Phytochemistry Letters最新文献_第9页

A new bisbenzoquinone with cytotoxicity from Chaetomium trilaterale 三边毛藻中一个具有细胞毒性的新双苯醌

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.phytol.2025.104069

Xin-Xin Liang , Lei Li , Jia-Yi Zhang , Xin-Yue Zhang , Yi-Kun Feng , Chen Gu , Si-Cheng Jin , Xiang-Guo Meng

引用次数: 0

Inhibition of protein tyrosine phosphatase 1B by phenolics and neolignans from Myristica fragrans seeds: Enzyme kinetics and molecular docking 香豆蔻种子酚类物质和新木质素对蛋白酪氨酸磷酸酶1B的抑制作用：酶动力学和分子对接

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-09-20 DOI: 10.1016/j.phytol.2025.103050

Thi Oanh Vu , Thi Ly Pham , Jieun Shin , Manh Tuan Ha , Jun-Kyu Byun , Byung Sun Min , Jeong Ah Kim

{"title":"Inhibition of protein tyrosine phosphatase 1B by phenolics and neolignans from Myristica fragrans seeds: Enzyme kinetics and molecular docking","authors":"Thi Oanh Vu , Thi Ly Pham , Jieun Shin , Manh Tuan Ha , Jun-Kyu Byun , Byung Sun Min , Jeong Ah Kim","doi":"10.1016/j.phytol.2025.103050","DOIUrl":"10.1016/j.phytol.2025.103050","url":null,"abstract":"<div><div><em>Myristica fragrans</em> Houtt. seeds, a recognized herbal remedy with diverse phytoconstituents and biological activities, have been traditionally used to manage various health conditions. While numerous studies have demonstrated the anti-diabetic properties of this plant, research focusing on the mechanism of protein tyrosine phosphatase 1B (PTP1B) inhibition remains limited. This study aimed to isolate and evaluate the PTP1B inhibitory activity of phenolics and neolignans from <em>M. fragrans</em> seeds. We successfully isolated a new benzofuranoid neolignan, 5-methoxy-eupomatenoid-7 (16), along with 15 known compounds (1–15). The chemical structure of the isolated secondary metabolites was elucidated using spectroscopic analyses, including nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-MS), and confirmed by comparison with previously reported data. The inhibitory potential of all isolated compounds against PTP1B was assessed, with isodihydrocarinatidin (11) identified as the most potent inhibitor, exhibiting an IC<sub>50</sub> value of 9.6 ± 0.65 μM. Notably, enzyme kinetic studies revealed that compound 11 inhibits PTP1B through an uncompetitive mechanism, a relatively uncommon mode of inhibition. Molecular docking analysis revealed the binding interactions between compound 11 and PTP1B, while treatment with compound <strong>11</strong> significantly enhanced glucose uptake. This study provides the first evidence that isodihydrocarinatidin acts as a novel PTP1B inhibitor, establishing a foundation for further investigations toward the development of antidiabetic therapies.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 103050"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isochlorogenic acid B targets COX-2 to protect against Hypoxia/Reoxygenation-induced cardiomyocyte injury through the RAGE signaling pathway 异绿原酸B通过RAGE信号通路靶向COX-2，保护缺氧/再氧诱导的心肌细胞损伤

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-10-22 DOI: 10.1016/j.phytol.2025.104062

Lirong Zheng , Jianguo Sun , Ruifen Zhang , Huan Li , Tingting Jia , Hairong Zhang , He Su

