Phytochemistry Letters最新文献

The synthesis of arylmethylene bisindoles catalyzed by nickel perchlorate as potential antifungal agent against Clarireedia homoeocarpa

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-24 DOI: 10.1016/j.phytol.2025.102966

Ye Zhou , Ruyuan Wang , Rui Feng , Bi Wang , Shu Xu , Mei Tian , Wenhao Liang , Jin Chen , Yu Chen , Xu Feng , Li Lin , Jinyue Luo , Jianlan Wang , Fei Liu

{"title":"The synthesis of arylmethylene bisindoles catalyzed by nickel perchlorate as potential antifungal agent against Clarireedia homoeocarpa","authors":"Ye Zhou , Ruyuan Wang , Rui Feng , Bi Wang , Shu Xu , Mei Tian , Wenhao Liang , Jin Chen , Yu Chen , Xu Feng , Li Lin , Jinyue Luo , Jianlan Wang , Fei Liu","doi":"10.1016/j.phytol.2025.102966","DOIUrl":"10.1016/j.phytol.2025.102966","url":null,"abstract":"<div><div>Arylmethylene bisindole alkaloids are predominantly found in cruciferous plants and as metabolites in marine organisms, exhibiting a diverse range of biological activities. In recent years, these alkaloids have been increasingly explored and utilized for controlling plant pathogenic fungi. However, the synthesis and underlying mechanisms, particularly their effectiveness against plant pathogens such as Clarireedia homoeocarpa, still require further investigation. In this study, a series of arylmethylene bisindoles were synthesized with high yield using aromatic aldehydes and indoles catalyzed by NiClO4·6H2O. These compounds showed spectral antibacterial activity against six major phytopathogenic fungi and A13 exhibiting the highest antifungal activity against C. homoeocarpa with an EC50 value of 0.74 mg/L. Furthermore, in vivo antifungal assays were performed to assess the efficacy of the active compounds against C. homoeocarpa. To elucidate the antifungal mechanism of arylmethylene bisindoles, a comprehensive analysis of physiological and biochemical indices, along with transcriptome profiling, was carried out to elucidate. The results demonstrated that A13 treatment can efficiently disrupt the cell membranes of C. homoeocarpa. Additionally, we identified and screened the candidate genes implicated in cell membrane alterations under A13 treatments. KEGG pathway analysis revealed that a considerable number of down-regulated DEGs were significantly enriched in metabolic pathways, biosynthesis of secondary metabolic, and ribosome biogenesis in eukaryotes. This research provides valuable insights for the effective management of lawn coin spot disease.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102966"},"PeriodicalIF":1.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new neolignans isolated from the endemic species Astracantha aitosensis

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-22 DOI: 10.1016/j.phytol.2025.102961

Yancho Zarev , Preslav Enchev , Rositsa Mihaylova , Georgi Momekov , Luc Pieters , Hans Michler , Iliana Ionkova

{"title":"Two new neolignans isolated from the endemic species Astracantha aitosensis","authors":"Yancho Zarev , Preslav Enchev , Rositsa Mihaylova , Georgi Momekov , Luc Pieters , Hans Michler , Iliana Ionkova","doi":"10.1016/j.phytol.2025.102961","DOIUrl":"10.1016/j.phytol.2025.102961","url":null,"abstract":"<div><div>Four compounds, a lignan 1, including two new neolignans 2 and 3, and one pterocarpan 4, were isolated from the arial parts of endemic Bulgarian species Astracantha aitosensis (syn. Astragalus aitosensis) (Ivan.) Fabaceae by means of conventional separation methods. The structure of those compounds was elucidated by means of spectroscopic methods, including 1D and 2D NMR, as well as HRESI-MS. Among the isolated compounds is a new neolignan (2) named astracandioxin and a new dihydrobenzofuran (3) named astracanamide, while for the maackiain-3-O-β-D-glucoside (4) this is the first report of isolation from the genus and for syringaresinol-4-O-β-D-glucoside (1) first report of isolation from A. aitosensis, respectively. The antiproliferative activity of the isolated compounds was assessed in a panel of human tumor cell lines of different origin.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102961"},"PeriodicalIF":1.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbonyl compounds and glycosides from the fruits of Alpinia oxyphylla as potential renoprotective agents

