α-Pyrones, root growth inhibitors from a mesophotic zone sponge-associated fungus Purpureocillium sp. NBUF263

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-03-19 DOI:10.1016/j.phytol.2025.102944

Yu-Ying Liu , Ting-Ting Wei , Guang-Jun Ran , Xiao-Hui Li , Salman Khan , Tao Cai , Chan-Ting Lai , Hong-Kun Wang , Bin Wu , Hai-Xiao Jin , Wei-Yan Zhang , Ting-Ting Wang , Shan He

{"title":"α-Pyrones, root growth inhibitors from a mesophotic zone sponge-associated fungus Purpureocillium sp. NBUF263","authors":"Yu-Ying Liu , Ting-Ting Wei , Guang-Jun Ran , Xiao-Hui Li , Salman Khan , Tao Cai , Chan-Ting Lai , Hong-Kun Wang , Bin Wu , Hai-Xiao Jin , Wei-Yan Zhang , Ting-Ting Wang , Shan He","doi":"10.1016/j.phytol.2025.102944","DOIUrl":null,"url":null,"abstract":"<div><div>Two new α-pyrones, pureones A (1) and B (2), one analog 6-carbomethoxymethyl-4-hydroxy-2-pyrone (3) (isolated as a natural product for the first time), together with 8-acetoxy pestalopyrone (4), 6-[(7S,8 R)-8-propyloxiran-1-yl]-4-methoxy-pyran-2-one (5), 6-pentyl-4-methoxy-pyran-2-one (6), pestalotin (LL-P880α) (7), LL-P880β (8) and annularin D (9) were identified from Purpureocillium sp. NBUF263, associated with an Ircinia sp. sponge from the mesophotic zone. The structures of all isolated compounds were elucidated by spectroscopic data analysis, and the absolute stereochemistry of 2 was determined by the modified Mosher's method. Compounds 2 and 3 exhibited root growth inhibition activities in Arabidopsis thaliana Columbia-0 model at 2.5 and 10.0 μM, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102944"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390025010304","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Two new α-pyrones, pureones A (1) and B (2), one analog 6-carbomethoxymethyl-4-hydroxy-2-pyrone (3) (isolated as a natural product for the first time), together with 8-acetoxy pestalopyrone (4), 6-[(7S,8 R)-8-propyloxiran-1-yl]-4-methoxy-pyran-2-one (5), 6-pentyl-4-methoxy-pyran-2-one (6), pestalotin (LL-P880α) (7), LL-P880β (8) and annularin D (9) were identified from Purpureocillium sp. NBUF263, associated with an Ircinia sp. sponge from the mesophotic zone. The structures of all isolated compounds were elucidated by spectroscopic data analysis, and the absolute stereochemistry of 2 was determined by the modified Mosher's method. Compounds 2 and 3 exhibited root growth inhibition activities in Arabidopsis thaliana Columbia-0 model at 2.5 and 10.0 μM, respectively.

查看原文本刊更多论文

α-吡啶酮，中厚叶区海绵相关真菌Purpureocillium sp. NBUF263的根生长抑制剂

两个新的α-pyrones, pureones B(1)和(2),一个模拟6-carbomethoxymethyl-4-hydroxy-2-pyrone(3)(孤立的自然产品第一次),连同8-acetoxy pestalopyrone(4), 6 -[(7, 8 R) 8-propyloxiran-1-yl] 4-methoxy-pyran-2-one (5), 6-pentyl-4-methoxy-pyran-2-one (6), pestalotin (LL-P880α)(7),LL-P880β(8)和annularin D(9)被确定Purpureocillium sp, NBUF263与一个Ircinia sp.海绵从mesophotic区。所有分离化合物的结构都通过光谱分析得到了证实，2的绝对立体化学用改进的Mosher法进行了测定。化合物2和3分别在2.5 μM和10.0 μM下对拟南芥Columbia-0模型的根生长有抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.