Lin-Fen Ding , Yi-Fan Shen , Qiu-Hua Wang , Qiu-Ye Zhao , Shi-Huan Yin , Liu-Dong Song , Xing-De Wu
{"title":"Four new sesquiterpenoids from Michelia yunnanensis Franch. ex Finet & Gagnep. and their nitric oxide inhibitory activity","authors":"Lin-Fen Ding , Yi-Fan Shen , Qiu-Hua Wang , Qiu-Ye Zhao , Shi-Huan Yin , Liu-Dong Song , Xing-De Wu","doi":"10.1016/j.phytol.2025.102952","DOIUrl":"10.1016/j.phytol.2025.102952","url":null,"abstract":"<div><div>Four new sesquiterpenoids, named michelianins A-D (<strong>1</strong>-<strong>4</strong>), were isolated from the branches and leaves of <em>Michelia yunnanensis</em> Franch. ex Finet & Gagnep., along with seven known compounds (<strong>5</strong>-<strong>11</strong>). The chemical structures of <strong>1</strong>-<strong>4</strong> were elucidated through comprehensive analysis using <sup>1</sup>H, <sup>13</sup>C, and 2D NMR, HR-ESI-MS, and IR data. The absolute configuration of all the new compounds remained unidentified. Structurally, michelianin A was a rare michampane sesquiterpenoid possessing a bicyclo[6.2.0]decane motif, and michelianins C and D were farnesane sesquiterpenoids containing a ditetrahydrofuran moiety. Compounds <strong>1</strong>-<strong>11</strong> were tested for their nitric oxide (NO) inhibitory activity. Among them, compound <strong>7</strong> displayed moderate inhibitory effect toward LPS-induced NO release in RAW 264.7 cells with an inhibitory rate of 47.63 % at a concentration of 50 <em>μ</em>M.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102952"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minghui Li , Hui Chai , Tianxiang Chao , Jianye Huang , Limin Han , Qingwang Liu , Lu Yang
{"title":"NMR-based metabolomics unveils the potential mechanism of tetrahydroxy stilbene glycoside in combating D-galactose-induced aging in rats","authors":"Minghui Li , Hui Chai , Tianxiang Chao , Jianye Huang , Limin Han , Qingwang Liu , Lu Yang","doi":"10.1016/j.phytol.2025.102955","DOIUrl":"10.1016/j.phytol.2025.102955","url":null,"abstract":"<div><div>Aging represents a significant threat to human health, underscoring the critical need for effective anti-aging interventions. In this study, we utilized a comprehensive approach combining ¹H NMR-based metabolomics, serum biochemical analysis, and liver histopathology to evaluate the protective effects of tetrahydroxy stilbene glycoside (TSG) on D-galactose-induced aging in rats. Our findings demonstrate that TSG significantly enhances antioxidant activity and alleviates D-galactose-induced liver damage. Metabolomic analysis revealed increased levels in 3-hydroxybutyrate, succinate, and tryptophan, alongside decreased levels in alanine, arginine, and acetate, in the serum of aging rats. TSG treatment effectively reversed these metabolic perturbations. Further pathway analysis indicated that TSG restored balance in several key metabolic pathways, such as phenylalanine and tyrosine metabolism, betaine metabolism, carnitine synthesis, and methionine metabolism. In summary, TSG not only bolstered antioxidant defenses and alleviated liver injury but also normalized metabolic dysregulation in aging rats. These findings highlight TSG's potential as a promising anti-aging agent and support its further exploration for clinical applications.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102955"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Yüzbaşıoğlu Baran , Nadire Özenver , Ayşe Kuruüzüm-Uz , L. Ömür Demirezer
{"title":"Acetyl alkannin: A promising naphthoquinone derivative for breast cancer drug development research","authors":"Merve Yüzbaşıoğlu Baran , Nadire Özenver , Ayşe Kuruüzüm-Uz , L. Ömür Demirezer","doi":"10.1016/j.phytol.2025.102953","DOIUrl":"10.1016/j.phytol.2025.102953","url":null,"abstract":"<div><div>Acetyl alkannin, a naphthoquinone derivative, has emerged as a promising anticancer agent for the treatment of breast cancer. This study investigated the cytotoxic effects of acetyl alkannin on various breast cancer cell lines, including MCF-7, SK-BR-3, MDA-MB-231, and MDA-MB-468, and elucidated its mechanism of action. Acetyl alkannin demonstrated potent antiproliferative activity across all tested breast cancer cell lines, with particularly high efficacy against the SK-BR-3 cell line, as evidenced by low IC<sub>50</sub> values compared to the positive control, doxorubicin (IC<sub>50</sub>= 0.48 ± 0.02, 0.08 ± 0.004, respectively). Importantly, acetyl alkannin exhibited selective cytotoxicity, preserving non-cancerous cell lines such as H9c2 rat cardiomyoblast cells and MCF-10A human breast epithelial cells, highlighting its safety profile in contrast to positive control doxorubicin, which is known to cause cardiotoxicity. Mechanistic studies revealed that acetyl alkannin caused cell