Chemical constituents from the stems of Erythropalum scandens

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-03-24 DOI:10.1016/j.phytol.2025.102947

Qiao-dan Pan , Yuan-he Huang , Li-yang Zhao , Wei-rui Wang , Bing-an Wei , Ying-ying Xu , Xian Wei

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Abstract

The phytochemical investigation on the EtOH extract of the stems of an ethnological herbal medicine Erythropalum scandens Blume led to the isolation thirteen secondary metabolites. The chemical structures of isolated compounds were elucidated by various spectroscopic techniques. Among them, compound 1, named scandenoside A (1), is a previously unreported aromatic glycoside. Compounds (3-7,9-10,12) were isolated from this plant for the first time. The inhibitory activity of the isolates against xanthine oxidase (XOD) was evaluated, with compound 11 exhibiting strong inhibitory activity and a half inhibitory concentration (IC₅₀) value of 706.35 ± 18.36 µM. Molecular docking analyses revealed that the compound could bind within the active pocket of the XOD enzyme through hydrogen bonding and hydrophobic interactions. These results suggest that the stems of E. scandens may have a potentially beneficial effect on hyperuricemia.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.