Phytochemistry Letters最新文献_第9页

Anti-inflammatory activity of phenolics from Dianella ensifolia 洋二仙草酚类化合物的抗炎活性

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-05-09 DOI: 10.1016/j.phytol.2024.05.001

Dan Xu, Yajun Chen, Xu-Xu Cao, Jingjie Zheng, Yao Wang, Yan-Yan Ma, Kun Zhang, Deng-Gao Zhao

引用次数: 0

Three new quinic acid derivatives and a new shikimic acid derivative from the leaves of Castanopsis orthacantha 从栲叶中提取的三种新的喹酸衍生物和一种新的莽草酸衍生物

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-05-07 DOI: 10.1016/j.phytol.2024.04.014

Xue-Xue Cheng , Ya-Feng Wang , Rui-Jie He , Bing-Yuan Yang , Zhang-Bin Liu , Yong-Lin Huang

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Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia 从 Lendenfeldia 属海绵中分离出 24-homoscalarane 酯类化合物

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-27 DOI: 10.1016/j.phytol.2024.04.013

Li-Guo Zheng , You-Yan Chen , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , Yi-Hao Lo , Yu-Chi Tsai , Hao-Chun Hu , You-Ying Chen , Tsong-Long Hwang , Tzu-Ming Ou , Ping-Jyun Sung

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Four new sesquiterpenes from Carpesium faberi 来自 Carpesium faberi 的四种新芝麻素

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-26 DOI: 10.1016/j.phytol.2024.04.001

Xiang-yu Zheng , Hong-xu Wan

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Flavonoids glycosides from Camellia phanii 山茶花中的黄酮甙

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-23 DOI: 10.1016/j.phytol.2024.04.012

Ninh Khac Thanh Tung , Hoang Thi Tuyet Lan , Tran Thuy Nga , Nguyen Thi Mai , Vu Mai Thao , Nguyen Viet Dung , Nguyen Tien Dat , Nguyen Xuan Nhiem , Nguyen Bao Tan , Hyung Min Kim , Jong Seong Kang

{"title":"Flavonoids glycosides from Camellia phanii","authors":"Ninh Khac Thanh Tung , Hoang Thi Tuyet Lan , Tran Thuy Nga , Nguyen Thi Mai , Vu Mai Thao , Nguyen Viet Dung , Nguyen Tien Dat , Nguyen Xuan Nhiem , Nguyen Bao Tan , Hyung Min Kim , Jong Seong Kang","doi":"10.1016/j.phytol.2024.04.012","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.012","url":null,"abstract":"<div>By combining chromatography methods, three new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (1), kaempferol 3-O-(4-acetyl)-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (2), and (2 R,3 S) 5,7,4′-tetrahydroxyﬂavanonol 3-O-(4-acetyl)-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (3) as well as three known compounds, chrysandroside A (4), p-hydroxybenzaldehyde (5), and p-hydroxybenzoic acid (6) were isolated from the leaves of Camellia phanii Hakoda & Ninh. Their structure was elucidated by 1D and 2D-NMR spectra and compared to previously published in literature. In addition, all compounds were evaluated for their ability to inhibit α-glucosidase activity. As the results, flavonoid glycosides 1-3 inhibited α-glucosidase activity with IC50 values of 276.8 ± 19.4, 258.9 ± 24.3, and 341.4 ± 25.6 µM; phenolics (5 and 6) inhibited α-glucosidase activity with IC50 values of 295.5 ± 15.1 and 217.4 ± 23.6 µM, respectively.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 166-170"},"PeriodicalIF":1.7,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140640981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemometric studies in Hymenaea martiana 马蹄莲的化学计量学研究

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-22 DOI: 10.1016/j.phytol.2024.04.008

Juliane M. dos S. Silva , Larissa A. Rolim , Jackson R.G. da S. Almeida , Thiala A. Feitosa , Daniel A. Nery , Camila de Souza Araújo , Ana Paula de Oliveira

