Phytochemistry Letters最新文献_第10页

Structures of new cytotoxic bicyclic hexapeptides with a phenylpropanoid unit from Rubia cordifolia 含苯丙类单位的新型细胞毒性双环六肽的结构

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2024.12.004

Haruhiko Fukaya , Rie Kitamura , Tomoyo Hasuda , Koichi Takeya , Yutaka Aoyagi , Takahisa Nakane , Yukio Hitotsuyanagi

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International Congress on Natural Products Research 2024 (ICNPR2024) – Editorial 国际天然产物研究大会2024 (ICNPR2024) -社论

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2025.02.011

Krystyna Skalicka-Woźniak, Franz Bucar, Michał Tomczyk

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Lathyrisol B, a new nor-ent-abietane diterpenoid from roots of Euphorbia lathyris L. 大戟醇B是一种从大戟根中分离得到的新的非正枞烷二萜。

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2024.12.009

Young Sook Yun , Miki Shimamura , Haruhiko Fukaya , Hiroyuki Fuchino , Nobuo Kawahara , Hideshi Inoue

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New dimeric 1,3-dihydroisobenzofuran from culture broth of Fennellia flavipes 茴香培养液中新的二聚体1,3-二氢异苯并呋喃

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2025.01.003

Dae-Cheol Choi , Dae-Won Ki , Ji-Yul Kim , In-Kyoung Lee , Bong-Sik Yun

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Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/S1874-3900(25)00010-2

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Bioassay-guided isolation of terpenoids from Rubus rosifolius 用生物测定法分离红毛蕊萜类化合物

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2025.01.006

Yihao Yin , Jiehui Li , Qi Cao , Jinxiu Yu , Baoli Chen , Zhigang She , Xiuping Zhang , Bo Wang

{"title":"Bioassay-guided isolation of terpenoids from Rubus rosifolius","authors":"Yihao Yin , Jiehui Li , Qi Cao , Jinxiu Yu , Baoli Chen , Zhigang She , Xiuping Zhang , Bo Wang","doi":"10.1016/j.phytol.2025.01.006","DOIUrl":"10.1016/j.phytol.2025.01.006","url":null,"abstract":"<div><div>Rubus rosifolius S.Vidal, a plant from the Rosaceae family, is a traditional Chinese herbal medicine utilized as an adjunctive therapy for cancer, and its bioactive chemical constituents need further unearthing. In this work, seven sesquiterpenoids (1 – 7) and eight triterpenoids (8 – 15), including an undescribed compound (1), are bioassay-guidedly isolated from the decoction of the whole herb of Rubus rosifolius. Their structures are elucidated via detailed HR-ESI-MS, extensive spectroscopic analyses, and modified Mosher ester method, and the absolute configuration of (-)-hyptishumulene I (2) was revised. In bioassay, corosolic acid (10) and maslinic acid (11) exhibit moderate cytotoxicity against all tested human cancer cell lines, A549, MDA-MB-435, and SNB19, with IC50 values in the range of 16.20 – 33.63 μM. Additionally, corosolic acid and maslinic acid have been reported to be capable of inhibiting STAT3 and NF-κB, or increasing membrane permeability of cancer cells and inducing apoptosis, which suggests they are the important bioactive anti-cancer components of the decoction of Rubus rosifolius.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 124-127"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Three new alkaloids from Haplophyllum tuberculatum as competitive type of in-vitro α-glucosidase inhibitors 三种新的结核单龙树生物碱作为α-葡萄糖苷酶体外竞争性抑制剂

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2024.12.006

Najeeb Ur Rehman , Kashif Rafiq , Saeed Ullah , Sobia Ahsan Halim , Ajmal Khan , Simon Gibbons , René Csuk , Ahmed Al-Harrasi

