Phytochemistry Letters最新文献_第2页

Sesquiterpenoids from Lindera aggregata with Keap1 binding affinity: Chemical diversity and bioactivity screening 具有Keap1结合亲和性的山茱萸倍半萜类化合物：化学多样性和生物活性筛选

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-29 DOI: 10.1016/j.phytol.2025.103035

Caixia Guo , Wenhui Liu , Haojing Jiang , Hai-Jiang Zhang , Yuanqiang Guo , Jing Xu

{"title":"Sesquiterpenoids from Lindera aggregata with Keap1 binding affinity: Chemical diversity and bioactivity screening","authors":"Caixia Guo , Wenhui Liu , Haojing Jiang , Hai-Jiang Zhang , Yuanqiang Guo , Jing Xu","doi":"10.1016/j.phytol.2025.103035","DOIUrl":"10.1016/j.phytol.2025.103035","url":null,"abstract":"<div><div>Phytochemical investigation of Lindera aggregata roots led to the isolation and identification of 20 sesquiterpenoids (1–20), including a new germacrane-type derivative (1) and five congeners (6, 10–11, and 14–15) reported for the first time in this genus. Structural elucidation, based on NMR, HRESIMS, and ECD analysis, classified these compounds into five distinct chemical subtypes: germacrane (1–6), eudesmane (7–16), guaiane (18–19), lindenane (17), and elemane (20). To assess their potential bioactivity, an affinity ultrafiltration screening (AUS) assay, coupled with ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis, was performed using Kelch-like ECH-associated protein 1 (Keap1) as the target protein. The results indicated that 14 compounds exhibited significant binding affinity to Keap1. Molecular docking studies further revealed that compounds 2, 4, and 8 displayed the strongest interactions, with binding energies of −9.6, −9.2, and −8.6 kcal/mol, respectively. These compounds primarily interact with Keap1 through hydrogen bonding with residues ASN-414, ARG-415, VAL-465, and ILE-559, and hydrophobic interactions with residues ALA-366, GLY-367, GLY-464, GLY-558, and Ile-559. These findings suggested that these sesquiterpenoids may exert antioxidant and neuroprotective effects by modulating the Keap1-Nrf2 signaling pathway, providing new insights into the pharmacological potential of L. aggregata.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103035"},"PeriodicalIF":1.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olasecuthones A-E: Undescribed xanthones from Securidaca Longipedunculata Fresen (Polygalaceae) Olasecuthones A-E：未描述的山仙子（蓼科）中的山酮类化合物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-28 DOI: 10.1016/j.phytol.2025.103040

Abdulkabir Oladele Oladimeji , K. Suresh Babu

引用次数: 0

Two pairs of isomeric resin glycosides from Argyreia obtusifolia 双异构体树脂苷的研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-25 DOI: 10.1016/j.phytol.2025.103036

Shuo Chen, Yi-Lin Niu, Zhi-Tong Li, Hong-Hua Cui, Yong-Qin Yin, Yan-Fen Chen

{"title":"Two pairs of isomeric resin glycosides from Argyreia obtusifolia","authors":"Shuo Chen, Yi-Lin Niu, Zhi-Tong Li, Hong-Hua Cui, Yong-Qin Yin, Yan-Fen Chen","doi":"10.1016/j.phytol.2025.103036","DOIUrl":"10.1016/j.phytol.2025.103036","url":null,"abstract":"<div><div>Argyreia obtusifolia is widely distributed in Guangdong, Guangxi, and Yunnan provinces of China and belongs to the Convolvulaceae family. It has been traditionally used for medicinal purposes, such as stopping bleeding and promoting tissue regeneration. The present study was designed to investigate the chemical composition of A. obtusifolia and predict the binding affinity between its chemical constituents and the 6NJS protein. Four new resin glycosides, named argyreia R-U (1-4), along with known compounds (5-9), were isolated from the aerial parts of the plant. The glycoside acid of compounds 1-4 is operculinic acid C (10). Compounds 1 and 3, as well as compounds 2 and 4 are isomers, with the differences between the two pairs of isomers attributed to variations in one substituent and the site of lactonisation. The structures of these compounds were elucidated using 1D and 2D NMR spectroscopy, HR-TOF-MS, and UV and IR spectra. Molecular docking results indicated that compounds 1-4 and 10 were successfully localised within the binding pocket of the protein complex (PDB ID: 6NJS), predicting moderate affinity for the 6NJS protein.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103036"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel chemical constituent from the stems of Akebia quinata and its diacylglycerol acyltransferase inhibitory activity 奎纳塔茎中的新化学成分及其二酰基甘油酰基转移酶抑制活性

