Phytochemistry Letters最新文献

Extraction and assessment of antifungal properties of natural products from the culture medium of Trichoderma sp. 18F0056 从毛霉 18F0056 培养基中提取天然产物并评估其抗真菌特性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-25 DOI: 10.1016/j.phytol.2024.10.009

Ming-Jen Cheng , Jih-Jung Chen , Hsia-Wei Liu , Ming-Der Wu , Yu-Hui Wei , Guey-Yuh Liou , Min Tseng

引用次数: 0

Two new compounds from Apiospora xenocordella culture medium and their inhibitory effects on TNF-α-induced ROS generation and MMP-1 secretion 从 Apiospora xenocordella 培养基中提取的两种新化合物及其对 TNF-α 诱导的 ROS 生成和 MMP-1 分泌的抑制作用

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-22 DOI: 10.1016/j.phytol.2024.11.005

Haeun Kwon , Hee Woon Ann , Jin Su Lee , Jaeyoung Kwon , Keunwan Park , Yuanqiang Guo , Bang Yeon Hwang , Jae-Jin Kim , Joung Han Yim , Il-Chan Kim , Dae Sik Jang , Sullim Lee , Dongho Lee

{"title":"Two new compounds from Apiospora xenocordella culture medium and their inhibitory effects on TNF-α-induced ROS generation and MMP-1 secretion","authors":"Haeun Kwon , Hee Woon Ann , Jin Su Lee , Jaeyoung Kwon , Keunwan Park , Yuanqiang Guo , Bang Yeon Hwang , Jae-Jin Kim , Joung Han Yim , Il-Chan Kim , Dae Sik Jang , Sullim Lee , Dongho Lee","doi":"10.1016/j.phytol.2024.11.005","DOIUrl":"10.1016/j.phytol.2024.11.005","url":null,"abstract":"<div><div>A new cytosporin derivative (<strong>1</strong>) and a new phenolic compound (<strong>2</strong>), together with cytosporin D (<strong>3</strong>), were isolated from an EtOAc extract of <em>Apiospora xenocordella</em> culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structures of the new compounds were determined by using MS and NMR spectroscopic techniques, and the absolute configurations were established by the modified Mosher’s method and quantum chemical calculation of electronic circular dichroism. UV radiation activates pro-inflammatory cytokines, such as TNF-α, a major contributor to skin aging through ROS generation and MMP-1 secretion. Cytosporin D (<strong>3</strong>) exhibited the inhibition of TNF-α-induced ROS and MMP-1. UV radiation activates pro-inflammatory cytokines including TNF-α which is a major contributor to skin aging through reactive oxygen species (ROS) generation and matrix metalloproteinase-1 (MMP-1) secretion. Cytosporin D (<strong>3</strong>) exhibited moderate inhibition against TNF-α-induced ROS and MMP-1. This compound docked computationally into the active site of MMP-1 (−5.9 kcal/mol). Compound <strong>1</strong>, though not tested due to limited quantity, showed a docking simulation result (−6.0 kcal/mol) similar to cytosporin D (<strong>3</strong>), indicating potential activity.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 38-43"},"PeriodicalIF":1.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The untargeted metabolomic analysis of Ammodaucus leucotrichus Coss. & Dur. seeds reveals previously undescribed polar lignans and terpenoids Ammodaucus leucotrichus Coss. & Dur.种子的非靶向代谢组分析揭示了以前未曾描述过的极性木脂素和萜类化合物

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-21 DOI: 10.1016/j.phytol.2024.11.006

Musa Kisiriko , Gabin T.M. Bitchagno , Clarice Noleto-Dias , Imane Naboulsi , Maria Anastasiadi , Leon A. Terry , Mansour Sobeh , Michael H. Beale , Jane L. Ward

{"title":"The untargeted metabolomic analysis of Ammodaucus leucotrichus Coss. & Dur. seeds reveals previously undescribed polar lignans and terpenoids","authors":"Musa Kisiriko , Gabin T.M. Bitchagno , Clarice Noleto-Dias , Imane Naboulsi , Maria Anastasiadi , Leon A. Terry , Mansour Sobeh , Michael H. Beale , Jane L. Ward","doi":"10.1016/j.phytol.2024.11.006","DOIUrl":"10.1016/j.phytol.2024.11.006","url":null,"abstract":"<div><div>The polar metabolome of the medicinal plant <em>Ammodaucus leucotrichus</em> Coss. & Dur. has not been comprehensively characterised. In this study, the chemical composition of a water/methanol (4:1) extract of seeds was determined through a combination of UHPLC-MS and NMR techniques. Sixty compounds were identified from the extract with 36 of these confirmed using UHPLC-MS and/or NMR data while the remaining 24 were given putative identifications based on UHPLC-MS data. The compounds included lignans, terpenes, phenolics, flavonoids, and alkaloid derivatives together with some amino- and organic acids. Of these 2 terpenoids and 3 lignans were found to be novel and were isolated and structures determined by comprehensive NMR studies. A further novel lignan glycoside was tentatively identified. Together these data represent the most comprehensive profile of this traditional medicinal plant, providing an annotated profile that can form the basis of future correlative metabolomic investigations to determine active principles behind its reported bioactivities.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 28-37"},"PeriodicalIF":1.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new furanoditerpene from Saururus chinensis aerial parts 从金鸡纳树气生部分提取的一种新的呋喃二萜

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-20 DOI: 10.1016/j.phytol.2024.11.009

Thi Tu Oanh Nguyen , Thi Minh Hang Nguyen , Mai Thao Vu , Yohan Seo , SeonJu Park , Van Cuong Pham , Van Hung Nguyen , Xuan Nhiem Nguyen

