to NIR spectroscopy, as it offers a cost-effective analytical tool that can be explored <em>in situ</em> using a portable miniaturized device in the future.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 37-46"},"PeriodicalIF":1.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical differences in wild and cultivated fruits of the ethnobotanical medicine black wolfberry (Lycium ruthenicum)","authors":"Mingzhu Li ,&nbsp;Weidong Wang ,&nbsp;Huilan Yue ,&nbsp;Huaixiu Wen ,&nbsp;Jiangyong Qu ,&nbsp;Zenggen Liu","doi":"10.1016/j.phytol.2024.09.006","DOIUrl":"10.1016/j.phytol.2024.09.006","url":null,"abstract":"<div><div><em>Lycium ruthenicum</em> Murr. (LR) is a notable medicinal and edible plant from Northwest China, rich in bioactive compounds. However, the phytochemical and metabolic differences between wild and cultivated LR are not well understood. This study used untargeted metabolomics to reveal the differences in metabolite accumulation between wild and cultivated LR. Metabolomics results identified a total of 466 metabolites, with 153 showing differential accumulation. These differential metabolites were predominantly enriched in pathways related to secondary metabolite biosynthesis, phenylpropanoid biosynthesis, and arginine and proline metabolism. Cultivated LR contained higher levels of flavonoids, amino acids and derivatives, lipids, nucleotides and derivatives, lignans, coumarins, and tannins compared to wild LR. Conversely, wild LR had significantly higher contents of most phenolic acids, alkaloids, organic acids, and terpenoids than cultivated LR. With significant differences in soil composition between the two growing regions, variations in the accumulation of flavonoids and phenolic acids were observed between wild and cultivated LR fruits, indicating that soil conditions during growth likely influence their metabolite levels. Therefore, exploring the metabolites of wild and cultivated LR offers new insights for agricultural breeding and cultivation and supports further research into its quality formation and evaluation.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 47-55"},"PeriodicalIF":1.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhizomes of Rumex abyssinicus Jacq.: Unveiling five new anthraquinones (Rumabynosides A-E) and a review on hepatoprotective potential of its phytochemicals","authors":"Leopoldine T. Lonkeng ,&nbsp;Paul Eckhardt ,&nbsp;Borice.T. Tsafack ,&nbsp;Robert Forster ,&nbsp;Beaudelaire K. Ponou ,&nbsp;Rémy B. Teponno ,&nbsp;Télesphore B. Nguelefack ,&nbsp;Till Opatz ,&nbsp;Léon A. Tapondjou","doi":"10.1016/j.phytol.2024.09.004","DOIUrl":"10.1016/j.phytol.2024.09.004","url":null,"abstract":"<div><div>Five hitherto unreported anthraquinone glycoside derivatives, rumabynosides <strong>A–E</strong> (<strong>1–5</strong>), along with twenty previously reported compounds, were isolated from the rhizomes of <em>Rumex abyssinicus</em>. Three of these new anthraquinones carried an uncommon substituent (3-hydroxy-3-methylglutaroyl) attached to the sugar moiety. Their structures were elucidated by comprehensive UV, IR, HRESIMS, 1D NMR (¹H and ¹³C NMR) and 2D NMR (HSQC, COSY, HMBC, NOESY) analyses. A literature survey revealed hepatoprotective activities of some of the isolated compounds, thus adding weight to the wide use of this plant against various liver diseases in traditional medicine.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 30-36"},"PeriodicalIF":1.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesquiterpenes from the leaves of Artemisia argyi and evaluation of their in vitro anti-inflammatory activities","authors":"Wu Yi-xun ,&nbsp;Wang Xiao-wei ,&nbsp;Wang Hai-bo ,&nbsp;Qin Zi-Fei ,&nbsp;Jia An ,&nbsp;Wei Wen-jun ,&nbsp;Guo Tao","doi":"10.1016/j.phytol.2024.09.008","DOIUrl":"10.1016/j.phytol.2024.09.008","url":null,"abstract":"<div><div>Two unreported sesquiterpenoids, 7-en-13-hytanaphallin (<strong>1</strong>) and 8´-en-achillinin C (<strong>2</strong>) along with two known sesquiterpenoid dimers were obtained from chloroform parts in the leaves of <em>Artemisia argyi</em> Lévl. et Vant, belonging to Asteraceae family. The planar structures and absolute configurations of two new compounds were characterized by HR-ESI-MS, IR, 1D and 2D NMR, and electronic circular dichroism analyses. Two known sesquiterpenoids, argyinolide O (<strong>3</strong>) and (+)-8-acetylarteminolide (<strong>4</strong>), exhibited potent activities against NO production from LPS-induced RAW264.7 cells with IC₅₀ values of 3.6 and 9.8 μM, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 25-29"},"PeriodicalIF":1.