Phytochemistry Letters最新文献

{"title":"Batzelladine Q, a new guanidine alkaloid from the marine sponge Monanchora arbuscula","authors":"Marcelo R. de Amorim ,&nbsp;Anderson L. Noronha ,&nbsp;Kamila L. Macedo ,&nbsp;Karina F. Baracco ,&nbsp;Caue A.W. Zuccarino ,&nbsp;Tiago A. Paz ,&nbsp;Antonio G. Ferreira ,&nbsp;Tiago Venâncio ,&nbsp;Eduardo Hajdu ,&nbsp;Roberto G.S. Berlinck","doi":"10.1016/j.phytol.2025.103005","DOIUrl":"10.1016/j.phytol.2025.103005","url":null,"abstract":"<div><div>A chemical investigation of the organic-soluble extract obtained from the marine sponge <em>Monanchora arbuscula</em>, collected at the southeastern coastline of Brazil, led to the isolation of a new minor guanidine alkaloid, batzelladine Q (<strong>1</strong>), along with known alkaloids batzelladines L (<strong>2</strong>) and F (<strong>3</strong>), clathriadic acid (<strong>4</strong>), mirabilin B (<strong>5</strong>), ptilocaulin (<strong>6</strong>), netamine M (<strong>7</strong>) and the degraded carotenoid derivative 9-apoastaxanthinone (<strong>8</strong>). All compounds were identified by analysis of spectroscopic data. The absolute configurations of compounds <strong>4</strong> and <strong>8</strong> were for the first time established by the comparison of experimental ECD spectra with calculated CD data.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103005"},"PeriodicalIF":1.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two undescribed C18-diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang","authors":"Wen-juan Xue ,&nbsp;Nurfida Ablajan ,&nbsp;Bo Zhao ,&nbsp;Yu-qing Yang ,&nbsp;Xue-ying Lu ,&nbsp;Jiang-yu Zhao ,&nbsp;Shamansur Sagdullaev ,&nbsp;Haji Akber Aisa","doi":"10.1016/j.phytol.2025.103000","DOIUrl":"10.1016/j.phytol.2025.103000","url":null,"abstract":"<div><div>Two C₁₈-diterpenoid alkaloids naviculamine A (<strong>1</strong>) and naviculamine B (<strong>2</strong>), together with one known C₁₉-diterpenoid alkaloids septentriodine (<strong>3</strong>) were isolated from the aerial part of <em>Delphinium naviculare</em> var<em>. lasiocarpum</em>. Compound <strong>1</strong> was an unprecedented skeleton C₁₈-diterpenoid alkaloid with chemical bond breakage between C-7 and C-17. Compound <strong>2</strong> was a relatively rare nitrone C₁₈-diterpenoid alkaloid discovered from natural. Their chemical structures were established on the basis of spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR spectroscopic data and ECD. The inhibitory effects of these diterpenoid alkaloids on hERG and CaV3.1 channels were also evaluated.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103000"},"PeriodicalIF":1.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gracilarioside A, New Glycolipid and other cytotoxic constituents from red algae Gracilaria edulis","authors":"Kotta Ramulu ,&nbsp;Solipeta Divya Reddy ,&nbsp;Bandi Siva ,&nbsp;Penta Poornima ,&nbsp;Lakkakula Satish ,&nbsp;B. Sridhar ,&nbsp;Katragadda Suresh Babu","doi":"10.1016/j.phytol.2025.103001","DOIUrl":"10.1016/j.phytol.2025.103001","url":null,"abstract":"<div><div>A comprehensive investigation of chemical constituents from red algae <em>Gracilaria edulis</em> led to the isolation and identification of 12 compounds, which include a new MGDG (Mono Galactosyl Diacyl Glycerol) glycolipid, Gracilarioside A (<strong>1</strong>) alongside with two known cerebrosides (<strong>2</strong>, <strong>3</strong>), sterols (<strong>4</strong>-<strong>7</strong>), nitrogen bases (<strong>8</strong>, <strong>9</strong>) and nucleosides (<strong>10</strong>-<strong>12</strong>). The structures of isolated compounds were elucidated by extensive spectroscopic techniques, (IR, MS, and 2D NMR) and single crystal X-ray diffraction studies. The crystal structure of <strong>4</strong> was reported for the first time. Further, anticancer activities of the extract and isolated compounds were assessed against a panel of cancer cell lines including DU145 (prostate), B16F10 (melanoma), HeLa (cervical), and MDA-MB 231 (breast) using MTT assay. Among the tested compounds, compounds <strong>1</strong>, <strong>3</strong>, <strong>4, 7</strong> and <strong>8</strong> displayed significant activities against MDA MB 231 [IC₅₀, 7.47 ± 0.05, 7.64 ± 0.34, 6.59 ± 0.21, 6.38 ± 0.49 and 7.19 ± 0.03 µM] while compounds <strong>4</strong>, <strong>5</strong>, <strong>6</strong> and <strong>7</strong> manifested moderate activities against B16F10 [7.0 ± 0.35, 7.20 ± 0.25, 7.26 ± 0.18 and 5.33 ± 0.04 µM] cell lines, respectively. Given their notable activity, compounds <strong>1</strong>, <strong>3</strong> and <strong>4</strong> were chosen for further investigation through detailed fluorescence assays, DCDFA assay and scratch assays against MDA MB-231 cell lines which suggested the induced cell death by apoptosis. Overall, the significant findings suggest that these compounds could be promising lead molecules in the development of new anticancer drug candidates.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103001"},"PeriodicalIF":1.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triterpenoids from Garcinia oligantha and their affinity with vascular endothelial growth factor receptor-2","authors":"Yupeng Zhai ,&nbsp;Caixia Guo ,&nbsp;Haojing Jiang ,&nbsp;Hai-Jiang Zhang ,&nbsp;Jing Xu ,&nbsp;Yuanqiang Guo","doi":"10.1016/j.phytol.2025.102998","DOIUrl":"10.1016/j.phytol.2025.102998","url":null,"abstract":"<div><div><em>Garcinia oligantha</em> Merr., a traditional herb, is widely used in folk medicines for the treatment of various ailments. To explore its potential medicinal value, a chemical investigation on <em>G. oligantha</em> was conducted, leading to the isolation and identification of five triterpenoids, including two new lupane-type triterpenes and three known oleanane-type triterpenes. The structures of these compounds were precisely elucidated using spectroscopic techniques, such as NMR, HRESIMS, and CD. To assess their potential bioactivity, affinity screening was performed, which revealed that compounds <strong>3</strong>−<strong>5</strong> exhibited significant affinity for vascular endothelial growth factor receptor 2 (VEGFR-2), an important target for anti-cancer drug development. Further molecular docking studies elucidated the binding modes of these compounds with VEGFR-2. This study not only enriches the understanding of the chemical constituents of <em>G. oligantha</em> but also provides potential bioactive molecules for the development of novel anti-cancer drugs.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102998"},"PeriodicalIF":1.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New alkaloids isolated from the fruits of Capparis spinosa L. and their xanthine oxidase inhibitory activity","authors":"Mingyu Ba ,&nbsp;Songfan Jiang ,&nbsp;Zhen He ,&nbsp;Wansheng Chen ,&nbsp;Doudou Huang ,&nbsp;Lianna Sun","doi":"10.1016/j.phytol.2025.103002","DOIUrl":"10.1016/j.phytol.2025.103002","url":null,"abstract":"<div><div>Two new alkaloids, 6-hydroxy-2′-(methylthio)-4′H-spiro[indoline-3,5′-thiazol]-2-one. (<strong>1</strong>), 2-(hydroxythio)-6-methoxy-1-methyl-1H-indole-3-carbaldehyde (<strong>2</strong>), as well as five known heteroauxin (<strong>3</strong>), 1,4-Dihydro-4-oxo-3-quinolinecarbonitrile (<strong>4</strong>), 3,4-dihydroxyquinoline-4-O-<em>β</em>-D-glucopyranoside (<strong>5</strong>), (2R,3R)-4-[5-(2-Furanyl)-2-pyrazinyl]-1,2,3-butanetriol (<strong>6</strong>) and 2-Methyl-7-benzoxazolecarboxylic acid (<strong>7</strong>) were isolated from the fruit of <em>Capparis spinosa</em> L. Their structures were elucidated mainly by NMR and HR-ESI-MS analysis, as well as on comparison with the data of known analogues. Compounds <strong>1</strong> and <strong>2</strong> exhibited xanthine oxidase (XOD) inhibitory activities, with values of 21.9 % and 19.8 % at 40 μM, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103002"},"PeriodicalIF":1.