{"title":"Isochlorogenic acid B targets COX-2 to protect against Hypoxia/Reoxygenation-induced cardiomyocyte injury through the RAGE signaling pathway","authors":"Lirong Zheng , Jianguo Sun , Ruifen Zhang , Huan Li , Tingting Jia , Hairong Zhang , He Su","doi":"10.1016/j.phytol.2025.104062","DOIUrl":"10.1016/j.phytol.2025.104062","url":null,"abstract":"<div><div>Hypoxia/Reoxygenation (H/R)-induced cardiomyocyte injury is the primary cause of Myocardial ischemia-reperfusion injury (MI/R injury), and protecting cardiomyocyte is an effective therapeutic strategy for MI/R injury. The Dangong-3 (DG3) is a common Mongolian medicine that exhibits a beneficial protective effect on cardiomyocytes, but the underlying mechanisms and key compounds of DG3 in protecting against H/R-mediated cardiomyocyte injury remain unclear. First, a total of 36 compounds of DG3 were identified by UPLC-Q-TOF-MS/MS analysis, and 306 potential targets of DG3 in protecting against H/R-mediated cardiomyocyte injury were screened out through network pharmacology. Moreover, protein-protein interaction analysis highlighted COX-2 as core target through which DG3 ameliorates H/R- induced cardiomyocyte injury, and KEGG enrichment analysis revealed that the AGE-RAGE signaling pathway plays a crucial role. Molecular docking was employed to screen key compounds of DG3 for protecting against H/R-induced cardiomyocyte injury, and compounds binding with core targets were validated by CETSA assay. The results showed 3,4-Dicaffeoylquinic acid, i.e. isochlorogenic acid B (ICha B), can bind well with COX-2 and may be the key compound of DG3. The CETSA assay also confirmed that ICha B can target COX-2. Western blotting indicated that ICha B exerts cardioprotective effects by suppressing the RAGE signaling pathway. In summary, we discovered that ICha B was the key compound of DG3, which can target and inhibit COX-2 to protect against H/R-induced cardiomyocyte injury by suppressing RAGE signaling pathway. These findings provide data support for further research and application of DG3 in the treatment of MI/R injury.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 104062"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 DOI: 10.1016/S1874-3900(25)02183-4

引用次数: 0

Two new compounds from the roots of Mirabilis jalapa L. and their cytotoxic activity in vitro 紫茉莉根中两种新化合物及其体外细胞毒活性研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1016/j.phytol.2025.103043

Xiao-Mei Yan , Tian-Tian Qu , Jie Luan , Hou-Run Zhang , Xiang-Qin Tang , Xiao-Xu Bi , Ying Wang , Bing Chen , Jiang-Bo He

{"title":"Two new compounds from the roots of Mirabilis jalapa L. and their cytotoxic activity in vitro","authors":"Xiao-Mei Yan , Tian-Tian Qu , Jie Luan , Hou-Run Zhang , Xiang-Qin Tang , Xiao-Xu Bi , Ying Wang , Bing Chen , Jiang-Bo He","doi":"10.1016/j.phytol.2025.103043","DOIUrl":"10.1016/j.phytol.2025.103043","url":null,"abstract":"<div><div>This study investigated the chemical composition of the roots of <em>Mirabilis jalapa</em> L. and evaluated the cytotoxic activity of its constituents. The ethyl acetate extract of <em>M. jalapa</em> roots was isolated and purified, and the structures of twelve isolated compounds were identified through modern spectroscopic methods and physicochemical analysis. These compounds were categorized into two groups: compounds <strong>1</strong>–<strong>7</strong> (rotenoid derivatives) and compounds <strong>8</strong>–<strong>12</strong> (feruloyl tyramine glycosides), Among which compounds <strong>1</strong> and <strong>8</strong> are new compounds. The cytotoxicity of these compounds was assessed using the CCK-8 assay against five tumor cell lines, namely HepG2, PANC-1, HeLa, SY5Y, and AGS. Results showed compounds <strong>4</strong>, <strong>5</strong>, and <strong>7</strong> exhibited strong anti-tumor cytotoxic activity. Furthermore, network pharmacology analysis identified EGFR and STAT3 as key antitumor targets, and this finding was validated by molecular docking experiments. Overall, this research highlights the chemical diversity of <em>M. jalapa</em> roots and provides insights into the potential development of antitumor agents from this plant.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"70 ","pages":"Article 103043"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olasecuthones A-E: Undescribed xanthones from Securidaca Longipedunculata Fresen (Polygalaceae) Olasecuthones A-E：未描述的山仙子（蓼科）中的山酮类化合物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1016/j.phytol.2025.103040

