Phytochemistry Letters最新文献

{"title":"Flower colors and their anthocyanins in Platycodon grandiflorus (Jacq.) A. DC. (Campanulaceae)","authors":"Fumi Tatsuzawa ,&nbsp;Kanae Takahashi ,&nbsp;Hiroyuki Sano ,&nbsp;Haruka Seto ,&nbsp;Yuko Mitobe ,&nbsp;Toshio Ando","doi":"10.1016/j.phytol.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.002","url":null,"abstract":"<div><p>The flower colors and anthocyanin composition of three strains (consisting of 18 cultivars) of <em>Platycodon grandiflorus</em> (Jacq.) A. DC. were surveyed to assess the relationship between these two parameters. Eleven anthocyanins, four flavones, chlorogenic acid, and 1-<em>O</em>-(<em>trans</em>-caffeoyl)-β-glucopyranoside were isolated from the flowers of these cultivars, and their structures were identified using chemical and spectroscopic methods. Among them, three undescribed anthocyanins, i.e., cyanidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside]-7-<em>O</em>-[6-<em>O</em>-(4-<em>O</em>-(6-<em>O</em>-(4-<em>O</em>-(β-glucopyranosyl)-<em>trans</em>-caffeoyl)-β-glucopyranosyl)-<em>trans</em>-caffeoyl)-β-glucopyranoisde] (for convenience, we termed this undescribed anthocyanin as purproplatyconin), pelargonidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside]-7-<em>O</em>-[6-<em>O</em>-(4-<em>O</em>-(6-<em>O</em>-(4-<em>O</em>-(β-glucopyranosyl)-<em>trans</em>-caffeoyl)-β-glucopyranosyl)-<em>trans</em>-caffeoyl)-β-glucopyranoside] (for convenience, we termed this undescribed anthocyanin as rubroplatyconin), and pelargonidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside]-7-<em>O</em>-[6-<em>O</em>-(4-<em>O</em>-(β-glucopyranosyl)-<em>trans</em>-caffeoyl)-β-glucopyranoside], were discovered in the corollas of the ‘Astra Pink’ and ‘Omotenashi Pink’ cultivars. Moreover, pelargonidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside]-7-<em>O</em>-(β-glucopyranoside), pelargonidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside], cyanidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside], and delphinidin 3-<em>O</em>-[6-<em>O</em>-(α-rhamnopyranosyl)-β-glucopyranoside] were also discovered in these cultivars for the first time in <em>P. grandiflorus</em>. The structures, conditions, and concentrations of these anthocyanins, as well as their intramolecular co-pigmentation effects were considered to be responsible for the flower color variation observed in <em>P. grandiflorus</em> cultivars.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 125-134"},"PeriodicalIF":1.7,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000569/pdfft?md5=df925f3f9308b8f213c4f96b5324ce1a&pid=1-s2.0-S1874390024000569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata","authors":"Ting-Yu Cheng ,&nbsp;Chia-Jung Yang ,&nbsp;Po-Jen Chen ,&nbsp;Yu-Li Chen ,&nbsp;Bo-Rong Peng ,&nbsp;Te-An Kung ,&nbsp;Zhi-Hong Wen ,&nbsp;Kuei-Hung Lai ,&nbsp;Hsu-Ming Chung","doi":"10.1016/j.phytol.2024.03.015","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.015","url":null,"abstract":"<div><p>Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (<strong>1</strong>) and B (<strong>2</strong>), were isolated from the soft coral <em>Capnella imbricata</em> in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, ¹H NMR, and ¹³C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids <strong>1</strong> and <strong>2</strong> exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 115-119"},"PeriodicalIF":1.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140549206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory activity of organic acids from the seeds of Phaseolus lunatus L.","authors":"Kun Li ,&nbsp;Jin-hui Bian ,&nbsp;Heng Wu ,&nbsp;Ya-lan Wang ,&nbsp;Yun-jia Feng ,&nbsp;Jia Nie ,&nbsp;Na Chen ,&nbsp;Han Yu ,&nbsp;Wan Li ,&nbsp;Yu-zhu Tan ,&nbsp;Guang-hua Lu","doi":"10.1016/j.phytol.