利用MS/MS-based分子网络技术发现从莪术中提取的一种新的降脂素衍生物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-09-20 DOI:10.1016/j.phytol.2025.103051

Nadiah Mad Nasir , Nur Kartinee Kassim , Hanan Hasan , Pavithren Devakrishnan , Intan Safinar Ismail

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引用次数: 0

摘要

Curculigo属是具有多种生物活性的次生代谢物的来源，包括抗糖尿病、抗菌、抗炎和抗氧化特性。本研究采用LC-MS/MS和分子网络（MN）分析方法对马来西亚西部的莪术进行了研究。在F14-17和L2中发现两个主要的聚类，去脂素和酚类苷。此外，本文还首次对其根茎部位中含量最多且具有抗氧化活性的化合物青葱苷元A与叶片部位中含量最多且具有抗金黄色葡萄球菌和枯草芽孢杆菌活性的化合物青葱苷元B进行了比较研究。我们分离了一种新的化合物curculatifolia(27)，使用mn引导方法并通过光谱技术（NMR， FTIR和MS）对其进行了表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Curculatifolia, a new norlignan derivative from Curculigo latifolia using MS/MS-based molecular networking discovery

The Curculigo genus is a source of secondary metabolites with various bioactivities, including antidiabetic, antibacterial, anti-inflammatory, and antioxidant properties. In this study, we investigated Curculigo latifolia from Western Malaysia using LC-MS/MS and molecular networking (MN) analysis. The analysis revealed two major clusters, norlignans and phenolic glycosides, in fractions F14–17 and L2. Furthermore, this paper presents the first comparative study of sinensigenin A, the most abundant compound in the rhizome fraction exhibiting antioxidant activity, and sinensigenin B, the most abundant compound in the leaf fraction, which demonstrates activity against Staphylococcus aureus and Bacillus subtilis. We isolated one new compound, curculatifolia (27), using an MN-guided approach and characterized it through spectroscopic techniques (NMR, FTIR, and MS).

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.