{"title":"Chemometric studies in Hymenaea martiana","authors":"Juliane M. dos S. Silva , Larissa A. Rolim , Jackson R.G. da S. Almeida , Thiala A. Feitosa , Daniel A. Nery , Camila de Souza Araújo , Ana Paula de Oliveira","doi":"10.1016/j.phytol.2024.04.008","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.008","url":null,"abstract":"<div>Hymenaea martiana Hayne's bark and resin are widely used in folk medicine for the treatment of various diseases, however the indiscriminate extractivism of its barks brings damage to its metabolism and development. In view this, the discovery of ways for a more rational use of the species becomes relevant. This study aims to evaluate possible similarities in chemical composition profile of different parts from H. martiana (barks, stalks and leaves) through the fingerprint by ¹H-NMR and FT-IR techniques. The principal component analysis (PCA) showed metabolic similarities between the barks and stalks in two spectroscopic techniques used. The similarity is explained by presence of sucrose and pinitol in both segments as main compounds of segments. The antioxidant activity profile, showed similarity corroborating thus, with observed in metabolic analysis, where IC50 values showed no statistical difference between the barks (10.73 ± 0.12 µg.mL−1) and stalks (8.40 ± 0.58 µg.mL−1). In our results, the PCA showed a difference in the leaves fingerprint of one specimen collected. As pointed also by PCA analysis, this individual was over stress situation which promoted the biosynthesis of monoterpene linalool, a compound with defensor properties from plants. Furthermore, the similarities between the barks and stalks observed may be an indication of similar biological activity and may direct other studies in order to reduce the extraction of the barks and minimize the damage to the species.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 158-165"},"PeriodicalIF":1.7,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140632802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new pregnane glycosides from the flower buds of Dregea volubilis 从 Dregea volubilis 的花蕾中提取的两种新的孕烷苷

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-17 DOI: 10.1016/j.phytol.2024.04.006

Xiao-Dong Zhang , Bin Qiu , Jie Yu , Ni-Man Bao

引用次数: 0

Thunbergiside A: An unprecedented neolignan isolated from Gardenia thunbergia L. f. and the antifungal activity of selected phytochemicals Thunbergiside A：从栀子中分离出的一种前所未有的新木质素以及某些植物化学物质的抗真菌活性

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-17 DOI: 10.1016/j.phytol.2024.04.009

Shaymaa M. Mohamed , Anber F. Mohammed , Samir A. Ross

{"title":"Thunbergiside A: An unprecedented neolignan isolated from Gardenia thunbergia L. f. and the antifungal activity of selected phytochemicals","authors":"Shaymaa M. Mohamed , Anber F. Mohammed , Samir A. Ross","doi":"10.1016/j.phytol.2024.04.009","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.009","url":null,"abstract":"<div>Phytochemical investigation of Gardenia thunbergia L. f. aerial parts led to the isolation of a previously undescribed neolignan 13, designated (thunbergiside A). This compound is classified as 2,3-dihydrobenzofuran that features a unique, highly substituted skeleton with functional diversity. The absolute configuration was established by comparing its experimental ECD spectrum and optical rotation values with those of related neolignans. In addition, seventeen diverse phytoconstituents were identified for the first time from this plant, expanding our knowledge of its chemical composition. These included oleanane-type saponins, phenolic derivatives, lignans, and neolignans, which serve as valuable chemotaxonomic markers. Considering the frequent emergence of infectious diseases, it is worth exploring additional antimicrobial agents. Selected isolated compounds were assessed for their antimycotic properties in an investigation for potential anti-infective agents. Various chromatographic procedures, spectroscopic, spectrometric analyses, and molecular modelling studies were employed for phytochemical investigation and structural characterization. Furthermore, the alamarBlue-based viability assay was employed for antifungal evaluation against three pathogenic fungi. Specifically, saponin 17, 3-O-(β-ᴅ-glucuronopyranoside) oleanolic acid, displayed moderate antifungal activity (IC50 = 11 µg/mL) against Candida albicans. Overall, this study identified an unprecedented neolignan along with other diverse constituents from Gardenia thunbergia. Moreover, the study presented a potential scaffold for antifungal drug development.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 153-157"},"PeriodicalIF":1.7,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140558908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annamiacids A and B: Two dissymmetric bis-diterpenes containing a rare ketal-γ-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase 琥珀酰二萜 A 和 B：两种不对称的双二萜，含有荚果琥珀中罕见的酮-γ-内酯基团，及其对 ATP-柠檬酸裂解酶的抑制作用

