Phytochemistry Letters最新文献_第2页

Two new aromatic meroterpenoids from the fruiting bodies of Ganoderma calidophilum 从芝灵芝子实体中分离出的两个新的芳香萜类化合物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI: 10.1016/j.phytol.2026.104122

Wei Liu , Li Yang , Qing-Yun Ma , Qing-Yi Xie , Jiao-Cen Guo , Hao-Fu Dai , Yan Hua , You-Xing Zhao

引用次数: 0

Development of a non-alcoholic extraction method for alkylamides in Echinacea purpurea 紫锥菊中烷基酰胺非酒精提取方法的研究

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-01-15 DOI: 10.1016/j.phytol.2026.104115

Zhixia (Grace) Chen , Michael Chamberlain , Xujiang Yuan

{"title":"Development of a non-alcoholic extraction method for alkylamides in Echinacea purpurea","authors":"Zhixia (Grace) Chen , Michael Chamberlain , Xujiang Yuan","doi":"10.1016/j.phytol.2026.104115","DOIUrl":"10.1016/j.phytol.2026.104115","url":null,"abstract":"<div><div>Introduction: Alkylamides are recognized as the main active constituents of Echinacea purpurea. Owing to their lipophilic nature, they are conventionally extracted using ethanol-based solvents. Ethanol-free preparations, including Echinacea glycerites and glycetracts, have emerged as alternatives; however, their alkylamides content has not been rigorously verified and is assumed to be low. The lack of ethanol-free extracts capable of preserving alkylamides potency presents a major challenge for product development. Method: E. purpurea were subjected to ultrasonic-assisted extraction using propylene glycol (PG) as the extraction solvent. Comparative analyses were conducted with E. purpurea glycerite, glycetract and hydroethanolic extracts. Results: Organoleptic evaluation indicated that PG-based extracts retained the characteristic tingling properties observed in hydroethanolic extracts. Quantitative HPLC analysis demonstrated that glycerite and glycetract preparations contained approximately 44 % of the alkylamides concentration measured in hydroethanolic extracts. In contrast, PG-based ultrasonic extracts achieved 83 % of the alkylamides yield of the hydroethanolic extract. Furthermore, alkylamides were not detected in the aerial parts extract. Conclusion: PG extract offers a viable ethanol-free E. purpurea alternative, while maintaining a high alkylamides content.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104115"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five new prenylated flavonoids derivatives from Dysosma versipellis and their DPPH radical scavenging activity 五种新戊基化黄酮类化合物及其清除DPPH自由基的活性

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-02-02 DOI: 10.1016/j.phytol.2026.104132

Meng Zhang , Hong-Yun Bai , Ling-Yu Ye , Xiao-Ke Zheng , Meng Li , Hui Chen , Jing-Ke Zhang , Zhi-You Hao , Shen Liang , Yan-Jun Sun , Wei-Sheng Feng

{"title":"Five new prenylated flavonoids derivatives from Dysosma versipellis and their DPPH radical scavenging activity","authors":"Meng Zhang , Hong-Yun Bai , Ling-Yu Ye , Xiao-Ke Zheng , Meng Li , Hui Chen , Jing-Ke Zhang , Zhi-You Hao , Shen Liang , Yan-Jun Sun , Wei-Sheng Feng","doi":"10.1016/j.phytol.2026.104132","DOIUrl":"10.1016/j.phytol.2026.104132","url":null,"abstract":"<div><div>Five new prenylated flavonoids, named dysosmaflavonoids G–K (1 – 5), along with ten known related analogues (6– 15), were isolated from the roots and rhizomes of Dysosma versipellis. Their structures were elucidated by comprehensive spectroscopic analysis, including NMR, IR, UV, and HRESIMS. The antioxidant activities of all isolated compounds were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. In comparison to trolox (IC50 = 9.67 μM), compounds 4, 6, and 9–14 exhibited significant DPPH scavenging capacity, with IC50 values of 16.63, 22.09, 12.50, 20.35, 20.43, 14.70, 6.56, and 8.27 μM, respectively. Notably, compound 13 demonstrated stronger DPPH radical scavenging activity than its prenylated derivatives (2 and 4). The presence of a catechol moiety on the flavonol scaffold was found to be crucial for effective DPPH radical scavenging activity, for example, compared 3 to 12, and 13 to 2. The preliminary structure-activity relationship analysis revealed that the DPPH radical scavenging activity of these flavonol derivatives correlates closely with the number and position of phenolic hydroxy groups and prenylated moieties.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104132"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory activity of alkaloids from the leaves of Atalantia buxifolia 柳叶生物碱的抗炎活性

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI: 10.1016/j.phytol.2026.104138