cycle arrest at the G1 phase, suggesting cell cycle disruption as a key mechanism of action. Notably, a significant dose-dependent increase in ROS production indicates oxidative stress as a contributing factor. However, mitochondrial membrane potential (MMP) remained unaffected, suggesting that acetyl alkannin induces cytotoxicity through a mitochondrial-independent pathway. Acetyl alkannin exhibited low caspase-3/7 activity, minimal DNA laddering, and statistically non-significant apoptosis based on Annexin V/PI staining in SK-BR-3 cells. These findings suggest that alternative cell death mechanisms, such as necroptosis, may contribute to the observed cytotoxicity, or that variations in treatment conditions, such as different concentrations or durations, could potentially enhance apoptotic responses.</div><div>Notably, acetyl alkannin maintained its cytotoxic effect in chemoresistant MDA-MB-231/BCRP cells, highlighting its potential to overcome chemoresistance.</div><div>These findings position acetyl alkannin as a promising candidate for further development as a novel anticancer agent, warranting future <em>in vivo</em> studies and clinical investigations to fully exploit its therapeutic potential in the treatment of breast cancer.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102953"},"PeriodicalIF":1.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui-Tzu Ni , Jih-Jung Chen , Hsia-Wei Liu , Jyh-Yih Leu , Ming-Der Wu , Yu-Hui Wei , Min Tseng , Yuan-Hsiang Yu , Ming-Jen Cheng
{"title":"Antifungal Natural Products from the Culture Medium of Trichoderma orarium 18F0041","authors":"Hui-Tzu Ni , Jih-Jung Chen , Hsia-Wei Liu , Jyh-Yih Leu , Ming-Der Wu , Yu-Hui Wei , Min Tseng , Yuan-Hsiang Yu , Ming-Jen Cheng","doi":"10.1016/j.phytol.2025.102945","DOIUrl":"10.1016/j.phytol.2025.102945","url":null,"abstract":"<div><div>Fractionation of an EtOAc-soluble partition of a solid fermentation of the endophytic fungus <em>Trichoderma orarium</em> 18F0041 resulted in the isolation of two new compounds, a γ-butyrolactone, 5-hydroxy-3-(methoxymethyl)-4-methylfuran-2(5<em>H</em>)-one (<strong>1</strong>), and a methylpentanoid derivative, 5-ethoxy-4-hydroxy-3-methyl-5-oxopentanoic acid (<strong>2</strong>). Additionally, two further metabolites were also isolated for the first time from a natural source, namely 2-hydroxypyridin-3-yl acetate (<strong>3</strong>) and (+)-<em>rel</em>-(4<em>S</em>,5<em>S</em>)-4,5-dihydroxytetrahydro-2<em>H</em>-pyran-2-one (<strong>4</strong>). All structures were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that some of the constituents possessed mild antifungal activity against <em>Fusarium</em> sp. LC8, <em>Neopestalotiopsis</em> sp. BCRC 35002, and <em>Colletotrichum gloeosporioides</em> BCRC 35178. Previously, δ-valerolactone derivatives were rarely reported in the genus <em>Trichoderma</em>. The discovery of these compounds in the fermentation products of this new <em>Trichoderma</em> species is therefore highly significant. Natural products of <em>Trichoderma</em> warrant further investigation as potential antifungal agents for biocontrol applications.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102945"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hussain Shakeel Butt , Lucía Bada , Karl Egil Malterud , Kari Tvete Inngjerdingen , Helle Wangensteen
{"title":"New coumarins from a hot water extract of Daphne mezereum bark","authors":"Hussain Shakeel Butt , Lucía Bada , Karl Egil Malterud , Kari Tvete Inngjerdingen , Helle Wangensteen","doi":"10.1016/j.phytol.2025.102954","DOIUrl":"10.1016/j.phytol.2025.102954","url":null,"abstract":"<div><div>This study aimed to investigate the low-molecular weight compounds in a hot water extract of the bark of <em>Daphne mezereum</em> L. (Thymelaceae), a medicinal plant with a longstanding medicinal use in Scandinavia. Among the fourteen isolated compounds, two coumarin glycosides are reported for the first time, and four known compounds were reported in <em>D. mezereum</em> for the first time. Their structures were elucidated by NMR, HRESIMS and methanolysis. The new compounds were identified as 3-(2-(β-<span>d</span>-glucopyranosyloxy)-4-[(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl)oxy]phenyl)propanoic acid (<strong>9</strong>), and 7-hydroxycoumarin-5,8-di-β-<span>d</span>-glucopyranoside (<strong>11</strong>). Cytotoxic effects were assessed by the MTT assay, while the anti-inflammatory effects were assessed by measuring the inhibition of NO-release by dendritic cells. The results revealed negligible cytotoxic effect and NO-inhibitory activity of compounds <strong>9</strong> and <strong>11</strong>.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102954"},"PeriodicalIF":1.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rui Wu , Dong Lu , Xin Luan , Weidong Zhang , Zhe Sun
