从栀子花中分离的一对木脂素及其抗炎活性

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-08-11 DOI:10.1016/j.phytol.2025.103034

Chen-Yi Yan , Miao Wang , Yu-Ting Mu , Li-Lian Zhao , Yu-Liang Guo , Wei-Zhen Dong , Yun Deng , Da-Le Guo

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引用次数: 0

摘要

从茉莉香（Trachelospermum jasminoides）中分离得到一对木脂素（±）-9-deoxycedrusin(1)，通过核磁共振（NMR）、高分辨率质量（HRMS）、屏蔽张量和CD曲线的化学计算，对其结构进行了明确的鉴定。化合物(+)-1在浓度为30 μM时通过抑制促炎因子相关基因的表达显示出潜在的抗炎活性。

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A pair of lignans isolated from Trachelospermum jasminoides and their anti-inflammatory activity

A pair of lignans, (±)-9-deoxycedrusin (1), were isolated from Trachelospermum jasminoides, and their structures were unambiguously determined by spectral evidence in nuclear magnetic resonance (NMR), high-resolution mass (HRMS), as well as chemical calculations of shielding tensors and CD curves. Compound (+)-1 showed potential anti-inflammatory activity by inhibiting the expression of pro-inflammatory factor-related genes at a concentration of 30 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.