大戟醇B是一种从大戟根中分离得到的新的非正枞烷二萜。

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-01 DOI:10.1016/j.phytol.2024.12.009

Young Sook Yun , Miki Shimamura , Haruhiko Fukaya , Hiroyuki Fuchino , Nobuo Kawahara , Hideshi Inoue

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引用次数: 0

摘要

从大戟（Euphorbia lathyris L.）根中分离到一种新的非正枞烷二萜(1)，通过hresms、NMR和x射线衍射分析确定了其结构和绝对构型。这种化合物被命名为lathyrisol B，它是一种在C-4位置有一个外环烯烃的非对枞烷二萜。在人胰腺癌细胞MIA - PaCa-2细胞中，发现Lathyrisol B在C/EBP同源蛋白（CHOP）启动子氨基酸反应元件（AARE）的控制下刺激报告基因的表达。

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Lathyrisol B, a new nor-ent-abietane diterpenoid from roots of Euphorbia lathyris L.

A new nor-ent-abietane diterpenoid (1) was isolated from the root of Euphorbia lathyris L. Its structure and absolute configuration were determined based on data obtained from HRESIMS, NMR, and X-ray diffraction analysis. This compound, named lathyrisol B, is a nor-ent-abietane diterpenoid with an exocyclic olefin at the C-4 position. Lathyrisol B was found to stimulate the expression of a reporter gene under the control of amino acid response elements (AARE) of C/EBP homologous protein (CHOP) promoter in MIA PaCa-2 cells, human pancreatic cancer cells.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.