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.004","url":null,"abstract":"<div><p>A new sesquiterpene acid, named dihydrophaseic acid A (<strong>1</strong>), along with four known organic acids, <em>p</em>-hydroxybenzoic acid (<strong>2</strong>), vanillic acid (<strong>3</strong>), dihydrophaseic acid (<strong>4</strong>), and 4-methylpyrazole-3-carboxylic acid (<strong>5</strong>), were obtained by isolation and purification from the ethyl acetate extract of the seeds of <em>Phaseolus lunatus</em> L. (Fabaceae). The structural elucidation of the new sesquiterpene acid was performed using a variety of spectroscopic methods (HRESIMS, UV, IR, 1D and 2D NMR) and ECD calculations. All compounds were evaluated for <em>in vitro</em> anti-inflammatory activity using mouse mononuclear macrophages cells (RAW264.7). The anti-inflammatory evaluation demonstrated that the new compound exhibited moderate NO inhibitory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells with IC₅₀ value of 28.30 ± 0.76 µM, compound <strong>5</strong> displayed the most active inhibitory activity with an IC₅₀ value of 5.55 ± 0.79 µM.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 120-124"},"PeriodicalIF":1.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140549207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive compounds isolated from the bark of Aesculus glabra Willd","authors":"Miriam Velazquez Cruz ,&nbsp;Eric Salinas-Arellano ,&nbsp;Ines Castro Dionicio,&nbsp;Jonathan G. Jeyaraj,&nbsp;Nathan P. Mirtallo Ezzone,&nbsp;Esperanza J. Carcache de Blanco","doi":"10.1016/j.phytol.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.005","url":null,"abstract":"<div><p>The <em>Aesculus</em> genus has several species, most notably <em>Aesculus hippocastanum</em>, with reported cytotoxic and venotonic effects. The angiogenic effect from <em>A. hippocastanum</em> is of interest given the current limitations of anti-angiogenic therapeutics. <em>Aesculus glabra</em> (Willdenow), known as the Ohio Buckeye Tree is a species native to North America with reported medicinal use by the Native Americans. Previous phytochemical studies have focused on the seed and leaf contents of the <em>glabra</em> species, with most of them reporting cytotoxic activity. In this study, we assessed preliminary anti-angiogenic activity and toxicity of isolated compounds from the bark of <em>A. glabra</em> utilizing a zebrafish (<em>Danio rerio</em>) model. Procyanidin A2 and epicatechin, two pure isolates, were tested using zebrafish and gave an anti-angiogenic response, suggesting an underlying mechanism involved in vascular development.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 106-114"},"PeriodicalIF":1.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000600/pdfft?md5=8d9c970e29dc18e99931b00c0410f7b4&pid=1-s2.0-S1874390024000600-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial on the 9th International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-10)","authors":"Ilkay Erdogan Orhan ,&nbsp;Nazım Şekeroğlu","doi":"10.1016/j.phytol.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.007","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 104-105"},"PeriodicalIF":1.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yunnanensine type indole and secostemmadenine-yunnanensine type bisindole alkaloids from the bark of Alstonia scholaris","authors":"Kuan-Hon Lim ,&nbsp;Chun-Wai Mai ,&nbsp;Soon-Kit Wong ,&nbsp;Yun-Yee Low ,&nbsp;Siew-Huah Lim ,&nbsp;Premanand Krishnan","doi":"10.1016/j.phytol.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.003","url":null,"abstract":"<div><p>Two previously undescribed monoterpenoid indole alkaloids, <em>N</em>-formylyunnanensine (<strong>1</strong>) and scholaphylline (<strong>2</strong>), along with eight known alkaloids, namely, 19,20-<em>E</em>-vallesamine (<strong>3</strong>), 19,20-<em>Z</em>-vallesamine (<strong>4</strong>), 19,20-<em>E</em>-vallesamine <em>N</em>-oxide (<strong>5</strong>), 6,7-<em>seco</em>-19,20α-epoxyangustilobine B (<strong>6</strong>), 16<em>R</em>-19,20-<em>E</em>-isositsirikine (<strong>7</strong>), <em>N</em>-demethylalstogustine <em>N</em>-oxide (<strong>8</strong>), <em>E</em>-vallesiachotamine (<strong>9</strong>), and <em>Z</em>-vallesiachotamine (<strong>10</strong>), were isolated from the bark of <em>Alstonia scholaris.