{"title":"Ginsenoside F2 inhibits MLCK to induce synthetic lethality in MYC-driven triple-negative breast cancer and pancreatic cancer","authors":"Rui Wu , Dong Lu , Xin Luan , Weidong Zhang , Zhe Sun","doi":"10.1016/j.phytol.2025.102949","DOIUrl":"10.1016/j.phytol.2025.102949","url":null,"abstract":"<div><div>Myosin Light Chain Kinase (MLCK) represents a synthetic lethal interaction with the “undruggable” oncoprotein MYC. In this study, we identified Ginsenoside F2 (GF2) as a novel MLCK inhibitor through molecular docking-based virtual screening of a natural compound library, followed by in vitro cellular validation. GF2 treatment inhibited MLCK kinase activity, as demonstrated by the reduced phosphorylation of its substrate, myosin II regulatory light chain (MLC). The direct binding of GF2 to MLCK was confirmed using the cellular thermal shift assay (CETSA), which revealed decreased MLCK thermotolerance after GF2 treatment. Notably, GF2 selectively induced apoptosis in MYC-transformed cells while sparing normal counterparts. Triple-negative breast cancer (TNBC) and pancreatic cancer cells with high MYC expression are sensitive to GF2 treatment. Moreover, combining GF2 with the Bcl2 inhibitor venetoclax synergistically enhanced apoptosis in MYC-driven cancer cells. These findings establish GF2 as a novel MLCK inhibitor and underscore the therapeutic potential of targeting MLCK in MYC-driven malignancies, particularly TNBC and pancreatic cancer.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102949"},"PeriodicalIF":1.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiao-dan Pan , Yuan-he Huang , Li-yang Zhao , Wei-rui Wang , Bing-an Wei , Ying-ying Xu , Xian Wei
{"title":"Chemical constituents from the stems of Erythropalum scandens","authors":"Qiao-dan Pan , Yuan-he Huang , Li-yang Zhao , Wei-rui Wang , Bing-an Wei , Ying-ying Xu , Xian Wei","doi":"10.1016/j.phytol.2025.102947","DOIUrl":"10.1016/j.phytol.2025.102947","url":null,"abstract":"<div><div>The phytochemical investigation on the EtOH extract of the stems of an ethnological herbal medicine <em>Erythropalum scandens</em> Blume led to the isolation thirteen secondary metabolites. The chemical structures of isolated compounds were elucidated by various spectroscopic techniques. Among them, compound <strong>1</strong>, named scandenoside A (<strong>1</strong>), is a previously unreported aromatic glycoside. Compounds (<strong>3</strong>-<strong>7</strong>,<strong>9</strong>-<strong>10</strong>,<strong>12</strong>) were isolated from this plant for the first time. The inhibitory activity of the isolates against xanthine oxidase (XOD) was evaluated, with compound <strong>11</strong> exhibiting strong inhibitory activity and a half inhibitory concentration (IC<sub>50</sub>) value of 706.35 ± 18.36 µM. Molecular docking analyses revealed that the compound could bind within the active pocket of the XOD enzyme through hydrogen bonding and hydrophobic interactions. These results suggest that the stems of <em>E. scandens</em> may have a potentially beneficial effect on hyperuricemia.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102947"},"PeriodicalIF":1.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Song Bai , Miaohe Zhang , Miao Li , Suran Wan , Fang Wang , Shouyin Tang , Lijun Chen , Xian Wei , Rong Wu
{"title":"Investigation of antibacterial activity and mechanism of action: Design and synthesis of coumarin derivatives containing sulfonamide groups","authors":"Song Bai , Miaohe Zhang , Miao Li , Suran Wan , Fang Wang , Shouyin Tang , Lijun Chen , Xian Wei , Rong Wu","doi":"10.1016/j.phytol.2025.102948","DOIUrl":"10.1016/j.phytol.2025.102948","url":null,"abstract":"<div><div>In this innovative study, we combined coumarin with a sulfonamide group and synthesized a series of coumarin derivatives. I<em>n vitro</em> antibacterial activity tests, these derivatives demonstrated antibacterial potential, especially compound <strong>27</strong>, whose antibacterial effect was particularly remarkable. Our experimental results revealed that compound <strong>27</strong> enhanced bacterial cell membrane permeability by disrupting the cell membrane of <em>Xanthomonas oryzae pv. oryzicola</em>, thereby effectively inhibiting its growth and reproduction. This not only provides insights into our understanding of the mechanism of action of compound <strong>27</strong>, but also represents a breakthrough in the development of novel antibacterial agents, offering unlimited possibilities for the future of agriculture and medicine.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102948"},"PeriodicalIF":1.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federico Brucoli , Gael N.N. Neba Ambe , Avninder S. Bhambra , Randolph R.J. Arroo
