Phytochemistry Letters最新文献

{"title":"Five new chromane meroditerpenoids from the brown alga Sargassum siliquastrum of China Sea","authors":"Junzhi Pan ,&nbsp;Huayuan Liu ,&nbsp;Junpeng Xu ,&nbsp;Xiaofeng Xu ,&nbsp;Yu Qi ,&nbsp;Chaojie Wang ,&nbsp;Changle Wu ,&nbsp;Zhongmin Sun ,&nbsp;Yali Lv ,&nbsp;Pengcheng Yan","doi":"10.1016/j.phytol.2024.11.001","DOIUrl":"10.1016/j.phytol.2024.11.001","url":null,"abstract":"<div><div>Five previously undescribed chromane-type meroditerpenoids, sargasilols J–N (<strong>1</strong>–<strong>5</strong>), were isolated from an EtOAc-soluble extract of the brown alga <em>Sargassum siliquastrum</em> collected in the China Sea. The chemical structures of these meroditerpenoids were determined by extensive spectroscopic analyses, including 1D/2D NMR, ECD, and HR-ESI-MS data. Compound <strong>3</strong> exhibited potent anti-neuroinflammatory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglia cells, with an IC₅₀ value of 9.9 <em>μ</em>M.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 133-137"},"PeriodicalIF":1.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-soluble amino acid derivatives isolated from cultures of three fungal strains","authors":"Matheus Gotha ,&nbsp;Gabriel C. Junqueira ,&nbsp;Ariane F. Bertonha ,&nbsp;Julie P.G. Rodríguez ,&nbsp;Juliana R. Gubiani ,&nbsp;Emanuele F. Pissinati ,&nbsp;Rafaely N. Lima ,&nbsp;Lara D. Sette ,&nbsp;Simone P. de Lira ,&nbsp;Luciane F.P. Oliveira ,&nbsp;Andrea N.L. Batista ,&nbsp;João M. Batista Jr. ,&nbsp;Antonio G. Ferreira ,&nbsp;Márcio W. Paixão ,&nbsp;Marcelo R. Amorim ,&nbsp;Roberto G.S. Berlinck","doi":"10.1016/j.phytol.2024.10.005","DOIUrl":"10.1016/j.phytol.2024.10.005","url":null,"abstract":"<div><div>The isolation of amino acid-derived metabolites from the aqueous fractions of cultures of three fungal strains is reported. From cultures of <em>Penicillium coffeae</em> M3 two β-carboline alkaloids were isolated and identified, the new (+)-(1<em>R</em>,3<em>R</em>)-1-methyl-1,2,3,4-tetrahydro-<em>β</em>-carboline-3-carboxylic acid (<strong>1</strong>) and the known (–)-lycoperodine-1 (<strong>2</strong>), along with the diketopiperazine <em>cyclo</em>[<span>l</span>-prolyl-<span>l</span>-tyrosyl] (<strong>3</strong>) and the isocoumarin 6,8-dihydroxy-3-methylisocoumarin (<strong>5</strong>). The diketopiperazines (<strong>3</strong>), <em>cyclo</em>[<span>d</span>-prolyl-<span>l</span>-phenylalanyl] (<strong>4</strong>) and <em>cyclo</em>[<span>l</span>-prolyl-<span>l</span>-phenylalanyl] (<strong>6</strong>) were isolated and identified from cultures of <em>Trichoderma</em> sp. L2–2. The peptaibol trichokonin VI (<strong>7</strong>) was also identified by UPLC-MS/MS analysis in aqueous fractions from cultures of the same <em>Trichoderma</em> sp. strain, by comparison with an authentic standard, isolated and identified from the organic fraction of the same fungus culture. The amino acid derivatives formyl-<span>l</span>-tryptophyl-<span>l</span>-alanine (<strong>8</strong>), <em>cyclo</em>-(<span>d</span>-Trp- <span>l</span>-Glu) (<strong>9</strong>), and (<em>S</em>)-<em>N</em>-acetyl-kynurenine (<strong>10</strong>), were isolated from cultures of the endophytic fungus <em>Paecilomyces</em> sp. Aa1. The planar structures of the amino acid derivatives <strong>1</strong>-<strong>4</strong>, <strong>6</strong>, <strong>8</strong>-<strong>10</strong>, as well as of the isocoumarin <strong>5</strong>, were established by analysis of spectroscopic data, including MS/MS fragmentation and comparison with literature data. The configurational assignments were performed by analysis of Marfey derivatives and/or by comparison between experimental and calculated ECD data. The results obtained give further support that investigation of aqueous fractions of fungal cultures may provide structurally relevant and potentially bioactive secondary metabolites.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 123-132"},"PeriodicalIF":1.