Phytochemistry Letters最新文献

{"title":"Announcements of the Phytochemical Society of Europe","authors":"","doi":"10.1016/S1874-3900(26)00113-8","DOIUrl":"10.1016/S1874-3900(26)00113-8","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"74 ","pages":"Article 104223"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesquiterpenoids with anti-neuroinflammatory effects in vitro from Laggera alata","authors":"Xingxi Li,&nbsp;Wenhao Qiao,&nbsp;Qian Yang,&nbsp;Mingzhu Hu,&nbsp;Enhui Wang,&nbsp;Rongping Zhang,&nbsp;Xinglong Chen","doi":"10.1016/j.phytol.2026.104114","DOIUrl":"10.1016/j.phytol.2026.104114","url":null,"abstract":"<div><div>A total of four sesquiterpenoids were isolated and identified from <em>Laggera alata</em>. Compounds <strong>1</strong> and <strong>2</strong> were previously undescribed compounds. The absolute configuration of compounds <strong>3</strong> and <strong>4</strong> were deduced for the first time. The new compounds were characterized using HRESIMS NMR, and ECD methods. They were (2<em>S</em>,4 <em>R</em>,5<em>S</em>,7<em>S</em>)-3-methoxy-arimophane-1(10),11(13)-diene-12-acid (<strong>1</strong>) and (7<em>S</em>,10<em>S</em>)-eudesmane-4,11(13)-diene-3-one-12-acid (<strong>2</strong>). All compounds were evaluated for their anti-neuroinflammatory activities on LPS-induced BV2 cells. Compound <strong>2</strong> exhibited significant anti-neuroinflammatory activity at concentrations of 10, 20, and 40 <em>μ</em>M. Only compounds <strong>1</strong>, <strong>3</strong>, and <strong>4</strong> showed anti-neuroinflammatory activity at a concentration of 40 <em>μ</em>M. These results confirm that <em>L. alata</em> contains sesquiterpenoids, which demonstrate potential anti-neuroinflammatory properties, thereby establishing a pharmacological foundation for combating neuroinflammation.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104114"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural diversity and cytotoxic secondary metabolites from the endophytic fungus Chaetomium globosum","authors":"Yizhou Bian ,&nbsp;Sulu Qin ,&nbsp;Shan Ran ,&nbsp;Tao Zhu ,&nbsp;Haiyan Fu ,&nbsp;Wenjing Wang ,&nbsp;Xiaolong Yang","doi":"10.1016/j.phytol.2026.104119","DOIUrl":"10.1016/j.phytol.2026.104119","url":null,"abstract":"<div><div>Chemical investigation of the endophytic fungus <em>Chaetomium globosum</em> yielded two undescribed compounds: biscognin C (<strong>1</strong>), identified as a methyl-migrated analogue of biscognin B, and a rare ethyl-substituted dihydropyran derivative (<strong>2</strong>), together with seven known compounds (<strong>3</strong>−<strong>9</strong>). Their structures were unambiguously established through NMR, UV, HRESIMS, and ECD analysis. Compound <strong>1</strong> represents the first reported methyl-migrated biscognin analog, while compound <strong>2</strong> possesses an ethyl substitution distinct from dihydrodehydroacetic acid. Notably, the known compound <strong>3</strong> exhibited potent cytotoxicity against triple-negative breast cancer cells (MDA-MB-231) with an IC₅₀ value of 1.64 <em>μ</em>M. These findings expand the structural diversity of fungal secondary metabolites and highlight their potential as anticancer agents.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104119"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three new pregnane alkaloids from Sarcococca hookeriana","authors":"Li-xia Zhang ,&nbsp;Xiao-hui Sun ,&nbsp;Gang Ke ,&nbsp;Fang-you Chen ,&nbsp;Ya-mei Zhang ,&nbsp;Pu-zhao Zhang","doi":"10.1016/j.phytol.2026.104117","DOIUrl":"10.1016/j.phytol.2026.104117","url":null,"abstract":"<div><div>Three new pregnane alkaloids, 3<em>β</em>,20<em>α</em>-bis(dimethylamino)pregn-4,6-diene (<strong>1</strong>), 20(<em>S</em>)-20-hydroxy-3<em>β</em>-<em>N</em>,<em>N</em>-dimethylamino-pregn-4,6-diene-16-one (<strong>2</strong>), 3<em>β</em>-senecioylamnino-20<em>α</em>-<em>N</em>,<em>N</em>-dimethylamino-6<em>α</em>-hydroxy-pregn-4-ene (<strong>3</strong>), was isolated from <em>Sarcococca hookeriana</em>. The chemical structures of <strong>1–3</strong> were elucidated following analysis of spectral data. Compound <strong>1</strong> demonstrated cytotoxic effect against human glioblastoma U251 cells with IC₅₀ value of 7.28 <em>μ</em>M with temozolomideused as a positive control (IC₅₀ = 220 <em>μ</em>M).