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-17 DOI: 10.1016/j.phytol.2025.102965

Xiao-Ning Liu , Yue-Tong Zhu , Bo-Tao Lu , Yong-Xian Cheng , Yan-Zhi Wang

引用次数: 0

New thiohydantoin derivatives from the roots of Lepidium meyenii

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-16 DOI: 10.1016/j.phytol.2025.102964

Wen-Xin Liu , Jun Li , Cheng-Juan Liao , Fu-Wen Yang , Hui-Chun Geng , Min Zhou

引用次数: 0

Isolation and structural elucidation of two novel lignans from the flowers of Gardenia jasminoides with potent α-glucosidase inhibitory activity 从具有强效α-葡萄糖苷酶抑制活性的栀子花中分离并阐明两种新型木脂素的结构

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-14 DOI: 10.1016/j.phytol.2025.102959

Qingsen Shao , Huiyu Li , Mingfeng Li , Wei Yi , Qiugui Zhou , Lijuan Zheng , Meng Wang , Hong-mei Hu , Chao Wen , Yun Tang , Wei Li

{"title":"Isolation and structural elucidation of two novel lignans from the flowers of Gardenia jasminoides with potent α-glucosidase inhibitory activity","authors":"Qingsen Shao , Huiyu Li , Mingfeng Li , Wei Yi , Qiugui Zhou , Lijuan Zheng , Meng Wang , Hong-mei Hu , Chao Wen , Yun Tang , Wei Li","doi":"10.1016/j.phytol.2025.102959","DOIUrl":"10.1016/j.phytol.2025.102959","url":null,"abstract":"<div><div>This research presents the isolation and structural elucidation of two novel lignans, designated as Jasminoside U (1) and Jasminoside W (2), from the flowers of Gardenia jasminoides. The structures of these compounds were determined using a comprehensive analytical approach that included NMR spectroscopy, HR-ESI-MS, and detailed analysis of ROE correlations and coupling constants. Additionally, the α-glucosidase inhibitory activities of compounds 1 and 2 were evaluated using a standard enzyme assay protocol. The assay results demonstrated that both Jasminoside U (1) and Jasminoside W (2) possess significant inhibitory effects on α-glucosidase, with IC50 values determined to be 266 and 323 μmol/L, respectively, indicating their potential as therapeutic agents for the treatment of diabetes and related metabolic disorders.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102959"},"PeriodicalIF":1.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isopimarane diterpene glycosides of endophytic fungus Xylaria sp. ZY-13 内生真菌 Xylaria sp. ZY-13 的异异丙基二萜苷类

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-14 DOI: 10.1016/j.phytol.2025.102963

Zhang Mingyue , Song Yongqi , Chen Xiaohui , Feng Yuxiao , Shi Jiaqi , Li Yonghui , Wang Shoudong , Guo Tao

引用次数: 0

Bioactive homoisoflavonoids from the fibrous roots of Ophiopogon japonicus

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-12 DOI: 10.1016/j.phytol.2025.102962

Li-Ping Feng , Zhan-Guo Li , Qian Ding , Chun Luo , Xue-Ping Lu , Xiao-Hui Li

引用次数: 0

A new β-caryophyllene type sesquiterpenoid pentoside with nine known compounds from the aerial parts of Biebersteinia heterostemon as a α-glucosidase inhibitor in vitro

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-11 DOI: 10.1016/j.phytol.2025.102956

Yu-hao Zhang , Deng-yi Du , Ruo-fei Bai , Cong-wei Zhou , Zi-jian Zhao , Shan-shan Yang