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of polyoxygenated briaranes from octocoral Briareum stechei","authors":"Yue-Wen Chuang ,&nbsp;Wei-Chen Ting ,&nbsp;Su-Ying Chien ,&nbsp;Li-Guo Zheng ,&nbsp;Chih-Yin Huang ,&nbsp;Zhi-Hong Wen ,&nbsp;Yu-Jen Wu ,&nbsp;Junichi Tanaka ,&nbsp;You-Ying Chen ,&nbsp;Jui-Hsin Su ,&nbsp;Ping-Jyun Sung","doi":"10.1016/j.phytol.2024.10.008","DOIUrl":"10.1016/j.phytol.2024.10.008","url":null,"abstract":"<div><div>A new 8,17-epoxybriarane, briastecholide O (<strong>1</strong>), was isolated from an encrusting algae-containing cultured octocoral <em>Briareum stechei</em>. Moreover, wild-type <em>B. stechei</em> collected from Okinawan waters yielded a new 8,17-epoxybriarane, briastecholide P (<strong>2</strong>), along with two known analogs, namely, briaexcavatins G (<strong>3</strong>) and X (<strong>4</strong>). Single-crystal X-ray diffraction was conducted to determine the absolute configurations of <strong>2</strong>–<strong>4</strong>, while the structure of <strong>1</strong> was established by spectroscopic elucidation. Briaranes <strong>1</strong> and <strong>3</strong> were active in enhancing the growth of MG-63 human mesenchymal stem cells.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 117-122"},"PeriodicalIF":1.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory pregnene steroids from the oleo-gum resin of Commiphora mukul: in-vitro and in-silico studies","authors":"Mohamed H. Abd El-Razek ,&nbsp;Ahmed H. Afifi ,&nbsp;Mohamed Hassan Nasraa ,&nbsp;Ahmed A. Elrashedy ,&nbsp;Mohamed Aboelmagd ,&nbsp;Abdelhalim A. Elgahamy ,&nbsp;Mai M. Elghonemy ,&nbsp;Tarik A. Mohamed ,&nbsp;Mohamed-Elamir F. Hegazy ,&nbsp;Ahmed H. El-Desoky","doi":"10.1016/j.phytol.2024.10.006","DOIUrl":"10.1016/j.phytol.2024.10.006","url":null,"abstract":"<div><div>Phytochemical investigation of a methanolic extract derived from the oleo-gum resin of <em>Commiphora mukul</em> resulted in the isolation of seven pregnene-type steroids (<strong>1</strong>-<strong>7</strong>), including a new compound named commukulsterol A (<strong>1</strong>). Their structures were decided by extensive analyses of 1D, 2D-NMR and Mass spectra. The relative configurations of commukulsterols A (<strong>1</strong>) and B (<strong>2</strong>) were determined <em>via</em> DFT calculations of their ¹H and ¹³C chemical shifts, followed by DP4+ statistical analysis. Absolute configurations were then decided by biogenetic similarities and specific rotations. Such analyses led to the revision of the structure of <strong>2</strong>, initially elucidated as 20<em>S</em>-acetyloxy-4-pregnene-3,16-dione, to pro-20<em>R</em>. <strong>1</strong>-<strong>7</strong> showed varying inhibitory effects on LPS-induced NO release in RAW264.7 macrophages, with IC₅₀ values ranging from 7.6 to 53.9 μM for (<strong>1</strong>-<strong>6)</strong>, while <strong>7</strong> didn’t show activity up to 100 μM. On the other hand, molecular docking revealed that <strong>3</strong> &amp; <strong>4</strong> could bind to the catalytic site of inducible nitric oxide synthase (iNOS). Moreover, molecular dynamics simulation of <strong>3</strong> &amp; <strong>4</strong> in association with iNOS were examined for 200 ns, revealing adequate stability. ADMET analysis indicated good oral bioavailability and drug-like properties. The observed chemical profile highlighted a unique chemical relationship between Burseraceae and Simaroubaceae families.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 106-116"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from Bambusae concretio Silicea and their anti-renal fibrosis activity","authors":"Hong Zhou ,&nbsp;Ye-Fei Chen ,&nbsp;Bin-Yuan Hu ,&nbsp;Qing-Qian Zeng ,&nbsp;Yong-Xian Cheng","doi":"10.1016/j.phytol.2024.10.004","DOIUrl":"10.1016/j.phytol.2024.10.004","url":null,"abstract":"<div><div>Two pairs of undescribed phenylpropanoids derivatives (±)-1 and (±)-2 together with sixteen known compounds (3–18) were isolated from the resin Bambusae concretio Silicea. Their structures were identified by spectroscopic analyses and computational methods. Furthermore, the anti-renal fibrosis activities of the new compounds were evaluated in transforming growth factor beta 1 (TGF-β1) stimulated NRK-52e cells by western blotting. As a result, compounds (±)-1 and (±)-2 were found to exhibit a dose-dependent inhibition of α-SMA, collagen I, and fibronectin expression in TGF-β1 stimulated NRK-52e cells.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 99-105"},"PeriodicalIF":1.