</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104117"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146025198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effect of jasmonic and salicylic acids foliar spray on the galanthamine and lycorine content and biological characteristics in Galanthus elwesii Hook” [Phytochem. Lett. 57 (2023) 140–150]","authors":"Ebru Batı Ay ,&nbsp;Muhammed Akif Açıkgöz ,&nbsp;Beril Kocaman ,&nbsp;Saadet Koç Güler","doi":"10.1016/j.phytol.2026.104134","DOIUrl":"10.1016/j.phytol.2026.104134","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104134"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass spectrometry-guided isolation of naphthalenoid pulvinic acids from the Ectomycorrhizal Fungus Pisolithus arhizus","authors":"Armelle T. Tsamo ,&nbsp;Pierre Le Pogam ,&nbsp;André L. Njouonkou ,&nbsp;Jérome Vanheuverzwijn ,&nbsp;Panagiotis Tsampanis ,&nbsp;Véronique Fontaine ,&nbsp;Karine Leblanc ,&nbsp;Somia Rharrabti ,&nbsp;Pierre Mkounga ,&nbsp;Augustin E. Nkengfack ,&nbsp;Mehdi A. Beniddir","doi":"10.1016/j.phytol.2026.104123","DOIUrl":"10.1016/j.phytol.2026.104123","url":null,"abstract":"<div><div><em>Pisolithus arhizus</em> is a worldwide distributed ectomycorrhizal fungus used in traditional medicine for wound healing and antimicrobial properties. It is also known for natural dye production, ecological significance, and ectomycorrhizal associations that detoxify polluted soils and support plant growth. In this study, an integrated dereplication strategy combining liquid chromatography-tandem mass spectrometry (LC-MS²) with molecular networking was employed to investigate the phytochemical profile of the dichloromethane-methanol crude extract from the fruiting bodies of <em>Pisolithus arhizus</em> (Sclerodermataceae). The molecular networking analysis revealed distinct clusters of naphthalenoid pulvinic acid derivatives and enabled the rapid targeting, isolation, structure elucidation, and identification of a previously undescribed pisoquinone close analogue, named methylpisoquinone (<strong>1</strong>), alongside the known norbadione A. The isolated compounds were evaluated for their antimicrobial activities against <em>Staphylococcus aureus</em>, <em>Escherichia coli</em>, <em>Candida albicans</em>, and <em>Mycobacterium bovis BCG</em>. Both compounds were inactive at the tested concentrations.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104123"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyarillosides A−C, three undescribed triterpenoid saponins from the roots of Polygala arillata","authors":"Tran Hong Quang ,&nbsp;Le Thi Vien ,&nbsp;Nguyen Thi Huong ,&nbsp;Ninh Thi Ngoc ,&nbsp;Dang Viet Anh ,&nbsp;Nguyen Hoang Nam ,&nbsp;Nguyen Thi Quynh Duong ,&nbsp;Nguyen Quoc Vuong ,&nbsp;Nguyen Thi Thanh Ngan","doi":"10.1016/j.phytol.2026.104133","DOIUrl":"10.1016/j.phytol.2026.104133","url":null,"abstract":"<div><div>The roots of the medicinal plant <em>Polygala arillata</em> have shown many therapeutic benefits, including the treatment of respiratory ailments such as cough, chronic bronchial asthma, whooping cough, cold, and rheumatism, as well as serving as a tonic. A phytochemical study of a methanol extract of <em>P. arillata</em> roots led to the isolation of three undescribed oleanane-type triterpenoid saponins (<strong>1 −3</strong>), named polyarillosides A−C, and 10 known analogs: arillatanoside E (<strong>4</strong>), tenuifolin (<strong>5</strong>), polyaureosides A−D (<strong>6 −9</strong>), arilloside A (<strong>10</strong>), polygalasaponin XXXIII (<strong>11</strong>), and arillatanosides A (<strong>12</strong>) and B (<strong>13</strong>). Their structures were identified by comprehensive analyses of the 1D and ²D NMR and MS spectra. Compounds <strong>8</strong> and <strong>10</strong> inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104133"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acorane-type sesquiterpenoids: A comprehensive review of their natural sources, structural diversity, and biological activities","authors":"Yhiya Amen ,&nbsp;Ahmed Othman","doi":"10.1016/j.phytol.2026.104139","DOIUrl":"10.1016/j.phytol.2026.104139","url":null,"abstract":"<div><div>Acorane-type sesquiterpenoids are a unique class of natural products characterized by a distinct spiro[4.5]decane carbon skeleton. This review provides a systematic overview of 159 acoranes isolated from 1961 to early 2025 across diverse natural sources, including terrestrial plants, marine organisms, and endophytic or deep-sea fungi. The structural diversity of this group is highlighted through various oxidation patterns, glycosylation, and rare rearrangements like the oxygen-bridged skeletons found in the proliferatorins. Furthermore, this review summarizes significant pharmacological advancements, ranging from nanomolar inhibition of 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1) by colletoic acid to potent anti-neuroinflammatory, antiviral, and cytotoxic activities. By consolidating over six decades of research, this work aims to guide future biosynthetic engineering and the therapeutic development of this promising scaffold.