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-16 DOI: 10.1016/j.phytol.2024.04.010

Chi Song , Ze-Yu Zhao , Jin-Xin Zhu , Yi Zang , Juan Xiong , Jia Li , Jin-Feng Hu

{"title":"Annamiacids A and B: Two dissymmetric bis-diterpenes containing a rare ketal-γ-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase","authors":"Chi Song , Ze-Yu Zhao , Jin-Xin Zhu , Yi Zang , Juan Xiong , Jia Li , Jin-Feng Hu","doi":"10.1016/j.phytol.2024.04.010","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.010","url":null,"abstract":"<div>Two undescribed dissymmetric bis-diterpenes, annamiacids A (1) and B (2), were isolated from the renewable twigs and leaves of Podocarpus annamiensis, a ‘vulnerable’ conifer endemic to China. Their structures and absolute configurations were determined by spectroscopic and computational methods. The homodimeric (abietane-O-abietane, 1) and heterodimeric (abietane-O-totarane, 2) dimers were constructed from an identical phenolic abietane unit through an ether linkage with a phenolic abietane acid and a phenolic totarane acid, respectively. Both comprise a rare intramolecular 6-ketal-19,6-γ-lactone motif. Compound 2 could significantly inhibit ATP-citrate lyase with an IC50 value of 5.92 μM. A molecular docking study disclosed alternative H-bonds/interacting amino acid residues and binding pockets between 2 and the ACL enzyme when compared with those of compound 1, which supports their in vitro data.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 142-148"},"PeriodicalIF":1.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absolute stereochemistry and anti-inflammatory activity of cycloisobrachycoumarin, brachycromone, cyclobrachycoumarin, and cyclobrachycoumarin 2’-epimer from Gerbera delavayi 来自非洲菊的环异布拉香豆素、布拉香豆酮、环布拉香豆素和环布拉香豆素 2'-epimer 的绝对立体化学和抗炎活性

IF 1.7 4区生物学

Phytochemistry Letters Pub Date : 2024-04-16 DOI: 10.1016/j.phytol.2024.04.011

Yong-xun Yang , Qun Wang , Xiao-nian Li , Hai-yan Huang , Hao Geng

{"title":"Absolute stereochemistry and anti-inflammatory activity of cycloisobrachycoumarin, brachycromone, cyclobrachycoumarin, and cyclobrachycoumarin 2’-epimer from Gerbera delavayi","authors":"Yong-xun Yang , Qun Wang , Xiao-nian Li , Hai-yan Huang , Hao Geng","doi":"10.1016/j.phytol.2024.04.011","DOIUrl":"https://doi.org/10.1016/j.phytol.2024.04.011","url":null,"abstract":"<div>Four isomeric 5-methyl-4-hydroxycoumarin-monoterpene hybrids (MMHs) comprising three known MMHs, cycloisobrachycoumarin (1), brachycromone (2), cyclobrachycoumarin (3), and a new epimer of 3, cyclobrachycoumarin 2’-epimer (4) were isolated from Gerbera delavayi. The absolute configuration of 1–4 was elucidated by utilizing ECD calculations and X-ray diffraction analysis. As a result, the absolute configurations of C-2’ and C-3’ in 1 and 2 were revised to be 2′S, 3′R and 2′R, 3′S respectively. Consequently, the diagnostic negative/positive cotton effect (CE) at around 210–220 nm for the stereochemistry of angular/linear furano-MMHs is discussed and formulated. Moreover, compounds 1–4 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that 1–4 significantly inhibited NO production at the concentration of 10.0 μM, indicating that 1–4 possessed potent anti-inflammatory activity.</div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 135-141"},"PeriodicalIF":1.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0