</em> Alkaloid <strong>1</strong> was determined to be the <em>N</em>-formyl derivative of the known alkaloid, yunnanensine, comprising a pair of inseparable <em>E</em>/<em>Z</em>-formamide rotamers, while scholaphylline (<strong>2</strong>) was identified as the first member of the <em>seco</em>stemmadenine-yunnanensine type bisindole alkaloid. The structures of these alkaloids and their absolute configurations were established based on detailed analysis of the spectroscopic data in conjunction with the TDDFT-ECD method. A possible biogenetic pathway to <strong>1</strong> and <strong>2</strong>, involving stemmadenine as the primary precursor, was proposed. Scholaphylline (<strong>2</strong>) showed modest cytotoxicity against Panc1 (IC₅₀ 27.7 ± 5.1 µM), MDA-MB-231 (IC₅₀ 32.0 ± 2.2 µM), and MDA-MB-468 (IC₅₀ 34.1 ± 3.3 µM) cancer cell lines, while <em>N</em>-formylyunnanensine (<strong>1</strong>) did not show appreciable cytotoxicity against any of the tested cell lines.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 97-103"},"PeriodicalIF":1.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000594/pdfft?md5=f0b0bbb59cf96972b0540d04061b8ee4&pid=1-s2.0-S1874390024000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)","authors":"Ahmed Boukeloua ,&nbsp;Soudani Leila ,&nbsp;Hamdi Bendif ,&nbsp;Ahmed Mustafa Elkadeem ,&nbsp;Mehmet Boga ,&nbsp;Maria Luísa Serralheiro ,&nbsp;Mustafa Abdullah Yilmaz ,&nbsp;Ismail Yener ,&nbsp;Stefania Garzoli","doi":"10.1016/j.phytol.2024.03.017","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.017","url":null,"abstract":"<div><p>The study aimed to analyse the chemical and biological composition of <em>Azadirachta indica</em> (A. Juss) (<em>A. indica</em>) leaves. Minerals were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Phenolic compounds and water-soluble vitamins were identified via LC-MS/MS. Antioxidant activity was assessed using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC), while anticholinesterase effect was tested against butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE). Results revealed significant levels of major elements (e.g., Zn, Cu) making it a promising source. Predominant phenolic acids included tannic and salicylic acid, with major flavonoids being hyperoside, kaempferol, and quercetin. Main water-soluble vitamins were nicotinic acid, nicotinamide, and pantothenic acid, followed by pyridoxine, thiamine, and riboflavin. Ethanol extract exhibited moderate antioxidant activity (30.02 % inhibition of ABTS radicals; IC50 0.918 μg/mL for CUPRAC and low inhibition of BChE and AChE (2.29 % and 3.17 % respectively). These findings highlight <em>A. indica</em> as a valuable natural source of nutritionally significant compounds and antioxidants.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 89-96"},"PeriodicalIF":1.7,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic-rich extract from Bryophyllum pinnatum leaf cultivated under drought stress conditions modulates the antioxidant and anti-inflammatory response","authors":"Natasha Lorenna Ferreira da Silva ,&nbsp;Renato Dantas-Medeiros ,&nbsp;Emanuella de Aragão Tavares ,&nbsp;Dayanne Lopes Porto ,&nbsp;Valéria Costa da Silva ,&nbsp;Jacinthia Beatriz Xavier-Santos ,&nbsp;Júlia Gabriela Ramos Passos ,&nbsp;Weslley de Souza Paiva ,&nbsp;Hugo Alexandre de Oliveira Rocha ,&nbsp;Matheus de Freitas Fernandes-Pedrosa ,&nbsp;Júlia Morais Fernandes ,&nbsp;Silvana Maria Zucolotto","doi":"10.1016/j.phytol.2024.03.013","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.013","url":null,"abstract":"<div><p><em>Bryophyllum pinnatum</em> (Lam) Pers (Crassulaceae) is used in traditional medicine to treat inflammatory diseases. There is preclinical and clinical evidence that proves its anti-inflammatory effect. This species is a good source of phenolic compounds such as flavonoids, being quercetin 3-<em>O</em>-<em>L-</em>arabinopyranosyl-(1→2)-<em>O-L</em>-rhamnopyranoside (Bp1), the main compound. However, to ensure the reproducibility of raw material as an active pharmaceutical ingredient, it is necessary to standardize the production chain from cultivation to the final product. The aim of this study was to understand whether water stress increases the phenolic content in <em>B. pinnatum</em> leaves and its effect on the modulation of anti-inflammatory and antioxidant responses. <em>B. pinnatum</em> was submitted to drought stress, with daily watering suspended for specified periods: 0, 