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of pharmacological effects and bioactive constituents of Euonymus alatus","authors":"Na Sun,&nbsp;Yujing Wang,&nbsp;Caihong Zhou,&nbsp;Huanhuan Kang,&nbsp;Run Wang,&nbsp;Xiu Feng,&nbsp;Shuo Ma,&nbsp;Linxuan Jin,&nbsp;Xin Zhang,&nbsp;Penghua Shu","doi":"10.1016/j.phytol.2025.103003","DOIUrl":"10.1016/j.phytol.2025.103003","url":null,"abstract":"<div><div>As a traditional Chinese medicine, <em>Euonymus alatus</em> is known as a good medicine for breaking blood and promoting menstruation, and was first recorded in the \"Shennong Bencao Jing\". Modern pharmacological studies have shown that it exhibits various pharmacological effects such as anti-diabetes, antioxidant, and anti-inflammatory. However, the pharmacological effects and related bioactive constituents of this herb have not been reviewed. In order to clarify the relationship between diseases and ingredients, this paper provides a comprehensive review of the pharmacological effects and related active ingredients of <em>Euonymus alatus</em>. The pharmacological effects of <em>Euonymus alatus</em> were classified and summarized by searching for relevant literature using PubMed, Web of Science, Scifinder, Google Scholar, Wanfang, and China National Knowledge Infrastructure databases. Furthermore, forty-seven corresponding active compounds were summarized and screened. This review provides a reference for the clinical application and drug discovery of <em>Euonymus alatus</em>.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 103003"},"PeriodicalIF":1.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing natural compounds as ligands to disrupt the binding of SARS-CoV-2 receptor-binding domain to angiotensin-converting enzyme 2, impeding viral infection","authors":"Jingyi Wu ,&nbsp;Ting-Hsu Chen ,&nbsp;Zi-han Shen ,&nbsp;May-Jywan Tsai ,&nbsp;Max K. Leong ,&nbsp;Yan-qiang Huang ,&nbsp;Ching-Feng Weng","doi":"10.1016/j.phytol.2025.102999","DOIUrl":"10.1016/j.phytol.2025.102999","url":null,"abstract":"<div><div>Currently, no specific antiviral drug has been definitively proven effective in treating patients with severe coronavirus disease 2019 (COVID-19). Various specific strategies have been employed against COVID-19; however, several potent antiviral candidates, including prodrugs and repurposed drugs, are still under urgent investigation, particularly in the search for molecular targets. This study aimed to evaluate the potential of natural compounds and chemicals against RNA viruses using a three-tiered approach to molecular docking. Binding scores obtained from ChemPLP revealed that natural compounds and repurposed drugs exhibited strong affinities for the binding sites on angiotensin-converting enzyme 2 (ACE2) receptors in host cells, the receptor-binding domain (RBD) site of the RBD-ACE2 complex, PL^pro, and 3CL^pro. Conclusively, these findings suggest that alternative medicines and antiviral drug repurposing strategies may provide promising therapeutic remedies for patients with COVID-19, along with further validation via preclinical and clinical trials.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102999"},"PeriodicalIF":1.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking and network pharmacology highlight salvianolic acids as potential inhibitors and therapeutic agents for COVID-19 treatment","authors":"Anathi Msobo ,&nbsp;Manamele Dannies Mashabela ,&nbsp;Gerrit Koorsen ,&nbsp;Teboho Nicolus Tsotetsi ,&nbsp;Lizelle Ann Piater ,&nbsp;Ntakadzeni Edwin Madala ,&nbsp;Tendamudzimu Tshiwawa ,&nbsp;Msizi Innocent Mhlongo","doi":"10.1016/j.phytol.2025.102991","DOIUrl":"10.1016/j.phytol.2025.102991","url":null,"abstract":"<div><div>Salvianolic acids have been shown to have therapeutic effects against COVID-19. However, their active compounds and underlying mechanisms have not yet been reported. This study aimed to investigate the effect of salvianolic acids against COVID-19 viral and human target proteins by integrating molecular docking and network pharmacology. Fourteen salvianolic acids were docked against 5 important viral proteins: Spike protein, main protease (Mpro), Helicase, RNA-dependent RNA polymerase (RdRp), and papain-like protease (PLpro). Network pharmacology was performed to identify the active compounds, potential targets and underlying mechanisms of salvianolic acids against COVID-19 human targets. The docking results revealed that 3 active compounds, namely salvianolic acids C, I, and N, bind to and stably interact with the active sites of PLpro, spike protein, Mpro, helicase, and RdRp, with low binding scores. From the network pharmacology results, a total of 7 active compounds and 12 core targets were selected for further analysis. The results of GO and