{"title":"Three new alkaloids from Haplophyllum tuberculatum as competitive type of in-vitro α-glucosidase inhibitors","authors":"Najeeb Ur Rehman , Kashif Rafiq , Saeed Ullah , Sobia Ahsan Halim , Ajmal Khan , Simon Gibbons , René Csuk , Ahmed Al-Harrasi","doi":"10.1016/j.phytol.2024.12.006","DOIUrl":"10.1016/j.phytol.2024.12.006","url":null,"abstract":"<div><div>In a search for new drug-like molecules, we investigated Haplophyllum tuberculatum as a potential source of α-glucosidase inhibitors. Three new natural products (2, 6, and 7), and one previously synthesized compound (4), isolated here as a natural product for the first time, were isolated from an ethyl acetate extract. Additionally, six known compounds (1, 3, 5, and 8–10) were also characterized. The structures of all compounds were elucidated by 1D- and 2D-NMR techniques and HR-ESI-MS. All phytochemicals were evaluated for inhibitory activity against α-glucosidase and eight natural products (1 and 4-10) exhibited appreciable activities with IC50 values ranging from 2.28 ± 0.64–71.10 ± 2.47 μM, whilst 2 and 3 exhibited weak activities with IC50 values of 146.73 ± 2.73 and 260.53 ± 3.18 μM, respectively. Compounds 10 (IC50 = 2.28 ± 0.64 μM), 8 (IC50 = 7.16 ± 0.23 μM) and 7 (IC50 = 8.95 ± 0.37 μM) displayed significant inhibition compared to the positive control acarbose (IC50, 875.75 ± 1.24 μM). The α-glucosidase inhibitory activities of all compounds are reported here for the first time. Furthermore, kinetic study of the most potent compounds 8 and 10 exhibited concentration dependent type of inhibition. In addition, molecular docking analysis displayed excellent binding of these molecules in the active site of the α-glucosidase enzyme and the in-silico results and in vitro analysis were well correlated.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 94-101"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The neurologic effects of Lavandula stoechas L. subsp. stoechas 薰衣草对神经系统的影响。stoechas

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2025.01.005

Sümeyye Ayhan , Omer Bayazeid , Merve Yüzbaşıoğlu Baran , Hasan S. Yusufoglu , Funda Nuray Yalçın , Ayşe Kuruüzüm-Uz

{"title":"The neurologic effects of Lavandula stoechas L. subsp. stoechas","authors":"Sümeyye Ayhan , Omer Bayazeid , Merve Yüzbaşıoğlu Baran , Hasan S. Yusufoglu , Funda Nuray Yalçın , Ayşe Kuruüzüm-Uz","doi":"10.1016/j.phytol.2025.01.005","DOIUrl":"10.1016/j.phytol.2025.01.005","url":null,"abstract":"<div><div>Lavandula stoechas L. subsp. stoechas has traditionally been used in folk medicine for central nervous system (CNS) disorders. In the present study, the potential neuroactive effect of the aqueous ethanol extract of the aerial parts of L. stoechas was investigated, and phytochemical studies were carried out to identify the compounds that may be responsible for this activity. Five compounds were isolated using various chromatographic methods, and their structures were elucidated as luteolin 7-O-β-D-glucopyranoside, rosmarinic acid, eriodictyol, 1-nonadecene, and ursolic acid by spectroscopic methods. Assessing the brain-derived neurotrophic factor (BDNF) level in SH-SY5Y cells was used as a biological screening tool to evaluate the activity, and the extracts, main fractions, and isolated compounds were generally found to increase BDNF levels. Among the isolated compounds, ursolic acid at a concentration of 5 μM, as well as eriodictyol and ursolic acid at a concentration of 10 μM, resulted in the highest increase in BDNF levels. In addition, the potential neuroprotective effects of the isolated compounds against H2O2-induced neuronal cell damage were investigated. The compounds were found to possess neuroprotective effects, with significant activity observed for eriodictyol at a concentration of 5 μM (p < 0.05) and for 1-nonadecene at concentrations of 2.5 μM (p < 0.001), 5 μM (p < 0.01), and 10 μM (p < 0.001). Additionally, L. stoechas demonstrated strong antioxidant activity, as evidenced by DPPH, SO, NO radical scavenging activity, CUPRAC, and FRAP methods. In conclusion, our results provide support for the traditional use of L. stoechas in CNS disorders.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 145-151"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Phenolic compounds from Dalbergia odorifera and their hepatoprotective activity 降香黄檀中酚类化合物及其保肝活性