5, 10, 20, and 30 days, along with a cyclic regimen involving 10 days of water deprivation followed by 10 days of regular watering for recovery (denoted as T0, T5t, T10t, T20t, T30t, and T10tcyc, respectively). For each water stress treatment (n = 10), there were control plants (n = 10) that received daily watering. After treatment, dry leaf extracts from each sample were prepared. Subsequently, the total flavonoids (TFC) and total phenolics (TPC) content were performed using spectrophotometric tests. Ultrafast liquid chromatography was used to quantify the main compound (Bp1) in the extracts. Extracts under different stress conditions showed no signs of cytotoxicity (RAW 264.7 cells) and were able to donate electrons in <em>in vitro assays</em> (CAT, reducing power, and DPPH). Extracts with high TPC (T20t and T30t) in the ear edema model induced by croton oil at a dose of 200 mg/kg orally showed an anti-inflammatory effect when compared to positive control, dexamethasone (1 mg/kg, orally). Regarding the Bp1 content, no major differences between the groups were observed. The results demonstrate that water stress is a promising and sustainable strategy for cultivating <em>B. pinnatum</em> to increase the phenolic content and positively modulate its pharmacological effects. Therefore, phenolic-rich extract of <em>B. pinnatum</em> can be obtained with low water resource consumption and it is a good source to use as an active ingredient in herbal medicines or supplements.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 78-88"},"PeriodicalIF":1.7,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anacardic acid derivatives with significant α-glucosidase inhibitory activity from Syzygium samarangense","authors":"Yikao Hu ,&nbsp;Wen Xu ,&nbsp;Li Wang ,&nbsp;Yuanbiao He ,&nbsp;Yong Zhao","doi":"10.1016/j.phytol.2024.03.016","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.016","url":null,"abstract":"<div><p>Our continuous effort to search for antidiabetic constituents from the leaves of <em>Syzygium samarangense</em> resulted in the isolation of one new anacardic acid derivative, 2-[(<em>Z</em>)-nonadec-14-enyl]-6-hydroxylbenzoic acid (<strong>1</strong>) along with four known analogues (<strong>2</strong>−<strong>5</strong>). The new structure was elucidated by means of extensive spectroscopic data including 1D and 2D NMR along with HRESIMS. The anacardic acid derivatives were isolated from this species for the first time<em>.</em> All compounds exhibited significant inhibitory effect with IC₅₀ value of 0.75−3.60 μM against <em>α</em>-glucosidase.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 75-77"},"PeriodicalIF":1.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sutherlandiosides E−K: Further cycloartane glycosides from Sutherlandia frutescens","authors":"Billy T. Tchegnitegni ,&nbsp;Mookho S. Lerata ,&nbsp;Denzil R. Beukes ,&nbsp;Edith M. Antunes","doi":"10.1016/j.phytol.2024.03.012","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.012","url":null,"abstract":"<div><p>A further chemical investigation of the butanol extract of leaves from the South African medicinal plant <em>Sutherlandia frutescens</em> led to the isolation of eight previously unreported saponins (<strong>1−8</strong>), together with the known sutherlandiosides A−D. Their structures were established by spectroscopic (1D and 2D NMR) analyses, CD, optical rotation, mass spectrometry, as well as chemical conversions. The isolates were screened for their cytotoxic activity against the MCF-7 human breast cancer cell line, although no significant activity was observed. In addition to the chemophenetic markers for this genus, <em>i.e.</em> the cycloartane glycosides, the present work also reports on the first isolation of an oleanan-type saponin from the <em>Sutherlandia</em> genus, forming an important fingerprint for the chemical composition of the plant.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 66-74"},"PeriodicalIF":1.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000508/pdfft?md5=c3af5d33d904c3a5fb94e6cd00c98502&pid=1-s2.0-S1874390024000508-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140328344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}