Qianwei Zhou, Min Xiang, Ziwei Feng, Jiyao Tan, Qiping Weng, Xuan He, Yan-Yan Ma, Deng-Gao Zhao

{"title":"Anti-inflammatory activity of alkaloids from the leaves of Atalantia buxifolia","authors":"Qianwei Zhou, Min Xiang, Ziwei Feng, Jiyao Tan, Qiping Weng, Xuan He, Yan-Yan Ma, Deng-Gao Zhao","doi":"10.1016/j.phytol.2026.104138","DOIUrl":"10.1016/j.phytol.2026.104138","url":null,"abstract":"<div><div>A chemical study on the leaves of Atalantia buxifolia afforded ten compounds. Among them, two were characterized as new alkaloids, namely a benzoyltyramine designated hortiamide B (1) and an acridone alkaloid named acrignine B (2), while the remaining eight were known analogues (3–10). Extensive spectroscopic techniques were employed to determine their structures, with the absolute configuration of 1 being unambiguously established by single-crystal X-ray diffraction analysis. In an evaluation of anti-inflammatory potential, all compounds were tested for their ability to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. This assay revealed that compounds 1, 9, and 10 possessed notable activity, with IC50 values of 8.5 ± 0.7, 12.7 ± 1.2, and 23.4 ± 2.1 μM, respectively. The present work enriches the phytochemical profile of A. buxifolia and highlights specific isolates as valuable candidates for future development of anti-inflammatory agents.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104138"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fusariacumines AC, indole alkaloids from Fusarium acuminatum J207-2 with antibacterial activity 镰刀菌J207-2中具有抗菌活性的吲哚类生物碱

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.phytol.2026.104120

Hua Guo , Quan-Ping Diao , Tao Feng , Juan He

引用次数: 0

GC-MS metabolite profiling and computational ranking of Butea monosperma and their predicted contribution to antimicrobial activity against MRSA Butea单精子的GC-MS代谢物分析和计算排序及其对MRSA抗菌活性的预测贡献

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.phytol.2026.104131

Pramod Kumar Mahish , Shweta Singh , Kaushal Kumar Sahu , Dakeshwar Kumar Verma , Gajanan Ghodake , Ravishankar Chauhan , Shushil Kumar Rai , Shailesh Kumar Jadhav

{"title":"GC-MS metabolite profiling and computational ranking of Butea monosperma and their predicted contribution to antimicrobial activity against MRSA","authors":"Pramod Kumar Mahish , Shweta Singh , Kaushal Kumar Sahu , Dakeshwar Kumar Verma , Gajanan Ghodake , Ravishankar Chauhan , Shushil Kumar Rai , Shailesh Kumar Jadhav","doi":"10.1016/j.phytol.2026.104131","DOIUrl":"10.1016/j.phytol.2026.104131","url":null,"abstract":"<div><div>Multi-drug resistance is a critical global health concern, exacerbated by the overuse of antibiotics, particularly during the current pandemic. Among various drug-resistant bacteria, Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to public health. To combat drug-resistant microbes, the scientific community is exploring various strategies. This study investigates potential bioactive compound from Butea monosperma against MRSA. A total of 27 phytochemicals were identified through GC-MS analysis, of which 20 demonstrated interactions with the cell wall-synthesizing and drug resistance-associated STK1 protein of MRSA. Molecular docking studies using the AutoDock program revealed a maximum docking efficiency of −6.7, with hydrogen, alkyl, pi, and sigma bonds being common interaction types between ligands and the target protein. Further evaluation of selected compounds was conducted using the SwissADME program to assess their physicochemical properties, pharmacokinetics, drug-likeness, medicinal chemistry, and water solubility. Bioavailability radar analysis, the boiled egg model, gastrointestinal absorption, and blood-brain barrier penetration studies, followed by the validation of molecules, confirmed that N-[5-(3-Hydroxy-2-methylpropenyl)-1,3,4,5-tetrahydrobenzo[cd]indol-3-yl]-N-methylacetamide, 5-Methoxy-3,7-dihydroxyflavanone, and Dibutyl phthalate were the most promising molecules against MRSA. Further pharmaceutical investigations are required to assess their potential for drug development.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104131"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pesticidal, antibacterial, and cytotoxic alkaloids from Stephania kwangsiensis 王思金娘的杀虫、抗菌和细胞毒性生物碱

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.phytol.2026.104125

Zou Biqun , Zeng Siwen , Nong Yanting , Yang Fanrong , Huang Yucheng , Li Jing , Wang Yafeng , Yang Bingyuan , Liu Zhangbin , Li Guiqin , Li Fangyao , Guo Lunfa , He Ruijie , Huang Yonglin