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104139"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid microwave-assisted synthesis of meroterpenoids from Psidium guajava","authors":"Kaori Ryu,&nbsp;Asuka Shimizu,&nbsp;Masashi Fukaya,&nbsp;Tetsuro Ito","doi":"10.1016/j.phytol.2026.104118","DOIUrl":"10.1016/j.phytol.2026.104118","url":null,"abstract":"<div><div>Meroterpenoids isolated from <em>Psidium guajava</em> (Myrtaceae) are expected to have many physiological activities due to their diverse condensation patterns and complex stereoisomers arising from asymmetric carbons. In this study, we focused on the biosynthetic pathway and succeeded in obtaining the meroterpenoids guajadial (<strong>1</strong>), psidial A (<strong>2</strong>), and a third diastereomer (<strong>3</strong>) in a simpler and faster manner using microwave-assisted synthesis. To the best of our knowledge, this is the first report of successful microwave-assisted syntheses of these meroterpenoids. Although the overall yield was lower than that of previously reported syntheses, the present method provides a rapid and practical approach for accessing structurally diverse meroterpenoids, thereby facilitating future studies on their stereochemistry and biological activity.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104118"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reaction of phytocannabinoids cannabigerol and cannabidiol with single electron transfer reagents","authors":"Chiara Collevecchio,&nbsp;Salvatore Genovese,&nbsp;Francesco Epifano,&nbsp;Serena Fiorito","doi":"10.1016/j.phytol.2026.104137","DOIUrl":"10.1016/j.phytol.2026.104137","url":null,"abstract":"<div><div>The oxidation reaction of two common and widespread phytocannabinoids, namely cannabigerol <strong>1</strong> and cannabidiol <strong>2</strong> with a panel of four single electron transfer reagents has been revised and further investigated. A certain degree of selectivity of the process described herein has been recorded. The fate of the reaction largely depends on the solvent used and the type of reagent. Thus, when cerium ammonium nitrate was employed, the mononitro derivatives <strong>3</strong> and <strong>4</strong> of both <strong>1</strong> and <strong>2</strong> were obtained when the process was carried out in CH₃CN, while cannabigeroquinone <strong>5</strong> and cannabidiolquinone <strong>6</strong> were the only products when Et₂O was used as the solvent. Mn(OAc)₃ yielded cannabigeroquinone <strong>5</strong> from cannabigerol <strong>1</strong>, while provided an inseparable mixture of products in the case of cannabigerol <strong>2</strong> as the substrate. Oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone resulted in the selective formation of cannabichromenequinone <strong>7</strong> from cannabigerol <strong>1</strong>, while cannabidiol <strong>2</strong> yielded an inseparable mixture of products also in this case. Finally, the reaction with 2,2,6,6-(tetramethylpiperidin-1-yl)oxyl free radical provided selectively the two quinones <strong>5</strong> and <strong>6</strong> from cannabigerol <strong>1</strong> and cannabidiol <strong>2</strong>, respectively. Yields of the above mentioned adducts ranged from 70 % to 90 %. Notably, while quinone forms and cyclized adducts like compounds <strong>5–7</strong> have been already described in the literature, nitro functionalization of phytocannabinoids as in 2-[(2<em>E</em>)-3,7-dimethylocta-2,6-dienyl]-4-nitro-5-pentylbenzene-1,3-diol <strong>3</strong> and 2-[(1 R,6 R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-nitro-5-pentylbenzene-1,3-diol <strong>4</strong> is disclosed herein for the first time.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104137"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}