引用次数: 0

Two hispidin dimers from Piptoporellus baudonii (Fomitopsidaceae) with anticancer activity 具有抗癌活性的 Piptoporellus baudonii（Fomitopsidaceae）中的两种糙二丁二聚体

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-15 DOI: 10.1016/j.phytol.2024.11.002

Jenifer Reine Ngnouzouba Kuete , Olyvia Gwladys Fadeyi , Boris Armel Olou , Frank Wilson Tiatsop Kenmoe , Bienvenu Tsakem , Rémy Bertrand Teponno , Léon Azefack Tapondjou , Simeon Fogue Kouam , Nourou Soulemane Yorou

{"title":"Two hispidin dimers from Piptoporellus baudonii (Fomitopsidaceae) with anticancer activity","authors":"Jenifer Reine Ngnouzouba Kuete , Olyvia Gwladys Fadeyi , Boris Armel Olou , Frank Wilson Tiatsop Kenmoe , Bienvenu Tsakem , Rémy Bertrand Teponno , Léon Azefack Tapondjou , Simeon Fogue Kouam , Nourou Soulemane Yorou","doi":"10.1016/j.phytol.2024.11.002","DOIUrl":"10.1016/j.phytol.2024.11.002","url":null,"abstract":"<div><div>Chemical analysis of the ethanol extract from the stromata of <em>Piptoporellus baudonii</em> led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (<strong>1</strong>) and laetipohispidin (<strong>2</strong>) together with two known terpenoids: ergosterol (<strong>3</strong>) and eburicoic acid (<strong>4</strong>). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite <strong>1</strong> was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds <strong>1</strong> and <strong>2</strong> were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (<strong>1</strong>) exhibited a moderate activity against all the tested human cancer cell lines with IC<sub>50</sub> values ranging from 25.79 to 73.41 µM.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 19-23"},"PeriodicalIF":1.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-15 DOI: 10.1016/S1874-3900(24)00157-5

引用次数: 0

Two new phenolic glycosides from the rhizomes of Paris yunnanensis 从云南巴黎根茎中提取的两种新的酚醛苷类化合物

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-14 DOI: 10.1016/j.phytol.2024.11.007

Yu-Rui Xie , Shan-Shan Ling , Yan-Xi Li , Mei-Ru Wang , Hai-Yang Liu

引用次数: 0

New yellow pigments related to the pitholides from the Endophyte Sordariomycetes sp. 内生菌索达里真菌（Sordariomycetes sp.

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-12 DOI: 10.1016/j.phytol.2024.11.008

Kousei Shimizu , Reo Takahashi , Zulfikar , Mayuka Hakozaki , Yuko Kanno , Shota Uesugi , Takuya Koseki , Yoshihito Shiono

引用次数: 0

Chalcones, flavonoids, and aristolactam alkaloids from Friesodielsia kingii and their biological activities 来自 Friesodielsia kingii 的查耳酮、类黄酮和马兜铃内酰胺生物碱及其生物活性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-12 DOI: 10.1016/j.phytol.2024.11.004

Sorraya Champakam , Virayu Suthiphasilp , Brian O. Patrick , Zi Han Loh , Tharakorn Maneerat , Thidarat Duangyod , Rawiwan Charoensup , Panom Winyayong , Phunrawie Promnart , Sarot Cheenpracha , Siau Hui Mah , Raymond J. Andersen , Surat Laphookhieo

{"title":"Chalcones, flavonoids, and aristolactam alkaloids from Friesodielsia kingii and their biological activities","authors":"Sorraya Champakam , Virayu Suthiphasilp , Brian O. Patrick , Zi Han Loh , Tharakorn Maneerat , Thidarat Duangyod , Rawiwan Charoensup , Panom Winyayong , Phunrawie Promnart , Sarot Cheenpracha , Siau Hui Mah , Raymond J. Andersen , Surat Laphookhieo","doi":"10.1016/j.phytol.2024.11.004","DOIUrl":"10.1016/j.phytol.2024.11.004","url":null,"abstract":"<div><div>A new chlorinated-chalcone derivative, friesokinone A (<strong>1</strong>), and a new 3-flavene, friesokinone B (<strong>20</strong>), together with 18 known compounds (<strong>2</strong>–<strong>19</strong>), were isolated from the twigs and leaves of <em>Friesodielsia kingii</em> (J. Sinclair) Steenis<em>.</em> The dehydration of 5-methoxy-8-formyl-4,7-dihydroxy-6-methylflavan (<strong>13</strong>) to <strong>20</strong> suggests the possibility that <strong>20</strong> may be an artifact. The structures of the new compounds were elucidated based on spectroscopic data and HRESITOFMS data. In addition, the structures of <strong>1</strong> and <strong>13</strong> were confirmed by single-crystal X-ray diffraction crystallography. Compounds isolated in sufficient quantities underwent evaluation for their nitric oxide (NO) production inhibitory, glucose consumption, and glucose uptake activities. Compounds <strong>2</strong>–<strong>5</strong> possessed NO production inhibition with IC<sub>50</sub> values ranging from 17.3 to 27.6 <em>μ</em>M. Notably, compound <strong>2</strong> exhibited the strongest inhibitory effect on NO production. Compound <strong>9</strong> promoted good activities for glucose consumption with an IC<sub>50</sub> value of 73.9 <em>μ</em>M and glucose uptake with a ratio of 2.0-fold.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 5-9"},"PeriodicalIF":1.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaloids from Dendrobium nobile and their anti-inflammatory activities 金钗石斛中的生物碱及其抗炎活性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2024-11-11 DOI: 10.1016/j.phytol.2024.11.003

Zao-Yu Xu , Chao-Fan Wang , Wen Li , Nan Fu , Rui Zhan

引用次数: 0