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted plant metabolomics reveals catechin derivatives as key contributors to the antidiabetic activity of Cecropia species","authors":"Aylin De Lora ,&nbsp;Yuliana Christopher ,&nbsp;Orlando Ortiz ,&nbsp;Dionisio Olmedo ,&nbsp;Yostin Añino ,&nbsp;Preslav Enchev ,&nbsp;Yancho Zarev ,&nbsp;Iliana Ionkova ,&nbsp;Andrés Rivera-Mondragón","doi":"10.1016/j.phytol.2024.10.007","DOIUrl":"10.1016/j.phytol.2024.10.007","url":null,"abstract":"<div><div>Guarumo leaves (<em>Cecropia</em> sp.) have been traditionally used in Latin America to manage diabetes mellitus. This work aimed to evaluate the potential <em>α</em>-glucosidase inhibitory activity of leaf extracts from six <em>Cecropia</em> species collected in Panama. Additionally, the chemical compounds associated with this activity were characterized. We identified the most likely bioactive candidates by using UPLC-MS untargeted metabolomics. Among the evaluated <em>Cecropia</em> species, <em>C. obtusifolia, C. hispidissima, C. longipes,</em> and <em>C. peltata</em> (CA) showed significant <em>α</em>-glucosidase inhibitory activity with IC₅₀ values ranging from 9.0 to 29.8 μg/mL, as compared to acarbose (5069.72 μg/mL), used as a positive control. In contrast, <em>C. insignis</em>, <em>C. heterochroma</em>, and <em>C. peltata</em> (SC) did not show a significant effect in this assay. The OPLS-DA model exhibited strong predictive performance, clearly distinguishing between active and inactive extracts. Through this analysis, we identified three putative bioactive compounds, namely Procyanidin B, ourateacatechin, and kaji-ichigoside F1, that were found in higher concentrations in the active extracts and demonstrated strong <em>α</em>-glucosidase inhibition. Additionally, the metabolites identified showed VIP scores &gt; 1.5, indicating their significant contribution to the observed activity. This research identifies four <em>Cecropia</em> species as promising natural sources of <em>α</em>-glucosidase inhibitors, which could lead to new treatments for type 2 diabetes by helping to manage blood sugar levels.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 93-98"},"PeriodicalIF":1.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gigantolevisins A–C, tyrosinase inhibitory benzylidenes from the shoots of Gigantochloa levis","authors":"Lina Sagaral-Lacandalo ,&nbsp;Chona D. Gelani ,&nbsp;Emi Ohta ,&nbsp;Shinji Ohta","doi":"10.1016/j.phytol.2024.10.003","DOIUrl":"10.1016/j.phytol.2024.10.003","url":null,"abstract":"<div><div>The excessive tyrosinase activity has been linked to the overproduction of melanin which can lead to hyperpigmentation, oxidative stress, browning, and an increased risk of melanoma. Due to these detrimental effects associated with the overexpression of tyrosinase, research efforts are focused on finding bioactive compounds that can inhibit this enzyme efficiently. This study, conducted to find tyrosinase inhibitors utilizing the shoots of <em>Gigantochloa levis</em> (<em>G. levis</em>), produced three previously undescribed benzylidene derivatives (<strong>1–3</strong>) and two known compounds, with promising anti-tyrosinase activity. The new compounds were designated as gigantolevisins A–C, and the two known compounds as (<em>E</em>)-3-(4-hydroxyphenyl)-2-phenylacrylaldehyde (<strong>4</strong>) and (<em>E</em>)-2,3-bis(4-hydroxyphenyl)acrylaldehyde (<strong>5</strong>), respectively, based on the spectroscopic data and X-ray crystallographic analysis. The isolated compounds showed inhibition effects against tyrosinase, ranging from 42 % to 58 % (IC₅₀ values of &gt;400–286 ± 15 μM) in comparison to the positive control Kojic acid with 100 % inhibition (IC₅₀ value of 43 ± 3 μM). The findings suggest that, while the isolated compounds are less potent than Kojic acid, they can be effective in inhibiting tyrosinase activity. Thus, the study highlights the therapeutic potential of <em>G. levis</em> shoots for treating melanin-related conditions.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 86-92"},"PeriodicalIF":1.