{"title":"Chemopreventive properties of naturally occurring methoxylated resveratrol analogues","authors":"Federico Brucoli , Gael N.N. Neba Ambe , Avninder S. Bhambra , Randolph R.J. Arroo","doi":"10.1016/j.phytol.2025.03.001","DOIUrl":"10.1016/j.phytol.2025.03.001","url":null,"abstract":"<div><div>Whereas thousands of papers have been published on the cancer chemopreventive properties of resveratrol (3,5,4′-trihydroxy-<em>trans</em>-stilbene) and related monomeric stilbenoids, there still is no consensus on their mechanism of action in a dietary setting. A widely held assumption is that the naturally occurring <em>trans</em> stilbenoids act as phytoestrogens, and thus affect cell metabolism of estrogen sensitive cells. This is known to be the mechanism of action for Tamoxifen, a synthetic drug with a stilbene moiety at its core, which is now approved as a chemopreventive agent. The bioavailability of resveratrol is low, which means that the doses known to inhibit cell proliferation <em>in vitro</em> (IC<sub>50</sub> in the range 3–30 µM) are never reached <em>in vivo</em>. The cytotoxic activity of a methoxylated analogue of resveratrol, pterostilbene (3,5-dimethoxy-4’-hydroxy <em>trans</em> stilbene), is in the same range as resveratrol. However, the methoxylated <em>trans</em> stilbenoid appears have better pharmacokinetic properties. Still, its overall bioavailability <em>in vivo</em> seems insufficient to make it have any significant effect on modulation of carcinogenesis. Polymethoxylated <em>cis</em>-stilbenoids (combretastatins), in contrast to the <em>trans</em>-stilbenoids, are too cytotoxic to be considered as chemopreventive agents. Combretastatin A4 has been considered as a cancer therapeutic agent; it inhibits tubulin polymerization by interacting at the colchicine binding site of microtubules, a mechanism of action that is fundamentally different from that of the <em>trans</em>-stilbenoids. It may be speculated that naturally occurring <em>trans</em> stilbenoids selectively accumulate in precancerous cells, thus locally reaching sufficiently high levels. This hypothesis may be difficult to prove experimentally. Further clues on the material properties of stilbenoids will most likely come from synthetic chemistry, where a wide range of analogues can be investigated for structure–activity relationships.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102943"},"PeriodicalIF":1.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamie Selby-Pham , Kimber Wise , Sophie Selby-Pham
{"title":"Antioxidant capacity prediction: Combining individual compound capacities to predict plant-extract capacities","authors":"Jamie Selby-Pham , Kimber Wise , Sophie Selby-Pham","doi":"10.1016/j.phytol.2025.102951","DOIUrl":"10.1016/j.phytol.2025.102951","url":null,"abstract":"<div><div>The antioxidant activity of plant extracts offer potential for preventing and managing degenerative diseases linked to oxidative stress. Whilst the structure-function relationship of individual compound antioxidant capacities is well-established, accurate prediction of the overall antioxidant capacity of complex mixtures such as plant extracts, remains challenging. In this study, we sourced a data set of 68 plant extracts with empirically determined antioxidant capacities via the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay (ABTS assay) and paired quantitatively determined metabolite profiles. Using a previously developed Trolox equivalent antioxidant capacity (TEAC) model, we predicted the antioxidant capacities of each phytochemical within these profiles. We then employed polynomial regression with k-fold cross-validation (k = 10) to develop a model predicting the antioxidant capacity of the plant extracts. The model, which utilised the count and sum of individual compound capacities of antioxidant-capable phytochemicals to predict log<sub>10</sub>(TEAC), achieved an R<sup>2</sup> of 92.28 % and a 10-fold cross-validated R<sup>2</sup> of 74.49 %. When transformed back to TEAC (mM), the model resulted in an R<sup>2</sup> of 94.59 %, with 77.9 % of predictions within 20 % of their true values. These results demonstrate the utility of statistical models in predicting individual phytochemical antioxidant capacities and their contributions to food functional properties. Our model represents a significant advancement in predicting plant-extract antioxidant capacities from their phytochemical compositions, with implications for optimising functional food value through targeted modulation of phytochemical profiles or strategic blending (fortification) of plant extracts.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102951"},"PeriodicalIF":1.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}