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-22 DOI: 10.1016/j.phytol.2025.103037

Yuan Gao , Ying-Xiao Xiao , Hao Xu , Xue-Feng Wu , Yi-Lin Li , Hyun-Sun Lee , Long Cui

引用次数: 0

Polycyclic polyprenylated acylphloroglucinols with cytotoxicity against human tongue squamous carcinoma cells in vitro from Hypericum curvisepalum 多环聚戊烯酰化酰基间苯三酚体外抗人舌鳞癌细胞毒性研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-22 DOI: 10.1016/j.phytol.2025.103038

Min-Min Cao , Xian Wei , Jie Huang , Zhong-Qiu Gan , Li-Ping Teng , Zhong-Bo Zhou

{"title":"Polycyclic polyprenylated acylphloroglucinols with cytotoxicity against human tongue squamous carcinoma cells in vitro from Hypericum curvisepalum","authors":"Min-Min Cao , Xian Wei , Jie Huang , Zhong-Qiu Gan , Li-Ping Teng , Zhong-Bo Zhou","doi":"10.1016/j.phytol.2025.103038","DOIUrl":"10.1016/j.phytol.2025.103038","url":null,"abstract":"<div><div>From the entire plant of Hypericum curvisepalum, two previously undescribed polycyclic polyprenylated acylphloroglucinols (1–2) and eleven structurally analogous compounds (3–13) were successfully isolated. The structural elucidation of these compounds was accomplished through a comprehensive approach, integrating extensive spectroscopic data analyses with [Mo₂(OAc)₄]- and [Rh₂(OCOCF₃)₄]-induced electronic circular dichroism experiments. Subsequently, the in vitro cytotoxic activities of the isolated compounds were evaluated against three distinct strains of tongue carcinoma cells. Among them, compounds 2 and 3 displayed moderate cytotoxic effects. Notably, compound 1 demonstrated potent activity against Cal-27 cells, with an IC₅₀ value of 18.55 ± 0.93 μM. Further investigations revealed that the cytotoxicity of compound 1 was closely associated with the promotion of ROS-mediated apoptosis and the inhibition of the S phase in the cell cycle.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103038"},"PeriodicalIF":1.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sesquiterpenes and isocoumarins from Diaporthe phaseolorum and their antibacterial activity against Pseudomonas syringae pv. actinidiae 皂荚的倍半萜和异香豆素及其对丁香假单胞菌的抑菌活性。actinidiae

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-18 DOI: 10.1016/j.phytol.2025.103033

Qing-Shu Chen , Tian Jin , Jiao-Xian Du , Shan-Shan Huang , Zheng-Hong Pan , Juan He

引用次数: 0

Studies on the chemical constituents of the stems and leaves of Murraya euchrestifolia 木犀叶茎叶化学成分的研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-13 DOI: 10.1016/j.phytol.2025.103023

Xiaowei Zhao , Chunhui Yu , Caixia Guo , Haojing Jiang , Hai-Jiang Zhang , Yuanqiang Guo , Jing Xu

