抗菌活性及作用机制的研究：含磺胺基香豆素衍生物的设计与合成

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-03-24 DOI:10.1016/j.phytol.2025.102948

Song Bai , Miaohe Zhang , Miao Li , Suran Wan , Fang Wang , Shouyin Tang , Lijun Chen , Xian Wei , Rong Wu

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引用次数: 0

摘要

在这项创新研究中，我们将香豆素与一个磺胺基团结合，合成了一系列香豆素衍生物。体外抑菌活性试验表明，这些衍生物均显示出抑菌潜力，尤其是化合物27，其抑菌效果尤为显著。我们的实验结果表明，化合物27通过破坏米黄单胞菌的细胞膜来增强细菌细胞膜的通透性。从而有效地抑制其生长和繁殖。这不仅让我们对化合物27的作用机制有了更深入的了解，也代表了新型抗菌剂开发的突破，为未来的农业和医学提供了无限的可能。

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Investigation of antibacterial activity and mechanism of action: Design and synthesis of coumarin derivatives containing sulfonamide groups

In this innovative study, we combined coumarin with a sulfonamide group and synthesized a series of coumarin derivatives. In vitro antibacterial activity tests, these derivatives demonstrated antibacterial potential, especially compound 27, whose antibacterial effect was particularly remarkable. Our experimental results revealed that compound 27 enhanced bacterial cell membrane permeability by disrupting the cell membrane of Xanthomonas oryzae pv. oryzicola, thereby effectively inhibiting its growth and reproduction. This not only provides insights into our understanding of the mechanism of action of compound 27, but also represents a breakthrough in the development of novel antibacterial agents, offering unlimited possibilities for the future of agriculture and medicine.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.