KEGG enrichment analysis indicated that the anti-COVID targets of salvianolic acids are mainly involved in inflammatory processes and could prevent COVID-19 by inhibiting 4 signaling pathways: Coronavirus disease pathway, Cytokine signaling in the immune system, Th17 cell differentiation and Oncostatin signaling pathway. Molecular docking results indicated that all active compounds (Salvianolic acids A, C, I, J, L, N, and Y) could bind to all 12 core targets. However, salvianolic acids C, J, and N were found to be the main active compounds that bind with low (favourable) scores to JAK2, TYK2, and MAPK3 that were found to be the main targets for the treatment of COVID-19. This study revealed the active compounds and potential molecular mechanisms of salvianolic acids against viral and human COVID-19 proteins. These results can serve as a comprehensive reference for studying the mechanism by which salvianolic acids act on COVID-19 and additional research that involves <em>in vitro</em> and <em>in vivo</em> methods.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102991"},"PeriodicalIF":1.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neoflavonoid from the stems and leaves of Paris tengchongensis and its inhibitory activity against vascular calcification","authors":"Yan Chen ,&nbsp;Shicheng Wu ,&nbsp;Xuan Chen ,&nbsp;Lin Zhang ,&nbsp;Xirong Chen ,&nbsp;Ya Zhu","doi":"10.1016/j.phytol.2025.102992","DOIUrl":"10.1016/j.phytol.2025.102992","url":null,"abstract":"<div><div>A previously undescribed neoflavonoid (<strong>1</strong>), as well as five known compounds including Kaempferol (<strong>2</strong>), isorhamnetin (<strong>3</strong>), quercetin (<strong>4</strong>), coumestrol (<strong>5</strong>), dalbergin (<strong>6</strong>) were isolated from the stems and leaves of <em>Paris tengchongensis</em>. Focusing on vascular protective activity, we found it can inhibit alkaline phosphatase (ALP) activity and reduce the level of advanced glycation end products (AGEs)in Human Aortic Smooth Muscle Cells (HASMCs).</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102992"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and antagonistic activities of withaferin A-producing endophytes from Withania somnifera and Withania coagulans","authors":"Morteza Parvandi ,&nbsp;Mohammad Hossein Mirjalili ,&nbsp;Mohammad Hassan Zarrin-Chang ,&nbsp;Mehdi Majidi ,&nbsp;Hassan Rezadoost ,&nbsp;Mohsen Farzaneh","doi":"10.1016/j.phytol.2025.102979","DOIUrl":"10.1016/j.phytol.2025.102979","url":null,"abstract":"<div><div>Microorganisms are increasingly studied in biotechnology for their potential in pharmaceutical compound production. Endophytes, microorganisms living within plants, can produce specialized metabolites similar to those of their host plants. This study focused on isolating and identifying withaferin A (WFA)-producing endophytes (WFAPEs) from various organs of <em>Withania somnifera</em> and <em>W. coagulans</em> using morphological characteristics and ITS1–5.8S-ITS2 sequencing. In total, 10 fungal endophytes (FEs) and four bacterial endophytes (BEs) were isolated from <em>W. somnifera</em>, and 11 FEs and two BEs from <em>W. coagulans</em> and WFA production was evaluated using HPLC-PDA-MS. The antioxidant activity of WFAPEs was assessed with the DPPH assay, while the antagonistic effects of BEs against FEs were examined through co-culture. Phytochemical analyses revealed that three FEs, including <em>Aspergillus lentulus</em> and <em>Chaetomium</em> sp. from <em>W. coagulans</em> and <em>Ascochyta rabiei</em> from <em>W. somnifera</em>, produced WFA. The highest WFA content (136.57 ± 2.00 µg g⁻¹ dry weight, DW) was produced by <em>A. lentulus</em>, which also exhibited the highest antioxidant activity (IC₅₀=15.38 μg mL⁻¹). Additionally, <em>Bacillus subtilis</em> SWSB1 showed antagonistic effects (4.96 ± 0.1 mm) against <em>Chaetomium</em> sp. <em>Aspergillus lentulus</em> isolated from <em>W. coagulans</em> appears to be a promising natural source for the commercial production of the anticancer compound WFA in fermentation systems.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"68 ","pages":"Article 102979"},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}