Phytochemistry Letters最新文献

{"title":"Editorial on the 9th International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-10)","authors":"Ilkay Erdogan Orhan , Nazım Şekeroğlu","doi":"10.1016/j.phytol.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.007","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 104-105"},"PeriodicalIF":1.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yunnanensine type indole and secostemmadenine-yunnanensine type bisindole alkaloids from the bark of Alstonia scholaris","authors":"Kuan-Hon Lim ,&nbsp;Chun-Wai Mai ,&nbsp;Soon-Kit Wong ,&nbsp;Yun-Yee Low ,&nbsp;Siew-Huah Lim ,&nbsp;Premanand Krishnan","doi":"10.1016/j.phytol.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.003","url":null,"abstract":"<div><p>Two previously undescribed monoterpenoid indole alkaloids, <em>N</em>-formylyunnanensine (<strong>1</strong>) and scholaphylline (<strong>2</strong>), along with eight known alkaloids, namely, 19,20-<em>E</em>-vallesamine (<strong>3</strong>), 19,20-<em>Z</em>-vallesamine (<strong>4</strong>), 19,20-<em>E</em>-vallesamine <em>N</em>-oxide (<strong>5</strong>), 6,7-<em>seco</em>-19,20α-epoxyangustilobine B (<strong>6</strong>), 16<em>R</em>-19,20-<em>E</em>-isositsirikine (<strong>7</strong>), <em>N</em>-demethylalstogustine <em>N</em>-oxide (<strong>8</strong>), <em>E</em>-vallesiachotamine (<strong>9</strong>), and <em>Z</em>-vallesiachotamine (<strong>10</strong>), were isolated from the bark of <em>Alstonia scholaris.</em> Alkaloid <strong>1</strong> was determined to be the <em>N</em>-formyl derivative of the known alkaloid, yunnanensine, comprising a pair of inseparable <em>E</em>/<em>Z</em>-formamide rotamers, while scholaphylline (<strong>2</strong>) was identified as the first member of the <em>seco</em>stemmadenine-yunnanensine type bisindole alkaloid. The structures of these alkaloids and their absolute configurations were established based on detailed analysis of the spectroscopic data in conjunction with the TDDFT-ECD method. A possible biogenetic pathway to <strong>1</strong> and <strong>2</strong>, involving stemmadenine as the primary precursor, was proposed. Scholaphylline (<strong>2</strong>) showed modest cytotoxicity against Panc1 (IC₅₀ 27.7 ± 5.1 µM), MDA-MB-231 (IC₅₀ 32.0 ± 2.2 µM), and MDA-MB-468 (IC₅₀ 34.1 ± 3.3 µM) cancer cell lines, while <em>N</em>-formylyunnanensine (<strong>1</strong>) did not show appreciable cytotoxicity against any of the tested cell lines.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 97-103"},"PeriodicalIF":1.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000594/pdfft?md5=f0b0bbb59cf96972b0540d04061b8ee4&pid=1-s2.0-S1874390024000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)","authors":"Ahmed Boukeloua ,&nbsp;Soudani Leila ,&nbsp;Hamdi Bendif ,&nbsp;Ahmed Mustafa Elkadeem ,&nbsp;Mehmet Boga ,&nbsp;Maria Luísa Serralheiro ,&nbsp;Mustafa Abdullah Yilmaz ,&nbsp;Ismail Yener ,&nbsp;Stefania Garzoli","doi":"10.1016/j.phytol.2024.03.017","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.017","url":null,"abstract":"<div><p>The study aimed to analyse the chemical and biological composition of <em>Azadirachta indica</em> (A. Juss) (<em>A. indica</em>) leaves. Minerals were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Phenolic compounds and water-soluble vitamins were identified via LC-MS/MS. Antioxidant activity was assessed using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC), while anticholinesterase effect was tested against butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE). Results revealed significant levels of major elements (e.g., Zn, Cu) making it a promising source. Predominant phenolic acids included tannic and salicylic acid, with major flavonoids being hyperoside, kaempferol, and quercetin. Main water-soluble vitamins were nicotinic acid, nicotinamide, and pantothenic acid, followed by pyridoxine, thiamine, and riboflavin. Ethanol extract exhibited moderate antioxidant activity (30.02 % inhibition of ABTS radicals; IC50 0.918 μg/mL for CUPRAC and low inhibition of BChE and AChE (2.29 % and 3.17 % respectively). These findings highlight <em>A. indica</em> as a valuable natural source of nutritionally significant compounds and antioxidants.