从长毛灵芝培养物中获得两对具有抗脂肪作用的新型异色罗曼酮衍生物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-09-06 DOI:10.1016/j.phytol.2025.103041

Yu-Jie Li , Xiao-Cui Liu , Yi Luo , Ming-Hua Qiu , Ping Zhao , Xing-Rong Peng

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引用次数: 0

摘要

两对未描述的异色甾酮衍生物，（）-ganogibbin A (1a), (+)-ganogibbin A (1b), (+)-ganogibbin B （2a）和（）-ganogibbin B （2b）首次从蘑菇Ganoderma gibbosum中分离得到。通过广泛的一维和二维核磁共振光谱、hremsims以及计算核磁共振和ECD方法获得了它们的结构，包括立体结构。进一步对化合物1和2的抗脂肪活性进行了评价，结果表明，化合物1和2在浓度为20 μM时可显著降低3T3-L1模型的脂质积累。此外，化合物2表现出浓度依赖性的抑制作用，并且在100 μM下没有毒性。

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Two pairs of novel isochromanone derivatives with antiadipogenic effects from the cultures of Ganoderma gibbosum

Two pairs of undescribed isochromanone derivatives, ()-ganogibbin A (1a), (+)-ganogibbin A (1b), (+)-ganogibbin B (2a), and ()-ganogibbin B (2b) were firstly isolated from the cultures of the mushroom Ganoderma gibbosum. Their structures including stereostructures were achieved by the extensive 1D and 2D NMR spectra, HRESIMS, and calculated NMR and ECD methods. Furthermore, antiadipogenic activities of compounds 1 and 2 were evaluated and the results showed that compounds 1 and 2 can significantly reduce the accumulation of lipid in the 3T3-L1 model at the concentration of 20 μM. Furthermore, compound 2 showed a concentration-dependent inhibition and had no toxicity at 100 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.