花椒中具有抑制一氧化氮活性的苯丙素

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-07-31 DOI:10.1016/j.phytol.2025.103024

Feng-Jiao Tang , Wei Wei , Bang-Yong Wang , Wei Zou , Qin-Gang Tan

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引用次数: 0

摘要

从花椒根中分离得到了一种新的苯基丙素zanitether(1)，并鉴定了22个已知化合物（2 ~ 23）。直流。抗炎评价显示，化合物1和6剂量依赖性地抑制脂多糖（LPS）刺激的RAW264.7巨噬细胞中一氧化氮（NO）的释放。1和6与关键靶点诱导型一氧化氮合酶（iNOS）的分子对接分析显示，在酶的活性位点有良好的结合作用，支持它们作为抗炎药的潜力。

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Phenylpropanoids with nitric oxide inhibitory activity from Zanthoxylum nitidum

A new phenylpropanoid zanitether (1), along with 22 known compounds (2−23), was isolated and characterized from the roots of Zanthoxylum nitidum (Roxb.) DC. Anti-inflammatory evaluation revealed that compounds 1 and 6 dose-dependently suppressed nitric oxide (NO) release in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Molecular docking analysis of 1 and 6 against the key target inducible nitric oxide synthase (iNOS) revealed favorable binding interactions at the enzyme’s active site, supporting their potential as anti-inflammatory agents.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.