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 89-96"},"PeriodicalIF":1.7,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic-rich extract from Bryophyllum pinnatum leaf cultivated under drought stress conditions modulates the antioxidant and anti-inflammatory response","authors":"Natasha Lorenna Ferreira da Silva ,&nbsp;Renato Dantas-Medeiros ,&nbsp;Emanuella de Aragão Tavares ,&nbsp;Dayanne Lopes Porto ,&nbsp;Valéria Costa da Silva ,&nbsp;Jacinthia Beatriz Xavier-Santos ,&nbsp;Júlia Gabriela Ramos Passos ,&nbsp;Weslley de Souza Paiva ,&nbsp;Hugo Alexandre de Oliveira Rocha ,&nbsp;Matheus de Freitas Fernandes-Pedrosa ,&nbsp;Júlia Morais Fernandes ,&nbsp;Silvana Maria Zucolotto","doi":"10.1016/j.phytol.2024.03.013","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.013","url":null,"abstract":"<div><p><em>Bryophyllum pinnatum</em> (Lam) Pers (Crassulaceae) is used in traditional medicine to treat inflammatory diseases. There is preclinical and clinical evidence that proves its anti-inflammatory effect. This species is a good source of phenolic compounds such as flavonoids, being quercetin 3-<em>O</em>-<em>L-</em>arabinopyranosyl-(1→2)-<em>O-L</em>-rhamnopyranoside (Bp1), the main compound. However, to ensure the reproducibility of raw material as an active pharmaceutical ingredient, it is necessary to standardize the production chain from cultivation to the final product. The aim of this study was to understand whether water stress increases the phenolic content in <em>B. pinnatum</em> leaves and its effect on the modulation of anti-inflammatory and antioxidant responses. <em>B. pinnatum</em> was submitted to drought stress, with daily watering suspended for specified periods: 0, 5, 10, 20, and 30 days, along with a cyclic regimen involving 10 days of water deprivation followed by 10 days of regular watering for recovery (denoted as T0, T5t, T10t, T20t, T30t, and T10tcyc, respectively). For each water stress treatment (n = 10), there were control plants (n = 10) that received daily watering. After treatment, dry leaf extracts from each sample were prepared. Subsequently, the total flavonoids (TFC) and total phenolics (TPC) content were performed using spectrophotometric tests. Ultrafast liquid chromatography was used to quantify the main compound (Bp1) in the extracts. Extracts under different stress conditions showed no signs of cytotoxicity (RAW 264.7 cells) and were able to donate electrons in <em>in vitro assays</em> (CAT, reducing power, and DPPH). Extracts with high TPC (T20t and T30t) in the ear edema model induced by croton oil at a dose of 200 mg/kg orally showed an anti-inflammatory effect when compared to positive control, dexamethasone (1 mg/kg, orally). Regarding the Bp1 content, no major differences between the groups were observed. The results demonstrate that water stress is a promising and sustainable strategy for cultivating <em>B. pinnatum</em> to increase the phenolic content and positively modulate its pharmacological effects. Therefore, phenolic-rich extract of <em>B. pinnatum</em> can be obtained with low water resource consumption and it is a good source to use as an active ingredient in herbal medicines or supplements.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 78-88"},"PeriodicalIF":1.7,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anacardic acid derivatives with significant α-glucosidase inhibitory activity from Syzygium samarangense","authors":"Yikao Hu ,&nbsp;Wen Xu ,&nbsp;Li Wang ,&nbsp;Yuanbiao He ,&nbsp;Yong Zhao","doi":"10.1016/j.phytol.2024.03.016","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.016","url":null,"abstract":"<div><p>Our continuous effort to search for antidiabetic constituents from the leaves of <em>Syzygium samarangense</em> resulted in the isolation of one new anacardic acid derivative, 2-[(<em>Z</em>)-nonadec-14-enyl]-6-hydroxylbenzoic acid (<strong>1</strong>) along with four known analogues (<strong>2</strong>−<strong>5</strong>). The new structure was elucidated by means of extensive spectroscopic data including 1D and 2D NMR along with HRESIMS. The anacardic acid derivatives were isolated from this species for the first time<em>.</em> All compounds exhibited significant inhibitory effect with IC₅₀ value of 0.75−3.60 μM against <em>α</em>-glucosidase.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 75-77"},"PeriodicalIF":1.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sutherlandiosides E−K: Further cycloartane glycosides from Sutherlandia frutescens","authors":"Billy T. Tchegnitegni ,&nbsp;Mookho S. Lerata ,&nbsp;Denzil R. Beukes ,&nbsp;Edith M. Antunes","doi":"10.1016/j.phytol.2024.03.012","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.012","url":null,"abstract":"<div><p>A further chemical investigation of the butanol extract of leaves from the South African medicinal plant <em>Sutherlandia frutescens</em> led to the isolation of eight previously unreported saponins (<strong>1−8</strong>), together with the known sutherlandiosides A−D. Their structures were established by spectroscopic (1D and 2D NMR) analyses, CD, optical rotation, mass spectrometry, as well as chemical conversions. The isolates were screened for their cytotoxic activity against the MCF-7 human breast cancer cell line, although no significant activity was observed. In addition to the chemophenetic markers for this genus, <em>i.e.</em> the cycloartane glycosides, the present work also reports on the first isolation of an oleanan-type saponin from the <em>Sutherlandia</em> genus, forming an important fingerprint for the chemical composition of the plant.