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of four new phenolic compounds from the fungus Talaromyces cellulolyticus","authors":"Zhijun Song ,&nbsp;Dawei Chen ,&nbsp;Jungui Dai","doi":"10.1016/j.phytol.2024.09.003","DOIUrl":"10.1016/j.phytol.2024.09.003","url":null,"abstract":"<div><div>Four new phenolic compounds talarocelic A–D (<strong>1</strong>–<strong>4</strong>), together with four known compounds (<strong>5</strong>–<strong>8</strong>) were isolated from the fungus <em>Talaromyces cellulolyticus</em> CBS136886. Their chemical structures were elucidated through extensive spectroscopic data analysis such as HR-ESI-MS, UV, IR, and 1D- and 2D-NMR. Biological assay results revealed that compound <strong>6</strong> displayed potent protein tyrosine phosphatase 1B and <em>α</em>-glucosidase inhibitory activities with inhibition rates of 91.7 % and 59.6 %, respectively, at 10 μM. In addition, compound <strong>6</strong> showed moderate anti-inflammatory activity with 56.4 % inhibition at 10 μM and anti-bacterial activity against <em>Staphylococcus aureus</em> with a minimum inhibitory concentration of 12.5 μg/mL. This work not only reveals that <em>T. cellulolyticus</em> is rich in phenolic compounds but also provides access to diverse bioactive lead compounds for drug discovery.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 19-24"},"PeriodicalIF":1.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8’,9’-Bis-nor-neolignans from Cedrela odorata and their antiangiogenic activity","authors":"Valeria Iobbi ,&nbsp;Shiva Pouramin Arabi ,&nbsp;Angela Bisio ,&nbsp;Valeria D’Angelo ,&nbsp;Maria Paola Germanò ,&nbsp;Alessandra Braca ,&nbsp;Nunziatina De Tommasi","doi":"10.1016/j.phytol.2024.09.002","DOIUrl":"10.1016/j.phytol.2024.09.002","url":null,"abstract":"<div><div>Two previously undescribed 8’,9’-bis-<em>nor</em>-neolignans, 9-acetyltoonin C (<strong>1</strong>) and <em>threo</em>-guaiacylglycerol-β-methyl vanillate ether (<strong>2</strong>), were isolated from the stem bark of <em>Cedrela odorata</em> (Meliaceae), together with 4,5-dihydroblumenol A, 2-(3,4-dimethoxyphenyl)ethyl-β-<span>d</span>-glucopyranoside, scopoletin, homovanillic alcohol, and 7-megastigmene-3,6,9-triol. All compounds were characterized by 1D and 2D NMR and HRESIMS data. The new compounds and other lignans obtained from our chemical library, namely <em>erythro</em>-4,7,9,9’-tetrahydroxy-3,3’-dimethoxy-8-<em>O</em>-4’-oxyneolignan (<strong>3</strong>), urolignoside (<strong>4</strong>), secoisolariciresinol 9-<em>O</em>-β-D-glucopyranoside (<strong>5</strong>), icariside E₃, and <em>erythro</em>-4,7,9,9’-tetrahydroxy-3,3’-dimethoxy-8-<em>O</em>-4’-oxyneolignan-9’-<em>O</em>-β-D-glucopyranoside, were then evaluated for their antiangiogenic activity by the <em>in vivo</em> zebrafish embryos test. Compounds <strong>1</strong>, <strong>2</strong>, and <strong>3</strong> exhibited the best antiangiogenic response, while <strong>4</strong> and <strong>5</strong> showed mild inhibitory effects on EAP release after treatment of zebrafish embryos. In particular, compound <strong>2</strong> induced an inhibition of 42.56 % at 10 μM, similarly to 2-methoxyestradiol used as reference compound.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 13-18"},"PeriodicalIF":1.