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights","authors":"Zi Tong Tey ,&nbsp;Khye Er Loh ,&nbsp;Siow-Ping Tan ,&nbsp;Chongjun Yuan ,&nbsp;Bimo Ario Tejo ,&nbsp;Intan Safinar Ismail ,&nbsp;Mohd Azlan bin Nafiah","doi":"10.1016/j.phytol.2024.10.002","DOIUrl":"10.1016/j.phytol.2024.10.002","url":null,"abstract":"<div><div>2-(3^’,4^’-dihydroxyphenyl)-3,6,7,8-tetramethoxy-4H-chromen-4-one (<strong>3</strong>), a new flavonoid was isolated from the ethyl acetate fraction of <em>Chrysanthemum morifolium</em> Ramat. dried flowers, while 4′,5-dihydroxy-3,3′,7,8-tetramethoxy-flavone (<strong>1</strong>) and casticine (<strong>5</strong>) were isolated from this plant for the first time, as well as two known flavonoids, eriodictyol-7-O-glucoside (<strong>2</strong>) and luteolin (<strong>4</strong>). Their structures were investigated over a broad spatial scale using chromatographic and spectroscopic techniques (NMR, FTIR, UV and HR-ESI-MS). Compound <strong>4</strong> showed the highest XO inhibition and the most favorable interaction with XO in molecular docking analysis. Compound <strong>2</strong>, <strong>3</strong> and <strong>4</strong> demonstrated stable interactions with catalytically important residues in xanthine oxidase via molecular dynamic analysis.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 68-78"},"PeriodicalIF":1.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new 2-pyrrolidinone from Cladosporium sp. associated with Rubus tephrodes","authors":"Shuaixing Liu ,&nbsp;Jiaqi Liu ,&nbsp;Liangrui Yang ,&nbsp;Shengqi Zhang ,&nbsp;Fengmei Zhang ,&nbsp;Le Cai","doi":"10.1016/j.phytol.2024.09.005","DOIUrl":"10.1016/j.phytol.2024.09.005","url":null,"abstract":"<div><div>The cultivation of <em>Cladosporium</em> sp., a fungus found in association with <em>Rubus tephrodes</em> Hance, resulted in the identification of sixteen compounds. New compound cladosporlactam (<strong>1</strong>) was distinguished by featuring a skeleton linked to a furan unit, with 3,4-dihydroxypyrrolidine-2-ketone as its characteristic structure. The structure of cladosporlactam was elucidated through meticulous analyses using NMR, electronic circular dichroism (ECD) calculations. Compound <strong>1</strong> could cause a gradual reduction in lipid droplets in a dose-dependent manner without inducing cytotoxicity and demonstrated intermediate antimicrobial activity against <em>Staphylococcus aureus</em> with MIC values of 8 μg/mL.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 79-85"},"PeriodicalIF":1.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-value flavonoids with potential anti-inflammatory benefits from Platanus × acerifolia Willd leaves: Turning waste into treasure","authors":"Xi-Ying Wu ,&nbsp;Ze-Yu Zhao ,&nbsp;Ezzat E.A. Osman ,&nbsp;Yeun-Mun Choo ,&nbsp;Juan Xiong ,&nbsp;Mark T. Hamann ,&nbsp;Jin-Feng Hu","doi":"10.1016/j.phytol.2024.10.001","DOIUrl":"10.1016/j.phytol.2024.10.001","url":null,"abstract":"<div><div>The London plane tree (<em>Platanus × acerifolia</em> Willd, P<em>a</em>W) is a deciduous urban ornamental tree extensively found in major cities in Southern China. It produces a significant volume of waste leaves, which hold the potential to serve as an abundant and valuable alternative source of bioactive flavonoids and other bioproducts. The seasonal variations of predominant flavonoids in leaves collected from the same individual P<em>a</em>W trees growing in Shanghai (China) during the life cycle [spring (May 2017), autumn (October 2017), and winter (January 2018)] were estimated according to their HPLC-PDA profiles, which revealed higher content in the samples of May (green pruning waste leaves) and January (brown fallen leaves). A total of 29 flavonoids (<strong>1</strong>–<strong>29</strong>) were subsequently isolated from an EtOAc fraction of the 90 % MeOH extract from the May leaves. Their structures were determined by spectroscopic methods, especially 1D- and 2D-NMR techniques. Platanosides <strong>1</strong>–<strong>3</strong> have been previously described as a unique chemical class of flavonoid glycosides, while isoprenylated flavonols <strong>4</strong> and <strong>5</strong> are reported for the first time in nature. The <em>in-silico</em> molecular docking and <em>in vitro</em> nitric oxide inhibitory studies provided compelling computational and experimental evidence supporting the anti-inflammatory potential of the isolated platanosides. These results demonstrate the significant potential of the waste P<em>a</em>W leaves as a sustainable raw material for large-scale production of flavonoids (especially platanosides), which are highly valued compounds with growing pharmaceutical interest.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"64 ","pages":"Pages 56-67"},"PeriodicalIF":1.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}