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2025.01.1001

Yu-Jia Zhang , Yan Wen , Kai-Wen Kang , Zhi-Xuan Li , Dong-Li Li , Jing-Wei Jin , Li-She Gan

{"title":"Phenolic compounds from Dalbergia odorifera and their hepatoprotective activity","authors":"Yu-Jia Zhang , Yan Wen , Kai-Wen Kang , Zhi-Xuan Li , Dong-Li Li , Jing-Wei Jin , Li-She Gan","doi":"10.1016/j.phytol.2025.01.1001","DOIUrl":"10.1016/j.phytol.2025.01.1001","url":null,"abstract":"<div><div>Twenty-one phenolic compounds, including two new diphenylpropenoids, R-7-methoxyodoriferin (1) and (Z)-1-(3-hydroxyphenyl)-1-(2,4,5-trimethoxyphenyl)-1-propen-3-ol (2), were isolated from the heartwood of Dalbergia odorifera. The structures of compounds 1 and 2 were determined through comprehensive spectroscopic analysis and quantum chemical calculations. A relaxed scan of the dihedral angle, combined with the reduced density gradient (RDG) method for analyzing noncovalent interactions, provided insights into the predominant conformation of compound 1, while theoretical ECD calculation confirmed its absolute configuration. The hepatoprotective activities of compounds 1, 5, 7, 12, 13, and 20 were evaluated using a D-GalN-induced AML12 hepatocyte injury model. Notably, compound 1 exhibited a significant hepatoprotective effect at 30 μM, comparable to that of silybin at the same concentration.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143269019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, antifungal activity, and 3D-QSAR study of novel L-carvone-based thiazole-hydrazone derivatives 新型l -香芹酮基噻唑腙衍生物的合成、抗真菌活性及3D-QSAR研究

IF 1.3 4区生物学

Phytochemistry Letters Pub Date : 2025-02-01 DOI: 10.1016/j.phytol.2024.12.001

Baoyu Li, Rongzhu Wen, Wengui Duan, Guishan Lin, Xinyan Liu

{"title":"Synthesis, antifungal activity, and 3D-QSAR study of novel L-carvone-based thiazole-hydrazone derivatives","authors":"Baoyu Li, Rongzhu Wen, Wengui Duan, Guishan Lin, Xinyan Liu","doi":"10.1016/j.phytol.2024.12.001","DOIUrl":"10.1016/j.phytol.2024.12.001","url":null,"abstract":"<div><div>For exploring novel potent fungicides derived from natural products, 24 L-carvone-based thiazole-hydrazone derivatives 5a-5x were synthesized, and confirmed for their molecular structures by 1H NMR, 13C NMR, FT-IR, and HRMS. Besides, all the target compounds were bio-assayed to evaluate the in vitro antifungal activity and the results revealed that some of the target compounds showed significant inhibitory activity against the tested plant pathogens, especially for Rhizoeotnia solani and Physalospora piricola. For example, compounds 5a (R = H), 5b (R = o-F), 5c (R = m-F), 5d (R = p-F), 5e (R = o,p-F), 5 f (R = m-Cl), 5j (R = m-NO2), 5q (R = o-OCH3), and 5r (R = m-OCH3) exhibited better antifungal activity against Physalospora piricola than that of chlorothalonil (51.2 %). In addition, the three-dimensional quantitative structure-activity relationship (3D-QSAR) study was conducted to investigate the relationship between the bioactivities of the target compounds and the substituted groups bonding to their common skeletons.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 58-63"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0