奎纳塔茎中的新化学成分及其二酰基甘油酰基转移酶抑制活性

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-08-22 DOI:10.1016/j.phytol.2025.103037

Yuan Gao , Ying-Xiao Xiao , Hao Xu , Xue-Feng Wu , Yi-Lin Li , Hyun-Sun Lee , Long Cui

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引用次数: 0

摘要

从秋葵茎中分离到1个新化学成分(1)和10个已知化合物（2 ~ 11）。通过广泛的光谱分析和电子圆二色性（ECD）计算证实了新化合物的结构。所有分离株对DGAT1和DGAT2的体外抑制活性进行了评价。其中，化合物1对DGAT1表现出选择性抑制活性，IC50值为54.1 ± 1.2 μM。

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A novel chemical constituent from the stems of Akebia quinata and its diacylglycerol acyltransferase inhibitory activity

One new chemical constituent (1), together with ten known compounds (2 – 11), was isolated from the stems of Akebia quinata. The structure of the new compound was elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. All the isolates were evaluated for their in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compound 1 exhibited selective inhibitory activity against DGAT1, with an IC₅₀ value of 54.1 ± 1.2 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.