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 66-74"},"PeriodicalIF":1.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000508/pdfft?md5=c3af5d33d904c3a5fb94e6cd00c98502&pid=1-s2.0-S1874390024000508-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140328344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory terpenoids from the seeds of Eucommia ulmoides","authors":"Bin He ,&nbsp;Lu Chen ,&nbsp;Cong Chen ,&nbsp;Jia Zeng ,&nbsp;Jingwen Xu ,&nbsp;Xiangjiu He ,&nbsp;Yihai Wang","doi":"10.1016/j.phytol.2024.03.011","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.011","url":null,"abstract":"<div><p><em>Eucommia ulmoides</em>, a highly valuable economic crop, has been used in traditional Chinese medicine for over 2000 years. In this study, three new iridoids and one new alkaloid, along with 16 known compounds, were isolated from the seeds of <em>E. ulmoides</em>. Their structures incorporating absolute configurations were elucidated based on the comprehensive analyses of NMR data, HR-ESI-MS spectrometry, optical rotation, and ECD data. All compounds were tested for their anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compounds <strong>14</strong>, <strong>17</strong>, and <strong>18</strong> significantly inhibited the production of NO with IC₅₀ values of 10.37, 27.34, and 21.58 <em>μ</em>M respectively. Further experiments demonstrated that compound <strong>17</strong> could intercept the nuclear translocation of NF-<em>κ</em>B, and down-regulate the expression of iNOS, COX-2, IL-1<em>β</em>, and IL-6 in a dose-dependent manner.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 44-51"},"PeriodicalIF":1.7,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140187700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of fucoxanthin as a promising bioactive compound in drug development","authors":"HS Kumarasinghe ,&nbsp;MDTL Gunathilaka","doi":"10.1016/j.phytol.2024.03.009","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.009","url":null,"abstract":"<div><p>Fucoxanthin is a unique carotenoid present in brown seaweed due to the presence of an allenic bond in its structure. Its chemical composition consists of a central core that is cyclic, many conjugated double bonds, and several functional groups. Fucoxanthin plays a critical role in photosynthesis, absorbing light energy and transferring it to chlorophyll a. It has been demonstrated to have a variety of health advantages as well as protective effects against conditions including diabetes, liver cirrhosis, obesity, and malignant cancer, etc. Therefore, fucoxanthin can be employed as a strong pharmaceutical and dietary components to stop the spread of a wide array of infectious disorders. The present review focuses on the most recent research related to the pharmaceutical properties of fucoxanthin including antibacterial, antioxidant, anti-inflammatory, skin-protective, anti-obesity, anti-diabetic, and other qualities, including bioavailability and stability traits. This review seeks to support future biochemical research in order to create new pharmaceutical and dietary supplements that work with fucoxanthin and its many metabolites.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 52-65"},"PeriodicalIF":1.7,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcements of the Phytochemical Society of Europe","authors":"","doi":"10.1016/S1874-3900(24)00047-8","DOIUrl":"https://doi.org/10.1016/S1874-3900(24)00047-8","url":null,"abstract":"","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"60 ","pages":"Pages I-III"},"PeriodicalIF":1.7,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1874390024000478/pdfft?md5=8ccc814de6db59d48a2efb75f5d1ed68&pid=1-s2.0-S1874390024000478-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two new lignans from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa","authors":"Xiang-Da Li ,&nbsp;Yan-Gang Cao ,&nbsp;Yu-Han Zhang ,&nbsp;Ying-Jie Ren ,&nbsp;Meng-Nan Zeng ,&nbsp;Yan-Ling Liu ,&nbsp;Xu Chen ,&nbsp;Xin-Yi Ma ,&nbsp;Bing-Xian Zhao ,&nbsp;Xiao-Ke Zheng ,&nbsp;Wei-Sheng Feng","doi":"10.1016/j.phytol.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.03.005","url":null,"abstract":"<div><p>Two new undescribed compounds, jiofuran acid A (<strong>1</strong>) and 8′-hydroxyl episesaminone (<strong>2</strong>), together with seven known compounds (<strong>3</strong>–<strong>9</strong>) were isolated from the fresh roots of Zhongsheng No.1 <em>Rehmannia glutinosa</em>. Their structures were established by spectroscopic techniques (HR-ESI-MS, 1D NMR, 2D NMR), and absolute configurations were resolved by comparing their experimental and calculated ECD spectra. Bioassay results demonstrated compounds <strong>1</strong>–<strong>3</strong> exhibited the obvious anti-pulmonary fibrosis activity.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 40-43"},"PeriodicalIF":1.7,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140162432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}