{"title":"Pesticidal, antibacterial, and cytotoxic alkaloids from Stephania kwangsiensis","authors":"Zou Biqun , Zeng Siwen , Nong Yanting , Yang Fanrong , Huang Yucheng , Li Jing , Wang Yafeng , Yang Bingyuan , Liu Zhangbin , Li Guiqin , Li Fangyao , Guo Lunfa , He Ruijie , Huang Yonglin","doi":"10.1016/j.phytol.2026.104125","DOIUrl":"10.1016/j.phytol.2026.104125","url":null,"abstract":"<div><div>Four previously undescribed alkaloids designated as kwangsine A (1), sinoacutine-O-pulchine (2), 4-hydroxylpalmatrubine (3), and 4-O-methylcolumbamine (4), together with nine known analogues, were isolated from the tubers of Stephania kwangsiensis. The structures of the new compounds (1–4) were elucidated via comprehensive MS and NMR spectroscopic analysis. Their absolute configurations were determined by comparing experimental and calculated ECD spectra or by DFT calculations. Thirty compounds, including the 13 isolates from this study and 17 previously obtained ones, were assessed for pesticidal, antibacterial, and cytotoxic activities. Bioassay results showed that thaicanine N-oxide (23) exhibited strong pesticidal activity against Diaphorina citri, achieving a corrected mortality rate of over 80 % at a concentration of 50 ppm. (6S,6aS,7R)-sukhodianine α-N-oxide (14) exhibited potent antibacterial activity against Bacillus cereus TKL1–3H with an MIC value of 32 μg/mL. Liriodenine (11) showed cytotoxic activity against MCF-7 cells, with IC50 values of 9.68 ± 0.36 μM.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104125"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New oxepin derivatives from Bauhinia saccocalyx stem bark and their tyrosinase inhibitory and antioxidant activities 从紫荆茎皮中提取新的奥塞平衍生物及其酪氨酸酶抑制和抗氧化活性

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1016/j.phytol.2026.104124

Supachai Jadsadajerm, Sutarin Preepram, Natchaya Sawatdirak, Awat Wisetsai

引用次数: 0

Secondary metabolites from the endophytic fungus Hypoxylon sp. HK-37 derived from Aquilaria sinensis 源自沉香的内生真菌HK-37的次生代谢物

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI: 10.1016/j.phytol.2026.104140

Zheng-Zhuo Ren , Kai-Lei He , Fei Wu , Li Yang , Jing-Zhe Yuan , Ze-Sheng Li , Hao-Fu Dai , Wen-Jian Zuo , Hui-Qin Chen

{"title":"Secondary metabolites from the endophytic fungus Hypoxylon sp. HK-37 derived from Aquilaria sinensis","authors":"Zheng-Zhuo Ren , Kai-Lei He , Fei Wu , Li Yang , Jing-Zhe Yuan , Ze-Sheng Li , Hao-Fu Dai , Wen-Jian Zuo , Hui-Qin Chen","doi":"10.1016/j.phytol.2026.104140","DOIUrl":"10.1016/j.phytol.2026.104140","url":null,"abstract":"<div><div>Two new compounds (1 and 2) and one known compound (3) were isolated from the secondary metabolites of endophytic fungus Hypoxylon sp. HK-37 derived from Aquilaria sinensis. Their structures were unambiguously elucidated as 7-ethyl-3,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (1), 3-(2,6-dihydroxy-4-methylphenyl)-7-methoxyisobenzofuran-1(3H)-one (2), and 6-hydroxy-8-methoxy-3-methyl-1H-2-benzopyran-1-one (3) through comprehensive spectroscopic analyses (HR-ESI-MS, 1D/2D NMR), electronic circular dichroism (ECD) calculations, and comparison with their literature comparison. In vitro biological evaluations revealed that compounds 2 and 3 exhibited weak acetylcholinesterase (AChE) inhibitory activity, while compound 1 demonstrated weak α-glucosidase inhibitory potential. However, none of the compounds (1-3) displayed anti-inflammatory effects. This study represents a significant advancement in exploring the secondary metabolites from A. sinensis-derived endophytic fungi, substantially expanding the chemical diversity and bioactivity profiles of this microbial resource.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"72 ","pages":"Article 104140"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular structure of a blue complex pigment from the blue flowers of Salvia patens, protodelphin 来自鼠尾草蓝色花的一种蓝色复合色素的分子结构

IF 1.4 4区生物学

Phytochemistry Letters Pub Date : 2026-04-01 Epub Date: 2026-02-24 DOI: 10.1016/j.phytol.2026.104135

Naohiro Matsugaki , Masaaki Shiono , Tetsuo Kokubun , Renée Jacqueline Grayer , Yoshinori Murai , Tsukasa Iwashina , Kosaku Takeda

引用次数: 0