Abdulkabir Oladele Oladimeji , K. Suresh Babu

引用次数: 0

Two pairs of novel isochromanone derivatives with antiadipogenic effects from the cultures of Ganoderma gibbosum 从长毛灵芝培养物中获得两对具有抗脂肪作用的新型异色罗曼酮衍生物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-10-01 Epub Date: 2025-09-06 DOI: 10.1016/j.phytol.2025.103041

Yu-Jie Li , Xiao-Cui Liu , Yi Luo , Ming-Hua Qiu , Ping Zhao , Xing-Rong Peng

引用次数: 0

Studies on the chemical constituents of the stems and leaves of Murraya euchrestifolia 木犀叶茎叶化学成分的研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1016/j.phytol.2025.103023

Xiaowei Zhao , Chunhui Yu , Caixia Guo , Haojing Jiang , Hai-Jiang Zhang , Yuanqiang Guo , Jing Xu

{"title":"Studies on the chemical constituents of the stems and leaves of Murraya euchrestifolia","authors":"Xiaowei Zhao , Chunhui Yu , Caixia Guo , Haojing Jiang , Hai-Jiang Zhang , Yuanqiang Guo , Jing Xu","doi":"10.1016/j.phytol.2025.103023","DOIUrl":"10.1016/j.phytol.2025.103023","url":null,"abstract":"<div><div>The ongoing importance of natural products in drug discovery is highlighted by our investigation. We report the isolation of a novel carbazole alkaloid (<strong>1</strong>) and 18 known compounds (<strong>2</strong>−<strong>19</strong>) from <em>Murraya euchrestifolia</em> to identify potential anti-tumor agents. The structures of these compounds were elucidated through various spectroscopic analysis including NMR, MS, electronic circular dichroism (ECD), and NMR calculations. The isolated compounds were subsequently evaluated for their affinity towards the vascular endothelial growth factor receptor-2 (VEGFR-2) through affinity screening. Molecular docking simulations, employing a hybrid Lamarckian Genetic Algorithm (LGA) to select conformations with binding energies ranging from −6.9 to −10.1 kcal/mol, revealed that compounds <strong>1</strong>, <strong>6</strong>, <strong>8</strong>, <strong>10</strong>−<strong>14</strong>, <strong>16</strong>, and <strong>19</strong> exhibited significant affinity for the VEGFR-2 protein. Furthermore, compounds <strong>1</strong>, <strong>6</strong>, <strong>8</strong>, <strong>13</strong>, and <strong>19</strong> demonstrated multiple binding sites with VEGFR-2, while compound <strong>10</strong> displayed the lowest binding energy (−10.1 kcal/mol). These findings provided a solid foundation for further investigation into the anti-tumor mechanisms of these compounds.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103023"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery and engineering of natural product molecules for drug development 用于药物开发的天然产物分子的发现和工程

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-10-01 Epub Date: 2025-10-28 DOI: 10.1016/j.phytol.2025.103079

David H. Sherman

引用次数: 0

Unprecedented bicyclic and tricyclic non-canonical terpenoids via synthetic biology platforms: Isolation and structure elucidation of unique C16 and C17 terpenoids 合成生物学平台上前所未有的双环和三环非规范萜类化合物：独特的C16和C17萜类化合物的分离和结构解析

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-10-01 Epub Date: 2025-10-28 DOI: 10.1016/j.phytol.2025.103081

Aikaterini Koutsaviti , Yao-Tao Duan , Mohamed A. Tammam , Maria Harizani , Codruta Ignea , Vassilios Roussis , Yong Zhao , Sotirios C. Kampranis , Efstathia Ioannou

引用次数: 0