{"title":"Studies on the chemical constituents of the stems and leaves of Murraya euchrestifolia","authors":"Xiaowei Zhao , Chunhui Yu , Caixia Guo , Haojing Jiang , Hai-Jiang Zhang , Yuanqiang Guo , Jing Xu","doi":"10.1016/j.phytol.2025.103023","DOIUrl":"10.1016/j.phytol.2025.103023","url":null,"abstract":"<div><div>The ongoing importance of natural products in drug discovery is highlighted by our investigation. We report the isolation of a novel carbazole alkaloid (1) and 18 known compounds (2−19) from Murraya euchrestifolia to identify potential anti-tumor agents. The structures of these compounds were elucidated through various spectroscopic analysis including NMR, MS, electronic circular dichroism (ECD), and NMR calculations. The isolated compounds were subsequently evaluated for their affinity towards the vascular endothelial growth factor receptor-2 (VEGFR-2) through affinity screening. Molecular docking simulations, employing a hybrid Lamarckian Genetic Algorithm (LGA) to select conformations with binding energies ranging from −6.9 to −10.1 kcal/mol, revealed that compounds 1, 6, 8, 10−14, 16, and 19 exhibited significant affinity for the VEGFR-2 protein. Furthermore, compounds 1, 6, 8, 13, and 19 demonstrated multiple binding sites with VEGFR-2, while compound 10 displayed the lowest binding energy (−10.1 kcal/mol). These findings provided a solid foundation for further investigation into the anti-tumor mechanisms of these compounds.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103023"},"PeriodicalIF":1.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pair of lignans isolated from Trachelospermum jasminoides and their anti-inflammatory activity 从栀子花中分离的一对木脂素及其抗炎活性

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-11 DOI: 10.1016/j.phytol.2025.103034

Chen-Yi Yan , Miao Wang , Yu-Ting Mu , Li-Lian Zhao , Yu-Liang Guo , Wei-Zhen Dong , Yun Deng , Da-Le Guo

引用次数: 0

Acylated petunidin glycosides in the flowers of Exacum affine (Gentianaceae) 仿射龙胆花中乙酰化牵牛花苷的研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-06 DOI: 10.1016/j.phytol.2025.103021

Fumi Tatsuzawa , Natsu Tanikawa

{"title":"Acylated petunidin glycosides in the flowers of Exacum affine (Gentianaceae)","authors":"Fumi Tatsuzawa , Natsu Tanikawa","doi":"10.1016/j.phytol.2025.103021","DOIUrl":"10.1016/j.phytol.2025.103021","url":null,"abstract":"<div><div>Four anthocyanins, along with one flavone, caffeoyl-glucose, and secoiridoid glycoside, were isolated from the violet-blue flowers of Exacum affine (Gentianaceae), and their structures were determined using chemical and spectroscopic techniques. Among them, petunidin 3-O-β-glucopyranoside-5-O-[6-O-(trans-caffeoyl)-β-glucopyranoside] is reported for the first time. For petunidin 3-O-β-glucopyranoside-5-O-[6-O-(trans-p-coumaroyl)-β-glucopyranoside], which had previously been identified Yu et al. (2024) via LC-MSn analyses, its exact structure has now been determined. Additionally, petunidin 3,5-di-O-β-glucopyranoside, petunidin 3-O-β-glucopyranoside-5-O-[6-O-(acetyl)-β-glucopyranoside], luteolin 4’-O-(β-glucopyranoside), 1-O-(trans-caffeoyl)-β-glucopyranose, and gentiopicroside were also identified from E. affine flowers. Since the pigment composition was nearly identical between the violet-blue flowers of ‘Royal Dane Blue Deep’ and the purple flowers of ‘Royal Dane Rose Deep,’ except for the amount of luteolin 4’-O-β-glucopyranoside, it was concluded that the bluer coloration of E. affine flowers results from the intermolecular co-pigmentation effect between anthocyanin and flavone.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"69 ","pages":"Article 103021"},"PeriodicalIF":1.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a new 1-monoglyceride from Streptomyces albogriseolus JM128 symbiotic with Lendenfeldia sponge 从与海绵Lendenfeldia共生的白灰链霉菌JM128中发现新的1-单甘油酯

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2025-08-05 DOI: 10.1016/j.phytol.2025.103026

Yun-Ting Zeng , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , You-Ying Chen , Li-Guo Zheng , Chih-Yin Huang , Hsi-Wen Sun , Ping-Jyun Sung

引用次数: 0