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-target anticancer activity of compounds isolated from galls of Pistacia chinensis subsp. integerrima: A mechanistic investigation","authors":"Abdur Rauf ,&nbsp;Majid Khan ,&nbsp;Arsalan Nizamani ,&nbsp;Humaira Hussain ,&nbsp;Zuneera Akram ,&nbsp;Yahya S. Al-Awthan ,&nbsp;Hassan A. Hemeg ,&nbsp;Omar S. Bahattab ,&nbsp;Giovanni Ribaudo","doi":"10.1016/j.phytol.2024.09.001","DOIUrl":"10.1016/j.phytol.2024.09.001","url":null,"abstract":"<div><p>The usage of <em>Pistacia chinensis</em> subsp. <em>integerrima</em> (J.L. Stewart) Rech. f. and its extracts in traditional medicine is well-documented, since this plant is known for its anti-infective, antidiabetic and antioxidant properties. Additionally, recent studies described the antiproliferative activity of its extracts on cancer cell models. Nevertheless, the mechanisms of action underlying this biological effect still have to be fully elucidated. In this study, we focused our attention on the characterization of the bioactivity profile of the flavonoids spinacetin (<strong>1</strong>) and patuletin (<strong>2</strong>) and of the triterpene pistagremic acid (<strong>3</strong>) extracted from the galls of <em>P. integerrima</em>. The compounds were tested <em>in vitro</em> against aldose reductase and thymidine phosphorylase, two targets that are attracting growing attention in the field of drug discovery due to their involvement in metabolism regulation and angiogenesis. Computational studies were used to rationalize experimental data, and the results support the potential of spinacetin (<strong>1</strong>) as a promising bioactive multi-target anticancer agent.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 6-12"},"PeriodicalIF":1.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcements of the Phytochemical Society of Europe","authors":"","doi":"10.1016/S1874-3900(24)00130-7","DOIUrl":"10.1016/S1874-3900(24)00130-7","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages I-III"},"PeriodicalIF":1.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024001307/pdfft?md5=79976aceaa879c02b41b243442079c51&pid=1-s2.0-S1874390024001307-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and antifungal activity assessment of natural compounds from the culture medium of actinobacterium Streptomyces sp. BC129-2","authors":"Ming-Jen Cheng ,&nbsp;Jih-Jung Chen ,&nbsp;Hsia-Wei Liu ,&nbsp;Jyh-Yih Leu ,&nbsp;Ming-Der Wu ,&nbsp;Min Tseng","doi":"10.1016/j.phytol.2024.08.002","DOIUrl":"10.1016/j.phytol.2024.08.002","url":null,"abstract":"<div><p>Two previously undescribed compounds, including one phenylpropanoid derivative, BC129–2 (<strong>1</strong>) and one <em>p</em>-menthane analogue, <em>cis</em>-<em>p</em>-menthane-7,8-diol (<strong>2</strong>), were isolated from the EtOAc-soluble fraction of the culture broth of an actinomycete <em>Streptomyces</em> sp. BC129–2. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that 2 constituents (compounds <strong>1</strong> &amp; <strong>2</strong>) possessed mild antifungal activity against <em>Fusarium</em> sp. LC8, <em>Neopestalotiopsis</em> sp. BCRC 35002, and <em>Colletotrichum gloeosporioides</em> BCRC 35178. It is worth mentioning that the chemical composition of the type strain <em>Streptomyces</em> sp. BC129–2 has never been studied.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 1-5"},"PeriodicalIF":1.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrogenous compounds from the Seeds of Sinapis alba","authors":"Xue Liu ,&nbsp;Degang Kong ,&nbsp;Liang Ding ,&nbsp;Honglei Zhou","doi":"10.1016/j.phytol.2024.08.009","DOIUrl":"10.1016/j.phytol.2024.08.009","url":null,"abstract":"<div><p>The dried and mature seeds of <em>Sinapis alba</em> were investigated. Two undescribed nitrogenous compounds, 3-(4′-hydroxybenzyloxy) pent-4-enenitrile (<strong>1</strong>), <em>N, N</em>-bis[(4-hydroxyphenyl)methyl] ethyl carbamate (<strong>2</strong>), together with two new natural products, <em>N</em>-(4-hydroxybenzyl) ethyl carbamate (<strong>3</strong>), 4-hydroxy-<em>N</em>-(4-hydroxyphenyl)benzeneacetamide (<strong>4</strong>), were isolated from the Seeds of <em>Sinapis alba</em>. The structures of the four compounds were elucidated by NMR and HR-ESI–MS analyses. The anti-inflammatory activity of compounds <strong>1</strong>, <strong>2</strong>, and <strong>4</strong> was screened using the zebrafish inflammation model induced by CuSO₄, which showed that compounds <strong>1</strong>, <strong>2</strong>, and <strong>4</strong> had obvious anti-inflammatory activity.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 101-106"},"PeriodicalIF":1.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}