{"title":"A new β-caryophyllene type sesquiterpenoid pentoside with nine known compounds from the aerial parts of Biebersteinia heterostemon as a α-glucosidase inhibitor in vitro","authors":"Yu-hao Zhang , Deng-yi Du , Ruo-fei Bai , Cong-wei Zhou , Zi-jian Zhao , Shan-shan Yang","doi":"10.1016/j.phytol.2025.102956","DOIUrl":"10.1016/j.phytol.2025.102956","url":null,"abstract":"<div><div>To elucidate the chemical basis of the hypoglycemic activity of Biebersteinia heterostemon Maxim, a Tibetan folk medicinal herb, a new β-caryophyllene type sesquiterpenoid pentoside (1) and nine known compounds (2–10) were isolated from its aerial part, and their structures were identified by the use of UV, NMR and HR-MS analyses. Significantly, the compound 1 was isolated from this plant for the first time in the form of a pentaglycoside. The results of α-glucosidase inhibitory activity assays indicated that the compound 1, ethyl acetate fraction, compound 2 and remaining aqueous fraction exhibited weak inhibitory activity, with IC50 values of 2.46, 3.59, 4.87 and 5.03 mg/mL, respectively, all of which were weaker inhibitory activity than that of the positive control, acarbose (IC50 = 0.78 mg/mL). Among the tested samples, compound 1 displayed the most promising inhibitory activity, with an inhibition rate of 70.90 ± 6.07 % at a concentration of 5.0 mg/mL. In contrast, among the other isolated compounds, especially the flavonoid compounds (5–10), some showed low inhibitory activities, while others showed no inhibitory activity at all.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102956"},"PeriodicalIF":1.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaloid induction by the interaction between Annona purpurea Moc. & Sessé ex Dunal Curvularia lunata (Wakker) Boedijn and Rhizopus stolonifer Ehrenb. (Ex Fr.) Lind.

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-08 DOI: 10.1016/j.phytol.2025.102958

K.A. Toledo-González , C.A. Riley-Saldaña , R. Salas-Lizana , I. De-la-Cruz-Chacón , A.R. González-Esquinca

{"title":"Alkaloid induction by the interaction between Annona purpurea Moc. & Sessé ex Dunal Curvularia lunata (Wakker) Boedijn and Rhizopus stolonifer Ehrenb. (Ex Fr.) Lind.","authors":"K.A. Toledo-González , C.A. Riley-Saldaña , R. Salas-Lizana , I. De-la-Cruz-Chacón , A.R. González-Esquinca","doi":"10.1016/j.phytol.2025.102958","DOIUrl":"10.1016/j.phytol.2025.102958","url":null,"abstract":"<div><div>Annona purpurea is a species of the Annonaceae family that biosynthesizes more than 50 alkaloids, most of them with benzylisoquinoline structure. Some alkaloids perform defense functions and can be grouped from the ecological perspective as constitutive and induced metabolites. Induced metabolites are expressed in response to changes in abiotic or biotic conditions that trigger plant stress. Few studies have been conducted on alkaloid production as a function of biotic stress. In this work, the response of the alkaloid metabolism of A. purpurea seedlings to infection with fungi Curvularia lunata and Rhizopus stolonifer was analyzed. To determine the alkaloid profile, methanolic extracts were obtained from leaves, stems and roots of control and infected seedlings, which were analyzed by Gas Chromatography coupled to Mass Spectrometry. Chemical diversity was determined by the presence and organ-specific abundance and by means of the adapted ecological indices of Margalef, Shannon and Simpson. In addition, Principal Component Analysis (PCA), PERMANOVA and paired PERMANOVA were performed. Induced responses with C. lunata and especially with R. stolonifer were found. Results indicate that seedlings have an arsenal of available alkaloids, some of which respond according to the infecting phytopathogen.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102958"},"PeriodicalIF":1.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three new sesquiterpenes with cytotoxic activity from Croton tiglium

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-04-07 DOI: 10.1016/j.phytol.2025.102957

Wen-Ying Zhou , Xiao-Xiao Zheng , Yang-Mei Ou , Yang-Lin Ou , Hong-Yu Jang , Yu-Xin Peng , Yi-Yi Wang , Bi-Qing Zhao , Li Li

引用次数: 0